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Volumn 10, Issue 1, 2012, Pages 61-76

Novel agents targeting nitric oxide

Author keywords

Atherosclerosis; Bioavailability; Endothelium; Nitric oxide; Oxidative stress

Indexed keywords

ALPHA TOCOPHEROL; ANGIOTENSIN RECEPTOR ANTAGONIST; ARGININE; ASCORBIC ACID; BRADYKININ; BRADYKININ B2 RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; ESTRADIOL; ESTRADIOL VALERATE; ESTROGEN; FLUINDOSTATIN; FOLIC ACID; HOMOCYSTEINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN SENSITIZING AGENT; N(G),N(G) DIMETHYLARGININE; NICORANDIL; NITRIC OXIDE; NITRIC OXIDE DONOR; PHOSPHATIDYLINOSITOL 3 KINASE; PIOGLITAZONE; PROSTACYCLIN; PROTEIN KINASE B; RHO KINASE; TELMISARTAN; TETRAHYDROBIOPTERIN;

EID: 84857137059     PISSN: 15701611     EISSN: 18756212     Source Type: Journal    
DOI: 10.2174/157016112798829805     Document Type: Article
Times cited : (13)

References (191)
  • 1
    • 0030694038 scopus 로고    scopus 로고
    • Biosynthesis and action of nitric oxide in mammalian cells
    • Mayer B, Hemmens B. Biosynthesis and action of nitric oxide in mammalian cells. Trends Biochem Sci 1997; 22: 477-81.
    • (1997) Trends Biochem Sci , vol.22 , pp. 477-481
    • Mayer, B.1    Hemmens, B.2
  • 2
    • 0032227694 scopus 로고    scopus 로고
    • Enzymology of nitric oxide synthases
    • Hemmens B, Mayer B. Enzymology of nitric oxide synthases. Methods Mol Biol 1998; 100: 1-32.
    • (1998) Methods Mol Biol , vol.100 , pp. 1-32
    • Hemmens, B.1    Mayer, B.2
  • 3
    • 0030988217 scopus 로고    scopus 로고
    • Structure-function aspects in the nitric oxide synthases
    • Stuehr DJ. Structure-function aspects in the nitric oxide synthases. Annu Rev Pharmacol Toxicol 1997; 37: 339-59.
    • (1997) Annu Rev Pharmacol Toxicol , vol.37 , pp. 339-359
    • Stuehr, D.J.1
  • 4
    • 0029914567 scopus 로고    scopus 로고
    • Intra-cellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells
    • Ayajiki K, Kindermann M, Hecker M, Fleming I, Busse R. Intra-cellular pH and tyrosine phosphorylation but not calcium determine shear stress-induced nitric oxide production in native endothelial cells. Circ Res 1996; 78: 750-8.
    • (1996) Circ Res , vol.78 , pp. 750-758
    • Ayajiki, K.1    Kindermann, M.2    Hecker, M.3    Fleming, I.4    Busse, R.5
  • 5
    • 0025114688 scopus 로고
    • The metabolism of L-arginine and its significance for the biosynthesis of endotheliumderived relaxing factor: L-glutamine inhibits the generation of Larginine by cultured endothelial cells
    • Sessa WC, Hecker M, Mitchell JA, Vane JR. The metabolism of L-arginine and its significance for the biosynthesis of endotheliumderived relaxing factor: L-glutamine inhibits the generation of Larginine by cultured endothelial cells. Proc Natl Acad Sci USA 1990; 87: 8607-11.
    • (1990) Proc Natl Acad Sci USA , vol.87 , pp. 8607-8611
    • Sessa, W.C.1    Hecker, M.2    Mitchell, J.A.3    Vane, J.R.4
  • 6
    • 33344471911 scopus 로고    scopus 로고
    • Nitric oxide in coronary artery disease: Effects of antioxidants
    • Tousoulis D, Antoniades C, Stefanadis C. Nitric oxide in coronary artery disease: effects of antioxidants. Eur J Clin Pharmacol 2006; 62: 101-7.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 101-107
    • Tousoulis, D.1    Antoniades, C.2    Stefanadis, C.3
  • 7
    • 33645780634 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase in vascular disease: From marvel to menace
    • Forstermann U, Munzel T. Endothelial nitric oxide synthase in vascular disease: from marvel to menace. Circulation 2006; 113: 1708-14.
    • (2006) Circulation , vol.113 , pp. 1708-1714
    • Forstermann, U.1    Munzel, T.2
  • 9
    • 0022869022 scopus 로고
    • EVect of hypercholesterolemia on vascular reactivity in the rabbit. II. InXuence of treatment with dipyridamole on endothelium-dependent and endothelium-independent responses in isolated aortas of control and hypercholesterolemic rabbits
    • Verbeuren TJ, Coene MC, Jordaens FH, Van Hove CE, Zonnekeyn LL, Herman AG. EVect of hypercholesterolemia on vascular reactivity in the rabbit. II. InXuence of treatment with dipyridamole on endothelium-dependent and endothelium-independent responses in isolated aortas of control and hypercholesterolemic rabbits. Circ Res 1986; 59: 496-504.
    • (1986) Circ Res , vol.59 , pp. 496-504
    • Verbeuren, T.J.1    Coene, M.C.2    Jordaens, F.H.3    van Hove, C.E.4    Zonnekeyn, L.L.5    Herman, A.G.6
  • 10
    • 0029047973 scopus 로고
    • Endogenous nitric oxide in cardiovascular disease and transplantation
    • Dusting GJ, Macdonald PS. Endogenous nitric oxide in cardiovascular disease and transplantation. Ann Med 1995; 27: 395-406.
    • (1995) Ann Med , vol.27 , pp. 395-406
    • Dusting, G.J.1    Macdonald, P.S.2
  • 12
    • 0033535841 scopus 로고    scopus 로고
    • T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm
    • Nakayama M, Yasue H, Yoshimura M, et al. T-786-->C mutation in the 5'-flanking region of the endothelial nitric oxide synthase gene is associated with coronary spasm. Circulation 1999; 99: 2864-70.
    • (1999) Circulation , vol.99 , pp. 2864-2870
    • Nakayama, M.1    Yasue, H.2    Yoshimura, M.3
  • 13
    • 6344257101 scopus 로고    scopus 로고
    • Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease
    • Cattaruzza M, Guzik TJ, Sodowski W, et al. Shear stress insensitivity of endothelial nitric oxide synthase expression as a genetic risk factor for coronary heart disease. Circ Res 2004; 95: 841-7.
    • (2004) Circ Res , vol.95 , pp. 841-847
    • Cattaruzza, M.1    Guzik, T.J.2    Sodowski, W.3
  • 14
    • 7744222619 scopus 로고    scopus 로고
    • Meta-analysis of genetic studies in ischemic stroke: Thirty-two genes involving approximately 18,000 cases and 58,000 controls
    • Casas JP, Hingorani AD, Bautista LE, Sharma P. Meta-analysis of genetic studies in ischemic stroke: thirty-two genes involving approximately 18,000 cases and 58,000 controls. Arch Neurol 2004; 61: 1652-61.
    • (2004) Arch Neurol , vol.61 , pp. 1652-1661
    • Casas, J.P.1    Hingorani, A.D.2    Bautista, L.E.3    Sharma, P.4
  • 15
    • 0038689472 scopus 로고    scopus 로고
    • Endothelial nitric oxide synthase polymorphisms and hypertension
    • Hingorani AD. Endothelial nitric oxide synthase polymorphisms and hypertension. Curr Hypertens Rep 2003; 5: 19-25.
    • (2003) Curr Hypertens Rep , vol.5 , pp. 19-25
    • Hingorani, A.D.1
  • 16
    • 18244410427 scopus 로고    scopus 로고
    • Modifier effect of ENOS in autosomal dominant polycystic kidney disease
    • Persu A, Stoenoiu MS, Messiaen T, et al. Modifier effect of ENOS in autosomal dominant polycystic kidney disease. Hum Mol Genet 2002; 11: 229-41.
    • (2002) Hum Mol Genet , vol.11 , pp. 229-241
    • Persu, A.1    Stoenoiu, M.S.2    Messiaen, T.3
  • 17
    • 11144222283 scopus 로고    scopus 로고
    • Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells
    • McDonald DM, Alp NJ, Channon KM. Functional comparison of the endothelial nitric oxide synthase Glu298Asp polymorphic variants in human endothelial cells. Pharmacogenetics 2004; 14: 831-9.
    • (2004) Pharmacogenetics , vol.14 , pp. 831-839
    • McDonald, D.M.1    Alp, N.J.2    Channon, K.M.3
  • 18
    • 0035932773 scopus 로고    scopus 로고
    • Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis
    • Guzik TJ, Black E, West NE, et al. Relationship between the G894T polymorphism (Glu298Asp variant) in endothelial nitric oxide synthase and nitric oxide-mediated endothelial function in human atherosclerosis. Am J Med Genet 2001; 100: 130-7.
    • (2001) Am J Med Genet , vol.100 , pp. 130-137
    • Guzik, T.J.1    Black, E.2    West, N.E.3
  • 19
    • 2942577486 scopus 로고    scopus 로고
    • Cardiovascular biology of the asymmetric dimethylarginine:Dimethylarginine dimethylaminohydrolase pathway
    • Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 2004; 24: 1023-30.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1023-1030
    • Vallance, P.1    Leiper, J.2
  • 20
    • 0141645386 scopus 로고    scopus 로고
    • Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells
    • Jones LC, Tran CT, Leiper JM, Hingorani AD, Vallance P. Common genetic variation in a basal promoter element alters DDAH2 expression in endothelial cells. Biochem Biophys Res Commun 2003; 310: 836-43.
    • (2003) Biochem Biophys Res Commun , vol.310 , pp. 836-843
    • Jones, L.C.1    Tran, C.T.2    Leiper, J.M.3    Hingorani, A.D.4    Vallance, P.5
  • 21
    • 1542283780 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
    • Alp NJ, Channon KM. Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler Thromb Vasc Biol 2004; 24: 413-20.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 413-420
    • Alp, N.J.1    Channon, K.M.2
  • 22
    • 17644412023 scopus 로고    scopus 로고
    • Inflammation, atherosclerosis, and coronary artery disease
    • Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med 2005; 352: 1685-95.
    • (2005) N Engl J Med , vol.352 , pp. 1685-1695
    • Hansson, G.K.1
  • 23
    • 33745571976 scopus 로고    scopus 로고
    • The immune response in atherosclerosis: A double-edged sword
    • Hansson GK, Libby P. The immune response in atherosclerosis: a double-edged sword. Nat Rev Immunol 2006; 6: 508-19.
    • (2006) Nat Rev Immunol , vol.6 , pp. 508-519
    • Hansson, G.K.1    Libby, P.2
  • 24
    • 0037180771 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis
    • Libby P. Inflammation in atherosclerosis. Nature 2002; 420: 868-74.
    • (2002) Nature , vol.420 , pp. 868-874
    • Libby, P.1
  • 25
    • 52949118482 scopus 로고    scopus 로고
    • The multifaceted contributions of leukocyte subsets to atherosclerosis: Lessons from mouse models
    • Weber C, Zernecke A, Libby P. The multifaceted contributions of leukocyte subsets to atherosclerosis: lessons from mouse models. Nat Rev Immunol 2008; 8: 802-15.
    • (2008) Nat Rev Immunol , vol.8 , pp. 802-815
    • Weber, C.1    Zernecke, A.2    Libby, P.3
  • 26
    • 0034769118 scopus 로고    scopus 로고
    • Nitric oxide and the immune response
    • Bogdan C. Nitric oxide and the immune response. Nat Immunol 2001; 2: 907-16.
    • (2001) Nat Immunol , vol.2 , pp. 907-916
    • Bogdan, C.1
  • 29
    • 33645470326 scopus 로고    scopus 로고
    • Threshold effects of nitric oxideinduced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells
    • Li CQ, Pang B, Kiziltepe T, et al. Threshold effects of nitric oxideinduced toxicity and cellular responses in wild-type and p53-null human lymphoblastoid cells. Chem Res Toxicol 2006; 19: 399-406.
    • (2006) Chem Res Toxicol , vol.19 , pp. 399-406
    • Li, C.Q.1    Pang, B.2    Kiziltepe, T.3
  • 31
    • 33646055216 scopus 로고    scopus 로고
    • The role of oxidants and free radicals in reperfusion injury
    • Zweier JL, Talukder MA. The role of oxidants and free radicals in reperfusion injury. Cardiovasc Res 2006; 70: 181-90.
    • (2006) Cardiovasc Res , vol.70 , pp. 181-190
    • Zweier, J.L.1    Talukder, M.A.2
  • 32
    • 38049113170 scopus 로고    scopus 로고
    • Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells
    • Stellos K, Langer H, Daub K, et al. Platelet-derived stromal cell-derived factor-1 regulates adhesion and promotes differentiation of human CD34+ cells to endothelial progenitor cells. Circulation 2008; 117: 206-15.
    • (2008) Circulation , vol.117 , pp. 206-215
    • Stellos, K.1    Langer, H.2    Daub, K.3
  • 33
    • 33646003861 scopus 로고    scopus 로고
    • Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells
    • Tarzami ST, Wang G, Li W, Green L, Singh JP. Thrombin and PAR-1 stimulate differentiation of bone marrow-derived endothelial progenitor cells. J Thromb Haemost 2006; 4: 656-63.
    • (2006) J Thromb Haemost , vol.4 , pp. 656-663
    • Tarzami, S.T.1    Wang, G.2    Li, W.3    Green, L.4    Singh, J.P.5
  • 34
    • 15744392514 scopus 로고    scopus 로고
    • Stimulation of endothelial progenitor cells: A new putative therapeutic effect of angiotensin II receptor antagonists
    • Bahlmann FH, de Groot K, Mueller O, Hertel B, Haller H, Fliser D. Stimulation of endothelial progenitor cells: a new putative therapeutic effect of angiotensin II receptor antagonists. Hypertension 2005; 45: 526-9.
    • (2005) Hypertension , vol.45 , pp. 526-529
    • Bahlmann, F.H.1    de Groot, K.2    Mueller, O.3    Hertel, B.4    Haller, H.5    Fliser, D.6
  • 35
    • 4544289556 scopus 로고    scopus 로고
    • Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia
    • Chen JZ, Zhang FR, Tao QM, et al. Number and activity of endothelial progenitor cells from peripheral blood in patients with hypercholesterolaemia. Clin Sci (Lond.) 2004; 107: 273-80.
    • (2004) Clin Sci (Lond.) , vol.107 , pp. 273-280
    • Chen, J.Z.1    Zhang, F.R.2    Tao, Q.M.3
  • 36
    • 34249696575 scopus 로고    scopus 로고
    • High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms
    • Chen YH, Lin SJ, Lin FY, et al. High glucose impairs early and late endothelial progenitor cells by modifying nitric oxide-related but not oxidative stress-mediated mechanisms. Diabetes 2007; 56: 1559-68.
    • (2007) Diabetes , vol.56 , pp. 1559-1568
    • Chen, Y.H.1    Lin, S.J.2    Lin, F.Y.3
  • 37
    • 16244403059 scopus 로고    scopus 로고
    • Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis
    • Laufs U, Wassmann S, Czech T, et al. Physical inactivity increases oxidative stress, endothelial dysfunction, and atherosclerosis. Arterioscler Thromb Vasc Biol 2005; 25: 809-14.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 809-814
    • Laufs, U.1    Wassmann, S.2    Czech, T.3
  • 38
    • 79958833427 scopus 로고    scopus 로고
    • Nitric oxide: A key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2
    • Hamed S, Brenner B,Roguin A. Nitric oxide: a key factor behind the dysfunctionality of endothelial progenitor cells in diabetes mellitus type-2. Cardiovasc Res 2011; 91: 9-15.
    • (2011) Cardiovasc Res , vol.91 , pp. 9-15
    • Hamed, S.1    Brenner, B.2    Roguin, A.3
  • 39
    • 15844378434 scopus 로고    scopus 로고
    • Evaluating endothelial function in humans: A guide to invasive and non-invasive techniques
    • Tousoulis D, Antoniades C, Stefanadis C. Evaluating endothelial function in humans: a guide to invasive and non-invasive techniques. Heart 2005; 91: 553-8.
    • (2005) Heart , vol.91 , pp. 553-558
    • Tousoulis, D.1    Antoniades, C.2    Stefanadis, C.3
  • 40
    • 0037031266 scopus 로고    scopus 로고
    • Prognostic value of coronary vascular endothelial dysfunction
    • Halcox JP, Schenke WH, Zalos G, et al. Prognostic value of coronary vascular endothelial dysfunction. Circulation 2002; 106: 653-8.
    • (2002) Circulation , vol.106 , pp. 653-658
    • Halcox, J.P.1    Schenke, W.H.2    Zalos, G.3
  • 41
    • 23044511501 scopus 로고    scopus 로고
    • Carotid artery intimal medial thickness, brachial artery flow-mediated vasodilation and cardiovascular risk factors in diabetic and non-diabetic indigenous Australians
    • Chan L, Shaw AG, Busfield F, et al. Carotid artery intimal medial thickness, brachial artery flow-mediated vasodilation and cardiovascular risk factors in diabetic and non-diabetic indigenous Australians. Atherosclerosis 2005; 180: 319-26.
    • (2005) Atherosclerosis , vol.180 , pp. 319-326
    • Chan, L.1    Shaw, A.G.2    Busfield, F.3
  • 42
    • 24944494906 scopus 로고    scopus 로고
    • Prognostic value of brachial artery endothelial function and wall thickness
    • Frick M, Suessenbacher A, Alber HF, et al. Prognostic value of brachial artery endothelial function and wall thickness. J Am Coll Cardiol 2005; 46: 1006-10.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1006-1010
    • Frick, M.1    Suessenbacher, A.2    Alber, H.F.3
  • 43
    • 0242349754 scopus 로고    scopus 로고
    • Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: Additive value of flow-mediated dilation to ankle-brachial pressure index
    • Brevetti G, Silvestro A, Schiano V, Chiariello M. Endothelial dysfunction and cardiovascular risk prediction in peripheral arterial disease: additive value of flow-mediated dilation to ankle-brachial pressure index. Circulation 2003; 108: 17, 2093-8.
    • (2003) Circulation , vol.108 , Issue.17 , pp. 2093-2098
    • Brevetti, G.1    Silvestro, A.2    Schiano, V.3    Chiariello, M.4
  • 44
    • 1842850657 scopus 로고    scopus 로고
    • Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy
    • Tentolouris C, Tousoulis D, Antoniades C, et al. Endothelial function and proinflammatory cytokines in patients with ischemic heart disease and dilated cardiomyopathy. Int J Cardiol 2004; 94: 301-5.
    • (2004) Int J Cardiol , vol.94 , pp. 301-305
    • Tentolouris, C.1    Tousoulis, D.2    Antoniades, C.3
  • 45
    • 17044427138 scopus 로고    scopus 로고
    • Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure
    • Tousoulis D, Charakida M, Stefanadis C. Inflammation and endothelial dysfunction as therapeutic targets in patients with heart failure. Int J Cardiol 2005; 100; 347-53.
    • (2005) Int J Cardiol , vol.100 , pp. 347-353
    • Tousoulis, D.1    Charakida, M.2    Stefanadis, C.3
  • 46
    • 24944461146 scopus 로고    scopus 로고
    • Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: Comparison with B-type natriuretic peptide
    • Meyer B, Mortl D, Strecker K, et al. Flow-mediated vasodilation predicts outcome in patients with chronic heart failure: comparison with B-type natriuretic peptide. J Am Coll Cardiol 2005; 46: 1011-8.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1011-1018
    • Meyer, B.1    Mortl, D.2    Strecker, K.3
  • 47
    • 0042234294 scopus 로고    scopus 로고
    • The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease
    • Chan SY, Mancini GB, Kuramoto L, Schulzer M, Frohlich J, Ignaszewski A. The prognostic importance of endothelial dysfunction and carotid atheroma burden in patients with coronary artery disease. J Am Coll Cardiol 2003; 42: 1037-43.
    • (2003) J Am Coll Cardiol , vol.42 , pp. 1037-1043
    • Chan, S.Y.1    Mancini, G.B.2    Kuramoto, L.3    Schulzer, M.4    Frohlich, J.5    Ignaszewski, A.6
  • 48
    • 34247144576 scopus 로고    scopus 로고
    • The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort
    • Shimbo D, Grahame-Clarke C, Miyake Y, et al. The association between endothelial dysfunction and cardiovascular outcomes in a population-based multi-ethnic cohort. Atherosclerosis 2006; 192: 197-203.
    • (2006) Atherosclerosis , vol.192 , pp. 197-203
    • Shimbo, D.1    Grahame-Clarke, C.2    Miyake, Y.3
  • 49
    • 0028784717 scopus 로고
    • Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle
    • Hashimoto M, Akishita M, Eto M, et al. Modulation of endothelium-dependent flow-mediated dilatation of the brachial artery by sex and menstrual cycle. Circulation 1995; 92: 3431-5.
    • (1995) Circulation , vol.92 , pp. 3431-3435
    • Hashimoto, M.1    Akishita, M.2    Eto, M.3
  • 50
    • 0032920067 scopus 로고    scopus 로고
    • Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation
    • Dørup I, Skajaa K, Sørensen KE. Normal pregnancy is associated with enhanced endothelium-dependent flow-mediated vasodilation. Am J Physiol 1999; 276: H821-5.
    • (1999) Am J Physiol , vol.276 , pp. 821-825
    • Dørup, I.1    Skajaa, K.2    Sørensen, K.E.3
  • 53
    • 0028358749 scopus 로고
    • Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women
    • Gilligan DM, Quyyumi AA, Cannon III, RO. Effects of physiological levels of estrogen on coronary vasomotor function in postmenopausal women. Circulation 1994; 89: 2545-51.
    • (1994) Circulation , vol.89 , pp. 2545-2551
    • Gilligan, D.M.1    Quyyumi, A.A.2    Cannon III, R.O.3
  • 54
    • 0031951052 scopus 로고    scopus 로고
    • Short-term effects of transdermal estrogen replacement therapy on coronary vascular reactivity in postmenopausal women with angina pectoris and normal results on coronary angiograms
    • Roqué M, Heras M, Roig E, et al. Short-term effects of transdermal estrogen replacement therapy on coronary vascular reactivity in postmenopausal women with angina pectoris and normal results on coronary angiograms. J Am Coll Cardiol 1998; 31: 139-43.
    • (1998) J Am Coll Cardiol , vol.31 , pp. 139-143
    • Roqué, M.1    Heras, M.2    Roig, E.3
  • 55
    • 0028076232 scopus 로고
    • Estrogen improves endothelium-dependent flow-mediated vasodilation in postmenopausal women
    • Lieberman EH, Gerhard MD, Uehata A, et al. Estrogen improves endothelium-dependent flow-mediated vasodilation in postmenopausal women. Ann Intern Med 1994; 121: 936-41.
    • (1994) Ann Intern Med , vol.121 , pp. 936-941
    • Lieberman, E.H.1    Gerhard, M.D.2    Uehata, A.3
  • 56
    • 33749593535 scopus 로고    scopus 로고
    • Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women
    • Ho JYP, Chen MJ, Sheu WHH, et al. Differential effects of oral conjugated equine estrogen and transdermal estrogen on atherosclerotic vascular disease risk markers and endothelial function in healthy postmenopausal women. Hum Reprod 2006; 21: 2715-20.
    • (2006) Hum Reprod , vol.21 , pp. 2715-2720
    • Ho, J.Y.P.1    Chen, M.J.2    Sheu, W.H.H.3
  • 57
    • 0028909159 scopus 로고
    • Effects of estrogen replacement therapy on peripheral vasomotor function in postmenopausal women
    • Gilligan DM, Badar DM, Panza JA, Quyyumi AA, Cannon III RO. Effects of estrogen replacement therapy on peripheral vasomotor function in postmenopausal women. Am J Cardiol 1995; 75: 264-8.
    • (1995) Am J Cardiol , vol.75 , pp. 264-268
    • Gilligan, D.M.1    Badar, D.M.2    Panza, J.A.3    Quyyumi, A.A.4    Cannon III, R.O.5
  • 58
    • 0001447433 scopus 로고    scopus 로고
    • Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women
    • Koh KK, Cardillo C, Bui MN, et al. Vascular effects of estrogen and cholesterol-lowering therapies in hypercholesterolemic postmenopausal women. Circulation 1999; 99: 354-60.
    • (1999) Circulation , vol.99 , pp. 354-360
    • Koh, K.K.1    Cardillo, C.2    Bui, M.N.3
  • 59
    • 0035499012 scopus 로고    scopus 로고
    • Vascular effects of estrogen in type II diabetic postmenopausal women
    • Koh KK, Kang MH, Jin DK, et al. Vascular effects of estrogen in type II diabetic postmenopausal women. J Am Coll Cardiol 2001; 38: 1409-15.
    • (2001) J Am Coll Cardiol , vol.38 , pp. 1409-1415
    • Koh, K.K.1    Kang, M.H.2    Jin, D.K.3
  • 60
    • 0035901620 scopus 로고    scopus 로고
    • Vascular effects of synthetic or natural progestagen combined with conjugated equine estrogen in healthy postmenopausal women
    • Koh KK, Jin DK, Yang SH, et al. Vascular effects of synthetic or natural progestagen combined with conjugated equine estrogen in healthy postmenopausal women. Circulation 2001; 103: 1961-6.
    • (2001) Circulation , vol.103 , pp. 1961-1966
    • Koh, K.K.1    Jin, D.K.2    Yang, S.H.3
  • 61
    • 0035861504 scopus 로고    scopus 로고
    • Effect of estradiol alone or in combination with cyproterone acetate upon vascular function of postmenopausal women at increased risk for cardiovascular disease
    • Vitale C, Fini M, Leonardo F, et al. Effect of estradiol alone or in combination with cyproterone acetate upon vascular function of postmenopausal women at increased risk for cardiovascular disease. Maturitas 2001; 40: 239-45.
    • (2001) Maturitas , vol.40 , pp. 239-245
    • Vitale, C.1    Fini, M.2    Leonardo, F.3
  • 62
    • 1542313936 scopus 로고    scopus 로고
    • Effect of lower dosage of oral conjugated equine estrogen on inflammatory markers and endothelial function in healthy postmenopausal women
    • Wakatsuki A, Ikenoue N, Shinohara K, Watanabe K, Fukaya T. Effect of lower dosage of oral conjugated equine estrogen on inflammatory markers and endothelial function in healthy postmenopausal women. Arterioscler Thromb Vasc Biol 2004; 24: 571-6.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 571-576
    • Wakatsuki, A.1    Ikenoue, N.2    Shinohara, K.3    Watanabe, K.4    Fukaya, T.5
  • 64
    • 38549103844 scopus 로고    scopus 로고
    • Time since menopause influences the acute and chronic effect of estrogens on endothelial function
    • Vitale C, Mercuro G, Cerquetani E, et al. Time since menopause influences the acute and chronic effect of estrogens on endothelial function. Arterioscler Thromb Vasc Biol 2008; 28: 348-52.
    • (2008) Arterioscler Thromb Vasc Biol , vol.28 , pp. 348-352
    • Vitale, C.1    Mercuro, G.2    Cerquetani, E.3
  • 66
    • 4043056380 scopus 로고    scopus 로고
    • Impaired endothelial function in young women with premature ovarian failure: Normalization with hormone therapy
    • Kalantaridou SN, Naka KK, Kalantaridou E, et al. Impaired endothelial function in young women with premature ovarian failure: normalization with hormone therapy. J Clin Endocrinol Metab 2004; 89: 3907-13.
    • (2004) J Clin Endocrinol Metab , vol.89 , pp. 3907-3913
    • Kalantaridou, S.N.1    Naka, K.K.2    Kalantaridou, E.3
  • 67
    • 0036045503 scopus 로고    scopus 로고
    • Effects of estrogen on the vascular wall: Vasomotor function and inflammation
    • Koh KK. Effects of estrogen on the vascular wall: vasomotor function and inflammation. Cardiovasc Res 2002; 55: 714-26.
    • (2002) Cardiovasc Res , vol.55 , pp. 714-726
    • Koh, K.K.1
  • 68
    • 0036798936 scopus 로고    scopus 로고
    • Estrogen modulation of endothelial nitric oxide synthase
    • Chambliss KL, Shaul PW. Estrogen modulation of endothelial nitric oxide synthase. Endocr Rev 2002; 23: 665-86.
    • (2002) Endocr Rev , vol.23 , pp. 665-686
    • Chambliss, K.L.1    Shaul, P.W.2
  • 69
    • 0022648118 scopus 로고
    • Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis
    • Newman WP, III, Freedman DS, Voors AW, et al. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study N Engl J Med. 1986; 314: 138-44.
    • (1986) The Bogalusa Heart Study N Engl J Med , vol.314 , pp. 138-144
    • Newman III, W.P.1    Freedman, D.S.2    Voors, A.W.3
  • 70
    • 0036344065 scopus 로고    scopus 로고
    • Elevated serum C-reactive protein levels and early arterial changes in healthy children
    • Jarvisalo MJ, Harmoinen A, Hakanen M, et al. Elevated serum C-reactive protein levels and early arterial changes in healthy children. Arterioscler Thromb Vasc Biol 2002; 22: 1323-8.
    • (2002) Arterioscler Thromb Vasc Biol , vol.22 , pp. 1323-1328
    • Jarvisalo, M.J.1    Harmoinen, A.2    Hakanen, M.3
  • 72
    • 21844475888 scopus 로고    scopus 로고
    • Early structural and functional changes of the vasculature in HIV-infected children: Impact of disease and antiretroviral therapy
    • Charakida M, Donald AE, Green H, et al. Early structural and functional changes of the vasculature in HIV-infected children: impact of disease and antiretroviral therapy. Circulation 2005; 112: 103-9.
    • (2005) Circulation , vol.112 , pp. 103-109
    • Charakida, M.1    Donald, A.E.2    Green, H.3
  • 73
    • 2342581610 scopus 로고    scopus 로고
    • Arterial stiffness and endothelial dysfunction in HIV-infected children
    • Bonnet D, Aggoun Y, Szezepanski I, Bellal N, Blanche S. Arterial stiffness and endothelial dysfunction in HIV-infected children. AIDS 2004; 18: 1037-41.
    • (2004) AIDS , vol.18 , pp. 1037-1041
    • Bonnet, D.1    Aggoun, Y.2    Szezepanski, I.3    Bellal, N.4    Blanche, S.5
  • 74
    • 77955380366 scopus 로고    scopus 로고
    • Assessment of endothelial function as a marker of cardio-vascular risk in patients with rheumatoid arthritis
    • Khan F. Assessment of endothelial function as a marker of cardio-vascular risk in patients with rheumatoid arthritis. Int J Rheum Dis 2010; 13: 189-95.
    • (2010) Int J Rheum Dis , vol.13 , pp. 189-195
    • Khan, F.1
  • 75
    • 0036792545 scopus 로고    scopus 로고
    • Evaluation by high-resolution ultrasonography of endothelial function in brachial artery after Kawasaki disease and the effects of intravenous administration of vitamin C
    • Deng YB, Xiang HJ, Chang Q, Li CL. Evaluation by high-resolution ultrasonography of endothelial function in brachial artery after Kawasaki disease and the effects of intravenous administration of vitamin C. Circ J 2002; 66: 908-12.
    • (2002) Circ J , vol.66 , pp. 908-912
    • Deng, Y.B.1    Xiang, H.J.2    Chang, Q.3    Li, C.L.4
  • 76
    • 0027255291 scopus 로고
    • Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents
    • Celermajer DS, Sorensen K, Ryalls M, et al. Impaired endothelial function occurs in the systemic arteries of children with homozygous homocystinuria but not in their heterozygous parents. J Am Coll Cardiol 1993; 22: 854-8.
    • (1993) J Am Coll Cardiol , vol.22 , pp. 854-858
    • Celermajer, D.S.1    Sorensen, K.2    Ryalls, M.3
  • 77
    • 0037117657 scopus 로고    scopus 로고
    • Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure?
    • Bennett-Richards K, Kattenhorn M, Donald A, et al. Does oral folic acid lower total homocysteine levels and improve endothelial function in children with chronic renal failure? Circulation 2002; 105: 1810-5.
    • (2002) Circulation , vol.105 , pp. 1810-1815
    • Bennett-Richards, K.1    Kattenhorn, M.2    Donald, A.3
  • 78
    • 0036378157 scopus 로고    scopus 로고
    • Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure
    • Bennett-Richards KJ, Kattenhorn M, Donald AE, et al. Oral L-arginine does not improve endothelial dysfunction in children with chronic renal failure. Kidney Int 2002; 62: 1372-8.
    • (2002) Kidney Int , vol.62 , pp. 1372-1378
    • Bennett-Richards, K.J.1    Kattenhorn, M.2    Donald, A.E.3
  • 79
    • 8544247899 scopus 로고    scopus 로고
    • Physiology and biochemistry of endothelial function in children with chronic renal failure
    • Kari JA, Donald AE, Vallance DT, et al. Physiology and biochemistry of endothelial function in children with chronic renal failure. Kidney Int 1997; 52: 468-72.
    • (1997) Kidney Int , vol.52 , pp. 468-472
    • Kari, J.A.1    Donald, A.E.2    Vallance, D.T.3
  • 80
    • 0030831087 scopus 로고    scopus 로고
    • Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease
    • Clarkson P, Celermajer DS, Powe AJ, Donald AE, Henry RM, Deanfield JE. Endothelium-dependent dilatation is impaired in young healthy subjects with a family history of premature coronary disease. Circulation 1997; 96: 3378-83.
    • (1997) Circulation , vol.96 , pp. 3378-3383
    • Clarkson, P.1    Celermajer, D.S.2    Powe, A.J.3    Donald, A.E.4    Henry, R.M.5    Deanfield, J.E.6
  • 81
    • 0036016003 scopus 로고    scopus 로고
    • Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia
    • de Jongh S, Lilien MR, Bakker HD, Hutten BA, Kastelein JJ, Stroes ES. Family history of cardiovascular events and endothelial dysfunction in children with familial hypercholesterolemia. Atherosclerosis 2002; 163: 193-7.
    • (2002) Atherosclerosis , vol.163 , pp. 193-197
    • de Jongh, S.1    Lilien, M.R.2    Bakker, H.D.3    Hutten, B.A.4    Kastelein, J.J.5    Stroes, E.S.6
  • 82
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000; 6: 1004-10.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3
  • 83
    • 33845707278 scopus 로고    scopus 로고
    • Statins activate AMP-activated protein kinase in vitro and in vivo
    • Sun W, Lee TS, Zhu M, et al. Statins activate AMP-activated protein kinase in vitro and in vivo. Circulation 2006; 114: 2655-62.
    • (2006) Circulation , vol.114 , pp. 2655-2662
    • Sun, W.1    Lee, T.S.2    Zhu, M.3
  • 84
    • 0032508533 scopus 로고    scopus 로고
    • Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase
    • Laufs U, Liao JK. Post-transcriptional regulation of endothelial nitric oxide synthase mRNA stability by Rho GTPase. J Biol Chem 1998; 273: 24266-71.
    • (1998) J Biol Chem , vol.273 , pp. 24266-24271
    • Laufs, U.1    Liao, J.K.2
  • 85
    • 79960026090 scopus 로고    scopus 로고
    • Molecular mechanism of vasorelaxant and antiatherogenic effects of the statins in the human saphenous vein graft
    • Yaktubay Döndaş N, Sucu N, Coşkun Yilmaz B, et al. Molecular mechanism of vasorelaxant and antiatherogenic effects of the statins in the human saphenous vein graft. Eur J Pharmacol 2011; 666: 150-7.
    • (2011) Eur J Pharmacol , vol.666 , pp. 150-157
    • Yaktubay Döndaş, N.1    Sucu, N.2    Coşkun Yilmaz, B.3
  • 86
    • 79957732380 scopus 로고    scopus 로고
    • Acute modulation of vasoconstrictor responses by pravastatin in small vessels
    • Ghaffari N, Ball C, Kennedy JA, Stafford I, Beltrame JF. Acute modulation of vasoconstrictor responses by pravastatin in small vessels. Circ J 2011;75: 1506-14.
    • (2011) Circ J , vol.75 , pp. 1506-1514
    • Ghaffari, N.1    Ball, C.2    Kennedy, J.A.3    Stafford, I.4    Beltrame, J.F.5
  • 87
    • 80052226689 scopus 로고    scopus 로고
    • Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells
    • Mangialardi G, Monopoli A, Ongini E, et al. Nitric oxide-donating statin improves multiple functions of circulating angiogenic cells. Br J Pharmacol 2011; 164: 570-83.
    • (2011) Br J Pharmacol , vol.164 , pp. 570-583
    • Mangialardi, G.1    Monopoli, A.2    Ongini, E.3
  • 88
    • 84655162686 scopus 로고    scopus 로고
    • Conflicting effects of nitric oxide and oxidative stress in chronic heart failure: Potential therapeutic strategies
    • Feb 4 [Epub ahead of print
    • Tousoulis D, Papageorgiou N, Briasoulis A, et al. Conflicting effects of nitric oxide and oxidative stress in chronic heart failure: potential therapeutic strategies. Heart Fail Rev 2011 Feb 4 [Epub ahead of print].
    • (2011) Heart Fail Rev
    • Tousoulis, D.1    Papageorgiou, N.2    Briasoulis, A.3
  • 89
    • 82655189971 scopus 로고    scopus 로고
    • Beneficial vasoactive endothelial effects of fluvastatin: Focus on prostacyclin and nitric oxide
    • Jan 7 [Epub ahead of print
    • Skogastierna C, Luksha L, Kublickiene K, Eliasson E, Rane A, Ekström L. Beneficial vasoactive endothelial effects of fluvastatin: focus on prostacyclin and nitric oxide. Heart Vessels 2011 Jan 7 [Epub ahead of print].
    • (2011) Heart Vessels
    • Skogastierna, C.1    Luksha, L.2    Kublickiene, K.3    Eliasson, E.4    Rane, A.5    Ekström, L.6
  • 90
    • 27644544308 scopus 로고    scopus 로고
    • Pleiotropic effects of statins: Benefit beyond cholesterol reduction? A metaregression analysis
    • Robinson JG, Smith B, Maheshwari N, Schrott H. Pleiotropic effects of statins: benefit beyond cholesterol reduction? A metaregression analysis. J Am Coll Cardiol 2005; 46: 1855-62.
    • (2005) J Am Coll Cardiol , vol.46 , pp. 1855-1862
    • Robinson, J.G.1    Smith, B.2    Maheshwari, N.3    Schrott, H.4
  • 91
    • 33646173813 scopus 로고    scopus 로고
    • Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: A meta-analysis of randomized controlled trials
    • Briel M, Schwartz GG, Thompson PL, et al. Effects of early treatment with statins on short-term clinical outcomes in acute coronary syndromes: a meta-analysis of randomized controlled trials. JAMA 2006; 295: 2046-56.
    • (2006) JAMA , vol.295 , pp. 2046-2056
    • Briel, M.1    Schwartz, G.G.2    Thompson, P.L.3
  • 92
    • 2942720651 scopus 로고    scopus 로고
    • Use of statins prior to percutaneous coronary intervention reduces myonecrosis and improves clinical outcome
    • Chang SM, Yazbek N, Lakkis NM. Use of statins prior to percutaneous coronary intervention reduces myonecrosis and improves clinical outcome. Catheter Cardiovasc Interv 2004; 62: 193-7.
    • (2004) Catheter Cardiovasc Interv , vol.62 , pp. 193-197
    • Chang, S.M.1    Yazbek, N.2    Lakkis, N.M.3
  • 93
    • 55749103045 scopus 로고    scopus 로고
    • Statins and nitric oxide production against ischemic stroke
    • Tsuda K. Statins and nitric oxide production against ischemic stroke. Stroke 2008; 39: e170.
    • (2008) Stroke , vol.39
    • Tsuda, K.1
  • 94
    • 0033210904 scopus 로고    scopus 로고
    • State-of-the-Art lecture. Statins and blockers of the renin-angiotensin system: Vascular protection beyond their primary mode of action
    • Faggiotto A, Paoletti R. State-of-the-Art lecture. Statins and blockers of the renin-angiotensin system: vascular protection beyond their primary mode of action. Hypertension 1999; 34: 987-96.
    • (1999) Hypertension , vol.34 , pp. 987-996
    • Faggiotto, A.1    Paoletti, R.2
  • 95
    • 9444280103 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing ENdothelial Dysfunction) Study
    • Mancini GB, Henry GC, Macaya C, et al. Angiotensin-converting enzyme inhibition with quinapril improves endothelial vasomotor dysfunction in patients with coronary artery disease. The TREND (Trial on Reversing ENdothelial Dysfunction) Study. Circulation 1996; 94: 258-65.
    • (1996) Circulation , vol.94 , pp. 258-265
    • Mancini, G.B.1    Henry, G.C.2    Macaya, C.3
  • 96
    • 80052595412 scopus 로고    scopus 로고
    • Effects of antihypertensive treatment on endothelial function
    • Virdis A, Ghiadoni L, Taddei S. Effects of antihypertensive treatment on endothelial function. Curr Hypertens Rep 2011; 13: 276-81.
    • (2011) Curr Hypertens Rep , vol.13 , pp. 276-281
    • Virdis, A.1    Ghiadoni, L.2    Taddei, S.3
  • 98
    • 77951621873 scopus 로고    scopus 로고
    • Expressions of inducible nitric oxide synthase and cyclooxygenase-2 in gastric ischemia-reperfusion: Role of angiotensin II
    • Gemici B, Tan R, Ongüt G, Izgüt-Uysal VN. Expressions of inducible nitric oxide synthase and cyclooxygenase-2 in gastric ischemia-reperfusion: role of angiotensin II. J Surg Res 2010; 161: 126-33.
    • (2010) J Surg Res , vol.161 , pp. 126-133
    • Gemici, B.1    Tan, R.2    Ongüt, G.3    Izgüt-Uysal, V.N.4
  • 99
    • 73849116443 scopus 로고    scopus 로고
    • Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries
    • Cousin M, Custaud MA, Baron-Menguy C, et al. Role of angiotensin II in the remodeling induced by a chronic increase in flow in rat mesenteric resistance arteries. Hypertension 2010; 55: 109-15.
    • (2010) Hypertension , vol.55 , pp. 109-115
    • Cousin, M.1    Custaud, M.A.2    Baron-Menguy, C.3
  • 100
    • 58249108732 scopus 로고    scopus 로고
    • Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus
    • Ritt M, Ott C, Raff U, et al. Renal vascular endothelial function in hypertensive patients with type 2 diabetes mellitus. Am J Kidney Dis 2009; 53: 281-9.
    • (2009) Am J Kidney Dis , vol.53 , pp. 281-289
    • Ritt, M.1    Ott, C.2    Raff, U.3
  • 101
    • 34249869003 scopus 로고    scopus 로고
    • Impact of telmisartan vs. ramipril on renal endothelial function in patients with hypertension and type 2 diabetes
    • Schmieder RE, Delles C, Mimran A, Fauvel JP, Ruilope LM. Impact of telmisartan vs. ramipril on renal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care 2007; 30: 1351-6.
    • (2007) Diabetes Care , vol.30 , pp. 1351-1356
    • Schmieder, R.E.1    Delles, C.2    Mimran, A.3    Fauvel, J.P.4    Ruilope, L.M.5
  • 102
    • 0033133528 scopus 로고    scopus 로고
    • Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus
    • O'Driscoll G, Green D, Maiorana A, Stanton K, Colreavy F, Taylor R. Improvement in endothelial function by angiotensin-converting enzyme inhibition in non-insulin-dependent diabetes mellitus. J Am Coll Cardiol 1999; 33: 1506-11.
    • (1999) J Am Coll Cardiol , vol.33 , pp. 1506-1511
    • O'Driscoll, G.1    Green, D.2    Maiorana, A.3    Stanton, K.4    Colreavy, F.5    Taylor, R.6
  • 103
    • 33748682592 scopus 로고    scopus 로고
    • Increased cardiac endothelial nitric oxide synthase expression in patients taking angiotensin-converting enzyme inhibitor therapy
    • Morawietz H, Rohrbach S, Rueckschloss U, et al. Increased cardiac endothelial nitric oxide synthase expression in patients taking angiotensin-converting enzyme inhibitor therapy. Eur J Clin Invest 2006; 36: 705-12.
    • (2006) Eur J Clin Invest , vol.36 , pp. 705-712
    • Morawietz, H.1    Rohrbach, S.2    Rueckschloss, U.3
  • 104
    • 0029977757 scopus 로고    scopus 로고
    • Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance
    • Steinberg HO, Chaker H, Leaming R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction. Implications for the syndrome of insulin resistance. J Clin Invest 1996; 97: 2601-10.
    • (1996) J Clin Invest , vol.97 , pp. 2601-2610
    • Steinberg, H.O.1    Chaker, H.2    Leaming, R.3    Johnson, A.4    Brechtel, G.5    Baron, A.D.6
  • 105
    • 0032847680 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction
    • Jackson SM, Parhami F, Xi XP, et al. Peroxisome proliferatoractivated receptor activators target human endothelial cells to inhibit leukocyte-endothelial cell interaction. Arterioscler Thromb Vasc Biol 1999; 19: 2094-104.
    • (1999) Arterioscler Thromb Vasc Biol , vol.19 , pp. 2094-2104
    • Jackson, S.M.1    Parhami, F.2    Xi, X.P.3
  • 106
    • 0034711678 scopus 로고    scopus 로고
    • Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferatoractivated receptor-gamma activators
    • Pasceri V, Wu HD, Willerson JT, Yeh ET. Modulation of vascular inflammation in vitro and in vivo by peroxisome proliferatoractivated receptor-gamma activators. Circulation 2000; 101: 235-8.
    • (2000) Circulation , vol.101 , pp. 235-238
    • Pasceri, V.1    Wu, H.D.2    Willerson, J.T.3    Yeh, E.T.4
  • 107
    • 53149142762 scopus 로고    scopus 로고
    • Peroxisome proliferatoractivated receptor-gamma (PPAR-gamma) ligands: Novel pharmacological agents in the treatment of ischemia reperfusion injury
    • Giaginis C, Tsourouflis G, Theocharis S. Peroxisome proliferatoractivated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury. Curr Mol Med 2008; 8: 562-79.
    • (2008) Curr Mol Med , vol.8 , pp. 562-579
    • Giaginis, C.1    Tsourouflis, G.2    Theocharis, S.3
  • 108
    • 0037302089 scopus 로고    scopus 로고
    • The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: A placebo-controlled randomized clinical trial
    • Caballero AE, Saouaf R, Lim SC, et al. The effects of troglitazone, an insulin-sensitizing agent, on the endothelial function in early and late type 2 diabetes: a placebo-controlled randomized clinical trial. Metabolism 2003; 52: 173-80.
    • (2003) Metabolism , vol.52 , pp. 173-180
    • Caballero, A.E.1    Saouaf, R.2    Lim, S.C.3
  • 109
    • 0034577620 scopus 로고    scopus 로고
    • Troglitazone improves endothelial dysfunction in patients with insulin resistance
    • Watanabe Y, Sunayama S, Shimada K, et al. Troglitazone improves endothelial dysfunction in patients with insulin resistance. J Atheroscler Thromb 2000; 7: 159-63.
    • (2000) J Atheroscler Thromb , vol.7 , pp. 159-163
    • Watanabe, Y.1    Sunayama, S.2    Shimada, K.3
  • 110
    • 33745488834 scopus 로고    scopus 로고
    • The role of PPARs in the microvascular dysfunction in diabetes
    • Vinik A, Parson H, Ullal J. The role of PPARs in the microvascular dysfunction in diabetes. Vascul Pharmacol 2006; 45: 54-64.
    • (2006) Vascul Pharmacol , vol.45 , pp. 54-64
    • Vinik, A.1    Parson, H.2    Ullal, J.3
  • 111
    • 77953229627 scopus 로고    scopus 로고
    • Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress
    • Hidaka T, Nakagawa K, Goto C, et al. Pioglitazone improves endothelium-dependent vasodilation in hypertensive patients with impaired glucose tolerance in part through a decrease in oxidative stress. Atherosclerosis 2010; 210: 521-4.
    • (2010) Atherosclerosis , vol.210 , pp. 521-524
    • Hidaka, T.1    Nakagawa, K.2    Goto, C.3
  • 112
    • 75649146989 scopus 로고    scopus 로고
    • Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats
    • Morsy MA, Ashour OM, Fouad AA, Abdel-Gaber SA. Gastroprotective effects of the insulin sensitizers rosiglitazone and metformin against indomethacin-induced gastric ulcers in Type 2 diabetic rats. Clin Exp Pharmacol Physiol 2010; 37: 173-7.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 173-177
    • Morsy, M.A.1    Ashour, O.M.2    Fouad, A.A.3    Abdel-Gaber, S.A.4
  • 113
    • 66149104384 scopus 로고    scopus 로고
    • Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction
    • Yasuda S, Kobayashi H, Iwasa M, et al. Antidiabetic drug pioglitazone protects the heart via activation of PPAR-gamma receptors, PI3-kinase, Akt, and eNOS pathway in a rabbit model of myocardial infarction. Am J Physiol Heart Circ Physiol 2009; 296: H1558-65.
    • (2009) Am J Physiol Heart Circ Physiol , vol.296 , pp. 1558-1565
    • Yasuda, S.1    Kobayashi, H.2    Iwasa, M.3
  • 114
    • 38049085145 scopus 로고    scopus 로고
    • Pioglitazone ameliorates endothelial dysfunction and restores ischemia-induced angiogenesis in diabetic mice
    • Huang PH, Sata M, Nishimatsu H, Sumi M, Hirata Y, Nagai R. Pioglitazone ameliorates endothelial dysfunction and restores ischemia-induced angiogenesis in diabetic mice. Biomed Pharmacother 2008; 62: 46-52.
    • (2008) Biomed Pharmacother , vol.62 , pp. 46-52
    • Huang, P.H.1    Sata, M.2    Nishimatsu, H.3    Sumi, M.4    Hirata, Y.5    Nagai, R.6
  • 117
    • 70049089859 scopus 로고    scopus 로고
    • Exploring mechanism of pioglitazoneinduced memory restorative effect in experimental dementia
    • Kaur B, Singh N, Jaggi AS. Exploring mechanism of pioglitazoneinduced memory restorative effect in experimental dementia. Fundam Clin Pharmacol 2009; 23: 557-66.
    • (2009) Fundam Clin Pharmacol , vol.23 , pp. 557-566
    • Kaur, B.1    Singh, N.2    Jaggi, A.S.3
  • 120
    • 0037465515 scopus 로고    scopus 로고
    • Antioxidants and atherosclerosis: Don't throw out the baby with the bath water
    • Jialal I, Devaraj S. Antioxidants and atherosclerosis: don't throw out the baby with the bath water. Circulation 2003; 107: 926-8.
    • (2003) Circulation , vol.107 , pp. 926-928
    • Jialal, I.1    Devaraj, S.2
  • 123
    • 4744339386 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the l-arginine paradox and acts as a novel cardiovascular risk factor
    • Boger RH. Asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, explains the l-arginine paradox and acts as a novel cardiovascular risk factor. J Nutr 2004; 134: 2842-7.
    • (2004) J Nutr , vol.134 , pp. 2842-2847
    • Boger, R.H.1
  • 124
    • 0036908442 scopus 로고    scopus 로고
    • Mechanisms of superoxide production in human blood vessels: Relationship to endothelial dysfunction, clinical and genetic risk factors
    • Channon KM, Guzik TJ. Mechanisms of superoxide production in human blood vessels: relationship to endothelial dysfunction, clinical and genetic risk factors. J Physiol Pharmacol 2002; 53: 515-24.
    • (2002) J Physiol Pharmacol , vol.53 , pp. 515-524
    • Channon, K.M.1    Guzik, T.J.2
  • 125
    • 0027256181 scopus 로고
    • Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers
    • Calver A, Collier J, Leone A, Moncada S, Vallance P. Effect of local intra-arterial asymmetric dimethylarginine (ADMA) on the forearm arteriolar bed of healthy volunteers. J Hum Hypertens 1993; 7: 193-4.
    • (1993) J Hum Hypertens , vol.7 , pp. 193-194
    • Calver, A.1    Collier, J.2    Leone, A.3    Moncada, S.4    Vallance, P.5
  • 126
    • 0041733065 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase
    • Achan V, Broadhead M, Malaki M, et al. Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase. Arterioscler Thromb Vasc Biol 2003; 23: 1455-9.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1455-1459
    • Achan, V.1    Broadhead, M.2    Malaki, M.3
  • 127
    • 0035936390 scopus 로고    scopus 로고
    • Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine
    • Valkonen VP, Paiva H, Salonen JT, et al. Risk of acute coronary events and serum concentration of asymmetrical dimethylarginine. Lancet 2001; 358: 2127-8.
    • (2001) Lancet , vol.358 , pp. 2127-2128
    • Valkonen, V.P.1    Paiva, H.2    Salonen, J.T.3
  • 128
    • 77951771350 scopus 로고    scopus 로고
    • A novel predictor of restenosis and adverse cardiac events: Asymmetric dimethylarginine
    • Ari H, Ari S, Erdogan E, et al. A novel predictor of restenosis and adverse cardiac events: asymmetric dimethylarginine. Heart Vessels 2010; 25: 19-26.
    • (2010) Heart Vessels , vol.25 , pp. 19-26
    • Ari, H.1    Ari, S.2    Erdogan, E.3
  • 129
    • 77952430963 scopus 로고    scopus 로고
    • Relation of baseline plasma ADMA levels to cardiovascular morbidity and mortality at two years in men with diabetes mellitus referred for coronary angiography
    • Cavusoglu E, Ruwende C, Chopra V, et al. Relation of baseline plasma ADMA levels to cardiovascular morbidity and mortality at two years in men with diabetes mellitus referred for coronary angiography. Atherosclerosis 2010; 210: 226-31.
    • (2010) Atherosclerosis , vol.210 , pp. 226-231
    • Cavusoglu, E.1    Ruwende, C.2    Chopra, V.3
  • 130
    • 77954773778 scopus 로고    scopus 로고
    • Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up instable angina
    • Surdacki A, Marewicz E, Wieczorek-Surdacka E, et al. Synergistic effects of asymmetrical dimethyl-L-arginine accumulation and endothelial progenitor cell deficiency on renal function decline during a 2-year follow-up instable angina. Nephrol Dial Transplant 2010; 25: 2576-83.
    • (2010) Nephrol Dial Transplant , vol.25 , pp. 2576-2583
    • Surdacki, A.1    Marewicz, E.2    Wieczorek-Surdacka, E.3
  • 131
    • 77954758345 scopus 로고    scopus 로고
    • Short communication: Asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism
    • Fleissner F, Jazbutyte V, Fiedler J, et al. Short communication: asymmetric dimethylarginine impairs angiogenic progenitor cell function in patients with coronary artery disease through a microRNA-21-dependent mechanism. Circ Res 2010; 107: 138-43.
    • (2010) Circ Res , vol.107 , pp. 138-143
    • Fleissner, F.1    Jazbutyte, V.2    Fiedler, J.3
  • 132
    • 33645501775 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA): A novel risk marker in cardiovascular medicine and beyond
    • Boger RH. Asymmetric dimethylarginine (ADMA): a novel risk marker in cardiovascular medicine and beyond. Ann Med 2006; 38: 126-36.
    • (2006) Ann Med , vol.38 , pp. 126-136
    • Boger, R.H.1
  • 133
    • 68549099682 scopus 로고    scopus 로고
    • Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic non-diabetic patients after an aortocoronary bypass
    • Lucotti P, Monti L, Setola E,et al. Oral L-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic non-diabetic patients after an aortocoronary bypass. Metabolism 2009; 58: 1270-6.
    • (2009) Metabolism , vol.58 , pp. 1270-1276
    • Lucotti, P.1    Monti, L.2    Setola, E.3
  • 134
    • 67349092191 scopus 로고    scopus 로고
    • L-arginine and tetrahydrobiopterin protects against ischemia/ reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease
    • Settergren M, Böhm F, Malmström RE, Channon KM, Pernow J. L-arginine and tetrahydrobiopterin protects against ischemia/ reperfusion-induced endothelial dysfunction in patients with type 2 diabetes mellitus and coronary artery disease. Atherosclerosis 2009; 204: 73-8.
    • (2009) Atherosclerosis , vol.204 , pp. 73-78
    • Settergren, M.1    Böhm, F.2    Malmström, R.E.3    Channon, K.M.4    Pernow, J.5
  • 135
    • 33750945444 scopus 로고    scopus 로고
    • L-arginine improves hemodynamic function and coronary flow in an experimental model of ischemia-reperfusion injury
    • Okonski P, Banach M, Rysz J, et al. L-arginine improves hemodynamic function and coronary flow in an experimental model of ischemia-reperfusion injury. Ann Transplant 2006; 11: 28-34.
    • (2006) Ann Transplant , vol.11 , pp. 28-34
    • Okonski, P.1    Banach, M.2    Rysz, J.3
  • 136
    • 0037031094 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • The-HPS-Study-Investigators
    • The-HPS-Study-Investigators. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 23-33.
    • (2002) Lancet , vol.360 , pp. 23-33
  • 137
    • 0037231551 scopus 로고    scopus 로고
    • Adverse effects of supplemental L-arginine in atherosclerosis: Consequences of methylation stress in a complex catabolism?
    • Loscalzo J. Adverse effects of supplemental L-arginine in atherosclerosis: consequences of methylation stress in a complex catabolism? Arterioscler Thromb Vasc Biol 2003; 23: 3-5.
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 3-5
    • Loscalzo, J.1
  • 139
    • 1542283780 scopus 로고    scopus 로고
    • Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease
    • Alp NJ, Channon KM. Regulation of endothelial nitric oxide synthase by tetrahydrobiopterin in vascular disease. Arterioscler Thromb Vasc Biol 2004; 24: 413-20.
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 413-420
    • Alp, N.J.1    Channon, K.M.2
  • 140
    • 0038604446 scopus 로고    scopus 로고
    • Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: Implications for uncoupling endothelial nitric-oxide synthase
    • Kuzkaya N, Weissmann N, Harrison DG, Dikalov S. Interactions of peroxynitrite, tetrahydrobiopterin, ascorbic acid, and thiols: implications for uncoupling endothelial nitric-oxide synthase. J Biol Chem 2003; 278: 22546-54.
    • (2003) J Biol Chem , vol.278 , pp. 22546-22554
    • Kuzkaya, N.1    Weissmann, N.2    Harrison, D.G.3    Dikalov, S.4
  • 141
    • 50449108911 scopus 로고    scopus 로고
    • Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: The possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase
    • Masano T, Kawashima S, Toh R, et al. Beneficial effects of exogenous tetrahydrobiopterin on left ventricular remodeling after myocardial infarction in rats: the possible role of oxidative stress caused by uncoupled endothelial nitric oxide synthase. Circ J 2008; 72: 1512-9.
    • (2008) Circ J , vol.72 , pp. 1512-1519
    • Masano, T.1    Kawashima, S.2    Toh, R.3
  • 142
    • 77954942970 scopus 로고    scopus 로고
    • Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice
    • Schmidt TS, McNeill E, Douglas G, et al. Tetrahydrobiopterin supplementation reduces atherosclerosis and vascular inflammation in apolipoprotein E-knockout mice. Clin Sci (Lond) 2010; 119: 131-42.
    • (2010) Clin Sci (Lond) , vol.119 , pp. 131-142
    • Schmidt, T.S.1    McNeill, E.2    Douglas, G.3
  • 143
    • 79956319474 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves cardiac and pulmonary function after cardiopulmonary bypass
    • Szabó G, Seres L, Soós P, et al. Tetrahydrobiopterin improves cardiac and pulmonary function after cardiopulmonary bypass. Eur J Cardiothorac Surg 2011; 40: 695-700.
    • (2011) Eur J Cardiothorac Surg , vol.40 , pp. 695-700
    • Szabó, G.1    Seres, L.2    Soós, P.3
  • 144
    • 0034602878 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase
    • Heitzer T, Brockhoff C, Mayer B, et al. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: evidence for a dysfunctional nitric oxide synthase. Circ Res 2000; 86: E36-41.
    • (2000) Circ Res , vol.86 , pp. 36-41
    • Heitzer, T.1    Brockhoff, C.2    Mayer, B.3
  • 145
    • 6044230924 scopus 로고    scopus 로고
    • Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease
    • Nystrom T, Nygren A, Sjoholm A. Tetrahydrobiopterin increases insulin sensitivity in patients with type 2 diabetes and coronary heart disease. Am J Physiol Endocrinol Metab 2004; 287: E919-25.
    • (2004) Am J Physiol Endocrinol Metab , vol.287 , pp. 919-925
    • Nystrom, T.1    Nygren, A.2    Sjoholm, A.3
  • 146
    • 0036182797 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia
    • Fukuda Y, Teragawa H, Matsuda K, Yamagata T, Matsuura H, Chayama K. Tetrahydrobiopterin restores endothelial function of coronary arteries in patients with hypercholesterolaemia. Heart 2002; 87: 264-9.
    • (2002) Heart , vol.87 , pp. 264-269
    • Fukuda, Y.1    Teragawa, H.2    Matsuda, K.3    Yamagata, T.4    Matsuura, H.5    Chayama, K.6
  • 147
    • 79952159762 scopus 로고    scopus 로고
    • Novel strategies to ameliorate radiation injury: A possible role for tetrahydrobiopterin
    • Berbée M, Fu Q, Kumar KS, Hauer-Jensen M. Novel strategies to ameliorate radiation injury: a possible role for tetrahydrobiopterin. Curr Drug Targets 2010; 11: 1366-74.
    • (2010) Curr Drug Targets , vol.11 , pp. 1366-1374
    • Berbée, M.1    Fu, Q.2    Kumar, K.S.3    Hauer-Jensen, M.4
  • 148
    • 77951438852 scopus 로고    scopus 로고
    • Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats
    • Gangula PR, Mukhopadhyay S, Ravella K, et al. Tetrahydrobiopterin (BH4), a cofactor for nNOS, restores gastric emptying and nNOS expression in female diabetic rats. Am J Physiol Gastrointest Liver Physiol 2010; 298: G692-9.
    • (2010) Am J Physiol Gastrointest Liver Physiol , vol.298 , pp. 692-699
    • Gangula, P.R.1    Mukhopadhyay, S.2    Ravella, K.3
  • 149
    • 77950521339 scopus 로고    scopus 로고
    • Tetrahydrobiopterin protects the kidney from ischemia-reperfusion injury
    • Sucher R, Gehwolf P, Oberhuber R, et al. Tetrahydrobiopterin protects the kidney from ischemia-reperfusion injury. Kidney Int 2010; 77: 681-9.
    • (2010) Kidney Int , vol.77 , pp. 681-689
    • Sucher, R.1    Gehwolf, P.2    Oberhuber, R.3
  • 150
    • 0037164375 scopus 로고    scopus 로고
    • Homocysteine and cardiovascular disease: Evidence on causality from a meta-analysis
    • Wald DS, Law M, Morris JK. Homocysteine and cardiovascular disease: evidence on causality from a meta-analysis. BMJ 2002; 325: 1202.
    • (2002) BMJ , vol.325 , pp. 1202
    • Wald, D.S.1    Law, M.2    Morris, J.K.3
  • 151
    • 0034043191 scopus 로고    scopus 로고
    • Low serum folate but normal homocysteine levels in patients with atherosclerotic vascular disease and matched healthy controls
    • Bunout D, Petermann M, Hirsch S, et al. Low serum folate but normal homocysteine levels in patients with atherosclerotic vascular disease and matched healthy controls. Nutrition. 2000; 16: 434-8.
    • (2000) Nutrition , vol.16 , pp. 434-438
    • Bunout, D.1    Petermann, M.2    Hirsch, S.3
  • 152
    • 0033609454 scopus 로고    scopus 로고
    • Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial
    • Verhaar MC, Wever RM, Kastelein JJ, et al. Effects of oral folic acid supplementation on endothelial function in familial hypercholesterolemia. A randomized placebo-controlled trial. Circulation 1999; 100: 335-8.
    • (1999) Circulation , vol.100 , pp. 335-338
    • Verhaar, M.C.1    Wever, R.M.2    Kastelein, J.J.3
  • 153
    • 0036140785 scopus 로고    scopus 로고
    • Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering
    • Doshi SN, McDowell IF, Moat SJ, et al. Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. Circulation 2002; 105: 22-6.
    • (2002) Circulation , vol.105 , pp. 22-26
    • Doshi, S.N.1    McDowell, I.F.2    Moat, S.J.3
  • 155
    • 80051915426 scopus 로고    scopus 로고
    • Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta-synthase-deficient mice
    • Cheng Z, Jiang X, Kruger WD, et al. Hyperhomocysteinemia impairs endothelium-derived hyperpolarizing factor-mediated vasorelaxation in transgenic cystathionine beta-synthase-deficient mice. Blood 2011; 118: 1998-2006.
    • (2011) Blood , vol.118 , pp. 1998-2006
    • Cheng, Z.1    Jiang, X.2    Kruger, W.D.3
  • 156
    • 78049302601 scopus 로고    scopus 로고
    • Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/ Akt/endothelial nitric oxide synthase signaling
    • Yan TT, Li Q, Zhang XH, et al. Homocysteine impaired endothelial function through compromised vascular endothelial growth factor/ Akt/endothelial nitric oxide synthase signaling. Clin Exp Pharmacol Physiol 2010; 37: 1071-7.
    • (2010) Clin Exp Pharmacol Physiol , vol.37 , pp. 1071-1077
    • Yan, T.T.1    Li, Q.2    Zhang, X.H.3
  • 157
    • 79959967404 scopus 로고    scopus 로고
    • AMP-activated protein kinase inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells
    • Jia F, Wu C, Chen Z, Lu G. AMP-activated protein kinase inhibits homocysteine-induced dysfunction and apoptosis in endothelial progenitor cells. Cardiovasc Drugs Ther 2011; 25: 21-9.
    • (2011) Cardiovasc Drugs Ther , vol.25 , pp. 21-29
    • Jia, F.1    Wu, C.2    Chen, Z.3    Lu, G.4
  • 158
    • 79960660336 scopus 로고    scopus 로고
    • Folic acid improves acetylcholine-induced vasoconstriction of coronary vessels isolated from hyperhomocysteinemic mice: An implication to coronary vasospasm
    • Qipshidze N, Metreveli N, Lominadze D, Tyagi SC. Folic acid improves acetylcholine-induced vasoconstriction of coronary vessels isolated from hyperhomocysteinemic mice: An implication to coronary vasospasm. J Cell Physiol 2010; 226: 2712-20.
    • (2010) J Cell Physiol , vol.226 , pp. 2712-2720
    • Qipshidze, N.1    Metreveli, N.2    Lominadze, D.3    Tyagi, S.C.4
  • 159
    • 0034639639 scopus 로고    scopus 로고
    • Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: A randomised, placebocontrolled trial
    • Vermeulen EG, Stehouwer CD, Twisk JW, et al. Effect of homocysteine-lowering treatment with folic acid plus vitamin B6 on progression of subclinical atherosclerosis: a randomised, placebocontrolled trial. Lancet 2000; 355: 517-22.
    • (2000) Lancet , vol.355 , pp. 517-522
    • Vermeulen, E.G.1    Stehouwer, C.D.2    Twisk, J.W.3
  • 160
    • 20144387819 scopus 로고    scopus 로고
    • Stehouwer. Sadenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: The Hoorn Study
    • Spijkerman AM, Smulders YM, Kostense PJ, et al. Stehouwer. Sadenosylmethionine and 5-methyltetrahydrofolate are associated with endothelial function after controlling for confounding by homocysteine: the Hoorn Study. Arterioscler Thromb Vasc Biol 2005; 25: 778-84.
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 778-784
    • Spijkerman, A.M.1    Smulders, Y.M.2    Kostense, P.J.3
  • 161
    • 33845648645 scopus 로고    scopus 로고
    • 5-methyltetrahydrofolate rapidly improves endothelial function and superoxide production in human atherosclerosis: Effects on tetrahydrobiopterin-dependent eNOS coupling
    • Antoniades C, Shirodaria C, Leeson P, et al. 5-methyltetrahydrofolate rapidly improves endothelial function and superoxide production in human atherosclerosis: Effects on tetrahydrobiopterin-dependent eNOS coupling. J Am Coll Cardiol 2006; 47: 356.
    • (2006) J Am Coll Cardiol , vol.47 , pp. 356
    • Antoniades, C.1    Shirodaria, C.2    Leeson, P.3
  • 162
    • 0032570254 scopus 로고    scopus 로고
    • 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia
    • Verhaar MC, Wever RM, Kastelein JJ, van Dam T, Koomans HA, Rabelink TJ. 5-methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia. Circulation 1998; 97: 237-41.
    • (1998) Circulation , vol.97 , pp. 237-241
    • Verhaar, M.C.1    Wever, R.M.2    Kastelein, J.J.3    van Dam, T.4    Koomans, H.A.5    Rabelink, T.J.6
  • 163
    • 0035721992 scopus 로고    scopus 로고
    • Folate improves endothelial function in coronary artery disease: An effect mediated by reduction of intracellular superoxide?
    • Doshi SN, McDowell IF, Moat SJ, et al. Folate improves endothelial function in coronary artery disease: an effect mediated by reduction of intracellular superoxide? Arterioscler Thromb Vasc Biol 2001; 21: 1196-202.
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 1196-1202
    • Doshi, S.N.1    McDowell, I.F.2    Moat, S.J.3
  • 166
    • 0027242030 scopus 로고
    • Hypercholesterolemia increases endothelial superoxide anion production
    • Ohara Y, Peterson TE, Harrison DG. Hypercholesterolemia increases endothelial superoxide anion production. J Clin Invest 1993; 91: 2546-51.
    • (1993) J Clin Invest , vol.91 , pp. 2546-2551
    • Ohara, Y.1    Peterson, T.E.2    Harrison, D.G.3
  • 167
    • 7044239191 scopus 로고    scopus 로고
    • Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response
    • Antoniades C, Tousoulis D, Vasiliadou C, et al. Combined effects of smoking and hypercholesterolemia on inflammatory process, thrombosis/fibrinolysis system, and forearm hyperemic response. Am J Cardiol 2004; 94: 1181-4.
    • (2004) Am J Cardiol , vol.94 , pp. 1181-1184
    • Antoniades, C.1    Tousoulis, D.2    Vasiliadou, C.3
  • 168
    • 2942610437 scopus 로고    scopus 로고
    • Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: The effects of vitamin C
    • Antoniades C, Tousoulis D, Tountas C, et al. Vascular endothelium and inflammatory process, in patients with combined Type 2 diabetes mellitus and coronary atherosclerosis: the effects of vitamin C. Diabet Med 2004; 21: 552-8.
    • (2004) Diabet Med , vol.21 , pp. 552-558
    • Antoniades, C.1    Tousoulis, D.2    Tountas, C.3
  • 171
    • 78249257619 scopus 로고    scopus 로고
    • Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults
    • Crecelius AR, Kirby BS, Voyles WF, Dinenno FA. Nitric oxide, but not vasodilating prostaglandins, contributes to the improvement of exercise hyperemia via ascorbic acid in healthy older adults. Am J Physiol Heart Circ Physiol 2010; 299: H1633-41.
    • (2010) Am J Physiol Heart Circ Physiol , vol.299 , pp. 1633-1641
    • Crecelius, A.R.1    Kirby, B.S.2    Voyles, W.F.3    Dinenno, F.A.4
  • 172
    • 77952246339 scopus 로고    scopus 로고
    • Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats
    • Muharis SP, Top AG, Murugan D, Mustafa MR. Palm oil tocotrienol fractions restore endothelium dependent relaxation in aortic rings of streptozotocin-induced diabetic and spontaneously hypertensive rats. Nutr Res 2010; 30: 209-16.
    • (2010) Nutr Res , vol.30 , pp. 209-216
    • Muharis, S.P.1    Top, A.G.2    Murugan, D.3    Mustafa, M.R.4
  • 173
    • 67651172755 scopus 로고    scopus 로고
    • Micronutrient prenatal supplementation prevents the development of hypertension and vascular endothelial damage induced by intrauterine malnutrition
    • Franco Mdo C, Ponzio BF, Gomes GN, et al. Micronutrient prenatal supplementation prevents the development of hypertension and vascular endothelial damage induced by intrauterine malnutrition. Life Sci 2009; 85: 327-33.
    • (2009) Life Sci , vol.85 , pp. 327-333
    • Franco, M.C.1    Ponzio, B.F.2    Gomes, G.N.3
  • 174
    • 0037031094 scopus 로고    scopus 로고
    • MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: A randomised placebo-controlled trial
    • The-HPS-Study-Investigators
    • The-HPS-Study-Investigators. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Lancet 2002; 360: 23-33.
    • (2002) Lancet , vol.360 , pp. 23-33
  • 175
    • 26444515018 scopus 로고    scopus 로고
    • Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis
    • Herman AG, Moncada S. Therapeutic potential of nitric oxide donors in the prevention and treatment of atherosclerosis. Eur Heart J 2005; 26: 1945-55.
    • (2005) Eur Heart J , vol.26 , pp. 1945-1955
    • Herman, A.G.1    Moncada, S.2
  • 176
    • 10344246078 scopus 로고    scopus 로고
    • Impact of nicorandil in angina: Subgroup analyses
    • The-IONA-Investigators
    • The-IONA-Investigators. Impact of nicorandil in angina: subgroup analyses. Heart 2004; 90: 1427-30.
    • (2004) Heart , vol.90 , pp. 1427-1430
  • 177
    • 0037070736 scopus 로고    scopus 로고
    • Effect of nicorandil on coronary events in patients with stable angina: The Impact Of Nicorandil in Angina (IONA) randomised trial
    • The-IONA-Investigators
    • The-IONA-Investigators. Effect of nicorandil on coronary events in patients with stable angina: the Impact Of Nicorandil in Angina (IONA) randomised trial. Lancet 2002; 359: 1269-75.
    • (2002) Lancet , vol.359 , pp. 1269-1275
  • 178
    • 1642504851 scopus 로고    scopus 로고
    • Effects of nicorandil on endogenous fibrinolytic capacity in patients with coronary artery disease
    • Sakamoto T, Kaikita K, Miyamoto S, et al. Effects of nicorandil on endogenous fibrinolytic capacity in patients with coronary artery disease. Circ J 2004; 68: 232-5.
    • (2004) Circ J , vol.68 , pp. 232-235
    • Sakamoto, T.1    Kaikita, K.2    Miyamoto, S.3
  • 179
    • 0035812866 scopus 로고    scopus 로고
    • Comparative vasodilation of peroxynitrite and 3-morpholinosydnonimine
    • Trakranrungsie N, Will JA. Comparative vasodilation of peroxynitrite and 3-morpholinosydnonimine. Life Sci 2001; 69: 2349-59.
    • (2001) Life Sci , vol.69 , pp. 2349-2359
    • Trakranrungsie, N.1    Will, J.A.2
  • 180
    • 0034110916 scopus 로고    scopus 로고
    • Molsidomine improves flow-dependent vasodilation in brachial arteries of patients with coronary artery disease
    • Belhassen L, Carville C, Pelle G, et al. Molsidomine improves flow-dependent vasodilation in brachial arteries of patients with coronary artery disease. J Cardiovasc Pharmacol 2000; 35: 560-3.
    • (2000) J Cardiovasc Pharmacol , vol.35 , pp. 560-563
    • Belhassen, L.1    Carville, C.2    Pelle, G.3
  • 181
    • 0030295229 scopus 로고    scopus 로고
    • Nitric oxide attenuates adhesion molecule expression in human endothelial cells
    • Takahashi M, Ikeda U, Masuyama J, Funayama H, Kano S, Shimada K. Nitric oxide attenuates adhesion molecule expression in human endothelial cells. Cytokine 1996; 8: 817-21.
    • (1996) Cytokine , vol.8 , pp. 817-821
    • Takahashi, M.1    Ikeda, U.2    Masuyama, J.3    Funayama, H.4    Kano, S.5    Shimada, K.6
  • 182
    • 23044506615 scopus 로고    scopus 로고
    • Longterm treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina
    • Van Hove C, Carreer-Bruhwyler F, Geczy J Herman AG. Longterm treatment with the NO-donor molsidomine reduces circulating ICAM-1 levels in patients with stable angina. Atherosclerosis 2005; 180: 399-405.
    • (2005) Atherosclerosis , vol.180 , pp. 399-405
    • van Hove, C.1    Carreer-Bruhwyler, F.2    Geczy, J.3    Herman, A.G.4
  • 183
    • 0036562261 scopus 로고    scopus 로고
    • Potential cardioprotective actions of no-releasing aspirin
    • Wallace JL, Ignarro LJ, Fiorucci S. Potential cardioprotective actions of no-releasing aspirin. Nat Rev Drug Discov 2002; 1: 375-82.
    • (2002) Nat Rev Drug Discov , vol.1 , pp. 375-382
    • Wallace, J.L.1    Ignarro, L.J.2    Fiorucci, S.3
  • 184
    • 0343628040 scopus 로고    scopus 로고
    • A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate
    • Grosser N, Schroder H. A common pathway for nitric oxide release from NO-aspirin and glyceryl trinitrate. Biochem Biophys Res Commun 2000; 274: 255-8.
    • (2000) Biochem Biophys Res Commun , vol.274 , pp. 255-258
    • Grosser, N.1    Schroder, H.2
  • 185
    • 0034886127 scopus 로고    scopus 로고
    • Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin: In vitro and in vivo studies in the rat by ESR spectroscopy
    • Carini M, Aldini G, Stefani R, Orioli M, Facino RM. Nitrosylhemoglobin, an unequivocal index of nitric oxide release from nitroaspirin: in vitro and in vivo studies in the rat by ESR spectroscopy. J Pharm Biomed Anal 2001; 26: 509-18.
    • (2001) J Pharm Biomed Anal , vol.26 , pp. 509-518
    • Carini, M.1    Aldini, G.2    Stefani, R.3    Orioli, M.4    Facino, R.M.5
  • 186
    • 33344467378 scopus 로고    scopus 로고
    • Nitric oxide-donating aspirin (NCX 4016): An overview of its pharmacological properties and clinical perspectives
    • Bolla M, Momi S, Gresele P, Del Soldato P. Nitric oxide-donating aspirin (NCX 4016): an overview of its pharmacological properties and clinical perspectives. Eur J Clin Pharmacol 2006; 62: 145-54.
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 145-154
    • Bolla, M.1    Momi, S.2    Gresele, P.3    Del Soldato, P.4
  • 187
    • 0036778552 scopus 로고    scopus 로고
    • NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function
    • Fiorucci S, Mencarelli A, Mannucci R, et al. NCX-4016, a nitric oxide-releasing aspirin, protects endothelial cells against apoptosis by modulating mitochondrial function. Faseb J 2002; 16: 1645-7.
    • (2002) Faseb J , vol.16 , pp. 1645-1647
    • Fiorucci, S.1    Mencarelli, A.2    Mannucci, R.3
  • 188
    • 4344677822 scopus 로고    scopus 로고
    • Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells
    • Muzaffar S, Shukla N, Angelini G, Jeremy JY. Nitroaspirins and morpholinosydnonimine but not aspirin inhibit the formation of superoxide and the expression of gp91phox induced by endotoxin and cytokines in pig pulmonary artery vascular smooth muscle cells and endothelial cells. Circulation 2004; 110: 1140-7.
    • (2004) Circulation , vol.110 , pp. 1140-1147
    • Muzaffar, S.1    Shukla, N.2    Angelini, G.3    Jeremy, J.Y.4
  • 189
    • 0037022334 scopus 로고    scopus 로고
    • Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis
    • Napoli C, Aldini G, Wallace JL, et al. Efficacy and age-related effects of nitric oxide-releasing aspirin on experimental restenosis. Proc Natl Acad Sci USA 2002; 99: 1689-94.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 1689-1694
    • Napoli, C.1    Aldini, G.2    Wallace, J.L.3
  • 190
    • 0034858876 scopus 로고    scopus 로고
    • Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats
    • Muscara MN, Lovren F, McKnight W, et al. Vasorelaxant effects of a nitric oxide-releasing aspirin derivative in normotensive and hypertensive rats. Br J Pharmacol 2001; 133: 1314-22.
    • (2001) Br J Pharmacol , vol.133 , pp. 1314-1322
    • Muscara, M.N.1    Lovren, F.2    McKnight, W.3
  • 191
    • 4043182018 scopus 로고    scopus 로고
    • Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans
    • Fiorucci S, Mencarelli A, Meneguzzi A, et al. Co-administration of nitric oxide-aspirin (NCX-4016) and aspirin prevents platelet and monocyte activation and protects against gastric damage induced by aspirin in humans. J Am Coll Cardiol 2004; 44: 635-41.
    • (2004) J Am Coll Cardiol , vol.44 , pp. 635-641
    • Fiorucci, S.1    Mencarelli, A.2    Meneguzzi, A.3


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