Oral l-arginine supplementation improves endothelial function and ameliorates insulin sensitivity and inflammation in cardiopathic nondiabetic patients after an aortocoronary bypass

Metabolism: Clinical and Experimental

Volumn 58, Issue 9, 2009, Pages 1270-1276

  Lucotti, Pietro ^a   Monti, Lucilla ^a   Setola, Emanuela ^a   La Canna, Giovanni ^a   Castiglioni, Alessandro ^a   Rossodivita, Alessandra ^a   Pala, Maria Grazia ^a   Formica, Francesco ^c   Paolini, Giovanni ^c   Catapano, Alberico Luigi ^d   Bosi, Emanuele ^a,b   Alfieri, Ottavio ^a,b   Piatti, PierMarco ^a,b  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c UNIVERSITY OF MILANO BICOCCA   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; ARGININE; INSULIN; INTERLEUKIN 6; MONOCYTE CHEMOTACTIC PROTEIN 1; N(G),N(G) DIMETHYLARGININE; NITRIC OXIDE;

ADULT; AGED; ARTICLE; BLOOD FLOW; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; CORONARY ARTERY DISEASE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENDOTHELIAL DYSFUNCTION; FEMALE; GLUCOSE TOLERANCE; HUMAN; HYPEREMIA; INFLAMMATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL;

ADMINISTRATION, ORAL; AGED; ARGININE; CARDIOVASCULAR DISEASES; CORONARY ARTERY BYPASS; DIETARY SUPPLEMENTS; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; GLUCOSE TOLERANCE TEST; HUMANS; INFLAMMATION; INSULIN RESISTANCE; MALE; MIDDLE AGED; PLACEBOS;

EID: 68549099682     PISSN: 00260495     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.metabol.2009.03.029     Document Type: Article

References (26)

1. Piatti P., Di Mario C., Monti L.D., et al. Association of insulin resistance, hyperleptinemia, and impaired nitric oxide release with in-stent restenosis in patients undergoing coronary stenting. Circulation 108 (2003) 2074-2081
2. Al Suwaidi J., Hamasaki S., Higano S.T., Nishimura R.A., Holmes D.R.J., and Lerman A. Long-term follow-up of patients with mild coronary artery disease and endothelial dysfunction. Circulation 101 (2000) 948-954
3. Böger R.H., and Ron E.S. l-Arginine improves vascular function by overcoming deleterious effects of ADMA, a novel cardiovascular risk factor. Altern Med Rev 10 (2005) 14-23
4. Hambrecht R., Hilbrich L., Erbs S., et al. Correction of endothelial dysfunction in chronic heart failure: additional effects of exercise training and oral l-arginine supplementation. J am Coll Cardiol 35 (2000) 706-713
5. Lucotti P., Setola E., Monti L.D., et al. Beneficial effects of a long-term oral l-arginine treatment added to a hypocaloric diet and exercise training program in obese, insulin-resistant type 2 diabetic patients. Am J Physiol Endocrinol Metab 291 (2006) 906-912
6. Palloshi A., Fragasso G., Piatti P., et al. Effect of oral l-arginine on blood pressure and symptoms and endothelial function in patients with systemic hypertension, positive exercise tests, and normal coronary arteries. Am J Cardiol 93 (2004) 933-935
7. Böger G.I., Rudolph T.K., Maas R., et al. Asymmetric dimethylarginine determines the improvement of endothelium-dependent vasodilation by simvastatin: effect of combination with oral l-arginine. J am Coll Cardiol 49 (2007) 2274-2282
8. Böger R.H. Asymmetric dimethylarginine (ADMA) modulates endothelial function-therapeutic implications. Vasc Med 8 (2003) 149-151
9. Vallance P., and Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol 24 (2004) 1023-1030
10. Kubota N., Terauchi Y., Yamauchi T., et al. Disruption of adiponectin causes insulin resistance and neointimal formation. J Biol Chem 277 (2002) 25863-25866
11. Setola E., Monti L.D., Galluccio E., et al. Insulin resistance and endothelial function are improved after folate and vitamin B12 therapy in patients with the metabolic syndrome: relationship between homocysteine levels and hyperinsulinemia. Eur J Endocrinol 151 (2004) 483-489
12. Alomari M.A., Solomito A., Reyes R., et al. Measurements of vascular function using strain-gauge plethysmography: technical considerations, standardization, and physiological findings. Am J Physiol Heart Circ Physiol 286 (2004) H99-H107
13. Irace C., Ceravolo R., Notarangelo L., et al. Comparison of endothelial function evaluated by strain gauge plethysmography and brachial artery ultrasound. Atherosclerosis 158 (2001) 53-59
14. Stumvoll M., Van Haeften T., Fritsche A., and Gerich J. Oral glucose tolerance test indexes for insulin sensitivity and secretion based on various availabilities of sampling times. Diabetes Care 24 (2001) 796-797
15. Verdon C.P., Burto B.A., and Prior R.L. Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitrite. Anal Biochem 224 (1995) 502-508
16. Setola E., Monti L.D., Lanzi R., et al. Effects of growth hormone treatment on arginine to asymmetric dimethylarginine ratio and endothelial function in patients with growth hormone deficiency. Metabolism 57 (2008) 1685-1690
17. Boger R.H. l-Arginine therapy in cardiovascular pathologies: beneficial or dangerous?. Curr Opin Clin Nutr Metab Care 11 (2008) 55-61
18. Lind L., Larsson A., and Teerlink T. l-Arginine is related to endothelium-dependent vasodilation in resistance and conduit arteries in divergent ways. The Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Atherosclerosis 203 (2009) 544-549
19. Piatti P.M., Monti L.D., Valsecchi G., et al. Long-term oral l-arginine administration improves peripheral and hepatic insulin sensitivity in type 2 diabetic patients. Diabetes Care 24 (2001) 875-880
20. Bobryshev Y.V. Monocyte recruitment and foam cell formation in atherosclerosis. Micron 37 (2006) 208-222
21. Kumada M., Kihara S., Noriyuki O., et al. Adiponectin specifically increased tissue inhibitor of metalloproteinase-1 through interleukin-10 expression in human macrophages. Circulation 109 (2004) 2046-2049
22. Mozaffarian D., Marfisi R., Levantesi G., et al. Incidence of new-onset diabetes and impaired fasting glucose in patients with recent myocardial infarction and the effect of clinical and lifestyle risk factors. Lancet 370 (2007) 667-675
23. Wascher T.C., Graier W.F., Dittrich P., et al. Effects of low-dose l-arginine on insulin-mediated vasodilatation and insulin sensitivity. Eur J Clin Invest 27 (1997) 690-695
24. Wilson A.M., Harada R., Nair N., et al. l-Arginine supplementation in peripheral arterial disease: no benefit and possible harm. Circulation 116 (2007) 188-195
25. Schulman S.P., Becker L.C., Kass D.A., et al. l-Arginine therapy in acute myocardial infarction: the Vascular Interaction with Age in Myocardial Infarction (VINTAGE MI) randomized clinical trial. JAMA 295 (2006) 58-64
26. Boger R.H. Letter to the editor re: JAMA article on l-arginine therapy in acute myocardial infarction. Altern Med Rev 11 (2006) 91-92