Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering

Circulation

Volumn 105, Issue 1, 2002, Pages 22-26

  Doshi, S N ^a   McDowell, I F W ^a   Moat, S J ^a   Payne, N ^a   Durrant, H J ^a   Lewis, M J ^a   Goodfellow, J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Coronary disease; Endothelium; Plasma; Risk factors

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; PLACEBO;

ADULT; ARTERY DILATATION; ARTERY ENDOTHELIUM; ARTICLE; BLOOD LEVEL; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; CORONARY ARTERY DISEASE; CORRELATION FUNCTION; DOUBLE BLIND PROCEDURE; DRUG MECHANISM; FEMALE; FOLIC ACID BLOOD LEVEL; HUMAN; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK FACTOR; TECHNIQUE;

CORONARY ARTERIOSCLEROSIS; DOUBLE-BLIND METHOD; ENDOTHELIUM, VASCULAR; FEMALE; FOLIC ACID; HEMATINICS; HOMOCYSTEINE; HUMANS; MALE; MIDDLE AGED; TETRAHYDROFOLATES; TIME FACTORS; TREATMENT OUTCOME; VASODILATION;

EID: 0036140785     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc0102.101388     Document Type: Article

References (26)

1. A quantitative assessment of plasma homocysteine as a risk factor for vascular disease: Probable benefits of increasing folic acid intakes
2. Plasma homocysteine predicts mortality independently of traditional risk factors and C-reactive protein in patients with angiographically defined coronary artery disease
3. Homocysteine and cardiovascular risk
4. Lowering blood homocysteine with folic acid based supplements: Meta-analysis of randomised trials
5. Reduction of homocysteine levels in coronary artery disease by low-dose folic acid combined with vitamins B6 and B12
6. The pathogenesis of atherosclerosis: A perspective for the 1990s
7. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
8. Effect of folic acid and antioxidant vitamins on endothelial dysfunction in patients with coronary artery disease
9. Improved vascular endothelial function after oral B vitamins: An effect mediated through reduced concentrations of free plasma homocysteine
10. Folate improves endothelial function in coronary artery disease: An effect mediated by reduction of intracellular superoxide?
11. Flow-mediated dilatation following wrist and upper arm occlusion in humans: The contribution of nitric oxide
12. Nitric oxide is responsible for flow-dependent dilatation of human peripheral conduit arteries in vivo
13. Dietary supplementation with marine omega-3 fatty acids improves systemic large artery endothelial function in subjects with hypercholesterolemia
14. Endothelial control of arterial distensibility is impaired in chronic heart failure
15. Determination of free and total homocysteine in human plasma by high-performance liquid chromatography with fluorescence detection
16. Measurement of 5-methyltetrahydrofolic acid in man by high-performance liquid chromatography
17. Normal ranges for brachial artery flow-mediated dilatation: A non-invasive ultrasound test of arterial endothelial function
18. Developments in the measurement of plasma total homocysteine
19. Unmetabolized folic acid in serum: Acute studies in subjects consuming fortified food and supplements
20. Stimulation of dihydrofolate reductase promoter activity by antimetabolic drugs
21. Reduction of plasma homocyst(e)ine levels by breakfast cereal fortified with folic acid in patients with coronary heart disease
22. Folic acid reverts dysfunction of endothelial nitric oxide synthase
23. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia
24. Hyperhomocysteinemia after an oral methionine load acutely impairs endothelial function in healthy adults
25. Endothelial dysfunction by acute hyperhomocyst(e)inaemia: Restoration by folic acid
26. Vitamin supplements and cardiovascular risk: Review of the randomized trials of homocysteine-lowering vitamin supplements