Interaction of 5-methyltetrahydrofolate and tetrahydrobiopterin on endothelial function

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 282, Issue 6 51-6, 2002, Pages

  Hyndman, Mathew Eric ^a   Verma, Subodh ^b   Rosenfeld, Robin J ^a   Anderson, Todd J ^b   Parsons, Howard G ^c  

^a UNIVERSITY OF CALGARY   (Canada)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF TORONTO   (Canada)

Author keywords

Folic acid; Nitric oxide

Indexed keywords

5 METHYLTETRAHYDROFOLIC ACID; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; SUPEROXIDE; TETRAHYDROBIOPTERIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG PROTEIN BINDING; ENDOTHELIUM; ENZYME ACTIVE SITE; HEART MUSCLE ISCHEMIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION;

EID: 0036083567     PISSN: 03636135     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpheart.00935.2001     Document Type: Article

References (28)

1. Chronic bosentan treatment improves renal artery vascular function in diabetes
2. The role of tetrahydrobiopterin in the activation of oxygen by nitric-oxide synthase
3. Nitric oxide, superoxide, and peroxynitrite: The good, the bad, and ugly
4. Tetrahydrobiopterin and endothelial function
5. Tetrahydrobiopterin and endothelial nitric oxide synthase activity
6. Sensitivity of the essential zinc-thiolate moiety of yeast alcohol dehydrogenase to hypochlorite and peroxynitrite
7. Structural characterization of nitric oxide synthase isoforms reveals striking active-site conservation
8. Inhibition of endotoxin-induced vascular hyporeactivity by 4-amino-tetrahydrobiopterin
9. Tetrahydrobiopterinfree neuronal nitric oxide synthase: Evidence for two identical highly anticooperative pteridine binding sites
10. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase
11. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with type II diabetes mellitus
12. LAscorbic acid potentiates nitric oxide synthesis in endothelial cells
13. L-ascorbic acid potentiates endothelial nitric oxide synthesis via a chemical stabilization of tetrahydrobiopterin
14. Dihydrorhodamine 123: A fluorescent probe for superoxide generation?
15. Effects of streptozotocin-induced diabetes and of insulin treatment on homocysteine metabolism in the rat
16. Peroxynitrite-mediated oxidation of dihydrorhodamine 123
17. Tetrahydrobiopterin improves endothelial function in patients with coronary artery disease
18. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin
19. Activation of neuronal nitric-oxide synthase by the 5-methyl analog of tetrahydrobiopterin. Functional evidence against reductive oxygen activation by the pterin cofactor
20. 2-imbalance in insulin-resistant rat aorta
21. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats
22. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
23. Folic acid reverts dysfunction of endothelial nitric oxide synthase
24. Restoration of endothelium-dependent vasodilation after reperfusion injury by tetrahydrobiopterin
25. Tetrahydrobiopterin restores endothelial function in long-term smokers
26. Endothelial dysfunction by acute hyperhomocyst(e)inaemia: Restoration by folic acid
27. 5-Methyltetrahydrofolate, the active form of folic acid, restores endothelial function in familial hypercholesterolemia
28. Tetrahydrobiopterin regulates superoxide and nitric oxide generation by recombinant endothelial nitric oxide synthase