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Volumn 53, Issue 4 I, 2002, Pages 515-524

Mechanisms of superoxide production in human blood vessels: Relationship to endothelial dysfunction, clinical and genetic risk factors

Author keywords

Endothelium; Human; Nitric oxide; Superoxide; Tetrahydrobiopterin

Indexed keywords

PROTEIN KINASE C; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SUPEROXIDE; TETRAHYDROBIOPTERIN;

EID: 0036908442     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Conference Paper
Times cited : (174)

References (62)
  • 1
    • 0028935790 scopus 로고
    • Nitric oxide in the regulation of blood flow and arterial pressure
    • Umans JG, Levi R. Nitric oxide in the regulation of blood flow and arterial pressure. Annu Rev Physiol 1995;57:771-790.
    • (1995) Annu Rev Physiol , vol.57 , pp. 771-790
    • Umans, J.G.1    Levi, R.2
  • 2
    • 0031054463 scopus 로고    scopus 로고
    • Nitric oxide synthase: Role in the genesis of vascular disease
    • Cooke JP, Dzau VJ. Nitric oxide synthase: Role in the genesis of vascular disease. Annu Rev Med 1997;48:489-509.
    • (1997) Annu Rev Med , vol.48 , pp. 489-509
    • Cooke, J.P.1    Dzau, V.J.2
  • 3
    • 0030711684 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of endothelial dysfunction
    • Harrison DG. Cellular and molecular mechanisms of endothelial dysfunction. J Clin Invest 1998;100:2153-157.
    • (1998) J Clin Invest , vol.100 , pp. 2153-2157
    • Harrison, D.G.1
  • 4
    • 0025015143 scopus 로고
    • Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease
    • Vita JA, Treasure CB, Nabel EG, et al. Coronary vasomotor response to acetylcholine relates to risk factors for coronary artery disease. Circulation 1990;81:491-497.
    • (1990) Circulation , vol.81 , pp. 491-497
    • Vita, J.A.1    Treasure, C.B.2    Nabel, E.G.3
  • 5
    • 0342424181 scopus 로고    scopus 로고
    • Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease
    • Schachinger V, Britten MB, Zeiher AM. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000;101:1899-1906.
    • (2000) Circulation , vol.101 , pp. 1899-1906
    • Schachinger, V.1    Britten, M.B.2    Zeiher, A.M.3
  • 6
    • 0035960677 scopus 로고    scopus 로고
    • Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease
    • Heitzer T, Schlinzig T, Krohn K, Meinertz T, Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 2001;104:2673-2678.
    • (2001) Circulation , vol.104 , pp. 2673-2678
    • Heitzer, T.1    Schlinzig, T.2    Krohn, K.3    Meinertz, T.4    Munzel, T.5
  • 7
    • 0029021148 scopus 로고
    • Hypertension in mice lacking the gene for endothelial nitric oxide synthase
    • Huang PL, Huang ZH, Mashimo H, et al. Hypertension in mice lacking the gene for endothelial nitric oxide synthase. Nature 1995;377:239-242.
    • (1995) Nature , vol.377 , pp. 239-242
    • Huang, P.L.1    Huang, Z.H.2    Mashimo, H.3
  • 8
    • 0032520153 scopus 로고    scopus 로고
    • Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling
    • Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. J Clin Invest 1998;101:731-736.
    • (1998) J Clin Invest , vol.101 , pp. 731-736
    • Rudic, R.D.1    Shesely, E.G.2    Maeda, N.3    Smithies, O.4    Segal, S.S.5    Sessa, W.C.6
  • 9
    • 0033903230 scopus 로고    scopus 로고
    • Nitric oxide synthase in atherosclerosis and vascular injury: Insights from experimental gene therapy
    • Channon KM, Qian HS, George SE. Nitric oxide synthase in atherosclerosis and vascular injury: Insights from experimental gene therapy. Arteriosclerosis Thromb Vasc Biol 2000;20:1873-1881.
    • (2000) Arteriosclerosis Thromb Vasc Biol , vol.20 , pp. 1873-1881
    • Channon, K.M.1    Qian, H.S.2    George, S.E.3
  • 11
    • 0022640297 scopus 로고
    • Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor
    • Gryglewski RJ, Palmer RM, Moncada S. Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature 1986;320:454-456.
    • (1986) Nature , vol.320 , pp. 454-456
    • Gryglewski, R.J.1    Palmer, R.M.2    Moncada, S.3
  • 12
    • 0028939151 scopus 로고
    • Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion
    • Harrison DG, Ohara Y. Physiologic consequences of increased vascular oxidant stresses in hypercholesterolemia and atherosclerosis: Implications for impaired vasomotion. Am J Cardiol 1995;75:75B-81B.
    • (1995) Am J Cardiol , vol.75
    • Harrison, D.G.1    Ohara, Y.2
  • 13
    • 0036285223 scopus 로고    scopus 로고
    • Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels
    • Guzik TJ, West N, Pillai R, Taggart D, Channon KM. Nitric oxide modulates superoxide release and peroxynitrite formation in human blood vessels. Hypertension 2002;39:1088-1094.
    • (2002) Hypertension , vol.39 , pp. 1088-1094
    • Guzik, T.J.1    West, N.2    Pillai, R.3    Taggart, D.4    Channon, K.M.5
  • 14
    • 0034123171 scopus 로고    scopus 로고
    • Interactions of oxidants with vascular signaling systems
    • Wolin MS. Interactions of oxidants with vascular signaling systems. Arterioscler Thromb Vasc Biol 2000;20:1430-1442.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 1430-1442
    • Wolin, M.S.1
  • 15
    • 0034640248 scopus 로고    scopus 로고
    • Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells
    • Ballinger SW, Patterson C, Yan CN, et al. Hydrogen peroxide- and peroxynitrite-induced mitochondrial DNA damage and dysfunction in vascular endothelial and smooth muscle cells. Circ Res 2000;86:960-966.
    • (2000) Circ Res , vol.86 , pp. 960-966
    • Ballinger, S.W.1    Patterson, C.2    Yan, C.N.3
  • 17
    • 0028260346 scopus 로고
    • Paradoxical fate and biological action of peroxynitrite on human platelets
    • Moro MA, Darley-Usmar VM, Goodwin DA, et al. Paradoxical fate and biological action of peroxynitrite on human platelets. Proc Natl Acad Sci U S A 1994;91:6702-6706.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 6702-6706
    • Moro, M.A.1    Darley-Usmar, V.M.2    Goodwin, D.A.3
  • 18
    • 0012906173 scopus 로고    scopus 로고
    • Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide
    • Wang HD, Pagano PJ, Du Y. et al. Superoxide anion from the adventitia of the rat thoracic aorta inactivates nitric oxide. Circ Res 1998;82:810-818.
    • (1998) Circ Res , vol.82 , pp. 810-818
    • Wang, H.D.1    Pagano, P.J.2    Du, Y.3
  • 19
    • 0344043305 scopus 로고    scopus 로고
    • Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis
    • Miller FJ, Jr., Guttennan DD, Rios CD, Heistad DD, Davidson BL. Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ Res 1998;82:1298-1305.
    • (1998) Circ Res , vol.82 , pp. 1298-1305
    • Miller F.J., Jr.1    Guttennan, D.D.2    Rios, C.D.3    Heistad, D.D.4    Davidson, B.L.5
  • 20
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress. Circ Res 2000;87:840-844.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 21
    • 0033662825 scopus 로고    scopus 로고
    • Upregulation of p67(phox) and gp91(phox) in aortas from angiotensin II-infused mice
    • Cifuentes ME, Rey FE, Carretero OA, Pagano PJ. Upregulation of p67(phox) and gp91(phox) in aortas from angiotensin II-infused mice. Am J Physiol 2000;279:H2234-H2240.
    • (2000) Am J Physiol , vol.279
    • Cifuentes, M.E.1    Rey, F.E.2    Carretero, O.A.3    Pagano, P.J.4
  • 22
    • 0034625073 scopus 로고    scopus 로고
    • Investigation into the sources of superoxide in human blood vessels: Angiotensin II increases superoxide production in human internal mammary arteries
    • Berry C, Hamilton CA, Brosnan MJ, et al. Investigation into the sources of superoxide in human blood vessels: Angiotensin II increases superoxide production in human internal mammary arteries. Circulation 2000;101:2206-2212.
    • (2000) Circulation , vol.101 , pp. 2206-2212
    • Berry, C.1    Hamilton, C.A.2    Brosnan, M.J.3
  • 23
    • 0032700284 scopus 로고    scopus 로고
    • Superoxide anion generation, superoxide dismutase activity, and nitric oxide release in human internal mammary artery and saphenous vein segments
    • Schmalfuss CM, Chen LY, Bott JN, Staples ED, Mehta JL. Superoxide anion generation, superoxide dismutase activity, and nitric oxide release in human internal mammary artery and saphenous vein segments: J Cardiovasc Pharmacol Ther 1999;4:249-257.
    • (1999) J Cardiovasc Pharmacol Ther , vol.4 , pp. 249-257
    • Schmalfuss, C.M.1    Chen, L.Y.2    Bott, J.N.3    Staples, E.D.4    Mehta, J.L.5
  • 24
    • 0034640107 scopus 로고    scopus 로고
    • Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors
    • Guzik TJ, West NEJ, Black E, et al. Vascular superoxide production by NAD(P)H oxidase: Association with endothelial dysfunction and clinical risk factors. Circ Res 2000;86:E85-E90.
    • (2000) Circ Res , vol.86
    • Guzik, T.J.1    West, N.E.J.2    Black, E.3
  • 25
    • 0034677947 scopus 로고    scopus 로고
    • NAD(P)H oxidase: Role in cardiovascular biology and disease
    • Griendling KK, Sorescu D, Ushio-Fukai M. NAD(P)H oxidase: Role in cardiovascular biology and disease. Circ Res 2000;86:494-501.
    • (2000) Circ Res , vol.86 , pp. 494-501
    • Griendling, K.K.1    Sorescu, D.2    Ushio-Fukai, M.3
  • 26
    • 0037177164 scopus 로고    scopus 로고
    • Superoxide production and expression of nox family proteins in human atherosclerosis
    • Sorescu D, Weiss D, Lassegue B, et al. Superoxide production and expression of nox family proteins in human atherosclerosis. Circulation 2002;105:1429-1435.
    • (2002) Circulation , vol.105 , pp. 1429-1435
    • Sorescu, D.1    Weiss, D.2    Lassegue, B.3
  • 27
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase
    • Guzik TJ, Mussa S, Gastaldi D, et al. Mechanisms of increased vascular superoxide production in human diabetes mellitus: Role of NAD(P)H oxidase and endothelial nitric oxide synthase. Circulation 2002;105:1656-1662.
    • (2002) Circulation , vol.105 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3
  • 28
    • 0037076798 scopus 로고    scopus 로고
    • Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II
    • Touyz RM, Chen X, Tabet F, et al. Expression of a functionally active gp91phox-containing neutrophil-type NAD(P)H oxidase in smooth muscle cells from human resistance arteries: Regulation by angiotensin II. Circ Res 2002;90:1205-1213.
    • (2002) Circ Res , vol.90 , pp. 1205-1213
    • Touyz, R.M.1    Chen, X.2    Tabet, F.3
  • 29
    • 0035834028 scopus 로고    scopus 로고
    • Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: Antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy
    • Rueckschloss U, Galle J, Holtz J, Zerkowski HR, Morawietz H. Induction of NAD(P)H oxidase by oxidized low-density lipoprotein in human endothelial cells: Antioxidative potential of hydroxymethylglutaryl coenzyme A reductase inhibitor therapy. Circulation 2001;104:1767-1772.
    • (2001) Circulation , vol.104 , pp. 1767-1772
    • Rueckschloss, U.1    Galle, J.2    Holtz, J.3    Zerkowski, H.R.4    Morawietz, H.5
  • 31
    • 0037040947 scopus 로고    scopus 로고
    • Effects of angiotensin 11 infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling
    • Mollnau H, Wendt M, Szocs K, et al. Effects of angiotensin 11 infusion on the expression and function of NAD(P)H oxidase and components of nitric oxide/cGMP signaling. Circ Res 2002;90:E58-65.
    • (2002) Circ Res , vol.90
    • Mollnau, H.1    Wendt, M.2    Szocs, K.3
  • 32
    • 0033547810 scopus 로고    scopus 로고
    • Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries
    • Huraux C, Makita T, Kurz S, et al. Superoxide production, risk factors, and endothelium-dependent relaxations in human internal mammary arteries. Circulation 1999;99:53-59.
    • (1999) Circulation , vol.99 , pp. 53-59
    • Huraux, C.1    Makita, T.2    Kurz, S.3
  • 34
    • 0033559692 scopus 로고    scopus 로고
    • Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase
    • Feron O, Dessy C, Moniotte S, Desager JP, Balligand JL. Hypercholesterolemia decreases nitric oxide production by promoting the interaction of caveolin and endothelial nitric oxide synthase. J Clin Invest 1999;103:897-905.
    • (1999) J Clin Invest , vol.103 , pp. 897-905
    • Feron, O.1    Dessy, C.2    Moniotte, S.3    Desager, J.P.4    Balligand, J.L.5
  • 35
    • 0028987622 scopus 로고
    • Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein
    • Liao JK, Clark SL. Regulation of G-protein alpha i2 subunit expression by oxidized low-density lipoprotein. J Clin Invest 1995;95:1457-1463.
    • (1995) J Clin Invest , vol.95 , pp. 1457-1463
    • Liao, J.K.1    Clark, S.L.2
  • 36
    • 0033538644 scopus 로고    scopus 로고
    • Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae
    • Peterson TE, Poppa V, Ueba H, Wu A, Yan C, Berk BC. Opposing effects of reactive oxygen species and cholesterol on endothelial nitric oxide synthase and endothelial cell caveolae. Circ Res 1999;85:29-37.
    • (1999) Circ Res , vol.85 , pp. 29-37
    • Peterson, T.E.1    Poppa, V.2    Ueba, H.3    Wu, A.4    Yan, C.5    Berk, B.C.6
  • 37
    • 0031940241 scopus 로고    scopus 로고
    • Polymorphisin of the NADH/NADPH oxidase p22 phox gene in patients with coronary artery disease
    • Inoue N, Kawashima S, Kanazawa K, Yamada S, Akita H, Yokoyama M. Polymorphisin of the NADH/NADPH oxidase p22 phox gene in patients with coronary artery disease. Circulation 1998;97:135-137.
    • (1998) Circulation , vol.97 , pp. 135-137
    • Inoue, N.1    Kawashima, S.2    Kanazawa, K.3    Yamada, S.4    Akita, H.5    Yokoyama, M.6
  • 38
    • 0034599040 scopus 로고    scopus 로고
    • A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis
    • Cahilly C, Ballantyne CM, Lim DS, Gotto A, Marian AJ. A variant of p22(phox), involved in generation of reactive oxygen species in the vessel wall, is associated with progression of coronary atherosclerosis. Circ Res 2000;86:391-395.
    • (2000) Circ Res , vol.86 , pp. 391-395
    • Cahilly, C.1    Ballantyne, C.M.2    Lim, D.S.3    Gotto, A.4    Marian, A.J.5
  • 39
    • 0034633838 scopus 로고    scopus 로고
    • Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox subunit on vascular superoxide production in atherosclerosis
    • Guzik TJ, West NEJ, Black E, et al. Functional effect of the C242T polymorphism in the NAD(P)H oxidase p22phox subunit on vascular superoxide production in atherosclerosis. Circulation 2000;102:1744-1747.
    • (2000) Circulation , vol.102 , pp. 1744-1747
    • Guzik, T.J.1    West, N.E.J.2    Black, E.3
  • 40
    • 0034937504 scopus 로고    scopus 로고
    • NADH/NADPH oxidase p22 phox gene polymorphism is associated with improved coronary endothelial vasodilator function
    • Schachinger V, Britten MB, Dimmeler S, Zeiher AM. NADH/NADPH oxidase p22 phox gene polymorphism is associated with improved coronary endothelial vasodilator function. Eur Heart J 2001;22:96-101.
    • (2001) Eur Heart J , vol.22 , pp. 96-101
    • Schachinger, V.1    Britten, M.B.2    Dimmeler, S.3    Zeiher, A.M.4
  • 41
    • 0035793313 scopus 로고    scopus 로고
    • Polymorphisms and promoter overactivity of the p22(phox) gene in vascular smooth muscle cells from spontaneously hypertensive rats
    • Zalba G, San Jose G, Beaumont FJ, Fortuno MA, Fortuno A, Diez J. Polymorphisms and promoter overactivity of the p22(phox) gene in vascular smooth muscle cells from spontaneously hypertensive rats. Circ Res 2001;88:217-222.
    • (2001) Circ Res , vol.88 , pp. 217-222
    • Zalba, G.1    San Jose, G.2    Beaumont, F.J.3    Fortuno, M.A.4    Fortuno, A.5    Diez, J.6
  • 42
    • 0028813306 scopus 로고
    • Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries
    • Cosentino F, Katusic ZS. Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries. Circulation 1995;91:139-144.
    • (1995) Circulation , vol.91 , pp. 139-144
    • Cosentino, F.1    Katusic, Z.S.2
  • 43
    • 0000921940 scopus 로고    scopus 로고
    • Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats
    • Cosentino F, Patton S, d'Uscio LV, et al. Tetrahydrobiopterin alters superoxide and nitric oxide release in prehypertensive rats. J Clin Invest 1998;101:1530-1537.
    • (1998) J Clin Invest , vol.101 , pp. 1530-1537
    • Cosentino, F.1    Patton, S.2    D'Uscio, L.V.3
  • 44
    • 0029900905 scopus 로고    scopus 로고
    • Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury
    • Xia Y, Dawson VL, Dawson TM, Snyder SH, Zweier JL. Nitric oxide synthase generates superoxide and nitric oxide in arginine-depleted cells leading to peroxynitrite-mediated cellular injury. Proc Natl Acad Sci U S A 1996;93:6770-6774.
    • (1996) Proc Natl Acad Sci U S A , vol.93 , pp. 6770-6774
    • Xia, Y.1    Dawson, V.L.2    Dawson, T.M.3    Snyder, S.H.4    Zweier, J.L.5
  • 45
    • 0030837996 scopus 로고    scopus 로고
    • High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells
    • Cosentino F, Hishikawa K, Katusic ZS, Luscher TF. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation 1997;96:25-28.
    • (1997) Circulation , vol.96 , pp. 25-28
    • Cosentino, F.1    Hishikawa, K.2    Katusic, Z.S.3    Luscher, T.F.4
  • 46
    • 0029133481 scopus 로고
    • Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion
    • Pritchard KA, Jr., Groszek L, Smalley DM, et al. Native low-density lipoprotein increases endothelial cell nitric oxide synthase generation of superoxide anion. Circ Res 1995;77:510-518.
    • (1995) Circ Res , vol.77 , pp. 510-518
    • Pritchard K.A., Jr.1    Groszek, L.2    Smalley, D.M.3
  • 47
    • 0036045827 scopus 로고    scopus 로고
    • GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: Effects on nitric oxide synthase activity, protein levels and dimerization
    • In press
    • Cai S, Alp NJ, Mc Donald D, Canevari L, Heales S, Channon KM. GTP cyclohydrolase I gene transfer augments intracellular tetrahydrobiopterin in human endothelial cells: Effects on nitric oxide synthase activity, protein levels and dimerization. Cardiovasc Res 2002; In press.
    • (2002) Cardiovasc Res
    • Cai, S.1    Alp, N.J.2    Mc Donald, D.3    Canevari, L.4    Heales, S.5    Channon, K.M.6
  • 48
    • 0032930417 scopus 로고    scopus 로고
    • Mammalian nitric oxide synthases
    • Stuehr DJ. Mammalian nitric oxide synthases. Biochim Biophys Acta 1999; 1411:217-30.
    • (1999) Biochim Biophys Acta , vol.1411 , pp. 217-230
    • Stuehr, D.J.1
  • 49
    • 0026556496 scopus 로고
    • Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells
    • Schmidt K, Werner ER, Mayer B, Wachter H, Kukovetz WR. Tetrahydrobiopterin-dependent formation of endothelium-derived relaxing factor (nitric oxide) in aortic endothelial cells. Biochem J 1992;281:297-300.
    • (1992) Biochem J , vol.281 , pp. 297-300
    • Schmidt, K.1    Werner, E.R.2    Mayer, B.3    Wachter, H.4    Kukovetz, W.R.5
  • 50
    • 0029618106 scopus 로고
    • Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line - H4B promotes assembly of enzyme subunits into an active enzyme
    • Tzeng E, Billiar TR, Robbins PD, Loftus M, Stuehr DJ. Expression of human inducible nitric oxide synthase in a tetrahydrobiopterin (H4B)-deficient cell line - H4B promotes assembly of enzyme subunits into an active enzyme. Proc Natl Acad Sci U S A 1995;92:11771-11775.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 11771-11775
    • Tzeng, E.1    Billiar, T.R.2    Robbins, P.D.3    Loftus, M.4    Stuehr, D.J.5
  • 51
    • 0027101755 scopus 로고
    • Tetrahydrobiopterin synthesis: An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle
    • Gross SS, Levi R. Tetrahydrobiopterin synthesis: An absolute requirement for cytokine-induced nitric oxide generation by vascular smooth muscle. J Biol Chem 1992;267:25722-25729.
    • (1992) J Biol Chem , vol.267 , pp. 25722-25729
    • Gross, S.S.1    Levi, R.2
  • 52
    • 0035814951 scopus 로고    scopus 로고
    • Endothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between pYroxynitrite and tetrahydrobiopterin
    • Laursen JB, Somers M, Kurz S, et al. Endothelial regulation of vasomotion in apoE-deficient mice: Implications for interactions between pYroxynitrite and tetrahydrobiopterin. Circulation 2001;103:1282-1288.
    • (2001) Circulation , vol.103 , pp. 1282-1288
    • Laursen, J.B.1    Somers, M.2    Kurz, S.3
  • 53
    • 0034235409 scopus 로고    scopus 로고
    • Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency
    • Meininger CJ, Marinos RS, Hatakeyama K, et al. Impaired nitric oxide production in coronary endothelial cells of the spontaneously diabetic BB rat is due to tetrahydrobiopterin deficiency. Biochem J 2000;349:353-356.
    • (2000) Biochem J , vol.349 , pp. 353-356
    • Meininger, C.J.1    Marinos, R.S.2    Hatakeyama, K.3
  • 54
    • 0034730795 scopus 로고    scopus 로고
    • Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats
    • Shinozaki K, Nishio Y, Okamura T, et al. Oral administration of tetrahydrobiopterin prevents endothelial dysfunction and vascular oxidative stress in the aortas of insulin-resistant rats. Circ Res 2000;87:566-573.
    • (2000) Circ Res , vol.87 , pp. 566-573
    • Shinozaki, K.1    Nishio, Y.2    Okamura, T.3
  • 55
    • 0035793616 scopus 로고    scopus 로고
    • Mechanisms underlying endothelial dysfunction in diabetes mellitus
    • Hink U, Li H, Mollnau H, et al. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res 2001;88:E14-22.
    • (2001) Circ Res , vol.88
    • Hink, U.1    Li, H.2    Mollnau, H.3
  • 56
    • 0033961048 scopus 로고    scopus 로고
    • Homocysteine-induced inhibition of endothelium-dependent relaxation in rabbit aorta: Role for superoxide anions
    • Lang D, Kredan MB, Moat SJ, et al. Homocysteine-induced inhibition of endothelium-dependent relaxation in rabbit aorta: Role for superoxide anions. Arterioscler Thromb Vasc Biol 2000;20:422-427.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 422-427
    • Lang, D.1    Kredan, M.B.2    Moat, S.J.3
  • 57
    • 0034602878 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase
    • Heitzer T, Brockhoff C, Mayer B, et al. Tetrahydrobiopterin improves endothelium-dependent vasodilation in chronic smokers: Evidence for a dysfunctional nitric oxide synthase. Circ Res 2000;86:E36-E41.
    • (2000) Circ Res , vol.86
    • Heitzer, T.1    Brockhoff, C.2    Mayer, B.3
  • 58
    • 0033752910 scopus 로고    scopus 로고
    • Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus
    • Heitzer T, Krohn K, Albers S, Meinertz T. Tetrahydrobiopterin improves endothelium-dependent vasodilation by increasing nitric oxide activity in patients with Type II diabetes mellitus. Diabetologia 2000;43:1435-1438.
    • (2000) Diabetologia , vol.43 , pp. 1435-1438
    • Heitzer, T.1    Krohn, K.2    Albers, S.3    Meinertz, T.4
  • 59
    • 0031018510 scopus 로고    scopus 로고
    • Tetrahydrobiopterin restores endothelial function in hypercholesterolemia
    • Stroes E, Kastelein J, Cosentino F, et al. Tetrahydrobiopterin restores endothelial function in hypercholesterolemia. J Clin Invest 1997;99:41-46.
    • (1997) J Clin Invest , vol.99 , pp. 41-46
    • Stroes, E.1    Kastelein, J.2    Cosentino, F.3
  • 60
    • 0037066021 scopus 로고    scopus 로고
    • Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment
    • Schulz E, Tsilimingas N, Rinze R, et al. Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment. Circulation 2002;105:1170-1175.
    • (2002) Circulation , vol.105 , pp. 1170-1175
    • Schulz, E.1    Tsilimingas, N.2    Rinze, R.3
  • 61
    • 0035806914 scopus 로고    scopus 로고
    • Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: A human in vivo study
    • Gori T, Burstein JM, Ahmed S, et al. Folic acid prevents nitroglycerin-induced nitric oxide synthase dysfunction and nitrate tolerance: A human in vivo study. Circulation 2001;104:1119-1123.
    • (2001) Circulation , vol.104 , pp. 1119-1123
    • Gori, T.1    Burstein, J.M.2    Ahmed, S.3
  • 62
    • 0037059549 scopus 로고    scopus 로고
    • Inhibition of Protein Kinase C beta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans
    • Beckman JA, Goldfine AB, Gordon MB, Garrett LA, Creager MA. Inhibition of Protein Kinase C beta prevents impaired endothelium-dependent vasodilation caused by hyperglycemia in humans. Circ Res 2002;90:107-111.
    • (2002) Circ Res , vol.90 , pp. 107-111
    • Beckman, J.A.1    Goldfine, A.B.2    Gordon, M.B.3    Garrett, L.A.4    Creager, M.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.