메뉴 건너뛰기




Volumn 10, Issue 1, 2012, Pages 19-26

Past, present, and future of entry inhibitors as HIV microbicides

Author keywords

CCR5; Coreceptor; CXCR4; Entry; Envelope; Gp120; Gp41; HIV; Microbicides; Resistance

Indexed keywords

ANTIRETROVIRUS AGENT; CD4 ANTIGEN; GLYCOPROTEIN GP 120; MICROBICIDE; NONOXINOL 9; SURFACTANT;

EID: 84857133441     PISSN: 1570162X     EISSN: 18734251     Source Type: Journal    
DOI: 10.2174/157016212799304616     Document Type: Article
Times cited : (21)

References (78)
  • 2
    • 0036113306 scopus 로고    scopus 로고
    • Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection
    • O'Connor DH, Allen TM, Vogel TU, et al. Acute phase cytotoxic T lymphocyte escape is a hallmark of simian immunodeficiency virus infection. Nat Med 2002; 8 [5]: 493-539.
    • (2002) Nat Med , vol.8 , Issue.5 , pp. 493-539
    • O'Connor, D.H.1    Allen, T.M.2    Vogel, T.U.3
  • 3
    • 0025248466 scopus 로고
    • HIV prevention: The need for methods women can use
    • Stein ZA. HIV prevention: the need for methods women can use. Am J Public Health 1990; 80 [4]: 460-462.
    • (1990) Am J Public Health , vol.80 , Issue.4 , pp. 460-462
    • Stein, Z.A.1
  • 4
    • 77955930318 scopus 로고    scopus 로고
    • Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women
    • Abdool KQ, Abdool Karim SS, Frohlich JA, et al. Effectiveness and safety of tenofovir gel, an antiretroviral microbicide, for the prevention of HIV infection in women. Science 2010; 329 [5996]: 1168-1174.
    • (2010) Science , vol.329 , Issue.5996 , pp. 1168-1174
    • Abdool, K.Q.1    Abdool, K.S.S.2    Frohlich, J.A.3
  • 6
    • 0033012398 scopus 로고    scopus 로고
    • Chemokine receptors as HIV- 1 coreceptors: Roles in viral entry, tropism, and disease
    • Berger EA, Murphy PM, Farber JM. Chemokine receptors as HIV- 1 coreceptors: roles in viral entry, tropism, and disease. Annu Rev Immunol 1999; 17: 657-700.
    • (1999) Annu Rev Immunol , vol.17 , pp. 657-700
    • Berger, E.A.1    Murphy, P.M.2    Farber, J.M.3
  • 7
    • 0023644926 scopus 로고
    • PH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane
    • Stein BS, Gowda SD, Lifson JD, Penhallow RC, Bensch KG, Engleman EG. pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane. Cell 1987; 49 [5]: 659-668.
    • (1987) Cell , vol.49 , Issue.5 , pp. 659-668
    • Stein, B.S.1    Gowda, S.D.2    Lifson, J.D.3    Penhallow, R.C.4    Bensch, K.G.5    Engleman, E.G.6
  • 8
    • 0027157736 scopus 로고
    • Folding and assembly of viral membrane proteins
    • Doms RW, Lamb RA, Rose JK, Helenius A. Folding and assembly of viral membrane proteins. Virology 1993; 193 [2]: 545-562.
    • (1993) Virology , vol.193 , Issue.2 , pp. 545-562
    • Doms, R.W.1    Lamb, R.A.2    Rose, J.K.3    Helenius, A.4
  • 9
    • 0026029621 scopus 로고
    • Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein
    • Earl PL, Moss B, Doms RW. Folding, interaction with GRP78-BiP, assembly, and transport of the human immunodeficiency virus type 1 envelope protein. J Virol 1991; 65 [4]: 2047-2055.
    • (1991) J Virol , vol.65 , Issue.4 , pp. 2047-2055
    • Earl, P.L.1    Moss, B.2    Doms, R.W.3
  • 10
    • 0034634728 scopus 로고    scopus 로고
    • Maturation of HIV envelope glycoprotein precursors by cellular endoproteases
    • Moulard M, Decroly E. Maturation of HIV envelope glycoprotein precursors by cellular endoproteases. Biochim Biophys Acta 2000; 1469(3): 121-132.
    • (2000) Biochim Biophys Acta , vol.1469 , Issue.3 , pp. 121-132
    • Moulard, M.1    Decroly, E.2
  • 11
    • 0037381269 scopus 로고    scopus 로고
    • The structural biology of type I viral membrane fusion
    • Colman PM, Lawrence MC. The structural biology of type I viral membrane fusion. Nat Rev Mol Cell Biol 2003; 4 [4]: 309-319.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.4 , pp. 309-319
    • Colman, P.M.1    Lawrence, M.C.2
  • 12
    • 0022978934 scopus 로고
    • Binding of the human retrovirus HTLVIII/ LAV/ARV/HIV to the CD4 (T4) molecule: Conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry
    • McDougal JS, Nicholson JK, Cross GD, Cort SP, Kennedy MS Mawle AC. Binding of the human retrovirus HTLVIII/ LAV/ARV/HIV to the CD4 (T4) molecule: conformation dependence, epitope mapping, antibody inhibition, and potential for idiotypic mimicry. J Immunol 1986; 137 [9]: 2937-2944. 11-1.
    • (1986) J Immunol , vol.137 , Issue.9 , pp. 2937-2944
    • McDougal, J.S.1    Nicholson, J.K.2    Cross, G.D.3    Cort, S.P.4    Kennedy, M.S.5    Mawle, A.C.6
  • 13
    • 33847101745 scopus 로고    scopus 로고
    • Structural definition of a conserved neutralization epitope on HIV-1 gp120
    • Zhou T, Xu L, Dey B, et al. Structural definition of a conserved neutralization epitope on HIV-1 gp120. Nature 2007; 445 [7129]: 732-737.
    • (2007) Nature , vol.445 , Issue.7129 , pp. 732-737
    • Zhou, T.1    Xu, L.2    Dey, B.3
  • 14
    • 0030986787 scopus 로고    scopus 로고
    • HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor
    • Bieniasz PD, Fridell RA, Aramori I, Ferguson SS, Caron MG, Cullen BR. HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. EMBO J 1997; 16 [10]: 2599-2609.
    • (1997) EMBO J , vol.16 , Issue.10 , pp. 2599-2609
    • Bieniasz, P.D.1    Fridell, R.A.2    Aramori, I.3    Ferguson, S.S.4    Caron, M.G.5    Cullen, B.R.6
  • 15
    • 0032543307 scopus 로고    scopus 로고
    • Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody
    • Kwong PD, Wyatt R, Robinson J, Sweet RW, Sodroski J, Hendrickson WA. Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature 1998; 393 [6686]: 648-659.
    • (1998) Nature , vol.393 , Issue.6686 , pp. 648-659
    • Kwong, P.D.1    Wyatt, R.2    Robinson, J.3    Sweet, R.W.4    Sodroski, J.5    Hendrickson, W.A.6
  • 16
    • 0034690683 scopus 로고    scopus 로고
    • Fine definition of a conserved CCR5- binding region on the human immunodeficiency virus type 1 glycoprotein 120
    • Rizzuto C, Sodroski J. Fine definition of a conserved CCR5- binding region on the human immunodeficiency virus type 1 glycoprotein 120. AIDS Res Hum Retroviruses 2000; 16 [8]: 741-749.
    • (2000) AIDS Res Hum Retroviruses , vol.16 , Issue.8 , pp. 741-749
    • Rizzuto, C.1    Sodroski, J.2
  • 17
    • 0027488547 scopus 로고
    • Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding
    • Sattentau QJ, Moore JP, Vignaux F, Traincard F, Poignard P. Conformational changes induced in the envelope glycoproteins of the human and simian immunodeficiency viruses by soluble receptor binding. J Virol 1993; 67 [12]: 7383-7393.
    • (1993) J Virol , vol.67 , Issue.12 , pp. 7383-7393
    • Sattentau, Q.J.1    Moore, J.P.2    Vignaux, F.3    Traincard, F.4    Poignard, P.5
  • 18
    • 16144365317 scopus 로고    scopus 로고
    • CD4-dependent, antibodysensitive interactions between HIV-1 and its co-receptor CCR-5
    • Trkola A, Dragic T, Arthos J, et al. CD4-dependent, antibodysensitive interactions between HIV-1 and its co-receptor CCR-5. Nature 1996; 384 [6605]: 184-187.
    • (1996) Nature , vol.384 , Issue.6605 , pp. 184-187
    • Trkola, A.1    Dragic, T.2    Arthos, J.3
  • 19
    • 0023669119 scopus 로고
    • Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus
    • Gallaher WR. Detection of a fusion peptide sequence in the transmembrane protein of human immunodeficiency virus. Cell 1987; 50 [3]: 327-328.
    • (1987) Cell , vol.50 , Issue.3 , pp. 327-328
    • Gallaher, W.R.1
  • 20
    • 0024564217 scopus 로고
    • Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the fusion peptide
    • Harter C, James P, Bachi T, Semenza G, Brunner J. Hydrophobic binding of the ectodomain of influenza hemagglutinin to membranes occurs through the fusion peptide. J Biol Chem 1989; 264 [11]: 6459-6464.
    • (1989) J Biol Chem , vol.264 , Issue.11 , pp. 6459-6464
    • Harter, C.1    James, P.2    Bachi, T.3    Semenza, G.4    Brunner, J.5
  • 21
    • 0024561088 scopus 로고
    • Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques
    • Watanabe M, Reimann KA, DeLong PA, Liu T, Fisher RA, Letvin NL. Effect of recombinant soluble CD4 in rhesus monkeys infected with simian immunodeficiency virus of macaques. Nature 1989; 337 [6204]: 267-270.
    • (1989) Nature , vol.337 , Issue.6204 , pp. 267-270
    • Watanabe, M.1    Reimann, K.A.2    Delong, P.A.3    Liu, T.4    Fisher, R.A.5    Letvin, N.L.6
  • 22
    • 0025093595 scopus 로고
    • Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase I-II escalating dosage trial
    • Schooley RT, Merigan TC, Gaut P, et al. Recombinant soluble CD4 therapy in patients with the acquired immunodeficiency syndrome (AIDS) and AIDS-related complex. A phase I-II escalating dosage trial. Ann Intern Med 1990; 112 [4]: 247-253.
    • (1990) Ann Intern Med , vol.112 , Issue.4 , pp. 247-253
    • Schooley, R.T.1    Merigan, T.C.2    Gaut, P.3
  • 23
    • 0029417004 scopus 로고
    • Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells [see comments]
    • Cocchi F, DeVico AL, Garzino-Demo A, Arya SK, Gallo RC, Lusso P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells [see comments]. Science 1995; 270 [5243]: 1811-1815.
    • (1995) Science , vol.270 , Issue.5243 , pp. 1811-1815
    • Cocchi, F.1    Devico, A.L.2    Garzino-Demo, A.3    Arya, S.K.4    Gallo, R.C.5    Lusso, P.6
  • 24
    • 0034092634 scopus 로고    scopus 로고
    • International union of pharmacology. XXII. Nomenclature for chemokine receptors
    • Murphy PM, Baggiolini M, Charo IF, et al. International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 2000; 52 [1]: 145-176.
    • (2000) Pharmacol Rev , vol.52 , Issue.1 , pp. 145-176
    • Murphy, P.M.1    Baggiolini, M.2    Charo, I.F.3
  • 25
    • 0030002637 scopus 로고    scopus 로고
    • HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor
    • Feng Y, Broder CC, Kennedy PE, Berger EA. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science 1996; 272 [5263]: 872-877.
    • (1996) Science , vol.272 , Issue.5263 , pp. 872-877
    • Feng, Y.1    Broder, C.C.2    Kennedy, P.E.3    Berger, E.A.4
  • 26
    • 0030018156 scopus 로고    scopus 로고
    • CC CKR5: A RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1
    • Alkhatib G, Combadiere C, Broder CC, et al. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 1996; 272 [5270]: 1955-1958.
    • (1996) Science , vol.272 , Issue.5270 , pp. 1955-1958
    • Alkhatib, G.1    Combadiere, C.2    Broder, C.C.3
  • 27
    • 0005014748 scopus 로고    scopus 로고
    • The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates
    • Choe H, Farzan M, Sun Y, et al. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 1996; 85 [7]: 1135-1148.
    • (1996) Cell , vol.85 , Issue.7 , pp. 1135-1148
    • Choe, H.1    Farzan, M.2    Sun, Y.3
  • 28
    • 15844419153 scopus 로고    scopus 로고
    • Identification of a major coreceptor for primary isolates of HIV-1
    • Deng H, Liu R, Ellmeier W, et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 1996; 381 [6584]: 661-666.
    • (1996) Nature , vol.381 , Issue.6584 , pp. 661-666
    • Deng, H.1    Liu, R.2    Ellmeier, W.3
  • 29
    • 15844389650 scopus 로고    scopus 로고
    • HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5
    • Dragic T, Litwin V, Allaway GP, et al. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 1996; 381 [6584]: 667-673.
    • (1996) Nature , vol.381 , Issue.6584 , pp. 667-673
    • Dragic, T.1    Litwin, V.2    Allaway, G.P.3
  • 30
    • 0030604727 scopus 로고    scopus 로고
    • A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors
    • Doranz BJ, Rucker J, Yi Y, et al. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 1996; 85 [7]: 1149-1158.
    • (1996) Cell , vol.85 , Issue.7 , pp. 1149-1158
    • Doranz, B.J.1    Rucker, J.2    Yi, Y.3
  • 31
    • 0031662094 scopus 로고    scopus 로고
    • An orphan seventransmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus
    • Edinger AL, Hoffman TL, Sharron M, et al. An orphan seventransmembrane domain receptor expressed widely in the brain functions as a coreceptor for human immunodeficiency virus type 1 and simian immunodeficiency virus. J Virol 1998; 72 [10]: 7934-7940.
    • (1998) J Virol , vol.72 , Issue.10 , pp. 7934-7940
    • Edinger, A.L.1    Hoffman, T.L.2    Sharron, M.3
  • 32
    • 0030749247 scopus 로고    scopus 로고
    • Two orphan seventransmembrane segment receptors which are expressed in CD4- positive cells support simian immunodeficiency virus infection
    • Farzan M, Choe H, Martin K, et al. Two orphan seventransmembrane segment receptors which are expressed in CD4- positive cells support simian immunodeficiency virus infection. J Exp Med 1997; 186 [3]: 405-411.
    • (1997) J Exp Med , vol.186 , Issue.3 , pp. 405-411
    • Farzan, M.1    Choe, H.2    Martin, K.3
  • 33
    • 0031008794 scopus 로고    scopus 로고
    • STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1
    • Liao F, Alkhatib G, Peden KW, Sharma G, Berger EA, Farber JM. STRL33, A novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1. J Exp Med 1997; 185 [11]: 2015-2023.
    • (1997) J Exp Med , vol.185 , Issue.11 , pp. 2015-2023
    • Liao, F.1    Alkhatib, G.2    Peden, K.W.3    Sharma, G.4    Berger, E.A.5    Farber, J.M.6
  • 35
    • 0031575431 scopus 로고    scopus 로고
    • Change in coreceptor use correlates with disease progression in HIV-1-- infected individuals
    • Connor RI, Sheridan KE, Ceradini D, Choe S, Landau NR. Change in coreceptor use correlates with disease progression in HIV-1-- infected individuals. J Exp Med 1997; 185 [4]: 621-628.
    • (1997) J Exp Med , vol.185 , Issue.4 , pp. 621-628
    • Connor, R.I.1    Sheridan, K.E.2    Ceradini, D.3    Choe, S.4    Landau, N.R.5
  • 36
    • 0023896246 scopus 로고
    • Differential syncytium-inducing capacity of HIV isolates. Frequent detection of syncityum-inducing isolates in patients with AIDS and ARC
    • Tersmette M, de Goede REY, Al BJM, et al. Differential syncytium-inducing capacity of HIV isolates. Frequent detection of syncityum-inducing isolates in patients with AIDS and ARC. J Virol 1988; 62: 2026-2032.
    • (1988) J Virol , vol.62 , pp. 2026-2032
    • Tersmette, M.1    de Goede, R.E.Y.2    Al, B.J.M.3
  • 37
    • 0026600926 scopus 로고
    • Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: Progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population
    • Schuitemaker H, Koot M, Kootstra NA, et al. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus population. J Virol 1992; 66 [3]: 1354-1360.
    • (1992) J Virol , vol.66 , Issue.3 , pp. 1354-1360
    • Schuitemaker, H.1    Koot, M.2    Kootstra, N.A.3
  • 38
    • 0027255393 scopus 로고
    • The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro
    • Jennings R, Clegg A. The inhibitory effect of spermicidal agents on replication of HSV-2 and HIV-1 in-vitro. J Antimicrob Chemother 1993; 32 [1]: 71-82.
    • (1993) J Antimicrob Chemother , vol.32 , Issue.1 , pp. 71-82
    • Jennings, R.1    Clegg, A.2
  • 39
    • 0027242131 scopus 로고
    • The cat/feline immunodeficiency virus model for transmucosal transmission of AIDS: Nonoxynol-9 contraceptive jelly blocks transmission by an infected cell inoculum
    • Moench TR, Whaley KJ, Mandrell TD, Bishop BD, Witt CJ, Cone RA. The cat/feline immunodeficiency virus model for transmucosal transmission of AIDS: nonoxynol-9 contraceptive jelly blocks transmission by an infected cell inoculum. AIDS 1993; 7 [6], 797-802.
    • (1993) AIDS , vol.7 , Issue.6 , pp. 797-802
    • Moench, T.R.1    Whaley, K.J.2    Mandrell, T.D.3    Bishop, B.D.4    Witt, C.J.5    Cone, R.A.6
  • 40
    • 0026684234 scopus 로고
    • Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes
    • Kreiss J, Ngugi E, Holmes K, et al. Efficacy of nonoxynol 9 contraceptive sponge use in preventing heterosexual acquisition of HIV in Nairobi prostitutes. JAMA 1992; 268 [4]: 477-482.
    • (1992) JAMA , vol.268 , Issue.4 , pp. 477-482
    • Kreiss, J.1    Ngugi, E.2    Holmes, K.3
  • 41
    • 0037190597 scopus 로고    scopus 로고
    • Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: A randomised controlled trial
    • Van DL, Ramjee G, Alary M, et al. Effectiveness of COL-1492, a nonoxynol-9 vaginal gel, on HIV-1 transmission in female sex workers: a randomised controlled trial. The Lancet 2002; 360 [9338]: 971-977.
    • (2002) The Lancet , vol.360 , Issue.9338 , pp. 971-977
    • Van, D.L.1    Ramjee, G.2    Alary, M.3
  • 42
    • 0034974386 scopus 로고    scopus 로고
    • Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: A randomized clinical trial
    • Richardson BA, Lavreys L, Martin HL, Jr., et al. Evaluation of a low-dose nonoxynol-9 gel for the prevention of sexually transmitted diseases: a randomized clinical trial. Sex Transm Dis 2001; 28 [7]: 394-400.
    • (2001) Sex Transm Dis , vol.28 , Issue.7 , pp. 394-400
    • Richardson, B.A.1    Lavreys, L.2    Martin Jr., H.L.3
  • 43
    • 41849087248 scopus 로고    scopus 로고
    • SAVVY vaginal gel (C31G) for prevention of HIV infection: A randomized controlled trial in Nigeria
    • Feldblum PJ, Adeiga A, Bakare R, Wevill S, Lendvay A, Obadaki F, et al. SAVVY vaginal gel (C31G) for prevention of HIV infection: a randomized controlled trial in Nigeria. PLoS ONE 2008; 3 [1]: e1474.
    • (2008) PLoS ONE , vol.3 , Issue.1
    • Feldblum, P.J.1    Adeiga, A.2    Bakare, R.3    Wevill, S.4    Lendvay, A.5    Obadaki, F.6
  • 44
    • 44349126694 scopus 로고    scopus 로고
    • SAVVY (C31G) gel for prevention of HIV infection in women: A Phase 3, double-blind, randomized, placebo-controlled trial in Ghana
    • Peterson L, Nanda K, Opoku BK, et al. SAVVY (C31G) gel for prevention of HIV infection in women: a Phase 3, double-blind, randomized, placebo-controlled trial in Ghana. PLoS ONE 2007; 2 [12]: e1312.
    • (2007) PLoS ONE , vol.2 , Issue.12
    • Peterson, L.1    Nanda, K.2    Opoku, B.K.3
  • 45
    • 57049091723 scopus 로고    scopus 로고
    • Efficacy of Carraguard for prevention of HIV infection in women in South Africa: A randomised, double-blind, placebo-controlled trial
    • Skoler-Karpoff S, Ramjee G, Ahmed K, et al. Efficacy of Carraguard for prevention of HIV infection in women in South Africa: a randomised, double-blind, placebo-controlled trial. The Lancet 2008; 372 [9654]: 1977-1987.
    • (2008) The Lancet , vol.372 , Issue.9654 , pp. 1977-1987
    • Skoler-Karpoff, S.1    Ramjee, G.2    Ahmed, K.3
  • 46
    • 48249154985 scopus 로고    scopus 로고
    • Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission
    • Van DL, Govinden R, Mirembe FM, et al. Lack of effectiveness of cellulose sulfate gel for the prevention of vaginal HIV transmission. N Engl J Med 2008; 359 [5]: 463-472.
    • (2008) N Engl J Med , vol.359 , Issue.5 , pp. 463-472
    • Van, D.L.1    Govinden, R.2    Mirembe, F.M.3
  • 47
    • 79954804509 scopus 로고    scopus 로고
    • Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women
    • Abdool Karim SS, Richardson BA, Ramjee G, et al. Safety and effectiveness of BufferGel and 0.5% PRO2000 gel for the prevention of HIV infection in women. AIDS 2011; 25 [7]: 957-966.
    • (2011) AIDS , vol.25 , Issue.7 , pp. 957-966
    • Abdool, K.S.S.1    Richardson, B.A.2    Ramjee, G.3
  • 48
    • 78349289575 scopus 로고    scopus 로고
    • The last decade of microbicide clinical trials in Africa: From hypothesis to facts
    • Ramjee G, Kamali A, McCormack S. The last decade of microbicide clinical trials in Africa: from hypothesis to facts. AIDS 2010; 24 Suppl 4: S40-S49.
    • (2010) AIDS , vol.24 , Issue.SUPPL 4
    • Ramjee, G.1    Kamali, A.2    McCormack, S.3
  • 49
    • 71149085990 scopus 로고    scopus 로고
    • Microbicides Development Programme: Design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention
    • Nunn A, McCormack S, Crook AM, Pool R, Rutterford C, Hayes R. Microbicides Development Programme: design of a phase III trial to measure the efficacy of the vaginal microbicide PRO 2000/5 for HIV prevention. Trials 2009; 10: 99.
    • (2009) Trials , vol.10 , pp. 99
    • Nunn, A.1    McCormack, S.2    Crook, A.M.3    Pool, R.4    Rutterford, C.5    Hayes, R.6
  • 51
    • 0034968797 scopus 로고    scopus 로고
    • Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models
    • Zeitlin L, Hoen TE, Achilles SL, et al. Tests of Buffergel for contraception and prevention of sexually transmitted diseases in animal models. Sex Transm Dis 2001; 28 [7]: 417-423.
    • (2001) Sex Transm Dis , vol.28 , Issue.7 , pp. 417-423
    • Zeitlin, L.1    Hoen, T.E.2    Achilles, S.L.3
  • 52
    • 45449092969 scopus 로고    scopus 로고
    • Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors
    • Pugach P, Ketas TJ, Michael E, Moore JP. Neutralizing antibody and anti-retroviral drug sensitivities of HIV-1 isolates resistant to small molecule CCR5 inhibitors. Virology 2008; 377 [2]: 401-407.
    • (2008) Virology , vol.377 , Issue.2 , pp. 401-407
    • Pugach, P.1    Ketas, T.J.2    Michael, E.3    Moore, J.P.4
  • 53
    • 27744571425 scopus 로고    scopus 로고
    • Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion
    • Veazey RS, Klasse PJ, Schader SM, et al. Protection of macaques from vaginal SHIV challenge by vaginally delivered inhibitors of virus-cell fusion. Nature 2005; 438 [7064]: 99-102.
    • (2005) Nature , vol.438 , Issue.7064 , pp. 99-102
    • Veazey, R.S.1    Klasse, P.J.2    Schader, S.M.3
  • 54
    • 77955673220 scopus 로고    scopus 로고
    • Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor
    • Veazey RS, Ketas TJ, Dufour J, et al. Protection of rhesus macaques from vaginal infection by vaginally delivered maraviroc, an inhibitor of HIV-1 entry via the CCR5 co-receptor. J Infect Dis 2010; 202 [5]: 739-744.
    • (2010) J Infect Dis , vol.202 , Issue.5 , pp. 739-744
    • Veazey, R.S.1    Ketas, T.J.2    Dufour, J.3
  • 55
    • 0345471066 scopus 로고    scopus 로고
    • Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120
    • Veazey RS, Shattock RJ, Pope M, et al. Prevention of virus transmission to macaque monkeys by a vaginally applied monoclonal antibody to HIV-1 gp120. Nat Med 2003; 9 [3]: 343-6.
    • (2003) Nat Med , vol.9 , Issue.3 , pp. 343-346
    • Veazey, R.S.1    Shattock, R.J.2    Pope, M.3
  • 56
    • 0345569681 scopus 로고    scopus 로고
    • Inhibiting sexual transmission of HIV-1 infection
    • Shattock RJ, Moore JP. Inhibiting sexual transmission of HIV-1 infection. Nat Rev Microbiol 2003; 1 [1]: 25-34.
    • (2003) Nat Rev Microbiol , vol.1 , pp. 25-34
    • Shattock, R.J.1    Moore, J.P.2
  • 57
    • 0042368611 scopus 로고    scopus 로고
    • Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques
    • Tsai CC, Emau P, Jiang Y, et al. Cyanovirin-N gel as a topical microbicide prevents rectal transmission of SHIV89.6P in macaques. AIDS Res Hum Retroviruses 2003; 19 [7]: 535-541.
    • (2003) AIDS Res Hum Retroviruses , vol.19 , Issue.7 , pp. 535-541
    • Tsai, C.C.1    Emau, P.2    Jiang, Y.3
  • 58
    • 0742272702 scopus 로고    scopus 로고
    • Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models
    • Tsai CC, Emau P, Jiang Y, et al. Cyanovirin-N inhibits AIDS virus infections in vaginal transmission models. AIDS Res Hum Retroviruses 2004; 20 [1]: 11-18.
    • (2004) AIDS Res Hum Retroviruses , vol.20 , Issue.1 , pp. 11-18
    • Tsai, C.C.1    Emau, P.2    Jiang, Y.3
  • 59
  • 60
    • 12144290487 scopus 로고    scopus 로고
    • Short-term safety and antiretroviral activity of T-1249, a second-generation fusion inhibitor of HIV
    • Eron JJ, Gulick RM, Bartlett JA, et al. Short-term safety and antiretroviral activity of T-1249, a second-generation fusion inhibitor of HIV. J Infect Dis 2004; 189 [6]: 1075-1083.
    • (2004) J Infect Dis , vol.189 , Issue.6 , pp. 1075-1083
    • Eron, J.J.1    Gulick, R.M.2    Bartlett, J.A.3
  • 61
    • 20144386372 scopus 로고    scopus 로고
    • T-1249 retains potent antiretroviral activity in patients who had experienced virological failure while on an enfuvirtide-containing treatment regimen
    • Lalezari JP, Bellos NC, Sathasivam K, et al. T-1249 retains potent antiretroviral activity in patients who had experienced virological failure while on an enfuvirtide-containing treatment regimen. J Infect Dis 2005; 191 [7]: 1155-1163.
    • (2005) J Infect Dis , vol.191 , Issue.7 , pp. 1155-1163
    • Lalezari, J.P.1    Bellos, N.C.2    Sathasivam, K.3
  • 62
    • 34147186687 scopus 로고    scopus 로고
    • Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes
    • Ketas TJ, Schader SM, Zurita J, et al. Entry inhibitor-based microbicides are active in vitro against HIV-1 isolates from multiple genetic subtypes. Virology 2007.
    • (2007) Virology
    • Ketas, T.J.1    Schader, S.M.2    Zurita, J.3
  • 63
    • 5644247983 scopus 로고    scopus 로고
    • Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5
    • Lederman MM, Veazey RS, Offord R, et al. Prevention of vaginal SHIV transmission in rhesus macaques through inhibition of CCR5. Science 2004; 306 [5695]: 485-487.
    • (2004) Science , vol.306 , Issue.5695 , pp. 485-487
    • Lederman, M.M.1    Veazey, R.S.2    Offord, R.3
  • 64
    • 0034004857 scopus 로고    scopus 로고
    • Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs
    • Torre VS, Marozsan AJ, Albright JL, et al. Variable sensitivity of CCR5-tropic human immunodeficiency virus type 1 isolates to inhibition by RANTES analogs. J Virol 2000; 74: 4868-4876.
    • (2000) J Virol , vol.74 , pp. 4868-4876
    • Torre, V.S.1    Marozsan, A.J.2    Albright, J.L.3
  • 65
    • 0037223692 scopus 로고    scopus 로고
    • Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors
    • Labrosse B, Labernardiere JL, Dam E, et al. Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors. J Virol 2003; 77 [2]: 1610-1613.
    • (2003) J Virol , vol.77 , Issue.2 , pp. 1610-1613
    • Labrosse, B.1    Labernardiere, J.L.2    Dam, E.3
  • 66
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitorbound receptor for entry
    • Westby M, Smith-Burchnell C, Mori J, et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitorbound receptor for entry. J Virol 2007; 81 [5]: 2359-2371.
    • (2007) J Virol , vol.81 , Issue.5 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3
  • 67
    • 33646443202 scopus 로고    scopus 로고
    • Emergence of CXCR4- using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
    • Westby M, Lewis M, Whitcomb J, et al. Emergence of CXCR4- using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J Virol 2006; 80 [10]: 4909-4920.
    • (2006) J Virol , vol.80 , Issue.10 , pp. 4909-4920
    • Westby, M.1    Lewis, M.2    Whitcomb, J.3
  • 68
    • 27644510382 scopus 로고    scopus 로고
    • Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity
    • Dorr P, Westby M, Dobbs S, et al. Maraviroc (UK-427,857), a potent, orally bioavailable, and selective small-molecule inhibitor of chemokine receptor CCR5 with broad-spectrum anti-human immunodeficiency virus type 1 activity. Antimicrob Agents Chemother 2005; 49 [11]: 4721-4732.
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.11 , pp. 4721-4732
    • Dorr, P.1    Westby, M.2    Dobbs, S.3
  • 69
    • 33747045164 scopus 로고    scopus 로고
    • An anti-CCR5 monoclonal antibody and small molecule CCR5 antagonists synergize by inhibiting different stages of human immunodeficiency virus type 1 entry
    • Safarian D, Carnec X, Tsamis F, Kajumo F, Dragic T. An anti-CCR5 monoclonal antibody and small molecule CCR5 antagonists synergize by inhibiting different stages of human immunodeficiency virus type 1 entry. Virology 2006; 352 [2]: 477-484.
    • (2006) Virology , vol.352 , Issue.2 , pp. 477-484
    • Safarian, D.1    Carnec, X.2    Tsamis, F.3    Kajumo, F.4    Dragic, T.5
  • 70
    • 0035940445 scopus 로고    scopus 로고
    • SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
    • Strizki JM, Xu S, Wagner NE, et al. SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc Natl Acad Sci USA 2001; 98 [22]: 12718-12723.
    • (2001) Proc Natl Acad Sci USA , vol.98 , Issue.22 , pp. 12718-12723
    • Strizki, J.M.1    Xu, S.2    Wagner, N.E.3
  • 71
    • 0037059049 scopus 로고    scopus 로고
    • Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    • Reeves JD, Gallo SA, Ahmad N, et al. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc Natl Acad Sci USA 2002; 99 [25]: 16249-16254.
    • (2002) Proc Natl Acad Sci USA , vol.99 , Issue.25 , pp. 16249-16254
    • Reeves, J.D.1    Gallo, S.A.2    Ahmad, N.3
  • 72
    • 0037223692 scopus 로고    scopus 로고
    • Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors
    • Labrosse B, Labernardiere JL, Dam E, et al. Baseline susceptibility of primary human immunodeficiency virus type 1 to entry inhibitors. J Virol 2003; 77 [2]: 1610-1613.
    • (2003) J Virol , vol.77 , Issue.2 , pp. 1610-1613
    • Labrosse, B.1    Labernardiere, J.L.2    Dam, E.3
  • 74
    • 2342514225 scopus 로고    scopus 로고
    • Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity
    • Reeves JD, Miamidian JL, Biscone MJ, et al. Impact of mutations in the coreceptor binding site on human immunodeficiency virus type 1 fusion, infection, and entry inhibitor sensitivity. J Virol 2004; 78 [10]: 5476-5485.
    • (2004) J Virol , vol.78 , Issue.10 , pp. 5476-5485
    • Reeves, J.D.1    Miamidian, J.L.2    Biscone, M.J.3
  • 75
    • 79952085104 scopus 로고    scopus 로고
    • HIV-1 Entry, Inhibitors, and Resistance
    • Lobritz MA, Ratcliff AN, Arts EJ. HIV-1 Entry, Inhibitors, and Resistance. Viruses 2010; 2 [5]: 1069-1105.
    • (2010) Viruses , vol.2 , pp. 1069-1105
    • Lobritz, M.A.1    Ratcliff, A.N.2    Arts, E.J.3
  • 76
    • 49149118151 scopus 로고    scopus 로고
    • In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject
    • Tsibris AM, Sagar M, Gulick RM, et al. In vivo emergence of vicriviroc resistance in a human immunodeficiency virus type 1 subtype C-infected subject. J Virol 2008; 82 [16]: 8210-8214.
    • (2008) J Virol , vol.82 , Issue.16 , pp. 8210-8214
    • Tsibris, A.M.1    Sagar, M.2    Gulick, R.M.3
  • 77
    • 65349147003 scopus 로고    scopus 로고
    • Selection of a simian-human immunodeficiency virus strain resistant to a vaginal microbicide in macaques
    • Dudley DM, Wentzel JL, Lalonde MS, Veazey RS, Arts EJ. Selection of a simian-human immunodeficiency virus strain resistant to a vaginal microbicide in macaques. J Virol 2009; 83 [10]: 5067-5076.
    • (2009) J Virol , vol.83 , Issue.10 , pp. 5067-5076
    • Dudley, D.M.1    Wentzel, J.L.2    Lalonde, M.S.3    Veazey, R.S.4    Arts, E.J.5
  • 78
    • 33847237614 scopus 로고    scopus 로고
    • Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitorbound receptor for entry
    • Westby M, Smith-Burchnell C, Mori J, et al. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitorbound receptor for entry. J Virol 2007; 81 [5]: 2359-2371.
    • (2007) J Virol , vol.81 , Issue.5 , pp. 2359-2371
    • Westby, M.1    Smith-Burchnell, C.2    Mori, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.