Two orphan seven-transmembrane segment receptors which are expressed in CD4-positive cells support simian immunodeficiency virus infection

Journal of Experimental Medicine

Volumn 186, Issue 3, 1997, Pages 405-411

  Farzan, Michael ^a   Choe, Hyeryun ^a   Martin, Kathleen ^c   Marcon, Luisa ^a,d   Hofmann, Wolfgang ^a   Karlsson, Gunilla ^a   Sun, Ying ^a   Barrett, Peter ^c   Marchand, Nathalie ^a   Sullivan, Nancy ^a   Gerard, Norma ^c   Gerard, Craig ^c   Sodroski, Joseph ^a,b,e  

^a HARVARD MEDICAL SCHOOL   (United States)

^b HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^c BOSTON CHILDREN S HOSPITAL   (United States)

^d UNIVERSITY OF PADUA MEDICAL SCHOOL   (Italy)

^e DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL CELL; ARTICLE; CENTRAL NERVOUS SYSTEM; CONFORMATIONAL TRANSITION; DENDRITIC CELL; DNA LIBRARY; IMMUNE DEFICIENCY; LUNG ALVEOLUS MACROPHAGE; MONONUCLEAR CELL; NONHUMAN; PHYLOGENY; PRIORITY JOURNAL; RECEPTOR AFFINITY; T LYMPHOCYTE ACTIVATION; TARGET CELL; VIRUS ENVELOPE; VIRUS EXPRESSION; VIRUS INFECTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; CLONING, MOLECULAR; HUMANS; MACACA MULATTA; MACROPHAGES, ALVEOLAR; MOLECULAR SEQUENCE DATA; RECEPTORS, CCR5; RECEPTORS, CYTOKINE; RECEPTORS, HIV; RECEPTORS, VIRUS; SIMIAN ACQUIRED IMMUNODEFICIENCY SYNDROME; SIMIAN IMMUNODEFICIENCY VIRUS;

EID: 0030749247     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.186.3.405     Document Type: Article

References (68)

1. Barre-Sinoussi, F., J.C. Chermann, F. Rey, M.T. Nugeyre, S. Charmaret, J. Gruest, C. Dauget, C. Axler-Bin, F. Vezinet-Brun, C. Rouzioux, et al. 1983. Isolation of a T-lymphocyte retrovirus from a patient at risk for acquired immunodeficiency syndrome (AIDS). Science (Wash. DC). 220:868-871.
2. Clavel, F. 1987. HIV-2, the West African AIDS virus. AIDS (Lond.). 1:135-140.
3. Desrosiers, R.C. 1990. The simian immunodeficiency viruses. Annu. Rev. Immunol. 8:557-578.
4. Gallo, R.C., S.Z. Salahuddin, M. Popovic, G.M. Shearer, M. Kaplan, B.F. Haynes, T.J. Palker, R. Redfield, J. Oleske, B. Safai, et al. 1984. Frequent detection and isolation of cytopathic retroviruses (HTLV-III) from patients with AIDS and at risk for AIDS. Science (Wash. DC). 272:872-877.
5. Letvin, N.L., M.D. Daniel, P.K. Sehgal, R.C. Desrosiers, R.D. Hunt, L.M. Waldron, J.J. MacKey, D.K. Schmidt, L.V. Chalifoux, and N.W. King. 1985. Induction of AIDS-like disease in macaque monkeys with T-cell tropic retrovrus STLV-III. Science (Wash. DC). 230:71-73.
6. Myers, G., S. Wain-Hobson, L. Henderson, B. Korber, K.-T. Jeang, and G. Pavlakis. 1994. Human Retroviruses and AIDS: A Compilation and Analysis of Nucleic Acid and Amino Acid Sequences. Los Alamos National Laboratory, Los Alamos, New Mexico. Section 111:23-31.
7. Kanki, P., M. McLane, N. King, and M. Essex. 1985. Serological identification and characterization of a macaque T-lymphocytic retrovirus closely related to HTLV-III. Science (Wash. DC). 228:1199-1201.
8. Weiss, R., P. Clapham, J. Weber, A. Dalgleish, L. Lasky, and P. Berman. 1986. Variable and conserved neutralization antigens of human immunodeficiency virus. Nature (Lond.). 324: 572-575.
9. Fauci, A., A. Macher, D. Longo, H.C. Lane, A. Rook, H. Masur, and E. Gelmann. 1984. Acquired immunodeficiency syndrome: epidemiologic, clinical, immunologic, and therapeutic considerations. Ann. Intern. Med. 100:92-106.
10. Desrosiers, R.C., A. Hansen-Moosa, K. Mori, D.P. Bouvier, N.W. King, M.D. Daniel, and D.J. Ringler. 1991. Macrophage-tropic variants of SIV are associated with specific AIDS-related lesions but are not essential for the development of AIDS. Am. J. Pathol. 139:29-35.
11. Gartner, S., P. Markovits, D. Markovitz, M.H. Kaplan, R.C. Gallo, and M. Popovic. 1986. The role of mononuclear phagocytes in HTLV-III/LAV infection. Science (Wash. DC). 233: 215-219.
12. Gendelman, H., J. Orenstein, M. Martin, C. Ferrva, R. Mitra, T. Phipps, L. Wahl, C. Lane, A. Fauci, and D. Burke. 1988. Efficient isolation and propagation of human immunodeficiency virus on recombinant colony-stimulating factor 1-treated monocytes. J. Exp. Med. 167:1428-1441.
13. Koenig, S., H.E. Gendelman, J.M. Orenstein, M.C. Dal Canto, G.H. Pezeshkpour, M. Yungbluth, F. Janotta, A. Aksamit, M.A. Martin, and A.S. Fauci. 1986. Detection of AIDS virus in macrophages in brain tissue from AIDS patients with encephalopathy. Science (Wash. DC). 233:1089-1093.
14. Ringler, D.J., M.S. Wyand, D.G. Walsh, J.J. MacKey, P.K. Sehgal, M.D. Daniel, R.C. Desrosiers, and N.W. King. 1989. The productive infection of alveolar macrophages by simian immunodeficiency virus. J. Med. Primatol. 18:217-226.
15. Pope, M., M. Betjes, N. Romani, H. Hirmand, P. Cameron, L. Hoffman, S. Gezelter, G. Schuler, and R. Steinman. 1994. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1. Cell. 78: 389-398.
16. Weissman, D., Y. Li, J. Ananworanich, L.-J. Zhou, J. Adelsberger, T. Tedder, M. Baseler, and A. Fauci. 1995. Three populations of cells with dendritic morphology exist in peripheral blood only one of which is infectable with human immunodeficiency virus type 1. Proc. Natl. Acad. Sci. USA. 92:826-830.
17. Dalgleish, A.G., P.C.L. Beverley, P.R. Clapham, D.H. Crawford, M.F. Greaves, and R.A. Weiss. 1984. The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature (Lond.). 312:763-767.
18. Klatzmann, D., E. Champagne, S. Chamaret, J. Gruest, D. Guetard, T. Hercend, J.C. Gluckman, and L. Montagnier. 1984. T-lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature (Lond.). 312:767-768.
19. Maddon, P.J., A.G. Dalgleish, J.S. McDougal, P.R. Clapham, R.A. Weiss, and R. Axel. 1986. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell. 47:333-348.
20. Allan, J., T.H. Lee, M.F. McLane, J. Sodroski, W. Haseltine, and M. Essex. 1983. Identification of the major envelope glycoprotein product of HTLV-III. Science (Wash. DC). 228: 1091-1094.
21. Robey, W.G., B. Safai, S. Oroszlan, L. Arthur, M. Gonda, R. Gallo, and P.J. Fischinger. 1985. Characterization of envelope and core structural gene products of HTLV-III with sera from AIDS patients. Science (Wash. DC). 228:593-595.
22. Lapham, C., J. Ouyang, B. Chandraseklar, N. Nguyen, D. Dimitrov, and H. Golding. 1996. Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science (Wash. DC). 274:602-605.
23. Wu, L., N. Gerard, R. Wyatt, H. Choe, C. Parolin, N. Ruffing, A. Borsetti, A. Cardoso, E. Desjardin, W. Newman, et al. 1996. CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR5. Nature (Lond.). 384:179-183.
24. Trkola, A., T. Dragic, J. Arthos, J.M. Binley, W.C. Olson, G.P. Allaway, C. Cheng-Mayer, J. Robinson, P.J. Maddon, and J.P. Moore. 1996. CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature (Lond.). 384:184-187.
25. Stein, B., S. Gouda, J. Lifson, R. Penhallow, K. Bensch, and E. Engelman. 1987. pH-independent HIV entry into CD4-positive T cells via virus envelope fusion to the plasma membrane. Cell. 49:659-668.
26. Kowalski, M., J. Potz, L. Basiripour, T. Dorfman, W.G. Goh, E. Terwilliger, A. Dayton, C. Rosen, W. Haseltine, and J. Sodroski. 1987. Functional regions of the human immunodeficiency virus envelope glycoproteins. Science (Wash. DC.). 237:1351-1355.
27. Helseth, E., M. Kowalski, D. Gabuzda, U. Olshevsky, W. Haseltine, and J. Sodroski. 1990. Rapid complementation assays measuring replicative potential of HIV-1 envelope glycoprotein mutants. J. Viral. 64:2416-2420.
28. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P.D. Ponath, L. Wu, C.R. Mackay, G. LaRosa, W. Newman, et al. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 85:1135-1148.
29. Cocchi, F., A. DeVico, A. Garzino-Demo, A. Cara, R.C. Gallo, and P. Lusso. 1996. The V3 domain of the HIV-1 gp120 glycoprotein is critical for chemokine-mediated blockade of infection. Nat. Med. 2:1244-1247.
30. Alkhatib, G., C. Combadiere, C.C. Broder, Y. Feng, P.M. Murphy, and E. Berger. 1996. CC-CKR5: a RANTES, MIP-1α, MIP-Iβ receptor as a fusion cofactor for macrophage-tropic HIV-1. Science (Wash. DC.). 272:1955-1958.
31. Deng, H.K., S. Choe, W. Ellmeier, R. Liu, D. Unutmaz, M. Burkhart, P. di Marzio, S. Marmon, R.E. Sutton, C.M. Hill, et al. 1996. Identificaation of a major co-receptor for primary isolates of HIV-1. Nature (Lond.). 381:661-666.
32. Doranz, B., J. Rucker, Y. Yi, R. Smyth, M. Samson, S. Peiper, M. Parmentier, R. Collman, and R. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKK-2b as fusion cofactors. Cell. 85:1149-1158.
33. + cells is mediated by the chemokine receptor CC-CKR-5. Nature (Lond.). 381:667-673.
34. Zhang, L., Y. Hsung, T. He, Y. Cao, and D.D. Ho. 1996. HIV-1 subtype and second-receptor use. Nature (Lond.). 383:768.
35. Connor, R.I., K.E. Sheridan, D. Ceradini, S. Choe, and N.R. Landau. 1997. Change in coreceptor use correlates with disease progression in HIV-1 infected individuals. J. Exp. Med. 185:621-628.
36. Wu, L., W.A. Paxton, N. Kassam, N. Ruffing, J.B. Rottman, N. Sullivan, H. Choe, J. Sodroski, W. Newman, R.A. Koup, and C.R. Mackay. 1997. CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1 in vitro. J. Exp. Med. 185:1681-1691.
37. Granelli-Piperno, A., B. Moser, M. Pope, D. Chen, Y. Wei, F. Isdell, U. O'Doherty, W. Paxton, R. Koup, S. Mojsov, et al. 1996. Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors. J. Exp. Med. 184:2433-2438.
38. Raport, C.J., J. Gosling, V.L. Schweickart, P.W. Gray, and I.E. Charo. 1996. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1β, and MIP-1α. J. Biol. Chem. 271: 17161-17166.
39. He, J., Y. Chen, M. Farzan, H. Choe, A. Ohagen, S. Gartner, J. Busciglio, X. Yang, W. Hofmann, W. Newman, et al. 1997. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia. Nature (Lond.). 385:645-649.
40. Liu, R., W. Paxton, S. Choe, D. Ceradini, S. Martin, R. Horuk, M. MacDonald, H. Stuhlmann, R. Koup, and N. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 86:367-378.
41. Dean, M., M. Carrington, C. Winkler, G.A. Huttley, MW. Smith, R. Allikmets, J.J. Goedert, S.P. Buchbinder, E. Vittinghoff, E. Gomperts, et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study. Science (Wash. DC). 273:1856-1862.
42. Samson, M., F. Libert, B. Doranz, B. Rucker, C. Liesnard, C. Farber, S. Saragosti, C. Lapouméroulie, J. Cognaux, C. Forceille, et al. 1996. Resistance to HIV-1 infection of Caucasian individuals bearing a mutant allele of the CCR5 chemokine receptor gene. Nature (Lond.). 382:722-725.
43. Simmons, G., D. Wilkinson, J.D. Reeves, M.T. Dittmar, S. Beddows, J. Weber, G. Carnegie, U. Desselberger, P.W. Gray, R.A. Weiss, and P.R. Clapham. 1996. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either LESTR or CCR5 as coreceptors for virus entry. J. Virol. 70:8355-8360.
44. Feng, Y., C.C. Broder, P.E. Kennedy, and E.A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science (Wash. DC). 272:872-877.
45. Schuitemaker, H., M. Koot, N.A. Koostra, M.W. Dercksen, R.E.Y. deGoede, R.P. van Steenwijk, J.M.A. Lange, J.K.M. Eeftink-Schattenkert, F. Miedema, and M. Tersmette. 1992. Biological phenotype of human immunodeficiency virus type 1 clones at different stages of infection: progression of disease is associated with a shift from monocytotropic to T-cell-tropic virus populations. J. Virol. 65:356-363.
46. Bleul, C.C., L. Wu, J.A. Hoxie, T.A. Springer, and C.R. Mackay. 1996. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes. Proc. Natl. Acad. Sci. USA. 94:1925-1930.
47. mac239). J. Virol 71:2522-2527.
48. Chen, Z., P. Zhou, D.D. Ho, N. Landau, and P. Marx. 1997. Genetically divergent strains of simian immunodeficiency virus use CCR5 as a coreceptor for entry. J. Virol. 71:2705-2714.
49. Cocchi, F., A. DeVico, A. Garzino-Demo, S. Arya, R. Gallo, and P. Lusso. 1995. Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science (Wash. DC). 270:1811-1815.
50. Endres, M., P. Clapham, M. Marsh, M. Ahuja, J. Turner, A. McKnight, J. Thomas, B. Stoebenau-Haggarty, S. Choe, P. Vance, et al. 1996. CD4-independent infection by HIV-2 is mediated by fusin/CXCR4. Cell. 87:745-756.
51. Clapham, P., D. Blanc, and R. Weiss. 1991. Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and by simian immunodeficiency virus. Virology. 181:703-715.
52. Kestler, H., D. Ringler, K. Mori, D. Panicali, P. Sehgal, M. Daniel, and R. Desrosiers. 1991. Importance of the nef gene for maintenance of high virus loads and for the development of AIDS. Cell. 65:651-662.
53. Marchese, A., J. Docherty, T. Nguyen, M. Heiber, R. Cheng, H. Heng, L. Tsui, X. Shi, S. George, and B. O'Dowd. 1994. Cloning of human genes encoding novel G protein-coupled receptors. Genomics. 23:609-618.
54. Heiber, M., A. Marchese, T. Nguyen, H. Heng, S. George, and B. O'Dowd. 1996. A novel human gene encoding a G-protein-coupled receptor (gpr15) is located on chromosome 3. Genomics. 32:462-465.
55. O'Dowd, B., M. Heiber, A. Chan, H. Heng, L. Tsui, J. Kennedy, X. Shi, A. Petronis, S. George, and T. Nguyen. 1993. A human gene that shows identity with the gene encoding the angiotensin receptor is located on chromosome 11. Gene (Amst.). 136:355-360.
56. Dobner, T., I. Wolf, T. Emrich, and M. Lipp. 1992. Differentiation-specific expression of a novel G protein-coupled receptor from Burkitt's lymphoma. Eur. J. Immunol. 22:2795-2799.
57. Samson, M., O. Labbe, C. Mollereau, G. Vassart, and M. Parmentier. 1996. Molecular cloning and functional expression of a new human CC-chemokine receptors gene. Biochemistry. 35:3362-3367.
58. Murphy, P.M., and H.L. Tiffany. 1991. Cloning of complementary DNA encoding a functional human interleukin-8 receptor. Science (Wash. DC). 253:1280-1283.
59. Holmes, W.E., J. Lee, W.J. Kuang, G.C. Rice, and W.I. Wood. 1991. Structure and functional expression of a human interleukin-8 receptor. Science (Wash. DC). 253:1278-1280.
60. Loetscher, M., B. Gerber, P. Loetscher, S.A. Jones, L. Piali, I. Clark-Lewis, M. Baggiolini, and B. Moser. 1996. Chemokine receptor specific for IP10 and mig: structure, function and expression in activated T-lymphocytes. J. Exp. Med. 184: 963-969.
61. Federsppiel, B., I.G. Melhado, A.M. Duncan, A. Delaney, K. Schappert, I. Clarke-Lewis, and F.R. Jink. 1993. Molecular cloning of the cDNA and chromosomal localization of the gene for a putative seven-transmembrane segment (7-TMS) receptor isolated from human spleen. Genomics. 16:706-712.
62. Methner, A., G. Hermey, B. Schinke, and I. Hermans-Borgmeyer. 1997. A novel G protein-coupled receptor with homology to neuropeptide and chemoattractant receptors expressed during bone development. Biochem. Biophys. Res. Commun. 238:836-842.
63. Birkenbach, M., K. Josefsen, R. Yalamanchili, G. Lenoir, and E. Kieff. 1993. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67:2209-2220.
64. Liao, F., H.H. Lee, and J.M. Farber. 1997. Cloning of STRL22, a new human gene encoding a G-protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. Genomics. 40:175-180.
65. Heiber, M., J.M. Docherty, G. Shah, T. Nguyen, R. Cheng, H. Heng, A. Marchese, L. Tsui, X. Shi, S.R. George, and B.F. O'Dowd. 1995. Isolation of three novel human genes encoding G protein-coupled receptors. DNA Cell Biol. 14: 25-35.
66. Libert, F., M. Parmentier, A. Lefort, J.E. Dumont, and G. Vassart. 1990. Complete nucleotide sequence of a putative G protein coupled receptor. RDC1. Nucleic Acids Res. 18:1917.
67. Napolitano, M., A. Zingoni, G. Bernardini, G. Spinett, A. Nista, C.T. Storlazzi, M. Rocchi, and A. Santoni. 1996. Molecular cloning of TER1, a chemokine receptor-like gene expressed by lymphoid tissues. J. Immunol. 157:2759-2763.
68. Combadiere, C, S.K. Ahuja, and P.M. Murphy. 1995. Cloning, chromosomal localization, and RNA expression of a human beta chemokine receptor-like gene. DNA Cell Biol. 14: 673-680.