HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor

EMBO Journal

Volumn 16, Issue 10, 1997, Pages 2599-2609

  Bieniasz, Paul D ^a   Fridell, Robert A ^a   Aramori, Ichiro ^a   Ferguson, Stephen S G ^a   Caron, Marc G ^a   Cullen, Bryan R ^a  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Chemokine receptors; HIV 1 co receptor

Indexed keywords

CHEMOKINE RECEPTOR; CHIMERIC PROTEIN; ENVELOPE PROTEIN; VIRUS RECEPTOR;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL FUSION; CONTROLLED STUDY; HUMAN IMMUNODEFICIENCY VIRUS 1; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; STRUCTURE ACTIVITY RELATION; VIRUS CELL INTERACTION; VIRUS ENVELOPE; VIRUS STRAIN;

AMINO ACID SEQUENCE; ANIMALS; CELL FUSION; CLONING, MOLECULAR; CYTOPATHOGENIC EFFECT, VIRAL; HIV ENVELOPE PROTEIN GP120; HIV-1; HUMANS; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; PEPTIDE FRAGMENTS; RECEPTORS, CCR5; RECEPTORS, CYTOKINE; RECEPTORS, HIV; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SPECIES SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; T-LYMPHOCYTES; VIRAL ENVELOPE PROTEINS;

ADA; ANIMALIA; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0030986787     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/16.10.2599     Document Type: Article

References (38)

1. Alkhatib, G., Combadiere, C., Broder, C.C., Feng, Y., Kennedy, P.E., Murphy, P.M. and Berger, E.A. (1996) CC CKR5: a RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1, Science, 272, 1955-1958.
2. Andersson, S., Davis, D.N., Dahlbäck, H., Jörnvall, H. and Russell, D.W. (1989) Cloning, structure and expression of the mitochondrial cytochrome P-450 sterol 26-hydroxylase, a bile acid biosynthetic enzyme. J. Biol. Chem., 264, 8222-8229.
3. Ashorn, P., Berger, E. and Moss, J. (1990) Human immunodeficiency virus envelope glycoprotein/CD4-mediated fusion of nonprimate cells with human cells. J. Virol., 64, 2149-2156.
4. Atchison, R.E., Gosling, J., Monteclaro, F.S., Franci, C., Digilio, L., Charo, I.F. and Goldsmith, M.A. (1996) Multiple extracellular elements of CCR5 and HIV-1 entry: dissociation from response to chemokines. Science, 274, 1924-1926.
5. Barak, L.S., Tiberi, M., Freedman, N.J., Kwatra, M.M., Lefkowitz, R.J. and Caron, M.G. (1994) A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated 2-adrenergic receptor sequestration. J. Biol. Chem., 269, 2790-2795.
6. Berger, J., Hauber, J., Hauber, R., Geiger, R. and Cullen, B.R. (1988) Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cells. Gene, 66, 1-10.
7. Boring, L., Gosling, J., Monteclaro, F.S., Lusis, A.J., Tsou, C.-L. and Charo, I.F. (1996) Molecular cloning and functional expression of murine JE (monocyte chemoattractant protein 1) and murine macrophage inflammatory protein 1α receptors. J. Biol. Chem., 271, 7551-7558.
8. Boyd, M.T., Simpson, G.R., Cann, A.J., Johnson, M.A. and Weiss, R.A. (1993) A single amino acid substitution in the V1 loop of human immunodeficiency virus type 1 gp120 alters cellular tropism. J. Virol., 67, 3649-3652.
9. Choe, H. et al. (1996) The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell, 85, 1135-1148.
10. Clapham, P.R., Blanc, D. and Weiss, R.A. (1991) Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by simian immunodeficiency virus. Virology, 181, 703-715.
11. Collman, R., Balliet, J.W., Gregory, S.A., Friedman, H., Kolson, D.L., Nathanson, N. and Srinivasan, A. (1992) An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1. J. Virol., 66, 7517-7521.
12. Cullen, B.R. (1986) Trans-activation of human immunodeficiency virus occurs via a bimodal mechanism. Cell, 46, 973-982.
13. Deng, H. et al. (1996) Identification of a major co-receptor for primary isolates of HIV-1. Nature, 381, 661-666.
14. Doranz, B.J., Rucker, J., Yi, Y., Smyth, R.J., Samson, M., Peiper, S.C. Parmentier, M., Collman, R.G. and Doms, R.W. (1996) A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell, 85, 1149-1158.
15. + cells is mediated by the chemokine receptor CC-CKR-5. Nature, 381, 667-673.
16. Feng, Y., Broder, C.C., Kennedy, P.E. and Berger, E.A. (1996) HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor. Science, 272, 872-877.
17. Gartner, S., Markovits, P., Markovitz, D., Kaplan, M., Gallo, R. and Popovic, M. (1986) The role of mononuclear phagocytes in HTLV-III/LAV infection. Science, 233, 215-219.
18. Hwang, S.S., Boyle, T.J., Lyerly, H.K. and Cullen, B.R. (1991) Identification of the envelope V3 loop as the primary determinant of cell tropism in HIV-1. Science, 253, 71-74.
19. Hwang, S.S., Boyle, T.J., Lyerly, H.K. and Cullen, B.R. (1992) Identification of envelope V3 loop as the major determinant of CD4 neutralization sensitivity of HIV-1. Science, 257, 535-537.
20. Ishikawa, Y., Katsushika, S., Chen, L., Halnon, N.J., Kawabe, J.-I. and Homcy, C.J. (1992) Isolation and characterization of a novel cardiac adenylylcyclase cDNA. J. Biol. Chem., 267, 13553-13557.
21. James, W., Weiss, R.A. and Simon, J.H. (1996) The receptor for HIV: dissection of CD4 and studies on putative accessory factors. Curr. Top. Microbiol Immunol., 205, 137-158.
22. Lapham, C.K., Ouyang, J., Chandrasekhar, B., Nguyen, N.Y., Dimitrov, D.S. and Golding, H. (1996) Evidence for cell-surface association between fusin and the CD4-gp120 complex in human cell lines. Science, 274, 602-605.
23. Maddon, P.J., Dalgleish, A.G., McDougal, J.S., Clapham, P.R., Weiss, R.A. and Axel, R. (1986) The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell, 47, 333-348.
24. McKnight, A., Weiss, R.A., Chotton, C., Takeuchi, Y., Hoshino, H. and Clapham, P.R. (1995) Change in tropism upon immune escape by human immunodeficiency virus. J. Virol. 69, 3167-3170.
25. Murphy, P.M. (1994) The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol., 12, 593-633.
26. O'Brien, W.A., Koyanagi, Y., Namazie, A., Zhao, J.-Q., Diagne, A., Idler, K., Zack, J.A. and Chen, I.S.Y. (1990) HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp 120 outside the CD4-binding domain. Nature, 348, 69-73.
27. Planelles, V., Li, Q.-X. and Chen, I.S.Y. (1993) The biological and molecular basis for cell tropism in HIV. In Cullen, B.R. (ed.), Human Retroviruses. Oxford University Press, Oxford, UK, pp. 17-48.
28. Rucker, J. et al. (1996) Regions in β-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity. Cell, 87, 437-446.
29. Samson, M., Labbe, O., Mollereau, C., Vassan, G. and Parmentier, M. (1996) Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry, 35, 3362-3367.
30. Schuitemaker, H., Kootstra, N., de Goede, R., de Wolf, F., Miedema, F. and Tersmette, M. (1991) Monocytotropic human immunodeficiency virus type 1 (HIV-1) variants detectable at all stages of HIV-1 infection lack T-cell line tropism and syncytium-inducing ability in primary T-cell culture. J. Virol., 65, 356-363.
31. 3H]cAMP in cell monolayers, cell suspensions, and tissue slices. Methods Enzymol., 195, 22-29.
32. Shioda, T., Levy, J.A. and Cheng-Mayer, C. (1991) Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature, 349, 167-169.
33. Simmons, G. et al. (1996) Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry. J. Virol., 70, 8355-8360.
34. Trkola, A. et al. (1996) CD4-dependent, antibody-sensitive interactions between HIV-1 and its co-receptor CCR-5. Nature, 384, 184-187.
35. Westervelt, P., Gendelman, H.E. and Ratner, L. (1991) Identification of a determinant within the human immunodeficiency virus 1 surface envelope glycoprotein critical for productive infection of primary monocytes. Proc. Natl Acad. Sci. USA, 88, 3097-3101.
36. Wilson, I.A., Niman, H.L., Houghten, R.A., Cherenson, A.R., Connolly, M.L. and Lerner, R.A. (1984) The structure of an antigenic determinant in a protein. Cell, 37, 767-778.
37. Wu, L. et al. (1996) CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5. Nature, 384, 179-183.
38. Zhang, L., Huang, Y., He, T., Cao, Y. and Ho, D.D. (1996) HIV-1 subtype and second-receptor use. Nature, 383, 768.