-
1
-
-
34347363143
-
Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss
-
Anastassopoulou, C. G., A. J. Marozsan, A. Matet, A. D. Snyder, E. J. Arts, S. E. Kuhmann, and J. P. Moore. 2007. Escape of HIV-1 from a small molecule CCR5 inhibitor is not associated with a fitness loss. PLoS Pathog. 3:e79.
-
(2007)
PLoS Pathog
, vol.3
-
-
Anastassopoulou, C.G.1
Marozsan, A.J.2
Matet, A.3
Snyder, A.D.4
Arts, E.J.5
Kuhmann, S.E.6
Moore, J.P.7
-
2
-
-
13044256383
-
A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity
-
Baba, M., O. Nishimura, N. Kanzaki, M. Okamoto, H. Sawada, Y. Iizawa, M. Shiraishi, Y. Aramaki, K. Okonogi, Y. Ogawa, K. Meguro, and M. Fujino. 1999. A small-molecule, nonpeptide CCR5 antagonist with highly potent and selective anti-HIV-1 activity. Proc. Natl. Acad. Sci. USA 96:5698-5703.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 5698-5703
-
-
Baba, M.1
Nishimura, O.2
Kanzaki, N.3
Okamoto, M.4
Sawada, H.5
Iizawa, Y.6
Shiraishi, M.7
Aramaki, Y.8
Okonogi, K.9
Ogawa, Y.10
Meguro, K.11
Fujino, M.12
-
3
-
-
34347379935
-
Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS clinical trials group 5211
-
Gulick, R. M., Z. Su, C. Flexner, M. D. Hughes, P. R. Skolnik, T. J. Wilkin, R. Gross, A. Krambrink, E. Coakley, W. L. Greaves, A. Zolopa, R. Reichman, C. Godfrey, M. Hirsch, and D. R. Kuritzkes. 2007. Phase 2 study of the safety and efficacy of vicriviroc, a CCR5 inhibitor, in HIV-1-infected, treatment-experienced patients: AIDS clinical trials group 5211. J. Infect. Dis. 196:304-312.
-
(2007)
J. Infect. Dis
, vol.196
, pp. 304-312
-
-
Gulick, R.M.1
Su, Z.2
Flexner, C.3
Hughes, M.D.4
Skolnik, P.R.5
Wilkin, T.J.6
Gross, R.7
Krambrink, A.8
Coakley, E.9
Greaves, W.L.10
Zolopa, A.11
Reichman, R.12
Godfrey, C.13
Hirsch, M.14
Kuritzkes, D.R.15
-
4
-
-
0026562720
-
Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene
-
Kimpton, J., and M. Emerman. 1992. Detection of replication-competent and pseudotyped human immunodeficiency virus with a sensitive cell line on the basis of activation of an integrated beta-galactosidase gene. J. Virol. 66:2232-2239.
-
(1992)
J. Virol
, vol.66
, pp. 2232-2239
-
-
Kimpton, J.1
Emerman, M.2
-
5
-
-
12144289333
-
Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor
-
Kuhmann, S. E., P. Pugach, K. J. Kunstman, J. Taylor, R. L. Stanfield, A. Snyder, J. M. Strizki, J. Riley, B. M. Baroudy, I. A. Wilson, B. T. Korber, S. M. Wolinsky, and J. P. Moore. 2004. Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor. J. Virol. 78:2790-2807.
-
(2004)
J. Virol
, vol.78
, pp. 2790-2807
-
-
Kuhmann, S.E.1
Pugach, P.2
Kunstman, K.J.3
Taylor, J.4
Stanfield, R.L.5
Snyder, A.6
Strizki, J.M.7
Riley, J.8
Baroudy, B.M.9
Wilson, I.A.10
Korber, B.T.11
Wolinsky, S.M.12
Moore, J.P.13
-
6
-
-
40549092975
-
Safety, pharmacokinetics, and antiviral activity of HGS004, a novel fully human IgG4 monoclonal antibody against CCR5, in HIV-1-infected patients
-
Lalezari, J., G. K. Yadavalli, M. Para, G. Richmond, E. Dejesus, S. J. Brown, W. Cai, C. Chen, J. Zhong, L. A. Novelle, M. M. Lederman, and G. M. Subramanian. 2008. Safety, pharmacokinetics, and antiviral activity of HGS004, a novel fully human IgG4 monoclonal antibody against CCR5, in HIV-1-infected patients. J. Infect. Dis. 197:721-727.
-
(2008)
J. Infect. Dis
, vol.197
, pp. 721-727
-
-
Lalezari, J.1
Yadavalli, G.K.2
Para, M.3
Richmond, G.4
Dejesus, E.5
Brown, S.J.6
Cai, W.7
Chen, C.8
Zhong, J.9
Novelle, L.A.10
Lederman, M.M.11
Subramanian, G.M.12
-
7
-
-
0038782215
-
Development of a yeast-based recombination cloning/system for the analysis of gene products from diverse human immunodeficiency virus type 1 isolates
-
Marozsan, A. J., and E. J. Arts. 2003. Development of a yeast-based recombination cloning/system for the analysis of gene products from diverse human immunodeficiency virus type 1 isolates. J. Virol. Methods 111:111-120.
-
(2003)
J. Virol. Methods
, vol.111
, pp. 111-120
-
-
Marozsan, A.J.1
Arts, E.J.2
-
8
-
-
20644453529
-
Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D)
-
Marozsan, A. J., S. E. Kuhmann, T. Morgan, C. Herrera, E. Rivera-Troche, S. Xu, B. M. Baroudy, J. Strizki, and J. P. Moore. 2005. Generation and properties of a human immunodeficiency virus type 1 isolate resistant to the small molecule CCR5 inhibitor, SCH-417690 (SCH-D). Virology 338:182-199.
-
(2005)
Virology
, vol.338
, pp. 182-199
-
-
Marozsan, A.J.1
Kuhmann, S.E.2
Morgan, T.3
Herrera, C.4
Rivera-Troche, E.5
Xu, S.6
Baroudy, B.M.7
Strizki, J.8
Moore, J.P.9
-
9
-
-
0025065099
-
HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain
-
O'Brien, W. A., Y. Koyanagi, A. Namazie, J. Q. Zhao, A. Diagne, K. Idler, J. A. Zack, and I. S. Chen. 1990. HIV-1 tropism for mononuclear phagocytes can be determined by regions of gp120 outside the CD4-binding domain. Nature 348:69-73.
-
(1990)
Nature
, vol.348
, pp. 69-73
-
-
O'Brien, W.A.1
Koyanagi, Y.2
Namazie, A.3
Zhao, J.Q.4
Diagne, A.5
Idler, K.6
Zack, J.A.7
Chen, I.S.8
-
10
-
-
0037311452
-
Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES
-
Pastore, C., G. R. Picchio, F. Galimi, R. Fish, O. Hartley, R. E. Offord, and D. E. Mosier. 2003. Two mechanisms for human immunodeficiency virus type 1 inhibition by N-terminal modifications of RANTES. Antimicrob. Agents Chemother. 47:509-517.
-
(2003)
Antimicrob. Agents Chemother
, vol.47
, pp. 509-517
-
-
Pastore, C.1
Picchio, G.R.2
Galimi, F.3
Fish, R.4
Hartley, O.5
Offord, R.E.6
Mosier, D.E.7
-
11
-
-
49149119321
-
-
Pfizer Inc. 24 April 2007, posting date. Maraviroc tablets NDA 22-128. Antiviral Drugs Advisory Committee (AVDAC) briefing document, p. 103. Pfizer Inc., New York, NY. http://www.fda.gov/OHRMS/DOCKETS/AC/07/briefing/2007- 4283b1-01-Pfizer.pdf.
-
Pfizer Inc. 24 April 2007, posting date. Maraviroc tablets NDA 22-128. Antiviral Drugs Advisory Committee (AVDAC) briefing document, p. 103. Pfizer Inc., New York, NY. http://www.fda.gov/OHRMS/DOCKETS/AC/07/briefing/2007- 4283b1-01-Pfizer.pdf.
-
-
-
-
12
-
-
0032789087
-
Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: Underrepresentation of X4 variants
-
Ping, L. H., J. A. Nelson, I. F. Hoffman, J. Schock, S. L. Lamers, M. Goodman, P. Vernazza, P. Kazembe, M. Maida, D. Zimba, M. M. Goodenow, J. J. Eron, Jr., S. A. Fiscus, M. S. Cohen, and R. Swanstrom. 1999. Characterization of V3 sequence heterogeneity in subtype C human immunodeficiency virus type 1 isolates from Malawi: underrepresentation of X4 variants. J. Virol. 73:6271-6281.
-
(1999)
J. Virol
, vol.73
, pp. 6271-6281
-
-
Ping, L.H.1
Nelson, J.A.2
Hoffman, I.F.3
Schock, J.4
Lamers, S.L.5
Goodman, M.6
Vernazza, P.7
Kazembe, P.8
Maida, M.9
Zimba, D.10
Goodenow, M.M.11
Eron Jr., J.J.12
Fiscus, S.A.13
Cohen, M.S.14
Swanstrom, R.15
-
13
-
-
34047271098
-
HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry
-
Pugach, P., A. J. Marozsan, T. J. Ketas, E. L. Landes, J. P. Moore, and S. E. Kuhmann. 2007. HIV-1 clones resistant to a small molecule CCR5 inhibitor use the inhibitor-bound form of CCR5 for entry. Virology 361:212-228.
-
(2007)
Virology
, vol.361
, pp. 212-228
-
-
Pugach, P.1
Marozsan, A.J.2
Ketas, T.J.3
Landes, E.L.4
Moore, J.P.5
Kuhmann, S.E.6
-
14
-
-
0037059049
-
Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
-
Reeves, J. D., S. A. Gallo, N. Ahmad, J. L. Miamidian, P. E. Harvey, M. Sharron, S. Pohlmann, J. N. Sfakianos, C. A. Derdeyn, R. Blumenthal, E. Hunter, and R. W. Doms. 2002. Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics. Proc. Natl. Acad. Sci. USA 99:16249-16254.
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 16249-16254
-
-
Reeves, J.D.1
Gallo, S.A.2
Ahmad, N.3
Miamidian, J.L.4
Harvey, P.E.5
Sharron, M.6
Pohlmann, S.7
Sfakianos, J.N.8
Derdeyn, C.A.9
Blumenthal, R.10
Hunter, E.11
Doms, R.W.12
-
15
-
-
0032546952
-
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding
-
Rizzuto, C. D., R. Wyatt, N. Hernandez-Ramos, Y. Sun, P. D. Kwong, W. A. Hendrickson, and J. Sodroski. 1998. A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science 280:1949-1953.
-
(1998)
Science
, vol.280
, pp. 1949-1953
-
-
Rizzuto, C.D.1
Wyatt, R.2
Hernandez-Ramos, N.3
Sun, Y.4
Kwong, P.D.5
Hendrickson, W.A.6
Sodroski, J.7
-
16
-
-
0026089184
-
Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene
-
Shioda, T., J. A. Levy, and C. Cheng-Mayer. 1991. Macrophage and T cell-line tropisms of HIV-1 are determined by specific regions of the envelope gp120 gene. Nature 349:167-169.
-
(1991)
Nature
, vol.349
, pp. 167-169
-
-
Shioda, T.1
Levy, J.A.2
Cheng-Mayer, C.3
-
17
-
-
49149115986
-
-
Strizki, J. M., P. Qiu, N. Murgolo, W. Greaves, R. Landovitz, and J. Whitcomb. 2006. 7th Annu. Symp. Antivir. Drug Resist., Chantilly, VA, 12 to 15 November, 2006, abstr. 36.
-
Strizki, J. M., P. Qiu, N. Murgolo, W. Greaves, R. Landovitz, and J. Whitcomb. 2006. 7th Annu. Symp. Antivir. Drug Resist., Chantilly, VA, 12 to 15 November, 2006, abstr. 36.
-
-
-
-
18
-
-
49149126003
-
Changes in HIV-1 co-receptor tropism for patients participating in the maraviroc MOTIVATE 1 and 2 clinical trials, abstr. H-715. Abstr. 47th Annu
-
September
-
van der Ryst, E., and M. Westby. 2007. Changes in HIV-1 co-receptor tropism for patients participating in the maraviroc MOTIVATE 1 and 2 clinical trials, abstr. H-715. Abstr. 47th Annu. Intersci. Conf. Antimicrob. Agents Chemother., Chicago, IL, 17 to 20 September 2007.
-
(2007)
Intersci. Conf. Antimicrob. Agents Chemother., Chicago, IL, 17 to 20
-
-
van der Ryst, E.1
Westby, M.2
-
19
-
-
15744391870
-
The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor
-
Watson, C., S. Jenkinson, W. Kazmierski, and T. Kenakin. 2005. The CCR5 receptor-based mechanism of action of 873140, a potent allosteric noncompetitive HIV entry inhibitor. Mol. Pharmacol. 67:1268-1282.
-
(2005)
Mol. Pharmacol
, vol.67
, pp. 1268-1282
-
-
Watson, C.1
Jenkinson, S.2
Kazmierski, W.3
Kenakin, T.4
-
20
-
-
33646443202
-
Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir
-
Westby, M., M. Lewis, J. Whitcomb, M. Youle, A. L. Pozniak, I. T. James, T. M. Jenkins, M. Perros, and E. van der Ryst. 2006. Emergence of CXCR4-using human immunodeficiency virus type 1 (HIV-1) variants in a minority of HIV-1-infected patients following treatment with the CCR5 antagonist maraviroc is from a pretreatment CXCR4-using virus reservoir. J. Virol. 80:4909-4920.
-
(2006)
J. Virol
, vol.80
, pp. 4909-4920
-
-
Westby, M.1
Lewis, M.2
Whitcomb, J.3
Youle, M.4
Pozniak, A.L.5
James, I.T.6
Jenkins, T.M.7
Perros, M.8
van der Ryst, E.9
-
21
-
-
33847237614
-
Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry
-
Westby, M., C. Smith-Burchnell, J. Mori, M. Lewis, M. Mosley, M. Stockdale, P. Dorr, G. Ciaramella, and M. Perros. 2007. Reduced maximal inhibition in phenotypic susceptibility assays indicates that viral strains resistant to the CCR5 antagonist maraviroc utilize inhibitor-bound receptor for entry. J. Virol. 81:2359-2371.
-
(2007)
J. Virol
, vol.81
, pp. 2359-2371
-
-
Westby, M.1
Smith-Burchnell, C.2
Mori, J.3
Lewis, M.4
Mosley, M.5
Stockdale, M.6
Dorr, P.7
Ciaramella, G.8
Perros, M.9
-
22
-
-
33846623260
-
Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism
-
Whitcomb, J. M., W. Huang, S. Fransen, K. Limoli, J. Toma, T. Wrin, C. Chappey, L. D. Kiss, E. E. Paxinos, and C. J. Petropoulos. 2007. Development and characterization of a novel single-cycle recombinant-virus assay to determine human immunodeficiency virus type 1 coreceptor tropism. Antimicrob. Agents Chemother. 51:566-575.
-
(2007)
Antimicrob. Agents Chemother
, vol.51
, pp. 566-575
-
-
Whitcomb, J.M.1
Huang, W.2
Fransen, S.3
Limoli, K.4
Toma, J.5
Wrin, T.6
Chappey, C.7
Kiss, L.D.8
Paxinos, E.E.9
Petropoulos, C.J.10
-
23
-
-
30344485709
-
Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant
-
Wu, X., A. B. Parast, B. A. Richardson, R. Nduati, G. John-Stewart, D. Mbori-Ngacha, S. M. Rainwater, and J. Overbaugh. 2006. Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant. J. Virol. 80:835-844.
-
(2006)
J. Virol
, vol.80
, pp. 835-844
-
-
Wu, X.1
Parast, A.B.2
Richardson, B.A.3
Nduati, R.4
John-Stewart, G.5
Mbori-Ngacha, D.6
Rainwater, S.M.7
Overbaugh, J.8
|