STRL33, a novel chemokine receptor-like protein, functions as a fusion cofactor for both macrophage-tropic and T cell line-tropic HIV-1

Journal of Experimental Medicine

Volumn 185, Issue 11, 1997, Pages 2015-2023

  Liao, Fang ^a   Alkhatib, Ghalib ^b   Peden, Keith W C ^c   Sharma, Geetika ^a   Berger, Edward A ^b   Farber, Joshua M ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

^b NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^c CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR; VIRUS ENVELOPE PROTEIN;

ANIMAL CELL; ARTICLE; CELL SPECIFICITY; CELL STRAIN 3T3; CHROMOSOME 3; CONTROLLED STUDY; GENE ISOLATION; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MACROPHAGE; MOUSE; NONHUMAN; PERIPHERAL LYMPHOCYTE; PRIORITY JOURNAL; VIRUS CELL INTERACTION;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD4; CELL FUSION; CELL LINE; CHEMOKINES; CHROMOSOMES, HUMAN, PAIR 3; CLONING, MOLECULAR; GTP-BINDING PROTEINS; HIV-1; HUMANS; MACROPHAGES; MICE; MOLECULAR SEQUENCE DATA; POLYMERASE CHAIN REACTION; RECEPTORS, CHEMOKINE; RECEPTORS, CYTOKINE; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, HIV; RECEPTORS, VIRUS; SEQUENCE ALIGNMENT; T-LYMPHOCYTES; TRANSFECTION; VIRAL ENVELOPE PROTEINS;

EID: 0031008794     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.11.2015     Document Type: Article

References (41)

1. Savarese, T.M., and C.M. Fraser. 1992. In vitro mutagenesis and the search for structure-function relationships among G protein-coupled receptors. Biochem. J. 283:1-19.
2. Murphy, P. 1994. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12:593-633.
3. Schall, T.J., and K. Bacon. 1994. Chemokines, leukocyte trafficking and inflammation. Curr. Opin. Immunol. 6:865-873.
4. Raport, C.J., V.L. Schweickart, D. Chantry, R.L.J. Eddy, T. Shows, R. Godiska, and P.W. Gray. 1996. New members of the chemokine receptor gene family. J. Leuk. Biol. 59:18-23.
5. Miedema, F., C. Meyaard, M. Koot, M.R. Klein, M.T. Roos, M. Groenink, R.A. Fouchier, and A. Van't Wout. 1994. Changing virus-host interactions in the course of HIV-1 infection. Immunol. Rev. 140:35-72.
6. Goudsmit, J. 1995. The role of viral diversity in HIV pathogenesis. J. Acquired Immune Defic. Syndr. Hum. Retrovirol. 10: S15-S19.
7. Cocchi, F., A.L. DeVico, A. Garzino-Demo, S.K. Arya, R.C. Gallo, and P. Lusso. 1995. Identification of RANTES, MIP-1α, and MIP-1β as the major HIV-suppressive factors produced by CD8+ T cells. Science (Wash. DC). 270:1811-1815.
8. Feng, Y., C.C. Broder, P.E. Kennedy, and E.A. Berger. 1996. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G-protein-coupled receptor. Science (Wash. DC). 272:872-877.
9. Bleul, C.C., M. Farzan, H. Choe, C. Parolin, I. Clark-Lewis, J. Sodroski, and T.A. Springer. 1996. The lymphocyte chemoattractant SDF-1 is a ligand for LESTER/fusin and blocks HIV-1 entry. Nature (Loud.). 382:829-833.
10. Oberlin, E., A. Amara, F. Bachelerie, C. Bessia, J.-L. Virelizier, F. Arenzana-Seisdedos, O. Schwartz, J.-M. Heard, I. Clark-Lewis, D.F. Legler et al. 1996. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature (Lond.). 382:833-835.
11. Alkhatib, G., C. Combadiere, C.C. Broder, Y. Feng, P.E. Kennedy, P.M. Murphy, and E.A. Berger. 1996. CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science (Wash. DC). 272: 1955-1958.
12. Deng, H., R. Liu, W. Ellmeier, S. Choe, D. Unutmaz, M. Burkhart, P. Di Marzio, S. Marmon, R.E. Sutton, C.M. Hill et al. 1996. Identification of a major co-receptor for primary isolates of HIV-1. Nature (Lond.). 381:661-666.
13. Choe, H., M. Farzan, Y. Sun, N. Sullivan, B. Rollins, P.D. Ponath, L. Wu, C.R. Mackay, G. LaRosa, W. Newman et al. 1996. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell. 85:1135-1148.
14. Doranz, B.J., J. Rucker, Y. Yi, R.J. Smyth, M. Samson, S.C. Peiper, M. Parmentier, R.G. Collman, and R.W. Doms. 1996. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell. 85:1149-1158.
15. + cells is mediated by the chemokine receptor CC-CKR-5. Nature (Lond.). 381:667-673.
16. Simmons, G., D. Wilkinson, J.D. Reeves, M.T. Dittmar, S. Beddews, J. Weber, G. Carnegie, U. Desselberger, P.W. Gray, R.A. Weiss, and P.R. Calpham. 1996. Primary, syncytium-inducing human immunodeficiency virus type I isolates are dual-tropic and most can use either Lestr or CCR-5 as co-receptors for virus entry. J. Virol. 70:8355-8360.
17. Samson, M., F. Libert, B.J. Doranz, J. Rucker, C. Liesnard, C.-M. Farber, S. Saragosti, C. Lapoumeroulie, J. Cognaux, C. Forceille et al. 1996. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature (Lond.). 382:722-725.
18. Liu, R., W.A. Paxton, S. Choe, D. Ceradini, S.R. Martin, R. Horuts, M.E. MacDonald, H. Stahlmann, R.A. Koup, and N.R. Candau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell. 86:367-377.
19. Dean, M., M. Carrington, C. Winkler, G.A. Huttley, M.W. Smith, R. Allikmets, J.J. Goedert S.P. Buchbinder, E. Vittinghoff, E. Gomperts et al. 1996. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science (Wash. DC). 273:1856-1862.
20. Zimmerman, P.A., A. Buckler-White, G. Alkhatib, T. Spalding, J. Kubofcik, C. Combadiere, D. Weissman, O. Cohen, A. Rubbert, G. Lam et al. 1996. Inherited resistance to HIV-1 conferred by an inactivating mutation in CC chemokine receptor 5: studies in populations with contrasting clinical phenotypes, defined racial background and quantified risk. Mol. Med. 3:23-36.
21. Biti, R., R. French, J. Young, B. Bennetts, and G.S. Stewart. 1997. HIV-1 infection in an individual homozygous for the CCR5 deletion allele. Nature Med. 3:252-253.
22. Liao, F., H.-H. Lee, and J.M. Farber. 1997. Cloning of STRL22, a new human gene encoding a G protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. Genomics. 40:175-180.
23. Vanguri, P., and J. Farber. 1990. Identification of CRG-2: an interferon-inducible mRNA predicted to encode a murine monokine. J. Biol. Chem. 265:15049-15057.
24. Amichay, D., R.T. Gazzinelli, G. Karupiah, T.R. Moench, A. Sher, and J.M. Farber. 1996. The gene for chemokines MuMig amd Crg-2 are induced in protozoan and viral infections in response to IFN-γ with patterns of tissue expression that suggest nonredundant roles in vivo. J. Immunol. 157: 4511-4520.
25. Kingston, R.E. 1996. Transfection of DNA into eukaryotic cells. Curr. Prot. Mol. Biol. 9:11-19.
26. Memon, S.A., D. Petrak, M.B. Moreno, and C.M. Zacharchuk. 1995. A simple assay for examining the effect of transiently expressed genes on programmed cell death. J. Immunol. Meth. 180:15-24.
27. Liao, F., R.L. Rabin, J.R. Yannelli, L.G. Koniaris, P. Vanguri, and J.M. Farber. 1995. Human Mig chemokine: biochemical and functional characterization. J. Exp. Med. 182: 1301-1314.
28. Nussbaum, O., C.C. Broder, and E.A. Berger. 1994. Fusogenic mechanisms of enveloped-virus glycoproteins analyzed by a novel recombinant vaccinia virus-based assay quantitating cell fusion-dependent reporter gene activation. J. Virol. 68:5411-5422.
29. Broder, C.C., D.S. Dimitrov, R. Blumenthal, and E.A. Berger. 1993. The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s). Virology. 193:483-491.
30. Fuerst, T.R., E.G. Niles, F.W. Studier, and B. Moss. 1986. Eukaryotic transient-expression system based on recombinant vaccinia virus that synthesized bacteriophage T7 RNA polymerase. Proc. Natl. Acad. Sci. USA. 83:8122-8126.
31. Alkhatib, G., C.C. Broder, and E.A. Berger. 1996. Cell type-specific cofactors determine human immunodeficiency virus type 1 tropism for T-cell lines versus primary macrophages. J. Virol. 70:5478-5494.
32. Broder, C.C., and E.A. Berger. 1995. Fusogenic selectivity of the envelope glycoprotein is a major determinant of human immunodeficiency virus type 1 tropism for CD4+ T-cell lines vs. primary macrophages. Proc. Natl. Acad. Sci. USA. 92: 9004-9008.
33. Collman, R., J.W. Balliet, S.A. Gregory, H. Friedman, D.L. Kolson, N. Nathanson, and A. Srinivasan. 1992. An infectious molecular clone of an unusual macrophage-tropic and highly cytopathic strain of human immunodeficiency virus type 1. J. Virol. 66:7517-7521.
34. EL1. Virology. 185:661-672.
35. Peden, K.W.C., and M.A. Martin. 1995. Virological and molecular genetic techniques for studies of established HIV isolates. In HIV: A Practical Approach. Vol. 1. Virology and Immunology. J. Karn, editor. Oxford University Press, Oxford, UK. 21-46.
36. Kozak, M. 1987. An analysis of 5′-noncoding sequences from 699 vertebrate messenger RNAs. Nucleic Acid. Res. 15:8125-8148.
37. Kozak, M. 1996. Interpreting cDNA sequences: some insights from studies on translation. Mammalian Genome. 7:563-574.
38. Altschul, S.F., W. Gish, W. Miller, E.W. Mayers, and D.J. Lipman. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410.
39. Birkenbach, M., K. Josefsen, R. Yalamanchili, G. Lenoir, and E. Kieff. 1993. Epstein-Barr virus-induced genes: first lymphocyte-specific G protein-coupled peptide receptors. J. Virol. 67:2209-2220.
40. Alizon, M., S. Wain-Hobson, L. Montagnier, and P. Sonigo. 1986. Genetic variability of the AIDS virus: nucleotide sequence analysis of two isolates from African patients. Cell. 46: 63-74.
41. Willey, R.L., M. Martin, and K.W.C. Peden. 1994. Increase in soluble CD4 binding to and CD4-induced dissociation of gp120 from virions correlates with infectivity of human immunodeficiency virus type 1. J. Virol. 68:1029-1039.