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Volumn 18, Issue 7, 2012, Pages 884-901

The therapeutic potential of sigma (σ) receptors for the treatment of central nervous system diseases: Evaluation of the evidence

Author keywords

Addiction; Alzheimer's disease; Anxiety; Central nervous system; Depression; Pain; Schizophrenia; Sigma receptor

Indexed keywords

4 (4 FLUOROPHENYL) 1,2,3,6 TETRAHYDRO 1 [4 (1,2,4 TRIAZOL 1 YL)BUTYL]PYRIDINE; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINEBUTANOL; AMANTADINE; CHLORPROMAZINE; CITALOPRAM; CLORGYLINE; CUTAMESINE; DEXETIMIDE; DONEPEZIL; FLUOXETINE; FLUVOXAMINE; FLUVOXAMINE MALEATE; HALOPERIDOL; HYPERICIN; IMIPRAMINE; KF 10047; MS 377; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; N ALLYLNORMETAZOCINE; NEUROLEPTIC AGENT; OPIPRAMOL; PANAMESINE; PENTAZOCINE; PERPHENAZINE; PIMOZIDE; PRASTERONE SULFATE; RIMCAZOLE; SELEGILINE; SERTRALINE; SIGMA RECEPTOR LIGAND; SIRAMESINE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84857130955     PISSN: 13816128     EISSN: 18734286     Source Type: Journal    
DOI: 10.2174/138161212799436539     Document Type: Review
Times cited : (41)

References (270)
  • 1
    • 70349116879 scopus 로고    scopus 로고
    • The pharmacology of sigma-1 receptors
    • Maurice T, Su T-P. The pharmacology of sigma-1 receptors. Pharmacol Ther 2009; 124: 195-206.
    • (2009) Pharmacol Ther , vol.124 , pp. 195-206
    • Maurice, T.1    Su, T.-P.2
  • 2
    • 67651033692 scopus 로고    scopus 로고
    • σ-1 receptors in major depression and anxiety
    • Kulkarni SK, Dhir A. σ-1 receptors in major depression and anxiety. Expert Rev Neurother 2009; 9: 1021-34.
    • (2009) Expert Rev Neurother , vol.9 , pp. 1021-1034
    • Kulkarni, S.K.1    Dhir, A.2
  • 3
    • 17144365477 scopus 로고    scopus 로고
    • The role of sigma receptors in depression
    • Bermack JE, Debonnel G. The role of sigma receptors in depression. J Pharmacol Sci 2005; 97: 317-36.
    • (2005) J Pharmacol Sci , vol.97 , pp. 317-336
    • Bermack, J.E.1    Debonnel, G.2
  • 4
    • 74049102232 scopus 로고    scopus 로고
    • The sigma-1 (σ) receptor and its role in the treatment of mood disorders
    • Hayashi T, Stahl SM. The sigma-1 (σ) receptor and its role in the treatment of mood disorders. Drugs Fut 2009; 34: 137-46.
    • (2009) Drugs Fut , vol.34 , pp. 137-146
    • Hayashi, T.1    Stahl, S.M.2
  • 5
    • 0024439325 scopus 로고
    • Receptor mechanisms in antipsychotic drug action: Focus on sigma receptors
    • Snyder SH, Largent BL. Receptor mechanisms in antipsychotic drug action: focus on sigma receptors. J Neuropsychiatry Clin Neurosci 1989; 1: 7-15.
    • (1989) J Neuropsychiatry Clin Neurosci , vol.1 , pp. 7-15
    • Snyder, S.H.1    Largent, B.L.2
  • 6
    • 0035142359 scopus 로고    scopus 로고
    • Opipramol for the treatment of generalized anxiety disorder: A placebo-controlled trial including an alprazolam-treated group
    • Moller HJ, Volz HP, Reimann IW, Stoll KD. Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol 2001; 21: 59-65.
    • (2001) J Clin Psychopharmacol , vol.21 , pp. 59-65
    • Moller, H.J.1    Volz, H.P.2    Reimann, I.W.3    Stoll, K.D.4
  • 8
    • 9644284695 scopus 로고    scopus 로고
    • Clinical trials with sigma ligands
    • Volz HP, Stoll KD. Clinical trials with sigma ligands. Pharmacopsychiatry 2004; 37 (Suppl 3): S214-20.
    • (2004) Pharmacopsychiatry , vol.37 , Issue.SUPPL. 3
    • Volz, H.P.1    Stoll, K.D.2
  • 9
    • 0026567933 scopus 로고
    • A proposal for the classification of sigma binding sites
    • Quirion R, Bowen WD, Itzhak Y, et al. A proposal for the classification of sigma binding sites. Trends Pharmacol Sci 1992; 13: 85-6.
    • (1992) Trends Pharmacol Sci , vol.13 , pp. 85-86
    • Quirion, R.1    Bowen, W.D.2    Itzhak, Y.3
  • 11
    • 35549006797 scopus 로고    scopus 로고
    • 2+ signaling and cell survival
    • Hayashi T, Su T-P. Sigma-1 receptor chaperones at the ERmitochondrion interface regulate Ca2+ signaling and cell survival. Cell 2007; 131: 596-610.
    • (2007) Cell , vol.131 , pp. 596-610
    • Hayashi, T.1    Su, T.-P.2
  • 13
    • 0037960938 scopus 로고    scopus 로고
    • Intracellular dynamics of σ-1 receptors (σ binding sites) in NG108-15 cells
    • Hayashi T, Su TP. Intracellular dynamics of σ-1 receptors (σ binding sites) in NG108-15 cells. J Pharmacol Exp Ther 2003; 306: 726-33.
    • (2003) J Pharmacol Exp Ther , vol.306 , pp. 726-733
    • Hayashi, T.1    Su, T.P.2
  • 14
  • 15
    • 0033151749 scopus 로고    scopus 로고
    • K+ channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors
    • Wilke RA, Lupardus PJ, Grandy DK, Rubinstein M, Low MJ, Jackson MB. K+ channel modulation in rodent neurohypophysial nerve terminals by sigma receptors and not by dopamine receptors. J Physiol 1999; 517: 391-406.
    • (1999) J Physiol , vol.517 , pp. 391-406
    • Wilke, R.A.1    Lupardus, P.J.2    Grandy, D.K.3    Rubinstein, M.4    Low, M.J.5    Jackson, M.B.6
  • 17
    • 0033841625 scopus 로고    scopus 로고
    • Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP
    • Lupardus PJ, Wilke RA, Aydar E, et al. Membrane-delimited coupling between sigma receptors and K+ channels in rat neurohypophysial terminals requires neither G-protein nor ATP. J Physiol 2000; 526: 527-39.
    • (2000) J Physiol , vol.526 , pp. 527-539
    • Lupardus, P.J.1    Wilke, R.A.2    Aydar, E.3
  • 18
    • 0037171847 scopus 로고    scopus 로고
    • The sigma receptor as a ligand-regulated auxiliary potassium channel subunit
    • Aydar E, Palmer CP, Klyachko VA, Jackson MB. The sigma receptor as a ligand-regulated auxiliary potassium channel subunit. Neuron 2002; 34: 399-410.
    • (2002) Neuron , vol.34 , pp. 399-410
    • Aydar, E.1    Palmer, C.P.2    Klyachko, V.A.3    Jackson, M.B.4
  • 19
    • 35648956677 scopus 로고    scopus 로고
    • Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells
    • Mavlyutov TA, Ruoho AE. Ligand-dependent localization and intracellular stability of sigma-1 receptors in CHO-K1 cells. J Mol Signal 2007; 2: 8.
    • (2007) J Mol Signal , vol.2 , pp. 8
    • Mavlyutov, T.A.1    Ruoho, A.E.2
  • 20
    • 34047276810 scopus 로고    scopus 로고
    • Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl-channels
    • Renaudo A, L'Hoste S, Guizouarn H, Borgese F, Soriani O. Cancer cell cycle modulated by a functional coupling between sigma-1 receptors and Cl-channels. J Biol Chem 2007; 282: 2259-67.
    • (2007) J Biol Chem , vol.282 , pp. 2259-2267
    • Renaudo, A.1    L'Hoste, S.2    Guizouarn, H.3    Borgese, F.4    Soriani, O.5
  • 21
    • 0025918138 scopus 로고
    • JO1784, a novel sigma ligand, potentiates [3H]acetylcholine release from rat hippocampal slices
    • Junien JL, Roman FJ, Brunelle G, Pascaud X. JO1784, a novel sigma ligand, potentiates [3H]acetylcholine release from rat hippocampal slices. Eur J Pharmacol 1991; 200: 343-5.
    • (1991) Eur J Pharmacol , vol.200 , pp. 343-345
    • Junien, J.L.1    Roman, F.J.2    Brunelle, G.3    Pascaud, X.4
  • 22
    • 0030426263 scopus 로고    scopus 로고
    • Enhancement of acetylcholine release by SA4503, a novel sigma 1 receptor agonist, in the rat brain
    • Kobayashi T, Matsuno K, Nakata K, Mita S. Enhancement of acetylcholine release by SA4503, a novel sigma 1 receptor agonist, in the rat brain. J Pharmacol Exp Ther 1996; 279: 106-13.
    • (1996) J Pharmacol Exp Ther , vol.279 , pp. 106-113
    • Kobayashi, T.1    Matsuno, K.2    Nakata, K.3    Mita, S.4
  • 23
    • 0029828054 scopus 로고    scopus 로고
    • Regional differences of the effect of sigma receptor ligands on the acetylcholine release in the rat brain
    • Kobayashi T, Matsuno K, Mita S. Regional differences of the effect of sigma receptor ligands on the acetylcholine release in the rat brain. J Neural Transm 1996; 103: 661-9.
    • (1996) J Neural Transm , vol.103 , pp. 661-669
    • Kobayashi, T.1    Matsuno, K.2    Mita, S.3
  • 24
    • 0030582094 scopus 로고    scopus 로고
    • Binding properties of SA4503, a novel and selective sigma 1 receptor agonist
    • Matsuno K, Nakazawa M, Okamoto K, Kawashima Y, Mita S. Binding properties of SA4503, a novel and selective sigma 1 receptor agonist. Eur J Pharmacol 1996; 306: 271-9.
    • (1996) Eur J Pharmacol , vol.306 , pp. 271-279
    • Matsuno, K.1    Nakazawa, M.2    Okamoto, K.3    Kawashima, Y.4    Mita, S.5
  • 25
    • 0030608952 scopus 로고    scopus 로고
    • Release of [3H]dopamine from guinea pig striatal slices is modulated by sigma1 receptor agonists
    • Gonzalez GM, Werling LL. Release of [3H]dopamine from guinea pig striatal slices is modulated by sigma1 receptor agonists. Naunyn-Schmiedeberg's Arch Pharmacol 1997; 356: 455-61.
    • (1997) Naunyn-Schmiedeberg's Arch Pharmacol , vol.356 , pp. 455-461
    • Gonzalez, G.M.1    Werling, L.L.2
  • 26
    • 0025228974 scopus 로고
    • N-methyl-Daspartate-induced neuronal activation is selectively modulated by sigma receptors
    • Monnet FP, Debonnel G, Junien JL, De Montigny C. N-methyl-Daspartate-induced neuronal activation is selectively modulated by sigma receptors. Eur J Pharmacol 1990; 179: 441-5.
    • (1990) Eur J Pharmacol , vol.179 , pp. 441-445
    • Monnet, F.P.1    Debonnel, G.2    Junien, J.L.3    de Montigny, C.4
  • 27
    • 0026650831 scopus 로고
    • In vivo electrophysiological evidence for a selective modulation of Nmethyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands
    • Monnet FP, Debonnel G, de Montigny C. In vivo electrophysiological evidence for a selective modulation of Nmethyl-D-aspartate-induced neuronal activation in rat CA3 dorsal hippocampus by sigma ligands. J Pharmacol Exp Ther 1992; 261: 123-30.
    • (1992) J Pharmacol Exp Ther , vol.261 , pp. 123-130
    • Monnet, F.P.1    Debonnel, G.2    de Montigny, C.3
  • 28
    • 0028171131 scopus 로고
    • Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands
    • Gonzalez-Alvear GM, Werling LL. Regulation of [3H]dopamine release from rat striatal slices by sigma receptor ligands. J Pharmacol Exp Ther 1994; 271: 212-9.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 212-219
    • Gonzalez-Alvear, G.M.1    Werling, L.L.2
  • 29
    • 0029417243 scopus 로고
    • Sigma1 Receptors in rat striatum regulate NMDA-stimulated [3H]dopamine release via a presynaptic mechanism
    • Gonzalez-Alvear GM, Werling LL. sigma1 Receptors in rat striatum regulate NMDA-stimulated [3H]dopamine release via a presynaptic mechanism. Eur J Pharmacol 1995; 294: 713-9.
    • (1995) Eur J Pharmacol , vol.294 , pp. 713-719
    • Gonzalez-Alvear, G.M.1    Werling, L.L.2
  • 30
    • 0028816772 scopus 로고
    • Sigma receptor regulation of norepinephrine release from rat hippocampal slices
    • Gonzalez-Alvear GM, Werling LL. Sigma receptor regulation of norepinephrine release from rat hippocampal slices. Brain Res 1995; 673: 61-9.
    • (1995) Brain Res , vol.673 , pp. 61-69
    • Gonzalez-Alvear, G.M.1    Werling, L.L.2
  • 31
    • 0028866959 scopus 로고
    • Modulation by [1] ligands of intracellular free Ca++ mobilization by N-methyl-Daspartate in primary culture of rat frontal cortical neurons
    • Hayashi T, Kagaya A, Takebayashi M, et al. Modulation by [1] ligands of intracellular free Ca++ mobilization by N-methyl-Daspartate in primary culture of rat frontal cortical neurons. J Pharmacol Exp Ther 1995; 275: 207-14.
    • (1995) J Pharmacol Exp Ther , vol.275 , pp. 207-214
    • Hayashi, T.1    Kagaya, A.2    Takebayashi, M.3
  • 32
    • 0029007089 scopus 로고
    • Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus
    • Monnet FP, Mahe V, Robel P, Baulieu EE. Neurosteroids, via sigma receptors, modulate the [3H]norepinephrine release evoked by N-methyl-D-aspartate in the rat hippocampus. Proc Natl Acad Sci USA 1995; 92: 3774-8.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3774-3778
    • Monnet, F.P.1    Mahe, V.2    Robel, P.3    Baulieu, E.E.4
  • 33
    • 0029792328 scopus 로고    scopus 로고
    • Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked[3H]-noradrenaline release in rat hippocampal slices
    • Monnet FP, de Costa BR, Bowen WD. Differentiation of sigma ligand-activated receptor subtypes that modulate NMDA-evoked[3H]-noradrenaline release in rat hippocampal slices. Br J Pharmacol 1996; 119: 65-72.
    • (1996) Br J Pharmacol , vol.119 , pp. 65-72
    • Monnet, F.P.1    de Costa, B.R.2    Bowen, W.D.3
  • 34
    • 0029912702 scopus 로고    scopus 로고
    • Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-Daspartate in the CA3 region of the rat dorsal hippocampus: An effect mediated via sigma receptors
    • Debonnel G, Bergeron R, de Montigny C. Potentiation by dehydroepiandrosterone of the neuronal response to N-methyl-Daspartate in the CA3 region of the rat dorsal hippocampus: an effect mediated via sigma receptors. J Endocrinol 1996; 150 (Suppl): S33-42.
    • (1996) J Endocrinol , vol.150 , Issue.SUPPL.
    • Debonnel, G.1    Bergeron, R.2    de Montigny, C.3
  • 35
    • 0029671401 scopus 로고    scopus 로고
    • Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: Possible implications for the treatment of psychiatric disorders
    • Debonnel G, de Montigny C. Modulation of NMDA and dopaminergic neurotransmissions by sigma ligands: possible implications for the treatment of psychiatric disorders. Life Sci 1996; 58: 721-34.
    • (1996) Life Sci , vol.58 , pp. 721-734
    • Debonnel, G.1    de Montigny, C.2
  • 36
    • 0032907911 scopus 로고    scopus 로고
    • Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartateinduced increase in intracellular calcium concentration: Involvement of protein kinase
    • Hayashi T, Su TP, Kagaya A, Nishida A, Shimizu M, Yamawaki S. Neuroleptics with differential affinities at dopamine D2 receptors and sigma receptors affect differently the N-methyl-D-aspartateinduced increase in intracellular calcium concentration: involvement of protein kinase. Synapse 1999; 31: 20-8.
    • (1999) Synapse , vol.31 , pp. 20-28
    • Hayashi, T.1    Su, T.P.2    Kagaya, A.3    Nishida, A.4    Shimizu, M.5    Yamawaki, S.6
  • 37
    • 0034779830 scopus 로고    scopus 로고
    • Modulation of serotonergic neurotransmission by short-and long-term treatments with sigma ligands
    • Bermack JE, Debonnel G. Modulation of serotonergic neurotransmission by short-and long-term treatments with sigma ligands. Br J Pharmacol 2001; 134: 691-9.
    • (2001) Br J Pharmacol , vol.134 , pp. 691-699
    • Bermack, J.E.1    Debonnel, G.2
  • 38
    • 44349148680 scopus 로고    scopus 로고
    • 1 agonist SA 4503: Electrophysiological, morphological and behavioural studies
    • Lucas G, Rymar VV, Sadikot AF, Debonnel G. Further evidence for an antidepressant potential of the selective σ1 agonist SA 4503: electrophysiological, morphological and behavioural studies. Int J Neuropsychopharmacol 2008; 11: 485-95.
    • (2008) Int J Neuropsychopharmacol , vol.11 , pp. 485-495
    • Lucas, G.1    Rymar, V.V.2    Sadikot, A.F.3    Debonnel, G.4
  • 39
    • 0025180755 scopus 로고
    • A sigma-like binding site in rat pheochromocytoma (PC12) cells: Decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain
    • Hellewell SB, Bowen WD. A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for (+)-benzomorphans and lower molecular weight suggest a different sigma receptor form from that of guinea pig brain. Brain Res 1990; 527: 244-53.
    • (1990) Brain Res , vol.527 , pp. 244-253
    • Hellewell, S.B.1    Bowen, W.D.2
  • 40
    • 0028180570 scopus 로고
    • 2 receptors: Characterization by ligand binding and photoaffinity labelin
    • Hellewell SB, Bruce A, Feinstein G, Orringer J, Williams W, Bowen WD. Rat liver and kidney contain high densities of σ1 and σ2 receptors: characterization by ligand binding and photoaffinity labeling. Eur J Pharmacol 1994; 268: 9-18.
    • (1199) Eur J Pharmaco , vol.268 , pp. 9-18
    • Hellewell, S.B.1    Bruce, A.2    Feinstein, G.3    Orringer, J.4    Williams, W.5    Bowen, W.D.6
  • 41
    • 34547124587 scopus 로고    scopus 로고
    • Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy
    • Zeng C, Vangveravong S, Xu J, et al. Subcellular localization of sigma-2 receptors in breast cancer cells using two-photon and confocal microscopy. Cancer Res 2007; 67: 6708-16.
    • (2007) Cancer Res , vol.67 , pp. 6708-6716
    • Zeng, C.1    Vangveravong, S.2    Xu, J.3
  • 43
    • 0034010937 scopus 로고    scopus 로고
    • Sigma-2 receptors as a biomarker of proliferation in solid tumours
    • Wheeler KT, Wang LM, Wallen CA, et al. Sigma-2 receptors as a biomarker of proliferation in solid tumours. Br J Cancer 2000; 82: 1223-32.
    • (2000) Br J Cancer , vol.82 , pp. 1223-1232
    • Wheeler, K.T.1    Wang, L.M.2    Wallen, C.A.3
  • 44
    • 0028795145 scopus 로고
    • Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines
    • Vilner BJ, John CS, Bowen WD. Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. Cancer Res 1995; 55: 408-13.
    • (1995) Cancer Res , vol.55 , pp. 408-413
    • Vilner, B.J.1    John, C.S.2    Bowen, W.D.3
  • 45
    • 0029032044 scopus 로고
    • Sigma receptors are expressed in human non-small cell lung carcinoma
    • John CS, Bowen WD, Varma VM, McAfee JG, Moody TW. Sigma receptors are expressed in human non-small cell lung carcinoma. Life Sci 1995; 56: 2385-92.
    • (1995) Life Sci , vol.56 , pp. 2385-2392
    • John, C.S.1    Bowen, W.D.2    Varma, V.M.3    McAfee, J.G.4    Moody, T.W.5
  • 46
    • 0036141493 scopus 로고    scopus 로고
    • Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines
    • Crawford KW, Bowen WD. Sigma-2 receptor agonists activate a novel apoptotic pathway and potentiate antineoplastic drugs in breast tumor cell lines. Cancer Res 2002; 62: 313-22.
    • (2002) Cancer Res , vol.62 , pp. 313-322
    • Crawford, K.W.1    Bowen, W.D.2
  • 47
    • 25444483322 scopus 로고    scopus 로고
    • Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress
    • Ostenfeld MS, Fehrenbacher N, Hoyer-Hansen M, Thomsen C, Farkas T, Jaattela M. Effective tumor cell death by sigma-2 receptor ligand siramesine involves lysosomal leakage and oxidative stress. Cancer Res 2005; 65: 8975-83.
    • (2005) Cancer Res , vol.65 , pp. 8975-8983
    • Ostenfeld, M.S.1    Fehrenbacher, N.2    Hoyer-Hansen, M.3    Thomsen, C.4    Farkas, T.5    Jaattela, M.6
  • 48
    • 79960099287 scopus 로고    scopus 로고
    • Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Putative sigma-2 receptor binding site
    • in press
    • Xu J, Zeng C, Chu Wx, et-al. Identification of the PGRMC1 protein complex as the putative sigma-2 receptor binding site. Nat Commun 2011; 2: in press.
    • (2011) Nat Commun , pp. 2
    • Xu, J.1    Zen, C.2    Chu, W.X.3
  • 49
    • 0022497711 scopus 로고
    • Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine
    • Gundlach AL, Largent BL, Snyder SH. Autoradiographic localization of sigma receptor binding sites in guinea pig and rat central nervous system with (+)3H-3-(3-hydroxyphenyl)-N-(1-propyl)piperidine. J Neurosci 1986; 6: 1757-70.
    • (1986) J Neurosci , vol.6 , pp. 1757-1770
    • Gundlach, A.L.1    Largent, B.L.2    Snyder, S.H.3
  • 50
    • 0026459402 scopus 로고
    • Sigma receptors are associated with cortical limbic areas in the primate brain
    • Mash DC, Zabetian CP. Sigma receptors are associated with cortical limbic areas in the primate brain. Synapse 1992; 12: 195-205.
    • (1992) Synapse , vol.12 , pp. 195-205
    • Mash, D.C.1    Zabetian, C.P.2
  • 51
    • 0023912240 scopus 로고
    • Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain
    • McLean S, Weber E. Autoradiographic visualization of haloperidol-sensitive sigma receptors in guinea-pig brain. Neuroscience 1988; 25: 259-69.
    • (1988) Neuroscience , vol.25 , pp. 259-269
    • McLean, S.1    Weber, E.2
  • 52
    • 0025101769 scopus 로고
    • Sigma receptors are highly concentrated in the rat pineal gland
    • Jansen KL, Dragunow M, Faull RL. Sigma receptors are highly concentrated in the rat pineal gland. Brain Res 1990; 507: 158-160.
    • (1990) Brain Res , vol.507 , pp. 158-160
    • Jansen, K.L.1    Dragunow, M.2    Faull, R.L.3
  • 53
    • 0026613078 scopus 로고
    • Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: A comparative study
    • Walker JM, Bowen WD, Goldstein SR, et al. Autoradiographic distribution of [3H](+)-pentazocine and [3H]1,3-di-o-tolylguanidine (DTG) binding sites in guinea pig brain: a comparative study. Brain Res 1992; 581: 33-8.
    • (1992) Brain Res , vol.581 , pp. 33-38
    • Walker, J.M.1    Bowen, W.D.2    Goldstein, S.R.3
  • 54
    • 0028232612 scopus 로고
    • Regional variation in the ratio of [1] [1] to [1] 2 binding in rat brain
    • Leitner ML, Hohmann AG, Patrick SL, Walker JM. Regional variation in the ratio of [1][1] to [1]2 binding in rat brain. Eur J Pharmacol 1994; 259: 65-9.
    • (1994) Eur J Pharmacol , vol.259 , pp. 65-69
    • Leitner, M.L.1    Hohmann, A.G.2    Patrick, S.L.3    Walker, J.M.4
  • 55
    • 0028240967 scopus 로고
    • Sigma-1 and sigma-2 sites in rat brain: Comparison of regional, ontogenetic, and subcellular patterns
    • McCann DJ, Weissman AD, Su TP. Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns. Synapse 1994; 17: 182-9.
    • (1994) Synapse , vol.17 , pp. 182-189
    • McCann, D.J.1    Weissman, A.D.2    Su, T.P.3
  • 56
    • 0030614697 scopus 로고    scopus 로고
    • 2 receptor subtypes
    • Bouchard P, Quirion R. [3H]1,3-di(2-tolyl)guanidine and [3H](+)pentazocine binding sites in the rat brain: autoradiographic visualization of the putative σ1 and σ2 receptor subtypes. Neuroscience 1997; 76: 467-77.
    • (1997) Neuroscience , vol.76 , pp. 467-477
    • Bouchard, P.1    Quirion, R.2
  • 58
    • 0026009873 scopus 로고
    • Autoradiographic distribution of sigma receptors in human neocortex, hippocampus, basal ganglia, cerebellum, pineal and pituitary glands
    • Jansen KL, Faull RL, Dragunow M, Leslie RA. Autoradiographic distribution of sigma receptors in human neocortex, hippocampus, basal ganglia, cerebellum, pineal and pituitary glands. Brain Res 1991; 559: 172-7.
    • (1991) Brain Res , vol.559 , pp. 172-177
    • Jansen, K.L.1    Faull, R.L.2    Dragunow, M.3    Leslie, R.A.4
  • 59
    • 0025790046 scopus 로고
    • Interaction of 1,3-di(2-[5-3H]tolyl) guanidine with sigma 2 binding sites in rat heart membrane preparations
    • Dumont M, Lemaire S. Interaction of 1,3-di(2-[5-3H]tolyl) guanidine with sigma 2 binding sites in rat heart membrane preparations. Eur J Pharmacol 1991; 209: 245-8.
    • (1991) Eur J Pharmacol , vol.209 , pp. 245-248
    • Dumont, M.1    Lemaire, S.2
  • 61
    • 0024518488 scopus 로고
    • Sigma-receptors in endocrine organs: Identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary
    • Wolfe SA, Jr., Culp SG, De Souza EB. Sigma-receptors in endocrine organs: identification, characterization, and autoradiographic localization in rat pituitary, adrenal, testis, and ovary. Endocrinology 1989; 124: 1160-72.
    • (1989) Endocrinology , vol.124 , pp. 1160-1172
    • Wolfe Jr., S.A.1    Culp, S.G.2    de Souza, E.B.3
  • 62
    • 0026585005 scopus 로고
    • Sigma receptors in rat brain and testes show similar reductions in response to chronic haloperidol
    • Jansen KL, Elliot M, Leslie RA. sigma receptors in rat brain and testes show similar reductions in response to chronic haloperidol. Eur J Pharmacol 1992; 214: 281-3.
    • (1992) Eur J Pharmacol , vol.214 , pp. 281-283
    • Jansen, K.L.1    Elliot, M.2    Leslie, R.A.3
  • 63
    • 0024364925 scopus 로고
    • Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig
    • Roman F, Pascaud X, Chomette G, Bueno L, Junien JL. Autoradiographic localization of sigma opioid receptors in the gastrointestinal tract of the guinea pig. Gastroenterology 1989; 97: 76-82.
    • (1989) Gastroenterology , vol.97 , pp. 76-82
    • Roman, F.1    Pascaud, X.2    Chomette, G.3    Bueno, L.4    Junien, J.L.5
  • 64
    • 0020615290 scopus 로고
    • High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments
    • Craviso GL, Musacchio JM. High-affinity dextromethorphan binding sites in guinea pig brain. II. Competition experiments. Mol Pharmacol 1983; 23: 629-40.
    • (1983) Mol Pharmacol , vol.23 , pp. 629-640
    • Craviso, G.L.1    Musacchio, J.M.2
  • 65
    • 0011190242 scopus 로고
    • 1,3-Di(2-[5-3H]tolyl)guanidine: A selective ligand that labels sigmatype receptors for psychotomimetic opiates and antipsychotic drugs
    • Weber E, Sonders M, Quarum M, McLean S, Pou S, Keana JF. 1,3-Di(2-[5-3H]tolyl)guanidine: a selective ligand that labels sigmatype receptors for psychotomimetic opiates and antipsychotic drugs. Proc Natl Acad Sci USA 1986; 83: 8784-8.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 8784-8788
    • Weber, E.1    Sonders, M.2    Quarum, M.3    McLean, S.4    Pou, S.5    Keana, J.F.6
  • 67
    • 0024451351 scopus 로고
    • High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents
    • Klein M, Musacchio JM. High affinity dextromethorphan binding sites in guinea pig brain. Effect of sigma ligands and other agents. J Pharmacol Exp Ther 1989; 251: 207-15.
    • (1989) J Pharmacol Exp Ther , vol.251 , pp. 207-215
    • Klein, M.1    Musacchio, J.M.2
  • 68
    • 0026473599 scopus 로고
    • Competitive interactions at [3H]1,3-di(2-tolyl)guanidine (DTG)-defined sigma recognition sites in guinea pig brain
    • DeHaven-Hudkins DL, Fleissner LC. Competitive interactions at [3H]1,3-di(2-tolyl)guanidine (DTG)-defined sigma recognition sites in guinea pig brain. Life Sci 1992; 50: PL 65-70.
    • (1992) Life Sci , vol.50 , pp. 65-70
    • Dehaven-Hudkins, D.L.1    Fleissner, L.C.2
  • 69
    • 0024281403 scopus 로고
    • Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems
    • Su TP, London ED, Jaffe JH. Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems. Science 1988; 240: 219-21.
    • (1988) Science , vol.240 , pp. 219-221
    • Su, T.P.1    London, E.D.2    Jaffe, J.H.3
  • 70
    • 0032756551 scopus 로고    scopus 로고
    • Neuroactive neurosteroids as endogenous effectors for the sigma1 (sigma1) receptor: Pharmacological evidence and therapeutic opportunities
    • Maurice T, Phan VL, Urani A, Kamei H, Noda Y, Nabeshima T. Neuroactive neurosteroids as endogenous effectors for the sigma1 (sigma1) receptor: pharmacological evidence and therapeutic opportunities. Jpn J Pharmacol 1999; 81: 125-55.
    • (1999) Jpn J Pharmacol , vol.81 , pp. 125-155
    • Maurice, T.1    Phan, V.L.2    Urani, A.3    Kamei, H.4    Noda, Y.5    Nabeshima, T.6
  • 71
    • 0034727778 scopus 로고    scopus 로고
    • Dueling enigmas: Neurosteroids and sigma receptors in the limelight
    • 2000: PE1
    • Gibbs TT, Farb DH. Dueling enigmas: neurosteroids and sigma receptors in the limelight. Sci. STKE 2000; 2000: PE1.
    • (2000) Sci. STKE
    • Gibbs, T.T.1    Farb, D.H.2
  • 72
    • 0035660075 scopus 로고    scopus 로고
    • The interaction between neuroactive steroids and the sigma1 receptor function: Behavioral consequences and therapeutic opportunities
    • Maurice T, Urani A, Phan VL, Romieu P. The interaction between neuroactive steroids and the sigma1 receptor function: behavioral consequences and therapeutic opportunities. Brain Res Rev 2001; 37: 116-32.
    • (2001) Brain Res Rev , vol.37 , pp. 116-132
    • Maurice, T.1    Urani, A.2    Phan, V.L.3    Romieu, P.4
  • 73
    • 33244462381 scopus 로고    scopus 로고
    • The sigma1 protein as a target for the nongenomic effects of neuro(active)steroids: Molecular, physiological, and behavioral aspects
    • Monnet FP, Maurice T. The sigma1 protein as a target for the nongenomic effects of neuro(active)steroids: molecular, physiological, and behavioral aspects. J Pharmacol Sci, 2006; 100: 93-118.
    • (2006) J Pharmacol Sci , vol.100 , pp. 93-118
    • Monnet, F.P.1    Maurice, T.2
  • 74
    • 0025738352 scopus 로고
    • Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes
    • McCann DJ, Su TP. Solubilization and characterization of haloperidol-sensitive (+)-[3H]SKF-10,047 binding sites (sigma sites) from rat liver membranes. J Pharmacol Exp Ther 1991; 257: 547-54.
    • (1991) J Pharmacol Exp Ther , vol.257 , pp. 547-554
    • McCann, D.J.1    Su, T.P.2
  • 75
    • 0030463477 scopus 로고    scopus 로고
    • Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to sigma 1 receptors in the mouse forebrain
    • Maurice T, Roman FJ, Privat A. Modulation by neurosteroids of the in vivo (+)-[3H]SKF-10,047 binding to sigma 1 receptors in the mouse forebrain. J Neurosci Res 1996; 46: 734-43.
    • (1996) J Neurosci Res , vol.46 , pp. 734-743
    • Maurice, T.1    Roman, F.J.2    Privat, A.3
  • 76
    • 0032969123 scopus 로고    scopus 로고
    • Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice
    • Phan VL, Su TP, Privat A, Maurice T. Modulation of steroidal levels by adrenalectomy/castration and inhibition of neurosteroid synthesis enzymes affect sigma1 receptor-mediated behaviour in mice. Eur J Neurosci 1999; 11: 2385-96.
    • (1999) Eur J Neurosci , vol.11 , pp. 2385-2396
    • Phan, V.L.1    Su, T.P.2    Privat, A.3    Maurice, T.4
  • 77
    • 0030010448 scopus 로고    scopus 로고
    • Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: Effects mediated via sigma receptors
    • Bergeron R, de Montigny C, Debonnel G. Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors. J Neurosci 1996; 16: 1193-202.
    • (1996) J Neurosci , vol.16 , pp. 1193-1202
    • Bergeron, R.1    de Montigny, C.2    Debonnel, G.3
  • 78
    • 0032514232 scopus 로고    scopus 로고
    • The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with sigma1 (σ1) receptors
    • Urani A, Privat A, Maurice T. The modulation by neurosteroids of the scopolamine-induced learning impairment in mice involves an interaction with sigma1 (σ1) receptors. Brain Res 1998; 799: 64-77.
    • (1998) Brain Res , vol.799 , pp. 64-77
    • Urani, A.1    Privat, A.2    Maurice, T.3
  • 81
    • 66149131076 scopus 로고    scopus 로고
    • When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor
    • Su T-P, Hayashi T, Vaupel DB. When the endogenous hallucinogenic trace amine N,N-dimethyltryptamine meets the sigma-1 receptor. Sci Signal 2009; 2: pe12.
    • (2009) Sci Signal , vol.2 , pp. 12
    • Su, T.-P.1    Hayashi, T.2    Vaupel, D.B.3
  • 82
    • 0031766818 scopus 로고    scopus 로고
    • Agonist properties of N,N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors
    • Smith RL, Canton H, Barrett RJ, Sanders-Bush E. Agonist properties of N,N-dimethyltryptamine at serotonin 5-HT2A and 5-HT2C receptors. Pharmacol Biochem Behav 1998; 61: 323-30.
    • (1998) Pharmacol Biochem Behav , vol.61 , pp. 323-330
    • Smith, R.L.1    Canton, H.2    Barrett, R.J.3    Sanders-Bush, E.4
  • 83
    • 0018829235 scopus 로고
    • Behavioural changes induced by N,N-dimethyl-tryptamine in rodents
    • Jenner P, Marsden CD, Thanki CM. Behavioural changes induced by N,N-dimethyl-tryptamine in rodents. Br J Pharmacol 1980; 69: 69-80.
    • (1980) Br J Pharmacol , vol.69 , pp. 69-80
    • Jenner, P.1    Marsden, C.D.2    Thanki, C.M.3
  • 84
    • 0024553608 scopus 로고
    • Evidence for a multi-site model of the rat brain sigma receptor
    • Bowen WD, Hellewell SB, McGarry KA. Evidence for a multi-site model of the rat brain sigma receptor. Eur J Pharmacol 1989; 163: 309-18.
    • (1989) Eur J Pharmacol , vol.163 , pp. 309-318
    • Bowen, W.D.1    Hellewell, S.B.2    McGarry, K.A.3
  • 85
    • 0141833322 scopus 로고
    • Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine
    • Largent BL, Gundlach AL, Snyder SH. Psychotomimetic opiate receptors labeled and visualized with (+)-[3H]3-(3-hydroxyphenyl)-N-(1-propyl)piperidine. Proc Natl Acad Sci USA 1984; 81: 4983-7.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 4983-4987
    • Largent, B.L.1    Gundlach, A.L.2    Snyder, S.H.3
  • 86
    • 0027078540 scopus 로고
    • Characterization of the binding of [3H](+)-pentazocine to sigma recognition sites in guinea pig brain
    • DeHaven-Hudkins DL, Fleissner LC, Ford-Rice FY. Characterization of the binding of [3H](+)-pentazocine to sigma recognition sites in guinea pig brain. Eur J Pharmacol 1992; 227: 371-8.
    • (1992) Eur J Pharmacol , vol.227 , pp. 371-378
    • Dehaven-Hudkins, D.L.1    Fleissner, L.C.2    Ford-Rice, F.Y.3
  • 87
    • 0027183754 scopus 로고
    • [3H]-(+)-Pentazocine: A potent and highly selective benzomorphan-based probe for sigma-1 receptors
    • Bowen WD, de Costa BR, Hellewell SB, Walker JM, Rice KC. [3H]-(+)-Pentazocine: A potent and highly selective benzomorphan-based probe for sigma-1 receptors. Mol Neuropharmacol 1993; 3: 117-26.
    • (1993) Mol Neuropharmacol , vol.3 , pp. 117-126
    • Bowen, W.D.1    de Costa, B.R.2    Hellewell, S.B.3    Walker, J.M.4    Rice, K.C.5
  • 88
    • 0029053594 scopus 로고
    • Characterization of two novel sigma receptor ligands: Antidystonic effects in rats suggest sigma receptor antagonism
    • Matsumoto RR, Bowen WD, Tom MA, Vo VN, Truong DD, De Costa BR. Characterization of two novel sigma receptor ligands: antidystonic effects in rats suggest sigma receptor antagonism. Eur J Pharmacol 1995; 280: 301-10.
    • (1995) Eur J Pharmacol , vol.280 , pp. 301-310
    • Matsumoto, R.R.1    Bowen, W.D.2    Tom, M.A.3    Vo, V.N.4    Truong, D.D.5    de Costa, B.R.6
  • 89
    • 0019619625 scopus 로고
    • Phencyclidine (angel dust)/sigma opiate receptor: Visualization by tritiumsensitive film
    • Quirion R, Hammer RP, Jr., Herkenham M, Pert CB. Phencyclidine (angel dust)/sigma opiate receptor: visualization by tritiumsensitive film. Proc Natl Acad Sci USA 1981; 78: 5881-5.
    • (1981) Proc Natl Acad Sci USA , vol.78 , pp. 5881-5885
    • Quirion, R.1    Hammer Jr., R.P.2    Herkenham, M.3    Pert, C.B.4
  • 90
    • 0021344633 scopus 로고
    • Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors
    • Zukin SR, Brady KT, Slifer BL, Balster RL. Behavioral and biochemical stereoselectivity of sigma opiate/PCP receptors. Brain Res 1984; 294: 174-7.
    • (1984) Brain Res , vol.294 , pp. 174-177
    • Zukin, S.R.1    Brady, K.T.2    Slifer, B.L.3    Balster, R.L.4
  • 91
    • 0022254579 scopus 로고
    • Sigma opioid receptor: Characterization and co-identity with the phencyclidine receptor
    • Mendelsohn LG, Kalra V, Johnson BG, Kerchner GA. Sigma opioid receptor: characterization and co-identity with the phencyclidine receptor. J Pharmacol Exp Ther 1985; 233: 597-602.
    • (1985) J Pharmacol Exp Ther , vol.233 , pp. 597-602
    • Mendelsohn, L.G.1    Kalra, V.2    Johnson, B.G.3    Kerchner, G.A.4
  • 92
    • 0018894455 scopus 로고
    • Phencyclidine-like discriminative effects of opioids in the rat
    • Holtzman SG. Phencyclidine-like discriminative effects of opioids in the rat. J Pharmacol Exp Ther 1980; 214: 614-9.
    • (1980) J Pharmacol Exp Ther , vol.214 , pp. 614-619
    • Holtzman, S.G.1
  • 93
    • 0019516571 scopus 로고
    • Evaluation of phencyclidine analogs on the basis of their discriminative stimulus properties in the rat
    • Shannon HE. Evaluation of phencyclidine analogs on the basis of their discriminative stimulus properties in the rat. J Pharmacol Exp Ther 1981; 216: 543-51.
    • (1981) J Pharmacol Exp Ther , vol.216 , pp. 543-551
    • Shannon, H.E.1
  • 94
    • 0020410669 scopus 로고
    • Phencyclidine-like discriminative stimuli of (+)-and (-)-N-allylnormetazocine in rats
    • Shannon HE. Phencyclidine-like discriminative stimuli of (+)-and (-)-N-allylnormetazocine in rats. Eur J Pharmacol 1982; 84: 225-8.
    • (1982) Eur J Pharmacol , vol.84 , pp. 225-228
    • Shannon, H.E.1
  • 95
    • 0020086084 scopus 로고
    • Stereoisomers of Nallylnormetazocine: Phencyclidine-like behavioral effects in squirrel monkeys and rats
    • Brady KT, Balster RL, May EL. Stereoisomers of Nallylnormetazocine: phencyclidine-like behavioral effects in squirrel monkeys and rats. Science 1982; 215: 178-80.
    • (1982) Science , vol.215 , pp. 178-180
    • Brady, K.T.1    Balster, R.L.2    May, E.L.3
  • 96
    • 0022548220 scopus 로고
    • A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes
    • Downes CP, Lewis PE, Stone MA. A comparison of the binding of sigma opioids and phencyclidine, and the interaction with antipsychotic drugs in rat brain membranes. Br J Pharmacol 1986; 88: 231-7.
    • (1986) Br J Pharmacol , vol.88 , pp. 231-237
    • Downes, C.P.1    Lewis, P.E.2    Stone, M.A.3
  • 97
    • 0022196308 scopus 로고
    • Phencyclidine and sigma opiate receptors in brain: Biochemical and autoradiographical differentiation
    • Gundlach AL, Largent BL, Snyder SH. Phencyclidine and sigma opiate receptors in brain: biochemical and autoradiographical differentiation. Eur J Pharmacol 1985; 113: 465-6.
    • (1985) Eur J Pharmacol , vol.113 , pp. 465-466
    • Gundlach, A.L.1    Largent, B.L.2    Snyder, S.H.3
  • 98
    • 0022576021 scopus 로고
    • Characterization and autoradiographic visualization of (+)-[3H]SKF10,047 binding in rat and mouse brain: Further evidence for phencyclidine/sigma opiate receptor commonality
    • Sircar R, Nichtenhauser R, Ieni JR, Zukin SR. Characterization and autoradiographic visualization of (+)-[3H]SKF10,047 binding in rat and mouse brain: further evidence for phencyclidine/sigma opiate receptor commonality. J Pharmacol Exp Ther 1986; 237: 681-8.
    • (1986) J Pharmacol Exp Ther , vol.237 , pp. 681-688
    • Sircar, R.1    Nichtenhauser, R.2    Ieni, J.R.3    Zukin, S.R.4
  • 99
    • 0024327214 scopus 로고
    • Phencyclidine and sigma receptors in rat spinal cord: Binding characterization and quantitative autoradiography
    • Aanonsen LM, Seybold VS. Phencyclidine and sigma receptors in rat spinal cord: binding characterization and quantitative autoradiography. Synapse, 1989; 4: 1-10.
    • (1989) Synapse , vol.4 , pp. 1-10
    • Aanonsen, L.M.1    Seybold, V.S.2
  • 101
    • 45949118722 scopus 로고
    • Classification and nomenclature of phencyclidine and sigma receptor sites
    • Quirion R, Chicheportiche R, Contreras PC, et al. Classification and nomenclature of phencyclidine and sigma receptor sites. Trends Neurosci 1987; 10: 444-6.
    • (1987) Trends Neurosci , vol.10 , pp. 444-446
    • Quirion, R.1    Chicheportiche, R.2    Contreras, P.C.3
  • 102
    • 0025009458 scopus 로고
    • Sigma binding sites in the brain; an emerging concept for multiple sites and their relevance for psychiatric disorders
    • Itzhak Y, Stein I. Sigma binding sites in the brain; an emerging concept for multiple sites and their relevance for psychiatric disorders. Life Sci 1990; 47: 1073-81.
    • (1990) Life Sci , vol.47 , pp. 1073-1081
    • Itzhak, Y.1    Stein, I.2
  • 103
    • 0025186752 scopus 로고
    • Noncompetitive excitatory amino acid receptor antagonists
    • Lodge D, Johnson KM. Noncompetitive excitatory amino acid receptor antagonists. Trends Pharmacol Sci 1990; 11: 81-6.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 81-86
    • Lodge, D.1    Johnson, K.M.2
  • 104
    • 0023818680 scopus 로고
    • [3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes
    • Wong EH, Knight AR, Woodruff GN. [3H]MK-801 labels a site on the N-methyl-D-aspartate receptor channel complex in rat brain membranes. J Neurochem 1988; 50: 274-81.
    • (1988) J Neurochem , vol.50 , pp. 274-281
    • Wong, E.H.1    Knight, A.R.2    Woodruff, G.N.3
  • 105
    • 69249128270 scopus 로고    scopus 로고
    • In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: Agonists and antagonists in biological assays
    • Colabufo NA, Contino M, Inglese C, et al. In vitro and ex vivo characterization of sigma-1 and sigma-2 receptors: agonists and antagonists in biological assays. Cent Nerv Syst Agents Med Chem 2009; 9: 161-71.
    • (2009) Cent Nerv Syst Agents Med Chem , vol.9 , pp. 161-171
    • Colabufo, N.A.1    Contino, M.2    Inglese, C.3
  • 106
    • 0028199907 scopus 로고
    • The effects of sigma ligands and of neuropeptide Y on N-methyl-Daspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin
    • Monnet FP, Debonnel G, Bergeron R, Gronier B, de Montigny C. The effects of sigma ligands and of neuropeptide Y on N-methyl-Daspartate-induced neuronal activation of CA3 dorsal hippocampus neurones are differentially affected by pertussin toxin. Br J Pharmacol 1994; 112: 709-15.
    • (1994) Br J Pharmacol , vol.112 , pp. 709-715
    • Monnet, F.P.1    Debonnel, G.2    Bergeron, R.3    Gronier, B.4    de Montigny, C.5
  • 107
    • 0029925866 scopus 로고    scopus 로고
    • Differential effects of sigma ligands on the N-methyl-D-aspartate response in the CA1 and CA3 regions of the dorsal hippocampus: Effect of mossy fiber lesioning
    • Debonnel G, Bergeron R, Monnet FP, De Montigny C. Differential effects of sigma ligands on the N-methyl-D-aspartate response in the CA1 and CA3 regions of the dorsal hippocampus: effect of mossy fiber lesioning. Neuroscience 1996; 71: 977-87.
    • (1996) Neuroscience , vol.71 , pp. 977-987
    • Debonnel, G.1    Bergeron, R.2    Monnet, F.P.3    de Montigny, C.4
  • 108
    • 0026717763 scopus 로고
    • Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency
    • Monnet FP, Blier P, Debonnel G, de Montigny C. Modulation by sigma ligands of N-methyl-D-aspartate-induced [3H]noradrenaline release in the rat hippocampus: G-protein dependency. Naunyn-Schmiedeberg's Arch Pharmacol, 1992; 346: 32-9.
    • (1992) Naunyn-Schmiedeberg's Arch Pharmacol , vol.346 , pp. 32-39
    • Monnet, F.P.1    Blier, P.2    Debonnel, G.3    de Montigny, C.4
  • 109
    • 0034053453 scopus 로고    scopus 로고
    • Modulation of cellular calcium by sigma-2 receptors: Release from intracellular stores in human SK-N-SH neuroblastoma cells
    • Vilner BJ, Bowen WD. Modulation of cellular calcium by sigma-2 receptors: release from intracellular stores in human SK-N-SH neuroblastoma cells. J Pharmacol Exp Ther 2000; 292: 900-11.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 900-911
    • Vilner, B.J.1    Bowen, W.D.2
  • 110
    • 0007957168 scopus 로고
    • Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes
    • Tam SW, Cook L. Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Proc Natl Acad Sci USA 1984; 81: 5618-21.
    • (1984) Proc Natl Acad Sci USA , vol.81 , pp. 5618-5621
    • Tam, S.W.1    Cook, L.2
  • 111
    • 0019935002 scopus 로고
    • Evidence for sigma opioid receptor: Binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain
    • Su TP. Evidence for sigma opioid receptor: binding of [3H]SKF-10047 to etorphine-inaccessible sites in guinea-pig brain. J Pharmacol Exp Ther 1982; 223: 284-90.
    • (1982) J Pharmacol Exp Ther , vol.223 , pp. 284-290
    • Su, T.P.1
  • 112
    • 0025274410 scopus 로고
    • Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors
    • Bowen WD, Moses EL, Tolentino PJ, Walker JM. Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D-2 receptors. Eur J Pharmacol 1990; 177: 111-8.
    • (1990) Eur J Pharmacol , vol.177 , pp. 111-118
    • Bowen, W.D.1    Moses, E.L.2    Tolentino, P.J.3    Walker, J.M.4
  • 113
  • 114
    • 0023002126 scopus 로고
    • HR 375: A potential antipsychotic drug that interacts with dopamine D2 receptors and sigma-receptors in the brain
    • Su TP. HR 375: a potential antipsychotic drug that interacts with dopamine D2 receptors and sigma-receptors in the brain. Neurosci Lett 1986; 71: 224-8.
    • (1986) Neurosci Lett , vol.71 , pp. 224-228
    • Su, T.P.1
  • 115
    • 84985757543 scopus 로고
    • Potential antipsychotic BMY 14802 selectively binds to sigma sites
    • Taylor DP, Dekleva J. Potential antipsychotic BMY 14802 selectively binds to sigma sites. Drug Dev Res 1987; 11: 65-70.
    • (1987) Drug Dev Res , vol.11 , pp. 65-70
    • Taylor, D.P.1    Dekleva, J.2
  • 116
    • 0025345113 scopus 로고
    • The sigma enigma: Biochemical and functional correlates emerge for the haloperidol-sensitive sigma binding site
    • Chavkin C. The sigma enigma: biochemical and functional correlates emerge for the haloperidol-sensitive sigma binding site. Trends Pharmacol Sci 1990; 11: 213-5.
    • (1990) Trends Pharmacol Sci , vol.11 , pp. 213-215
    • Chavkin, C.1
  • 117
    • 0019925913 scopus 로고
    • BW234U,(cis-9-[3-(3,5-dimethyl-1-piperazinyl) propyl]carbazole dihydrochloride): A novel antipsychotic agent
    • Ferris RM, Harfenist M, McKenzie GM, Cooper B, Soroko FE, Maxwell RA. BW234U,(cis-9-[3-(3,5-dimethyl-1-piperazinyl) propyl]carbazole dihydrochloride): a novel antipsychotic agent. J Pharm Pharmacol 1982; 34: 388-90.
    • (1982) J Pharm Pharmacol , vol.34 , pp. 388-390
    • Ferris, R.M.1    Harfenist, M.2    McKenzie, G.M.3    Cooper, B.4    Soroko, F.E.5    Maxwell, R.A.6
  • 118
    • 1642412431 scopus 로고    scopus 로고
    • Review of the pharmacological and clinical profile of rimcazole
    • Gilmore DL, Liu Y, Matsumoto RR. Review of the pharmacological and clinical profile of rimcazole. CNS Drug Rev, 2004; 10: 1-22.
    • (2004) CNS Drug Rev , vol.10 , pp. 1-22
    • Gilmore, D.L.1    Liu, Y.2    Matsumoto, R.R.3
  • 119
    • 0020577102 scopus 로고
    • Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose-range study
    • Guy W, Manov G, Wilson WH, et al. Psychotropic actions of BW 234U in the treatment of inpatient schizophrenics: A dose-range study. Drug Dev Res 1983; 3: 245-52.
    • (1983) Drug Dev Res , vol.3 , pp. 245-252
    • Guy, W.1    Manov, G.2    Wilson, W.H.3
  • 120
    • 0021224644 scopus 로고
    • An early Phase II clinical trial of BW234U in the treatment of acute schizophrenia in newly admitted patients
    • Chouinard G, Annable L. An early Phase II clinical trial of BW234U in the treatment of acute schizophrenia in newly admitted patients. Psychopharmacology (Berl) 1984; 84: 282-4.
    • (1984) Psychopharmacology (Berl) , vol.84 , pp. 282-284
    • Chouinard, G.1    Annable, L.2
  • 121
    • 0021879890 scopus 로고
    • Open label evaluation of the novel antipsychotic compound BW234U in chronic schizophrenics
    • Schwarcz G, Halaris A, Dren A, Manberg P. Open label evaluation of the novel antipsychotic compound BW234U in chronic schizophrenics. Drug Dev Res 1985; 5: 387-93.
    • (1985) Drug Dev Res , vol.5 , pp. 387-393
    • Schwarcz, G.1    Halaris, A.2    Dren, A.3    Manberg, P.4
  • 122
    • 0024324034 scopus 로고
    • Rimcazole (BW234U) in the maintenance treatment of outpatients with schizophrenia
    • Munetz MR, Schulz SC, Bellin M, Harty I. Rimcazole (BW234U) in the maintenance treatment of outpatients with schizophrenia. Drug Dev Res 1989; 16: 79-83.
    • (1989) Drug Dev Res , vol.16 , pp. 79-83
    • Munetz, M.R.1    Schulz, S.C.2    Bellin, M.3    Harty, I.4
  • 123
    • 0025826148 scopus 로고
    • Does sigma receptor antagonism predict clinical antipsychotic efficacy?
    • Borison RL, Diamond BI, Dren AT. Does sigma receptor antagonism predict clinical antipsychotic efficacy? Psychopharmacol Bull 1991; 27: 103-6.
    • (1991) Psychopharmacol Bull , vol.27 , pp. 103-106
    • Borison, R.L.1    Diamond, B.I.2    Dren, A.T.3
  • 124
    • 0022455440 scopus 로고
    • Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain
    • Ferris RM, Tang FL, Chang KJ, Russell A. Evidence that the potential antipsychotic agent rimcazole (BW 234U) is a specific, competitive antagonist of sigma sites in brain. Life Sci 1986; 38: 2329-37.
    • (1986) Life Sci , vol.38 , pp. 2329-2337
    • Ferris, R.M.1    Tang, F.L.2    Chang, K.J.3    Russell, A.4
  • 125
    • 0032747157 scopus 로고    scopus 로고
    • Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl] carbazole (rimcazole) analogues
    • Husbands SM, Izenwasser S, Kopajtic T, et al. Structure-activity relationships at the monoamine transporters and sigma receptors for a novel series of 9-[3-(cis-3, 5-dimethyl-1-piperazinyl)propyl] carbazole (rimcazole) analogues. J Med Chem 1999; 42: 4446-55.
    • (1999) J Med Chem , vol.42 , pp. 4446-4455
    • Husbands, S.M.1    Izenwasser, S.2    Kopajtic, T.3
  • 127
    • 0030017532 scopus 로고    scopus 로고
    • EMD 57445: A selective sigma receptor ligand with the profile of an atypical neuroleptic
    • Bartoszyk GD, Bender HM, Hellmann J, Schnorr C, Seyfried CA. EMD 57445: A selective sigma receptor ligand with the profile of an atypical neuroleptic. CNS Drug Rev 1996; 2: 175-94.
    • (1996) CNS Drug Rev , vol.2 , pp. 175-194
    • Bartoszyk, G.D.1    Bender, H.M.2    Hellmann, J.3    Schnorr, C.4    Seyfried, C.A.5
  • 128
    • 0030597312 scopus 로고    scopus 로고
    • Neuropharmacological profile of EMD 57445, a sigma receptor ligand with potential antipsychotic activity
    • Maj J, Rogoz Z, Skuza G, Mazela H. Neuropharmacological profile of EMD 57445, a sigma receptor ligand with potential antipsychotic activity. Eur J Pharmacol 1996; 315: 235-43.
    • (1996) Eur J Pharmacol , vol.315 , pp. 235-243
    • Maj, J.1    Rogoz, Z.2    Skuza, G.3    Mazela, H.4
  • 130
    • 0032922010 scopus 로고    scopus 로고
    • Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: An open clinical trial
    • Huber MT, Gotthardt U, Schreiber W, Krieg JC. Efficacy and safety of the sigma receptor ligand EMD 57445 (panamesine) in patients with schizophrenia: an open clinical trial. Pharmacopsychiatry 1999; 32: 68-72.
    • (1999) Pharmacopsychiatry , vol.32 , pp. 68-72
    • Huber, M.T.1    Gotthardt, U.2    Schreiber, W.3    Krieg, J.C.4
  • 131
    • 0342979843 scopus 로고    scopus 로고
    • Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: An open clinical trial
    • Muller MJ, Grunder G, Wetzel H, et al. Antipsychotic effects and tolerability of the sigma ligand EMD 57445 (panamesine) and its metabolites in acute schizophrenia: an open clinical trial. Psychiatry Res 1999; 89: 275-80.
    • (1999) Psychiatry Res , vol.89 , pp. 275-280
    • Muller, M.J.1    Grunder, G.2    Wetzel, H.3
  • 132
    • 0032826204 scopus 로고    scopus 로고
    • Occupancy of striatal D2-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic
    • Grunder G, Muller MJ, Andreas J, et al. Occupancy of striatal D2-like dopamine receptors after treatment with the sigma ligand EMD 57445, a putative atypical antipsychotic. Psycho-pharmacology (Berl) 1999; 146: 81-6.
    • (1999) Psycho-pharmacology (Berl) , vol.146 , pp. 81-86
    • Grunder, G.1    Muller, M.J.2    Andreas, J.3
  • 133
    • 0028211481 scopus 로고
    • BMY 14802, a sigma receptor ligand for the treatment of schizophrenia
    • Gewirtz GR, Gorman JM, Volavka J, et al. BMY 14802, a sigma receptor ligand for the treatment of schizophrenia. Neuropsychopharmacology 1994; 10: 37-40.
    • (1994) Neuropsychopharmacology , vol.10 , pp. 37-40
    • Gewirtz, G.R.1    Gorman, J.M.2    Volavka, J.3
  • 134
    • 0032442582 scopus 로고    scopus 로고
    • E-5842: A new potent and preferential sigma ligand. Preclinical pharmacological profile
    • Guitart X, Codony X, Ballarin M, Dordal A, Farre AJ. E-5842: a new potent and preferential sigma ligand. Preclinical pharmacological profile. CNS Drug Rev 1998; 4: 201-24.
    • (1998) CNS Drug Rev , vol.4 , pp. 201-224
    • Guitart, X.1    Codony, X.2    Ballarin, M.3    Dordal, A.4    Farre, A.J.5
  • 135
    • 0032995091 scopus 로고    scopus 로고
    • E-5842: Antipsychotic σ-receptor ligand
    • Guitart X, Ballarin M, Codony X, et al. E-5842: antipsychotic σ-receptor ligand. Drugs Fut 1999; 24: 386-92.
    • (1999) Drugs Fut , vol.24 , pp. 386-392
    • Guitart, X.1    Ballarin, M.2    Codony, X.3
  • 137
    • 0032784317 scopus 로고    scopus 로고
    • Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for sigma receptors
    • Takahashi S, Sonehara K, Takagi K, et al. Pharmacological profile of MS-377, a novel antipsychotic agent with selective affinity for sigma receptors. Psychopharmacology (Berl) 1999; 145: 295-302.
    • (1999) Psychopharmacology (Berl) , vol.145 , pp. 295-302
    • Takahashi, S.1    Sonehara, K.2    Takagi, K.3
  • 138
    • 0034647337 scopus 로고    scopus 로고
    • Binding properties of [3H]MS-377, a novel sigma receptor ligand, to rat brain membranes
    • Karasawa J, Takahashi S, Horikomi K. Binding properties of [3H]MS-377, a novel sigma receptor ligand, to rat brain membranes. Eur J Pharmacol 2000; 400: 51-7.
    • (2000) Eur J Pharmacol , vol.400 , pp. 51-57
    • Karasawa, J.1    Takahashi, S.2    Horikomi, K.3
  • 139
    • 0034933415 scopus 로고    scopus 로고
    • Effects of a novel, selective, sigma1-ligand, MS-377, on phencyclidine-induced behaviour
    • Takahashi S, Takagi K, Horikomi K. Effects of a novel, selective, sigma1-ligand, MS-377, on phencyclidine-induced behaviour. Naunyn-Schmiedeberg's Arch Pharmacol 2001; 364: 81-6.
    • (2001) Naunyn-Schmiedeberg's Arch Pharmacol , vol.364 , pp. 81-86
    • Takahashi, S.1    Takagi, K.2    Horikomi, K.3
  • 140
    • 0036345624 scopus 로고    scopus 로고
    • Effects of [1] [1] receptor ligand MS-377 on D2 antagonists-induced behaviors
    • Karasawa J, Takahashi S, Takagi K, Horikomi K. Effects of [1][1] receptor ligand MS-377 on D2 antagonists-induced behaviors. Pharmacol Biochem Behav 2002; 73: 505-10.
    • (2002) Pharmacol Biochem Behav , vol.73 , pp. 505-510
    • Karasawa, J.1    Takahashi, S.2    Takagi, K.3    Horikomi, K.4
  • 142
    • 0031960333 scopus 로고    scopus 로고
    • Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats
    • Tran TT, de Costa BR, Matsumoto RR. Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats. Psychopharmacology (Berl) 1998; 137: 191-200.
    • (1998) Psychopharmacology (Berl) , vol.137 , pp. 191-200
    • Tran, T.T.1    de Costa, B.R.2    Matsumoto, R.R.3
  • 143
    • 0032553577 scopus 로고    scopus 로고
    • Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia
    • Ishiguro H, Ohtsuki T, Toru M, et al. Association between polymorphisms in the type 1 sigma receptor gene and schizophrenia. Neurosci Lett 1998; 257: 45-8.
    • (1998) Neurosci Lett , vol.257 , pp. 45-48
    • Ishiguro, H.1    Ohtsuki, T.2    Toru, M.3
  • 144
    • 0034615092 scopus 로고    scopus 로고
    • Polymorphisms of the [1][1] receptor gene in schizophrenia: An association study
    • Ohmori O, Shinkai T, Suzuki T, et al. Polymorphisms of the [1][1] receptor gene in schizophrenia: An association study. Am J Med Genet 2000; 96: 118-22.
    • (2000) Am J Med Genet , vol.96 , pp. 118-122
    • Ohmori, O.1    Shinkai, T.2    Suzuki, T.3
  • 145
    • 2642570958 scopus 로고    scopus 로고
    • No association between the sigma receptor type 1 gene and schizophrenia: Results of analysis and meta-analysis of case-control studies
    • Uchida N, Ujike H, Nakata K, et al. No association between the sigma receptor type 1 gene and schizophrenia: results of analysis and meta-analysis of case-control studies. BMC Psychiatry 2003; 3: 13.
    • (2003) BMC Psychiatry , vol.3 , pp. 13
    • Uchida, N.1    Ujike, H.2    Nakata, K.3
  • 146
    • 4243187147 scopus 로고    scopus 로고
    • Lack of association between sigma receptor gene variants and schizophrenia
    • Satoh F, Miyatake R, Furukawa A, Suwaki H. Lack of association between sigma receptor gene variants and schizophrenia. Psychiatry Clin Neurosci 2004; 58: 359-63.
    • (2004) Psychiatry Clin Neurosci , vol.58 , pp. 359-363
    • Satoh, F.1    Miyatake, R.2    Furukawa, A.3    Suwaki, H.4
  • 148
    • 0002516456 scopus 로고    scopus 로고
    • The potential contribution of sigma receptors to antidepressant actions
    • Leonard BE. The potential contribution of sigma receptors to antidepressant actions. Antidepressants 1997: 159-72.
    • (1997) Antidepressants , pp. 159-172
    • Leonard, B.E.1
  • 149
    • 9644274318 scopus 로고    scopus 로고
    • A perspective on the new mechanism of antidepressants: Neuritogenesis through sigma-1 receptors
    • Takebayashi M, Hayashi T, Su TP. A perspective on the new mechanism of antidepressants: neuritogenesis through sigma-1 receptors. Pharmacopsychiatry 2004; 37 (Suppl 3): S208-13.
    • (2004) Pharmacopsychiatry , vol.37 , Issue.SUPPL. 3
    • Takebayashi, M.1    Hayashi, T.2    Su, T.P.3
  • 150
    • 17144367298 scopus 로고    scopus 로고
    • Antidepressant treatment of psychotic major depression: Potential role of the sigma receptor
    • Stahl SM. Antidepressant treatment of psychotic major depression: potential role of the sigma receptor. CNS Spectr 2005; 10: 319-23.
    • (2005) CNS Spectr , vol.10 , pp. 319-323
    • Stahl, S.M.1
  • 151
    • 67649573893 scopus 로고    scopus 로고
    • Current investigational drugs for major depression
    • Kulkarni SK, Dhir A. Current investigational drugs for major depression. Expert Opin Invest Drugs 2009; 18: 767-88.
    • (2009) Expert Opin Invest Drugs , vol.18 , pp. 767-788
    • Kulkarni, S.K.1    Dhir, A.2
  • 152
    • 77954244972 scopus 로고    scopus 로고
    • Sigma receptors: Potential targets for a new class of antidepressant drug
    • Fishback JA, Robson MJ, Xu Y-T, Matsumoto RR. Sigma receptors: Potential targets for a new class of antidepressant drug. Pharmacol Ther 2010; 127: 271-82.
    • (2010) Pharmacol Ther , vol.127 , pp. 271-282
    • Fishback, J.A.1    Robson, M.J.2    Xu, Y.-T.3    Matsumoto, R.R.4
  • 153
    • 0024328732 scopus 로고
    • Sertraline potently displaces (+)-[3H]3-PPP binding to sigma sites in rat brain
    • Schmidt A, Lebel L, Koe BK, Seeger T, Heym J. Sertraline potently displaces (+)-[3H]3-PPP binding to sigma sites in rat brain. Eur J Pharmacol 1989; 165: 335-6.
    • (1989) Eur J Pharmacol , vol.165 , pp. 335-336
    • Schmidt, A.1    Lebel, L.2    Koe, B.K.3    Seeger, T.4    Heym, J.5
  • 154
    • 0025099110 scopus 로고
    • Clorgyline displays high affinity for sigma binding sites in C57BL/6 mouse brain
    • Itzhak Y, Kassim CO. Clorgyline displays high affinity for sigma binding sites in C57BL/6 mouse brain. Eur J Pharmacol 1990; 176: 107-8.
    • (1990) Eur J Pharmacol , vol.176 , pp. 107-108
    • Itzhak, Y.1    Kassim, C.O.2
  • 155
    • 0031050392 scopus 로고    scopus 로고
    • Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike?
    • Sanchez C, Meier E. Behavioral profiles of SSRIs in animal models of depression, anxiety and aggression. Are they all alike? Psychopharmacology (Berl) 1997; 129: 197-205.
    • (1997) Psychopharmacology (Berl) , vol.129 , pp. 197-205
    • Sanchez, C.1    Meier, E.2
  • 156
    • 0030594575 scopus 로고    scopus 로고
    • Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain
    • Narita N, Hashimoto K, Tomitaka S, Minabe Y. Interactions of selective serotonin reuptake inhibitors with subtypes of sigma receptors in rat brain. Eur J Pharmacol 1996; 307: 117-9.
    • (1996) Eur J Pharmacol , vol.307 , pp. 117-119
    • Narita, N.1    Hashimoto, K.2    Tomitaka, S.3    Minabe, Y.4
  • 157
    • 0027264824 scopus 로고
    • pchlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain
    • Shirayama Y, Nishikawa T, Umino A, Takahashi K. pchlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain. Eur J Pharmacol 1993; 237: 117-26.
    • (1993) Eur J Pharmacol , vol.237 , pp. 117-126
    • Shirayama, Y.1    Nishikawa, T.2    Umino, A.3    Takahashi, K.4
  • 158
    • 1642463533 scopus 로고    scopus 로고
    • 1) knockout mice
    • Langa F, Codony X, Tovar V, et al. Generation and phenotypic analysis of sigma receptor type I (σ1) knockout mice. Eur J Neurosci 2003; 18: 2188-96.
    • (2003) Eur J Neurosci , vol.18 , pp. 2188-2196
    • Langa, F.1    Codony, X.2    Tovar, V.3
  • 160
    • 12344283814 scopus 로고    scopus 로고
    • Forced swimming test in mice: A review of antidepressant activity
    • Petit-Demouliere B, Chenu F, Bourin M. Forced swimming test in mice: a review of antidepressant activity. Psychopharmacology (Berl) 2005; 177: 245-55.
    • (2005) Psychopharmacology (Berl) , vol.177 , pp. 245-255
    • Petit-Demouliere, B.1    Chenu, F.2    Bourin, M.3
  • 161
    • 19944380200 scopus 로고    scopus 로고
    • The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice
    • Cryan JF, Mombereau C, Vassout A. The tail suspension test as a model for assessing antidepressant activity: Review of pharmacological and genetic studies in mice. Neurosci Biobehav Rev 2005; 29: 571-625.
    • (2005) Neurosci Biobehav Rev , vol.29 , pp. 571-625
    • Cryan, J.F.1    Mombereau, C.2    Vassout, A.3
  • 162
    • 34447573756 scopus 로고    scopus 로고
    • Effect of various classes of antidepressants in behavioral paradigms of despair
    • Kulkarni SK, Dhir A. Effect of various classes of antidepressants in behavioral paradigms of despair. Prog Neuropsychopharmacol Biol Psychiatry 2007; 31: 1248-54.
    • (2007) Prog Neuropsychopharmacol Biol Psychiatry , vol.31 , pp. 1248-1254
    • Kulkarni, S.K.1    Dhir, A.2
  • 163
    • 0030567874 scopus 로고    scopus 로고
    • Sigma 1 receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test
    • Matsuno K, Kobayashi T, Tanaka MK, Mita S. Sigma 1 receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test. Eur J Pharmacol 1996; 312: 267-71.
    • (1996) Eur J Pharmacol , vol.312 , pp. 267-271
    • Matsuno, K.1    Kobayashi, T.2    Tanaka, M.K.3    Mita, S.4
  • 164
    • 0034891123 scopus 로고    scopus 로고
    • 1-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test
    • Urani A, Roman FJ, Phan VL, Su TP, Maurice T. The antidepressant-like effect induced by σ1-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test. J Pharmacol Exp Ther 2001; 298: 1269-79.
    • (2001) J Pharmacol Exp Ther , vol.298 , pp. 1269-1279
    • Urani, A.1    Roman, F.J.2    Phan, V.L.3    Su, T.P.4    Maurice, T.5
  • 165
    • 34548663639 scopus 로고    scopus 로고
    • Novel sigma (σ) receptor agonists produce antidepressant-like effects in mice
    • Wang J, Mack AL, Coop A, Matsumoto RR. Novel sigma (σ) receptor agonists produce antidepressant-like effects in mice. Eur Neuropsychopharmacol 2007; 17: 708-16.
    • (2007) Eur Neuropsychopharmacol , vol.17 , pp. 708-716
    • Wang, J.1    Mack, A.L.2    Coop, A.3    Matsumoto, R.R.4
  • 166
    • 0031792987 scopus 로고    scopus 로고
    • Beneficial effects of acute and repeated administrations of sigma receptor agonists on behavioral despair in mice exposed to tail suspension
    • Ukai M, Maeda H, Nanya Y, Kameyama T, Matsuno K. Beneficial effects of acute and repeated administrations of sigma receptor agonists on behavioral despair in mice exposed to tail suspension. Pharmacol Biochem Behav 1998; 61: 247-52.
    • (1998) Pharmacol Biochem Behav , vol.61 , pp. 247-252
    • Ukai, M.1    Maeda, H.2    Nanya, Y.3    Kameyama, T.4    Matsuno, K.5
  • 167
    • 0034719438 scopus 로고    scopus 로고
    • 3,4-dihydro-2(1H)-quinolinone as a novel antidepressant drug: Synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4-dihydro-5-methoxy-2(1H)-quinolinone and its derivatives
    • Oshiro Y, Sakurai Y, Sato S, et al. 3,4-dihydro-2(1H)-quinolinone as a novel antidepressant drug: synthesis and pharmacology of 1-[3-[4-(3-chlorophenyl)-1-piperazinyl]propyl]-3,4-dihydro-5-methoxy-2(1H)-quinolinone and its derivatives. J Med Chem 2000; 43: 177-89.
    • (2000) J Med Chem , vol.43 , pp. 177-189
    • Oshiro, Y.1    Sakurai, Y.2    Sato, S.3
  • 168
    • 0035662833 scopus 로고    scopus 로고
    • Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523
    • Tottori K, Miwa T, Uwahodo Y, et al. Antidepressant-like responses to the combined sigma and 5-HT1A receptor agonist OPC-14523. Neuropharmacology 2001; 41: 976-88.
    • (2001) Neuropharmacology , vol.41 , pp. 976-988
    • Tottori, K.1    Miwa, T.2    Uwahodo, Y.3
  • 169
    • 3342920765 scopus 로고    scopus 로고
    • Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl] propyl]-5-methoxy-3,4-dihydro-2-quinolino ne monomethanesulfonate] a combined sigma and 5-HT1A ligand: Modulation of neuronal activity in the dorsal raphe nucleus
    • Bermack JE, Haddjeri N, Debonnel G. Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl)-1-piperazinyl] propyl]-5-methoxy-3,4-dihydro-2-quinolino ne monomethanesulfonate] a combined sigma and 5-HT1A ligand: modulation of neuronal activity in the dorsal raphe nucleus. J Pharmacol Exp Ther 2004; 310: 578-83.
    • (2004) J Pharmacol Exp Ther , vol.310 , pp. 578-583
    • Bermack, J.E.1    Haddjeri, N.2    Debonnel, G.3
  • 170
    • 42549120255 scopus 로고    scopus 로고
    • Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT1A receptor agonist in the forced swimming test in rats
    • Skuza G, Rogoz Z. Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT1A receptor agonist in the forced swimming test in rats. Pharmacol Rep 2007; 59: 773-7.
    • (2007) Pharmacol Rep , vol.59 , pp. 773-777
    • Skuza, G.1    Rogoz, Z.2
  • 171
    • 0033624109 scopus 로고    scopus 로고
    • 2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression
    • Sanchez C, Papp M. The selective σ2 ligand Lu 28-179 has an antidepressant-like profile in the rat chronic mild stress model of depression. Behav Pharmacol 2000; 11: 117-24.
    • (2000) Behav Pharmacol , vol.11 , pp. 117-124
    • Sanchez, C.1    Papp, M.2
  • 172
    • 0031283066 scopus 로고    scopus 로고
    • 2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents
    • Sanchez C, Arnt J, Costall B, et al. The selective σ2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J Pharmacol Exp Ther 1997; 283: 1323-32.
    • (1997) J Pharmacol Exp Ther , vol.283 , pp. 1323-1332
    • Sanchez, C.1    Arnt, J.2    Costall, B.3
  • 175
    • 0034991042 scopus 로고    scopus 로고
    • Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats
    • Perfumi M, Panocka I, Ciccocioppo R, Vitali D, Froldi R, Massi M. Effects of a methanolic extract and a hyperforin-enriched CO2 extract of Hypericum perforatum on alcohol intake in rats. Alcohol Alcohol 2001; 36: 199-206.
    • (2001) Alcohol Alcohol , vol.36 , pp. 199-206
    • Perfumi, M.1    Panocka, I.2    Ciccocioppo, R.3    Vitali, D.4    Froldi, R.5    Massi, M.6
  • 176
    • 0032513119 scopus 로고    scopus 로고
    • Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals σ receptor binding
    • Raffa RB. Screen of receptor and uptake-site activity of hypericin component of St. John's wort reveals σ receptor binding. Life Sciences 1998; 62: PL265-70.
    • (1998) Life Sciences , vol.62 , pp. 265-270
    • Raffa, R.B.1
  • 177
    • 0034926582 scopus 로고    scopus 로고
    • In vitro binding studies with two hypericum perforatum extracts-hyperforin, hypericin and biapigenin-on 5-HT6, 5-HT7, GABAA/ benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters
    • Gobbi M, Moia M, Pirona L, Morizzoni P, Mennini T. In vitro binding studies with two hypericum perforatum extracts-hyperforin, hypericin and biapigenin-on 5-HT6, 5-HT7, GABAA/ benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters. Pharmacopsychiatry 2001; 34 (Suppl 1): S45-8.
    • (2001) Pharmacopsychiatry , vol.34 , Issue.SUPPL. 1
    • Gobbi, M.1    Moia, M.2    Pirona, L.3    Morizzoni, P.4    Mennini, T.5
  • 178
    • 2942682962 scopus 로고    scopus 로고
    • The antidepressant mechanism of Hypericum perforatum
    • Mennini T, Gobbi M. The antidepressant mechanism of Hypericum perforatum. Life Sci 2004; 75: 1021-7.
    • (2004) Life Sci , vol.75 , pp. 1021-1027
    • Mennini, T.1    Gobbi, M.2
  • 179
    • 0142091252 scopus 로고    scopus 로고
    • Specific modulation of sigma binding sites by the anxiolytic drug opipramol
    • Holoubek G, Muller WE. Specific modulation of sigma binding sites by the anxiolytic drug opipramol. J Neural Transm 2003; 110: 1169-79.
    • (2003) J Neural Transm , vol.110 , pp. 1169-1179
    • Holoubek, G.1    Muller, W.E.2
  • 180
  • 181
    • 70149124100 scopus 로고    scopus 로고
    • Targeting sigma receptors: Novel medication development for drug abuse and addiction
    • Matsumoto RR. Targeting sigma receptors: novel medication development for drug abuse and addiction. Expert Rev Clin Pharmacol 2009; 2: 351-8.
    • (2009) Expert Rev Clin Pharmacol , vol.2 , pp. 351-358
    • Matsumoto, R.R.1
  • 182
    • 23944504501 scopus 로고    scopus 로고
    • Involvement of sigma (σ) receptors in the acute actions of methamphetamine: Receptor binding and behavioral studies
    • Nguyen EC, McCracken KA, Liu Y, Pouw B, Matsumoto RR. Involvement of sigma (σ) receptors in the acute actions of methamphetamine: receptor binding and behavioral studies. Neuropharmacology 2005; 49: 638-45.
    • (2005) Neuropharmacology , vol.49 , pp. 638-645
    • Nguyen, E.C.1    McCracken, K.A.2    Liu, Y.3    Pouw, B.4    Matsumoto, R.R.5
  • 183
    • 33751179441 scopus 로고    scopus 로고
    • Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors
    • Brammer MK, Gilmore DL, Matsumoto RR. Interactions between 3,4-methylenedioxymethamphetamine and sigma1 receptors. Eur J Pharmacol, 2006; 553: 141-5.
    • (2006) Eur J Pharmacol , vol.553 , pp. 141-145
    • Brammer, M.K.1    Gilmore, D.L.2    Matsumoto, R.R.3
  • 184
    • 0028140473 scopus 로고
    • Pharmacotherapy of cocaine abuse: Preclinical development
    • Witkin JM. Pharmacotherapy of cocaine abuse: preclinical development. Neurosci Biobehav Rev 1994; 18: 121-42.
    • (1994) Neurosci Biobehav Rev , vol.18 , pp. 121-142
    • Witkin, J.M.1
  • 185
    • 0036627707 scopus 로고    scopus 로고
    • 1) receptor antagonists represent a new strategy against cocaine addiction and toxicity
    • Maurice T, Martin-Fardon R, Romieu P, Matsumoto RR. Sigma(1) (σ1) receptor antagonists represent a new strategy against cocaine addiction and toxicity. Neurosci Biobehav Rev 2002; 26: 499-527.
    • (2002) Neurosci Biobehav Rev , vol.26 , pp. 499-527
    • Maurice, T.1    Martin-Fardon, R.2    Romieu, P.3    Matsumoto, R.R.4
  • 186
    • 0038054062 scopus 로고    scopus 로고
    • Sigma receptors: Potential medications development target for anticocaine agents
    • Matsumoto RR, Liu Y, Lerner M, Howard EW, Brackett DJ. Sigma receptors: potential medications development target for anticocaine agents. Eur J Pharmacol, 2003; 469: 1-12.
    • (2003) Eur J Pharmacol , vol.469 , pp. 1-12
    • Matsumoto, R.R.1    Liu, Y.2    Lerner, M.3    Howard, E.W.4    Brackett, D.J.5
  • 187
    • 77955857758 scopus 로고    scopus 로고
    • 1) protein as a new target for anti-cocaine therapy
    • In: Pizzoli LA, Ed., Hauppauge, NY: Nova Science Publishers
    • Romieu P, Maurice T. The sigma1 (σ1) protein as a new target for anti-cocaine therapy. In: Pizzoli LA, Ed. Cocaine and heroin abuse research. Hauppauge, NY: Nova Science Publishers 2006; pp. 37-60.
    • (2006) Cocaine and Heroin Abuse Research , pp. 37-60
    • Romieu, P.1    Maurice, T.2
  • 188
    • 0242576358 scopus 로고    scopus 로고
    • Monoamine transporters and psychostimulant drugs
    • Rothman RB, Baumann MH. Monoamine transporters and psychostimulant drugs. Eur J Pharmacol 2003; 479: 23-40.
    • (2003) Eur J Pharmacol , vol.479 , pp. 23-40
    • Rothman, R.B.1    Baumann, M.H.2
  • 191
    • 0036063299 scopus 로고    scopus 로고
    • Involvement of sigma receptors in the behavioral effects of cocaine: Evidence from novel ligands and antisense oligodeoxynucleotides
    • Matsumoto RR, McCracken KA, Pouw B, Zhang Y, Bowen WD. Involvement of sigma receptors in the behavioral effects of cocaine: evidence from novel ligands and antisense oligodeoxynucleotides. Neuropharmacology 2002; 42: 1043-55.
    • (2002) Neuropharmacology , vol.42 , pp. 1043-1055
    • Matsumoto, R.R.1    McCracken, K.A.2    Pouw, B.3    Zhang, Y.4    Bowen, W.D.5
  • 192
    • 0021163480 scopus 로고
    • Death caused by recreational cocaine use: An update
    • Mittleman RE, Wetli CV. Death caused by recreational cocaine use: an update. J Am Med Assoc 1984; 252: 1889-93.
    • (1984) J Am Med Assoc , vol.252 , pp. 1889-1893
    • Mittleman, R.E.1    Wetli, C.V.2
  • 193
    • 0032436807 scopus 로고    scopus 로고
    • Measuring reward with the conditioned place preference paradigm: A comprehensive review of drug effects, recent progress and new issues
    • Tzschentke TM. Measuring reward with the conditioned place preference paradigm: a comprehensive review of drug effects, recent progress and new issues. Prog Neurobiol 1998; 56: 613-72.
    • (1998) Prog Neurobiol , vol.56 , pp. 613-672
    • Tzschentke, T.M.1
  • 194
    • 0034637730 scopus 로고    scopus 로고
    • 1 receptor in the cocaine-induced conditioned place preference
    • Romieu P, Martin-Fardon R, Maurice T. Involvement of the σ1 receptor in the cocaine-induced conditioned place preference. Neuroreport 2000; 11: 2885-8.
    • (2000) Neuroreport , vol.11 , pp. 2885-2888
    • Romieu, P.1    Martin-Fardon, R.2    Maurice, T.3
  • 195
    • 0036196967 scopus 로고    scopus 로고
    • 1 receptor in cocaine-induced conditioned place preference: Possible dependence on dopamine uptake blockade
    • Romieu P, Phan VL, Martin-Fardon R, Maurice T. Involvement of the σ1 receptor in cocaine-induced conditioned place preference: possible dependence on dopamine uptake blockade. Neuropsychopharmacology 2002; 26: 444-55.
    • (2002) Neuropsychopharmacology , vol.26 , pp. 444-455
    • Romieu, P.1    Phan, V.L.2    Martin-Fardon, R.3    Maurice, T.4
  • 196
    • 0038206598 scopus 로고    scopus 로고
    • 1 receptorrelated neuroactive steroids modulate cocaine-induced reward
    • Romieu P, Martin-Fardon R, Bowen WD, Maurice T. σ1 receptorrelated neuroactive steroids modulate cocaine-induced reward. J Neurosci 2003; 23: 3572-6.
    • (2003) J Neurosci , vol.23 , pp. 3572-3576
    • Romieu, P.1    Martin-Fardon, R.2    Bowen, W.D.3    Maurice, T.4
  • 197
    • 4544268439 scopus 로고    scopus 로고
    • The sigma1 (σ1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming
    • Romieu P, Meunier J, Garcia D, et al. The sigma1 (σ1) receptor activation is a key step for the reactivation of cocaine conditioned place preference by drug priming. Psychopharmacology (Berl) 2004; 175: 154-62.
    • (2004) Psychopharmacology (Berl) , vol.175 , pp. 154-162
    • Romieu, P.1    Meunier, J.2    Garcia, D.3
  • 198
    • 0033555570 scopus 로고    scopus 로고
    • Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine
    • McCracken KA, Bowen WD, Matsumoto RR. Novel sigma receptor ligands attenuate the locomotor stimulatory effects of cocaine. Eur J Pharmacol 1999; 365: 35-8.
    • (1999) Eur J Pharmacol , vol.365 , pp. 35-38
    • McCracken, K.A.1    Bowen, W.D.2    Matsumoto, R.R.3
  • 199
    • 0032937758 scopus 로고    scopus 로고
    • Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity
    • McCracken KA, Bowen WD, de Costa BR, Matsumoto RR. Two novel sigma receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity. Eur J Pharmacol 1999; 370: 225-32.
    • (1999) Eur J Pharmacol , vol.370 , pp. 225-232
    • McCracken, K.A.1    Bowen, W.D.2    de Costa, B.R.3    Matsumoto, R.R.4
  • 200
    • 0035815645 scopus 로고    scopus 로고
    • (+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice
    • Matsumoto RR, Mack AL. (+/-)-SM 21 attenuates the convulsive and locomotor stimulatory effects of cocaine in mice. Eur J Pharmacol 2001; 417: R1-2.
    • (2001) Eur J Pharmacol , vol.417
    • Matsumoto, R.R.1    Mack, A.L.2
  • 202
    • 0035847141 scopus 로고    scopus 로고
    • N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice
    • Matsumoto RR, McCracken KA, Pouw B, et al. N-alkyl substituted analogs of the sigma receptor ligand BD1008 and traditional sigma receptor ligands affect cocaine-induced convulsions and lethality in mice. Eur J Pharmacol 2001; 411: 261-73.
    • (2001) Eur J Pharmacol , vol.411 , pp. 261-273
    • Matsumoto, R.R.1    McCracken, K.A.2    Pouw, B.3
  • 203
    • 2442558113 scopus 로고    scopus 로고
    • Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice
    • Matsumoto RR, Gilmore DL, Pouw B, et al. Novel analogs of the sigma receptor ligand BD1008 attenuate cocaine-induced toxicity in mice. Eur J Pharmacol 2004; 492: 21-6.
    • (2004) Eur J Pharmacol , vol.492 , pp. 21-26
    • Matsumoto, R.R.1    Gilmore, D.L.2    Pouw, B.3
  • 204
    • 1942487797 scopus 로고    scopus 로고
    • Structure-activity comparison of YZ-069, a novel sigma ligand, and four analogs in receptor binding and behavioral studies
    • Matsumoto RR, Potelleret FH, Mack A, Pouw B, Zhang Y, Bowen WD. Structure-activity comparison of YZ-069, a novel sigma ligand, and four analogs in receptor binding and behavioral studies. Pharmacol Biochem Behav 2004; 77: 775-81.
    • (2004) Pharmacol Biochem Behav , vol.77 , pp. 775-781
    • Matsumoto, R.R.1    Potelleret, F.H.2    Mack, A.3    Pouw, B.4    Zhang, Y.5    Bowen, W.D.6
  • 205
    • 0034778556 scopus 로고    scopus 로고
    • Rimcazole analogs attenuate the convulsive effects of cocaine: Correlation with binding to sigma receptors rather than dopamine transporters
    • Matsumoto RR, Hewett KL, Pouw B, et al. Rimcazole analogs attenuate the convulsive effects of cocaine: correlation with binding to sigma receptors rather than dopamine transporters. Neuropharmacology 2001; 41: 878-86.
    • (2001) Neuropharmacology , vol.41 , pp. 878-886
    • Matsumoto, R.R.1    Hewett, K.L.2    Pouw, B.3
  • 206
    • 0026704462 scopus 로고
    • Supersensitivity of sigma receptors after repeated administration of cocaine
    • Ujike H, Tsuchida K, Akiyama K, Otsuki S. Supersensitivity of sigma receptors after repeated administration of cocaine. Life Sci 1992; 51: PL31-6.
    • (1992) Life Sci , vol.51
    • Ujike, H.1    Tsuchida, K.2    Akiyama, K.3    Otsuki, S.4
  • 207
    • 0029670662 scopus 로고    scopus 로고
    • sigma Receptor antagonists block the development of sensitization to cocaine
    • Ujike H, Kuroda S, Otsuki S. sigma Receptor antagonists block the development of sensitization to cocaine. Eur J Pharmacol 1996; 296: 123-8.
    • (1996) Eur J Pharmacol , vol.296 , pp. 123-128
    • Ujike, H.1    Kuroda, S.2    Otsuki, S.3
  • 208
    • 9644310531 scopus 로고    scopus 로고
    • 1 receptor in the appetitive effects of cocaine
    • Maurice T, Romieu P. Involvement of the σ1 receptor in the appetitive effects of cocaine. Pharmacopsychiatry 2004; 37 (Suppl 3): S198-207.
    • (2004) Pharmacopsychiatry , vol.37 , Issue.SUPPL. 3
    • Maurice, T.1    Romieu, P.2
  • 209
    • 0026542483 scopus 로고
    • Persistent supersensitivity of sigma receptors develops during repeated methamphetamine treatment
    • Ujike H, Okumura K, Zushi Y, Akiyama K, Otsuki S. Persistent supersensitivity of sigma receptors develops during repeated methamphetamine treatment. Eur J Pharmacol 1992; 211: 323-8.
    • (1992) Eur J Pharmacol , vol.211 , pp. 323-328
    • Ujike, H.1    Okumura, K.2    Zushi, Y.3    Akiyama, K.4    Otsuki, S.5
  • 210
    • 0343443375 scopus 로고
    • Sigma (σ) antagonist BMY 14802 prevents methamphetamine-induced sensitization
    • Ujike H, Kanzaki A, Okumura K, Akiyama K, Otsuki S. Sigma (σ) antagonist BMY 14802 prevents methamphetamine-induced sensitization. Life Sci 1992; 50: PL129-34.
    • (1992) Life Sci , vol.50
    • Ujike, H.1    Kanzaki, A.2    Okumura, K.3    Akiyama, K.4    Otsuki, S.5
  • 211
    • 0034726011 scopus 로고    scopus 로고
    • 1 receptors in methamphetamine-induced behavioral sensitization in rats
    • Takahashi S, Miwa T, Horikomi K. Involvement of σ1 receptors in methamphetamine-induced behavioral sensitization in rats. Neurosci Lett 2000; 289: 21-4.
    • (2000) Neurosci Lett , vol.289 , pp. 21-24
    • Takahashi, S.1    Miwa, T.2    Horikomi, K.3
  • 212
    • 0027492177 scopus 로고
    • Repeated methamphetamine-treatment alters brain sigma receptors
    • Itzhak Y. Repeated methamphetamine-treatment alters brain sigma receptors. Eur J Pharmacol 1993; 230: 243-4.
    • (1993) Eur J Pharmacol , vol.230 , pp. 243-244
    • Itzhak, Y.1
  • 213
    • 53649087671 scopus 로고    scopus 로고
    • Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies
    • Matsumoto RR, Shaikh J, Wilson LL, Vedam S, Coop A. Attenuation of methamphetamine-induced effects through the antagonism of sigma (σ) receptors: Evidence from in vivo and in vitro studies. Eur Neuropsychopharmacol 2008; 18: 871-81.
    • (2008) Eur Neuropsychopharmacol , vol.18 , pp. 871-881
    • Matsumoto, R.R.1    Shaikh, J.2    Wilson, L.L.3    Vedam, S.4    Coop, A.5
  • 214
    • 0035943337 scopus 로고    scopus 로고
    • 1 receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats
    • Horan B, Gardner EL, Dewey SL, Brodie JD, Ashby CR. The selective σ1 receptor agonist, 1-(3,4-dimethoxyphenethyl)-4-(phenylpropyl)piperazine (SA4503), blocks the acquisition of the conditioned place preference response to (-)-nicotine in rats. Eur J Pharmacol 2001; 426: R1-2.
    • (2001) Eur J Pharmacol , vol.426
    • Horan, B.1    Gardner, E.L.2    Dewey, S.L.3    Brodie, J.D.4    Ashby, C.R.5
  • 215
  • 216
    • 67649933389 scopus 로고    scopus 로고
    • Selective reduction of alcohol drinking in Sardinian alcoholpreferring rats by a sigma-1 receptor antagonist
    • Sabino V, Cottone P, Zhao Y, Steardo L, Koob GF, Zorrilla EP. Selective reduction of alcohol drinking in Sardinian alcoholpreferring rats by a sigma-1 receptor antagonist. Psychopharmacology (Berl) 2009; 205: 327-335.
    • (2009) Psychopharmacology (Berl) , vol.205 , pp. 327-335
    • Sabino, V.1    Cottone, P.2    Zhao, Y.3    Steardo, L.4    Koob, G.F.5    Zorrilla, E.P.6
  • 217
    • 64949109371 scopus 로고    scopus 로고
    • The [1]-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking
    • Sabino V, Cottone P, Zhao Y, et al. The [1]-receptor antagonist BD-1063 decreases ethanol intake and reinforcement in animal models of excessive drinking. Neuropsychopharmacology 2009; 34: 1482-93.
    • (2009) Neuropsychopharmacology , vol.34 , pp. 1482-1493
    • Sabino, V.1    Cottone, P.2    Zhao, Y.3
  • 218
    • 0030951630 scopus 로고    scopus 로고
    • Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands
    • Maurice T, Lockhart BP. Neuroprotective and anti-amnesic potentials of sigma (σ) receptor ligands. Prog Neuropsychopharmacol Biol Psychiatry 1997; 21: 69-102.
    • (1997) Prog Neuropsychopharmacol Biol Psychiatry , vol.21 , pp. 69-102
    • Maurice, T.1    Lockhart, B.P.2
  • 219
    • 23044437134 scopus 로고    scopus 로고
    • Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity
    • Marrazzo A, Caraci F, Salinaro ET, Su TP, Copani A, Ronsisvalle G. Neuroprotective effects of sigma-1 receptor agonists against beta-amyloid-induced toxicity. Neuroreport 2005; 16: 1223-6.
    • (2005) Neuroreport , vol.16 , pp. 1223-1226
    • Marrazzo, A.1    Caraci, F.2    Salinaro, E.T.3    Su, T.P.4    Copani, A.5    Ronsisvalle, G.6
  • 221
    • 0142075862 scopus 로고    scopus 로고
    • 1) receptor expression and behavioral efficacy in the aged C57BL/6 mouse
    • Phan VL, Urani A, Sandillon F, Privat A, Maurice T. Preserved sigma1 (σ1) receptor expression and behavioral efficacy in the aged C57BL/6 mouse. Neurobiol Aging 2003; 24: 865-81.
    • (2003) Neurobiol Aging , vol.24 , pp. 865-881
    • Phan, V.L.1    Urani, A.2    Sandillon, F.3    Privat, A.4    Maurice, T.5
  • 222
    • 0033049889 scopus 로고    scopus 로고
    • 2 sites
    • Maurice T, Phan VL, Noda Y, Yamada K, Privat A, Nabeshima T. The attenuation of learning impairments induced after exposure to CO or trimethyltin in mice by sigma (σ) receptor ligands involves both σ1 and σ2 sites. Br J Pharmacol 1999; 127: 335-42.
    • (1999) Br J Pharmacol , vol.127 , pp. 335-342
    • Maurice, T.1    Phan, V.L.2    Noda, Y.3    Yamada, K.4    Privat, A.5    Nabeshima, T.6
  • 223
    • 3242804298 scopus 로고    scopus 로고
    • 1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats
    • Meunier J, Gue M, Recasens M, Maurice T. Attenuation by a sigma1 (σ1) receptor agonist of the learning and memory deficits induced by a prenatal restraint stress in juvenile rats. Br J Pharmacol, 2004; 142: 689-700.
    • (2004) Br J Pharmacol , vol.142 , pp. 689-700
    • Meunier, J.1    Gue, M.2    Recasens, M.3    Maurice, T.4
  • 224
    • 4644371862 scopus 로고    scopus 로고
    • 1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine
    • Meunier J, Maurice T. Beneficial effects of the σ1 receptor agonists igmesine and dehydroepiandrosterone against learning impairments in rats prenatally exposed to cocaine. Neurotoxicol Teratol 2004; 26: 783-97.
    • (2004) Neurotoxicol Teratol , vol.26 , pp. 783-797
    • Meunier, J.1    Maurice, T.2
  • 225
    • 0036972396 scopus 로고    scopus 로고
    • 1 receptor agonists
    • Maurice T. Improving Alzheimer's disease-related cognitive deficits with σ1 receptor agonists. Drug News Perspect 2002; 15: 617-625.
    • (2002) Drug News Perspect , vol.15 , pp. 617-625
    • Maurice, T.1
  • 226
    • 33645739693 scopus 로고    scopus 로고
    • A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease
    • Uchida N, Ujike H, Tanaka Y, et al. A variant of the sigma receptor type-1 gene is a protective factor for Alzheimer disease. Am J Geriatr Psychiatry 2005; 13: 1062-6.
    • (2005) Am J Geriatr Psychiatry , vol.13 , pp. 1062-1066
    • Uchida, N.1    Ujike, H.2    Tanaka, Y.3
  • 227
    • 0033593489 scopus 로고    scopus 로고
    • TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons
    • Kato K, Hayako H, Ishihara Y, Marui S, Iwane M, Miyamoto M. TAK-147, an acetylcholinesterase inhibitor, increases choline acetyltransferase activity in cultured rat septal cholinergic neurons. Neurosci Lett 1999; 260: 5-8.
    • (1999) Neurosci Lett , vol.260 , pp. 5-8
    • Kato, K.1    Hayako, H.2    Ishihara, Y.3    Marui, S.4    Iwane, M.5    Miyamoto, M.6
  • 228
    • 69749122515 scopus 로고    scopus 로고
    • 1 receptors in the human brain after single oral administration of donepezil: A positron emission tomography study using [11C]SA4503
    • Ishikawa M, Sakata M, Ishii K, et al. High occupancy of σ1 receptors in the human brain after single oral administration of donepezil: a positron emission tomography study using [11C]SA4503. Int J Neuropsychopharmacol 2009; 12: 1127-31.
    • (2009) Int J Neuropsychopharmacol , vol.12 , pp. 1127-1131
    • Ishikawa, M.1    Sakata, M.2    Ishii, K.3
  • 229
    • 51349124733 scopus 로고    scopus 로고
    • Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: Role of sigma-1 receptors and IP3 receptors
    • Ishima T, Nishimura T, Iyo M, Hashimoto K. Potentiation of nerve growth factor-induced neurite outgrowth in PC12 cells by donepezil: role of sigma-1 receptors and IP3 receptors. Prog Neuropsychopharmacol Biol Psychiatry, 2008; 32: 1656-9.
    • (2008) Prog Neuropsychopharmacol Biol Psychiatry , vol.32 , pp. 1656-1659
    • Ishima, T.1    Nishimura, T.2    Iyo, M.3    Hashimoto, K.4
  • 230
    • 33645885043 scopus 로고    scopus 로고
    • 1 protein, but not N-methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil
    • Maurice T, Meunier J, Feng B, Ieni J, Monaghan DT. Interaction with σ1 protein, but not N-methyl-D-aspartate receptor, is involved in the pharmacological activity of donepezil. J Pharmacol Exp Ther 2006; 317: 606-14.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 606-614
    • Maurice, T.1    Meunier, J.2    Feng, B.3    Ieni, J.4    Monaghan, D.T.5
  • 231
    • 33646757887 scopus 로고    scopus 로고
    • Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas
    • Meunier J, Ieni J, Maurice T. Antiamnesic and neuroprotective effects of donepezil against learning impairments induced in mice by exposure to carbon monoxide gas. J Pharmacol Exp Ther 2006; 317: 1307-19.
    • (2006) J Pharmacol Exp Ther , vol.317 , pp. 1307-1319
    • Meunier, J.1    Ieni, J.2    Maurice, T.3
  • 232
    • 33845651380 scopus 로고    scopus 로고
    • 1 receptor
    • Meunier J, Ieni J, Maurice T. The anti-amnesic and neuroprotective effects of donepezil against amyloid σ 25-35 peptide-induced toxicity in mice involve an interaction with the σ1 receptor. Br J Pharmacol 2006; 149: 998-1012.
    • (2006) Br J Pharmacol , vol.149 , pp. 998-1012
    • Meunier, J.1    Ieni, J.2    Maurice, T.3
  • 233
    • 0028979294 scopus 로고
    • 1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats
    • Matsuno K, Senda T, Kobayashi T, Mita S. Involvement of σ1 receptor in (+)-N-allylnormetazocine-stimulated hippocampal cholinergic functions in rats. Brain Res 1995; 690: 200-6.
    • (1995) Brain Res , vol.690 , pp. 200-206
    • Matsuno, K.1    Senda, T.2    Kobayashi, T.3    Mita, S.4
  • 234
    • 0030574257 scopus 로고    scopus 로고
    • 1 receptor agonist, on memory impairments induced by cholinergic dysfunction in rats
    • Senda T, Matsuno K, Okamoto K, Kobayashi T, Nakata K, Mita S. Ameliorating effect of SA4503, a novel σ1 receptor agonist, on memory impairments induced by cholinergic dysfunction in rats. Eur J Pharmacol 1996; 315: 1-10.
    • (1996) Eur J Pharmacol , vol.315 , pp. 1-10
    • Senda, T.1    Matsuno, K.2    Okamoto, K.3    Kobayashi, T.4    Nakata, K.5    Mita, S.6
  • 236
    • 0031594365 scopus 로고    scopus 로고
    • Sigma1 ([1] 1) receptor agonists and neurosteroids attenuate σ 25-35-amyloid peptide-induced amnesia in mice through a common mechanism
    • Maurice T, Su TP, Privat A. Sigma1 ([1]1) receptor agonists and neurosteroids attenuate σ 25-35-amyloid peptide-induced amnesia in mice through a common mechanism. Neuroscience 1998; 83: 413-28.
    • (1998) Neuroscience , vol.83 , pp. 413-428
    • Maurice, T.1    Su, T.P.2    Privat, A.3
  • 237
    • 0035853486 scopus 로고    scopus 로고
    • 1) receptor agonists confirmed by in vivo antisense strategy in the mouse
    • Maurice T, Phan VL, Privat A. The anti-amnesic effects of sigma1 (σ1) receptor agonists confirmed by in vivo antisense strategy in the mouse. Brain Res 2001; 898: 113-21.
    • (2001) Brain Res , vol.898 , pp. 113-121
    • Maurice, T.1    Phan, V.L.2    Privat, A.3
  • 238
    • 0034009454 scopus 로고    scopus 로고
    • Non-dopaminergic therapy in Parkinson's disease
    • Przuntek H. Non-dopaminergic therapy in Parkinson's disease. J Neurol, 2000; 247 (Suppl 2): II19-24.
    • (2000) J Neurol , vol.247 , Issue.SUPPL. 2
    • Przuntek, H.1
  • 239
    • 0029414738 scopus 로고
    • The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue
    • Kornhuber J, Herr B, Thome J, Riederer P. The antiparkinsonian drug budipine binds to NMDA and sigma receptors in postmortem human brain tissue. J Neural Transm Suppl 1995; 46: 131-7.
    • (1995) J Neural Transm Suppl , vol.46 , pp. 131-137
    • Kornhuber, J.1    Herr, B.2    Thome, J.3    Riederer, P.4
  • 241
    • 0027133193 scopus 로고
    • Affinity of 1-aminoadamantanes for the sigma binding site in post-mortem human frontal cortex
    • Kornhuber J, Schoppmeyer K, Riederer P. Affinity of 1-aminoadamantanes for the sigma binding site in post-mortem human frontal cortex. Neurosci Lett 1993; 163: 129-31.
    • (1993) Neurosci Lett , vol.163 , pp. 129-131
    • Kornhuber, J.1    Schoppmeyer, K.2    Riederer, P.3
  • 242
    • 17144469178 scopus 로고
    • Binding of dexetimide and levetimide to [3H](+)pentazocine-and [3H]1,3-di(2-tolyl)guanidinedefined sigma recognition sites
    • DeHaven-Hudkins DL, Hudkins RL. Binding of dexetimide and levetimide to [3H](+)pentazocine-and [3H]1,3-di(2-tolyl)guanidinedefined sigma recognition sites. Life Sci 1991; 49: PL135-9.
    • (1991) Life Sci , vol.49 , pp. 119-135
    • Dehaven-Hudkins, D.L.1    Hudkins, R.L.2
  • 243
    • 0027383469 scopus 로고
    • 1 system
    • Chien CC, Pasternak GW. Functional antagonism of morphine analgesia by (+)-pentazocine: evidence for an anti-opioid σ1 system. Eur J Pharmacol 1993; 250: R7-8.
    • (1993) Eur J Pharmacol , vol.250
    • Chien, C.C.1    Pasternak, G.W.2
  • 244
    • 0028149215 scopus 로고
    • Selective antagonism of opioid analgesia by a sigma system
    • Chien CC, Pasternak GW. Selective antagonism of opioid analgesia by a sigma system. J Pharmacol Exp Ther 1994; 271: 1583-90.
    • (1994) J Pharmacol Exp Ther , vol.271 , pp. 1583-1590
    • Chien, C.C.1    Pasternak, G.W.2
  • 245
    • 0028930208 scopus 로고
    • Sigma antagonists potentiate opioid analgesia in rats
    • Chien CC, Pasternak GW. Sigma antagonists potentiate opioid analgesia in rats. Neurosci Lett 1995; 190: 137-9.
    • (1995) Neurosci Lett , vol.190 , pp. 137-139
    • Chien, C.C.1    Pasternak, G.W.2
  • 246
    • 0036008324 scopus 로고    scopus 로고
    • 1 Receptor modulation of opioid analgesia in the mouse
    • Mei J, Pasternak GW. σ1 Receptor modulation of opioid analgesia in the mouse. J Pharmacol Exp Ther 2002; 300: 1070-4.
    • (2002) J Pharmacol Exp Ther , vol.300 , pp. 1070-1074
    • Mei, J.1    Pasternak, G.W.2
  • 248
    • 69249149994 scopus 로고    scopus 로고
    • 1) receptor antagonists: Emerging target for the treatment of neuropathic pain
    • Díaz JL, Zamanillo D, Corbera J, et al. Selective sigma1 (σ1) receptor antagonists: emerging target for the treatment of neuropathic pain. Cent Nerv Syst Agents Med Chem 2009; 9: 172-183.
    • (2009) Cent Nerv Syst Agents Med Chem , vol.9 , pp. 172-183
    • Díaz, J.L.1    Zamanillo, D.2    Corbera, J.3
  • 249
    • 56149124983 scopus 로고    scopus 로고
    • 1 receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain
    • Roh DH, Kim HW, Yoon SY, et al. Intrathecal injection of the σ1 receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain. Anesthesiology 2008; 109: 879-89.
    • (2008) Anesthesiology , vol.109 , pp. 879-889
    • Roh, D.H.1    Kim, H.W.2    Yoon, S.Y.3
  • 250
    • 69649106397 scopus 로고    scopus 로고
    • Central sensitization needs sigma receptors
    • Drews E, Zimmer A. Central sensitization needs sigma receptors. Pain 2009; 145: 269-70.
    • (2009) Pain , vol.145 , pp. 269-270
    • Drews, E.1    Zimmer, A.2
  • 251
    • 77955590146 scopus 로고    scopus 로고
    • The evidence for pharmacological treatment of neuropathic pain
    • Finnerup NB, Sindrup SH, Jensen TS. The evidence for pharmacological treatment of neuropathic pain. Pain 2010; 150: 573-81.
    • (2010) Pain , vol.150 , pp. 573-581
    • Finnerup, N.B.1    Sindrup, S.H.2    Jensen, T.S.3
  • 252
    • 0033526651 scopus 로고    scopus 로고
    • Neuropathic pain: Aetiology, symptoms, mechanisms, and management
    • Woolf CJ, Mannion RJ. Neuropathic pain: aetiology, symptoms, mechanisms, and management. The Lancet 1999; 353: 1959-64.
    • (1999) The Lancet , vol.353 , pp. 1959-1964
    • Woolf, C.J.1    Mannion, R.J.2
  • 253
    • 67349154763 scopus 로고    scopus 로고
    • 1 ligands and sigma-1 knockout mice
    • Entrena JM, Cobos EJ, Nieto FR, et al. σ1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective σ1 ligands and sigma-1 knockout mice. Pain 2009; 143: 252-61.
    • (2009) Pain , vol.143 , pp. 252-261
    • Entrena, J.M.1    Cobos, E.J.2    Nieto, F.R.3
  • 255
    • 69649104522 scopus 로고    scopus 로고
    • 1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury
    • de la Puente B, Nadal X, Portillo-Salido E, et al. σ1 receptors regulate activity-induced spinal sensitization and neuropathic pain after peripheral nerve injury. Pain 2009; 145: 294-303.
    • (2009) Pain , vol.145 , pp. 294-303
    • de la Puente, B.1    Nadal, X.2    Portillo-Salido, E.3
  • 258
    • 0031056396 scopus 로고    scopus 로고
    • The pharmacology of the novel and selective sigma ligand, PD 144418
    • Akunne HC, Whetzel SZ, Wiley JN, et al. The pharmacology of the novel and selective sigma ligand, PD 144418. Neuropharmacology 1997; 36: 51-62.
    • (1997) Neuropharmacology , vol.36 , pp. 51-62
    • Akunne, H.C.1    Whetzel, S.Z.2    Wiley, J.N.3
  • 259
    • 0029417151 scopus 로고
    • (-)-Pentazocine analgesia in mice: Interactions with a sigma receptor system
    • Chien CC, Pasternak GW. (-)-Pentazocine analgesia in mice: interactions with a sigma receptor system. Eur J Pharmacol 1995; 294: 303-8.
    • (1995) Eur J Pharmacol , vol.294 , pp. 303-308
    • Chien, C.C.1    Pasternak, G.W.2
  • 261
  • 262
    • 0027080120 scopus 로고
    • Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents
    • Yevich JP, New JS, Lobeck WG, et al. Synthesis and biological characterization of alpha-(4-fluorophenyl)-4-(5-fluoro-2-pyrimidinyl)-1-piperazinebutanol and analogues as potential atypical antipsychotic agents. J Med Chem 1992; 35: 4516-25.
    • (1992) J Med Chem , vol.35 , pp. 4516-4525
    • Yevich, J.P.1    New, J.S.2    Lobeck, W.G.3
  • 263
    • 0028049301 scopus 로고
    • NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain
    • Chaki S, Tanaka M, Muramatsu M, Otomo S. NE-100, a novel potent sigma ligand, preferentially binds to sigma 1 binding sites in guinea pig brain. Eur J Pharmacol 1994; 251: R1-2.
    • (1994) Eur J Pharmacol , vol.251
    • Chaki, S.1    Tanaka, M.2    Muramatsu, M.3    Otomo, S.4
  • 264
    • 0030017401 scopus 로고    scopus 로고
    • Ne-100: A novel sigma receptor antagonist
    • Okuyama S, Nakazato A. NE-100: A novel sigma receptor antagonist. CNS Drug Rev 1996; 2: 226-37.
    • (1996) CNS Drug Rev , vol.2 , pp. 226-237
    • Okuyama, S.1    Nakazato, A.2
  • 265
    • 0034999712 scopus 로고    scopus 로고
    • multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[σ-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites
    • Berardi F, Ferorelli S, Colabufo NA, Leopoldo M, Perrone R, Tortorella V. A multireceptorial binding reinvestigation on an extended class of sigma ligands: N-[σ-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards sigma1 and EBP sites. Bioorg Med Chem 2001; 9: 1325-35.
    • (2001) Bioorg Med Chem , vol.9 , pp. 1325-1335
    • Berardi, F.1    Ferorelli, S.2    Colabufo, N.A.3    Leopoldo, M.4    Perrone, R.5    Tortorella, V.A.6
  • 266
    • 0029065278 scopus 로고
    • 2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles
    • Perregaard J, Moltzen EK, Meier E, Sanchez C. Sigma ligands with subnanomolar affinity and preference for the σ2 binding site. 1. 3-(omega-aminoalkyl)-1H-indoles. J Med Chem 1995; 38: 1998-2008.
    • (1995) J Med Chem , vol.38 , pp. 1998-2008
    • Perregaard, J.1    Moltzen, E.K.2    Meier, E.3    Sanchez, C.4
  • 268
    • 33847042772 scopus 로고    scopus 로고
    • 2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice
    • Matsumoto RR, Pouw B, Mack AL, Daniels A, Coop A. Effects of UMB24 and (+/-)-SM 21, putative σ2-preferring antagonists, on behavioral toxic and stimulant effects of cocaine in mice. Pharmacol Biochem Behav 2007; 86: 86-91.
    • (2007) Pharmacol Biochem Behav , vol.86 , pp. 86-91
    • Matsumoto, R.R.1    Pouw, B.2    Mack, A.L.3    Daniels, A.4    Coop, A.5
  • 269
    • 0032480908 scopus 로고    scopus 로고
    • Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands
    • Zhang Y, Williams W, Torrence-Campbell C, Bowen WD, Rice KC. Characterization of novel N,N'-disubstituted piperazines as sigma receptor ligands. J Med Chem 1998; 41: 4950-7.
    • (1998) J Med Chem , vol.41 , pp. 4950-4957
    • Zhang, Y.1    Williams, W.2    Torrence-Campbell, C.3    Bowen, W.D.4    Rice, K.C.5
  • 270
    • 0026319468 scopus 로고
    • Sigma compounds derived from phencyclidine: Identification of PRE-084, a new, selective sigma ligand
    • Su TP, Wu XZ, Cone EJ, et al. Sigma compounds derived from phencyclidine: identification of PRE-084, a new, selective sigma ligand. J Pharmacol Exp Ther 1991; 259: 543-50.
    • (1991) J Pharmacol Exp Ther , vol.259 , pp. 543-550
    • Su, T.P.1    Wu, X.Z.2    Cone, E.J.3


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