A multireceptorial binding reinvestigation on an extended class of σ ligands: N-[ω-(indan-1-yl and tetralin-1-yl)alkyl] derivatives of 3,3-dimethylpiperidine reveal high affinities towards σ1 and EBP sites

Bioorganic and Medicinal Chemistry

Volumn 9, Issue 5, 2001, Pages 1325-1335

  Berardi, Francesco ^a   Ferorelli, Savina ^a   Colabufo, Nicola Antonio ^a   Leopoldo, Marcello ^a   Perrone, Roberto ^a   Tortorella, Vincenzo ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

1 (3,4 DIMETHOXYPHENETHYL) 4 (3 PHENYLPROPYL)PIPERAZINE; 1 [2 (2,3 DIHYDRO 1H INDEN 1 YL)ETHYL] 3,3 DIMETHYLPIPERIDINE; 1 [4 (2,3 DIHYDRO 1H INDEN 1 YL)BUTYL] 3,3 DIMETHYLPIPERIDINE; 1 [4 (2,3 DIHYDRO 1H INDEN YL)BUTYL] 3,3 DIMETHYLPIPERIDINE; 1 [5 (2,3 DIHYDRO 1H INDEN 1 YL)PENTYL] 3,3 DIMETHYLPIPERIDINE; 1 [5 (2,3 DIHYDRO 5 METHOXY 1H INDEN 1 YL)PENTYL] 3,3 DIMETHYLPIPERIDINE; 1 [OMEGA (1,2,3,4 TETRAHYDRONAPHTHALENE 1 YL)]; 1 [OMEGA (2,3 DIHYDRO 1H INDEN YL)]; 1 [OMEGA (2,3 DIHYDRO 5 METHOXY 1H INDEN 1 YL)]; 1 [OMEGA (6 FLUORO 1,2,3,4 TETRAHYDRONAPHTHALENE 1 YL)]; 1 [OMEGA (6 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALENE 1 YL)]; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; 3,3 DIMETHYL 1 [2 (6 METHOXY 1,2,3,4 TETRAHYDRONAPHTHALENE 1 YL)BUTYL]PIPERIDINE; 3,3 DIMETHYL 1 [5 (6 FLUORO 1,2,3,4 TETRAHYDRONAPHTHALENE 1 YL)PENTYL]PIPERIDINE; 3,3 DIMETHYLPIPERIDINE DERIVATIVE; BINDING PROTEIN; CALCIUM CHANNEL L TYPE; EMOPAMIL; ISOMERASE; N [2 (3,4 DICHLOROPHENYL)ETHYL] N METHYL 2 (1 PYRROLIDINYL)ETHYLAMINE; PENTAZOCINE; PHENYL GROUP; RADIOLIGAND; SIGMA 1 OPIATE RECEPTOR; SIGMA 2 OPIATE RECEPTOR; STEROL; TERTIARY AMINE; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; BRAIN MEMBRANE; CHEMICAL REACTION; CONTROLLED STUDY; DERIVATIZATION; DRUG SYNTHESIS; GUINEA PIG; LIGAND BINDING; LIVER MEMBRANE; NONHUMAN; RAT; RECEPTOR BINDING; RECEPTOR SENSITIVITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BINDING SITES; BRAIN; CALCIUM CHANNELS, L-TYPE; CARRIER PROTEINS; DIZOCILPINE MALEATE; GUANIDINES; GUINEA PIGS; INHIBITORY CONCENTRATION 50; LIGANDS; LIVER; PENTAZOCINE; PIPERIDINES; RADIOLIGAND ASSAY; RATS; RECEPTORS, OPIOID, DELTA; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034999712     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(01)00011-6     Document Type: Article

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