Effects of the potential antidepressant OPC-14523 [1-[3-[4-(3-chlorophenyl) -1-piperazinyl]propyl]-5-methoxy-3,4-dihydro-2-quinolinone monomethanesulfonate] a combined σ and 5-HT1A ligand: Modulation of neuronal activity in the dorsal raphe nucleus

Journal of Pharmacology and Experimental Therapeutics

Volumn 310, Issue 2, 2004, Pages 578-583

  Bermack, Jordanna E ^a   Haddjeri, Nasser ^b   Debonnel, Guy ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITÉ LYON 1   (France)

Author keywords

[No Author keywords available]

Indexed keywords

1 [3 [4 (3 CHLOROPHENYL) 1 PIPERAZINYL]PROPYL] 5 METHOXY 3,4 DIHYDRO 2 QUINOLINONE MONOMETHANESULFONATE; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; 2 DIPROPYLAMINO 8 HYDROXYTETRALIN; ANTIDEPRESSANT AGENT; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; OPC 14523; PAROXETINE; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SEROTONIN ANTAGONIST; SEROTONIN RECEPTOR; SEROTONIN UPTAKE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; CONTROLLED STUDY; DESENSITIZATION; DORSAL RAPHE NUCLEUS; DRUG EFFECT; DRUG MECHANISM; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; IN VIVO STUDY; MALE; NERVE CONDUCTION; NEUROTRANSMISSION; NONHUMAN; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM;

ACTION POTENTIALS; ANIMALS; ANTIDEPRESSIVE AGENTS; DOSE-RESPONSE RELATIONSHIP, DRUG; MALE; PAROXETINE; PIPERAZINES; QUINOLONES; RAPHE NUCLEI; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RECEPTORS, SIGMA; SEROTONIN UPTAKE INHIBITORS;

EID: 3342920765     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.104.066472     Document Type: Article

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