Sigma-2 receptors as a biomarker of proliferation in solid tumours

British Journal of Cancer

Volumn 82, Issue 6, 2000, Pages 1223-1232

  Wheeler, K T ^a   Wang, L M ^a   Wallen, C A ^a   Childers, S R ^a   Cline, J M ^a   Keng, P C ^b   Mach, R H ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

Biomarkers; Functional imaging; Proliferative tumour cells; Quiescent tumour cells; Sigma 2 receptors; Solid tumours

Indexed keywords

BIOLOGICAL MARKER; SIGMA OPIATE RECEPTOR; TAMOXIFEN; TUMOR MARKER;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CELL PROLIFERATION; MOUSE; NONHUMAN; NUDE MOUSE; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RECEPTOR AFFINITY; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOLID TUMOR; TUMOR CELL;

EID: 0034010937     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1054/bjoc.1999.1067     Document Type: Article

References (42)

1. Al-Nabulsi I, Mach RH, Wang L-M, Wallen CA, Keng PC, Sten K, Childers SR and Wheeler KT (1999) Effect of ploidy, recruitment, environmental factors, and tamoxifen on the expression of sigma-2 receptors in proliferating and quiescent tumour cells. Br J Cancer 81: 925-933
2. Amano S, Inoue T, Tomiyoshi K, Ando T and Endo K (1998) In vivo comparison of PET and SPECT radiopharmaceuticals in detecting breast cancer. J Nucl Med 39: 1424-1427
3. pot! Int J Radiat Oncol Biol Phys 32: 1539-1541
4. Begg AC, Hofland I, Van Glabbeke M and Horiot JC (1992) Predictive value of potential doubling time for radiotherapy of head and neck tumor patients. Results from the EORTC cooperative trial 22851. Semin Rad Oncol 1: 22-25
5. Bem WT, Thomas GE, Mamone JY, Homan SM, Levy BK, Johnson FE and Coscia CJ (1991) Overexpression of σ receptors in nonneural human tumors. Cancer Res 51: 6558-6562
6. Bradford MM (1976) A rapid and sensitive method for quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72: 248-254
7. Corro R, Giaretti W, Sanguinet G, Geido E, Orechia R, Guenzi M, Margarino G, Bacigalupo A, Garaventa G, Barbieri M and Vitale V (1995) In vivo cell kinetics in head and neck squamous cell carcinomas predicts local control and helps guide radiotherapy regimen. J Clin Oncol 13: 1843-1850
8. Dong H, Bertler C, Schneider E and Ritter MA (1997) Assessment of cell proliferation by AgNOR scores and Ki-67 labeling indices and a comparison with potential doubling times. Cytometry 28: 280-288
9. Dressler LG (1993) DNA flow cytometry measurements and their clinical relevance in node-negative breast cancer patients. Recent Results Cancer Res 127: 61-69
10. Ehmann UK and Wheeler KT (1979) Cinemicrographic determination of progression and division abnormalities after treatment with 1,3 bis(2-chloroethyl)-1-nitrosourea. Eur J Cancer 15: 461-473
11. Ehmann UK, Nagasawa H, Petersen DF and Lett JT (1974) Symptoms of X-ray damage to radiosensitive mouse leukemic cells: asynchronous populations. Radiat Res 60: 453-472
12. Gatenby RA, Kessler HB, Rosenblum JS, Coia LR, Moldofsky PJ, Hartz WH and Broder GJ (1988) Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 14: 831-838
13. Haberkorn U, Strauss JG, Reisser CH, Haag D, Dimitrakopoulou A, Ziegler S, Oberdorfer F, Rudat VA and Van Kaick G (1991) Glucose uptake, perfusion and cell proliferation in head and neck tumors: relation of positron emission tomography to flow cytometry. J Nucl Med 32: 1548-1555
14. 1 binding site. Proc Natl Acad Sci USA 93: 8072-8077
15. pot) be compared between laboratories? A quality control study. Cytometry 19: 154-163
16. Hayes DF (1996) Serum (circulating) tumor markers for breast cancer. Recent Results Cancer Res 140: 101-113
17. Hedley DW, Clark GM, Cornelisse CJ, Killander D, Kute T and Merkel D (1993) Consensus review of the clinical utility of DNA cytometry in carcinoma of the breast. Cytometry 14: 482-485
18. 2 receptors: characterization by ligand binding and photoaffinity labeling. Eur J Pharmacol Mol Pharmacol Sec 268: 9-18
19. 2 tension measurements. Cancer Res 51: 6098-6102
20. Kaufman M (1996) Review of known prognostic variables. Recent Results Cancer Res 140: 77-87
21. Kekuda R, Prasad P, Fei Y-J, Leibach FH and Ganapathy V (1996) Cloning and functional expression of the human type one sigma receptor (hSigma R1). Biochem Biophys Res Commun 223: 553-558
22. 11C-methionine in breast cancer studied by PET. An association with the size of the S-phase fraction. Br J Cancer 64: 1121-1124
23. Liu A, Dence CS, Welch MJ and Katzenellenbogen JA (1992) Fluorine-18-labeled androgens: radiochemical synthesis and tissue distribution studies on six fluorine-substituted androgens, potential imaging agents for prostatic cancer. J Nucl Med 33: 724-734
24. 2 receptors as potential biomarkers of proliferation in breast cancer. Cancer Res 57: 156-161
25. Martiat PH, Ferrant A, Labar D, Cogneau M, Bol A, Michael C, Michaux JL and Sokal G (1988) In vivo measurement of carbon-11 thymidine uptake in non-Hodgkins lymphoma using positron emission tomography. J Nucl Med 29: 1633-1637
26. 18F]fluorodeoxyglucose scintigraphy in diagnosis and follow-up of treatment in advanced breast cancer. Eur J Nucl Med 15: 61-66
27. Minn J, Joensuu H, Ahonen A and Klemi P (1988) Fluorodeoxyglucose imaging: a method to assess proliferative activity of human cancer in vivo. Cancer 61: 1776-1781
28. Miyazawa H, Arai T, Iio M and Hara T (1993) PET imaging of non-small cell lung carcinoma with carbon-11-methionine: relationship between radioactivity uptake and flow-cytometric parameters. J Nucl Med 43: 1886-1891
29. Moebius FF, Stiessnig J and Glossman H (1997) The mysteries of the sigma receptors: new family members reveal a role in cholesterol synthesis. TIPS 18: 67-70
30. Okada J, Yoshikawa K, Itami M, Imaseki K, Uno K, Itami J, Kuyama J, Mikata A and Arimizu N (1992) Positron emission tomography using fluorine-18-fluorodeoxyglucose in malignant lymphoma: a comparison with proliferative activity. J Nucl Med 33: 325-329
31. Schabel FM (1969) The use of tumor growth kinetics in planning "curative" chemotherapy of advanced solid tumors. Cancer Res 29: 2384-2389
32. Seth P, Leibach FH and Ganapathy V (1997) Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor. Biochem Biophys Res Commun 241: 535-540
33. Seth P, Fei Y-J, Li HW, Huang W, Leibach FH and Ganapathy V (1998) Cloning and functional characterization of a σ receptor from rat brain. J Neurochem 70: 922-931
34. Siemann DW, Lord EM, Keng PC and Wheeler KT (1984) Cell subpopulations dispersed from solid tumors and separated by centrifugal elutriation. Br J Cancer 44: 100-108
35. Takeda N, Diksic M and Yamamoto YL (1996) The sequencial changes in DNA synthesis, glucose utilization, protein synthesis, and peripheral benzodiazepine receptor density in C6 brain tumors after chemotherapy to predict the response of tumors to chemotherapy. Cancer 77: 1167-1179
36. Thames HD, Peters LJ, Withers HR and Fletcher GH (1983) Accelerated fractionation vs hyperfractionation: rationales for several treatments per day. Int J Radiat Oncol Biol Phys 9: 127-138
37. pot in cancer of the uterine cervix: correlation between two laboratories and preliminary clinical results. Int J Radiat Oncol Biol Phys 32: 1319-1329
38. Vilner BJ and Bowen WD (1992) Characterization of sigma-like binding properties of NB41A3, S-20Y, and N1E-115 neuroblastoma, C6 glioma, and NG108-15 neuroblastoma-glioma hybrid cells. Further evidence for sigma receptors. In: Multiple Sigma and PCP Receptor Ligands: Mechanisms for Neuromodulation and Neuroprotection, Kamenka JM, Domino EF (eds) pp 341-353. NPP Books: Ann Arbor
39. Vilner BJ, John CS and Bowen WD (1995) Sigma-1 and sigma-2 receptors are expressed in a wide variety of human and rodent tumor cell lines. Cancer Res 55: 408-413
40. Walker JM, Bowen WD, Walker FO, Matsumoto RE, De Costa B and Rice KR (1990) Sigma receptors: biology and function. Pharmacol Rev 42: 355-402
41. Wallen CA, Higashikubo R and Dethlefsen LA (1984a) Murine mammary tumor cells in vitro. I. The development of a quiescent state. Cell Tissue Kinet 17: 65-77
42. Wallen CA, Higashikubo R and Dethlefsen LA (1984b) Murine mammary tumor cells in vitro. II. Recruitment of quiescent cells. Cell Tissue Kinet 17: 79-89