Sigma-1 receptors are essential for capsaicin-induced mechanical hypersensitivity: Studies with selective sigma-1 ligands and sigma-1 knockout mice

Pain

Volumn 143, Issue 3, 2009, Pages 252-261

  Entrena, José Manuel ^a,b   Cobos, Enrique José ^a,b   Nieto, Francisco Rafael ^a   Cendán, Cruz Miguel ^a   Gris, Georgia ^c   Del Pozo, Esperanza ^a   Zamanillo, Daniel ^c   Baeyens, José Manuel ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c Laboratorios Dr Esteve SA   (Spain)

Author keywords

Capsaicin; Hyperalgesia; Knockout mice; Mechanical allodynia; Pain behavior; Sigma 1 receptors

Indexed keywords

1 PHENYLCYCLOHEXANECARBOXYLIC ACID 2 MORPHOLINOETHYL ESTER; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; [1 [2 (3,4 DICHLOROPHENYL)ETHYL] 4 METHYLPIPERAZINE DIHYDROCHLORIDE]; BD 1063; CAPSAICIN; MEXILETINE; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 DIMETHYLAMINO N METHYLETHYLAMINE; OPIATE ANTAGONIST; PENTAZOCINE; PREGABALIN; SIGMA 1 OPIATE RECEPTOR; TETRODOTOXIN; UNCLASSIFIED DRUG;

ALLODYNIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINOCICEPTION; ARTICLE; BINDING ASSAY; BINDING SITE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ANTAGONISM; FEMALE; MALE; MOUSE; NEUROPATHIC PAIN; NOCICEPTION; NONHUMAN; PRIORITY JOURNAL; SEX DIFFERENCE;

ANIMALS; ANISOLES; CAPSAICIN; DNA; ETHYLENEDIAMINES; FEMALE; HYPERALGESIA; MICE; MICE, KNOCKOUT; MORPHOLINES; NOCICEPTORS; PAIN MEASUREMENT; PAIN THRESHOLD; PHYSICAL STIMULATION; PIPERAZINES; POLYMERASE CHAIN REACTION; PROPYLAMINES; REACTION TIME; RECEPTORS, SIGMA; SENSORY RECEPTOR CELLS; SENSORY SYSTEM AGENTS; SPINAL CORD;

EID: 67349154763     PISSN: 03043959     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pain.2009.03.011     Document Type: Article

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