Differentiation of σ ligand-activated receptor subtypes that modulate NMDA-evoked [3H]-noradrenaline release in rat hippocampal slices

British Journal of Pharmacology

Volumn 119, Issue 1, 1996, Pages 65-72

  Monnet, François P ^a,b,c   De Costa, Brian R ^d   Bowen, Wayne D ^d  

^a INSERM   (France)

^b ASSISTANCE PUBLIQUE HÔPITAUX DE PARIS   (France)

^c CNRS   (France)

^d NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

(+) pentazocine; 1,3 di(2 tolyl)guanidine (DTG); BD 1008; BD 1063; BD 737; Haloperidol; N methyl D aspartate (NMDA); NE 100; Rat hippocampus; receptors

Indexed keywords

1,3 BIS(2 METHYLPHENYL)GUANIDINE; 2 [4 METHOXY 3 (2 PHENYLETHOXY)PHENYL] N,N DIPROPYLETHYLAMINE; BRAIN RECEPTOR; CYCLOHEXYLAMINE DERIVATIVE; ETHYLAMINE; HALOPERIDOL; LIGAND; N METHYL DEXTRO ASPARTIC ACID; NORADRENALIN; PENTAZOCINE; PIPERAZINE DERIVATIVE; RECEPTOR SUBTYPE; REDUCED HALOPERIDOL; SIGMA OPIATE RECEPTOR; SPIPERONE; TRITIUM;

ANIMAL TISSUE; ARTICLE; BRAIN SLICE; CONTROLLED STUDY; HIPPOCAMPUS; MALE; NONHUMAN; NORADRENALIN RELEASE; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

EID: 0029792328     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1476-5381.1996.tb15678.x     Document Type: Article

References (52)

1. BERGERON, R., DEBONNEL, G. & DE MONTIGNY, C. (1993). Modification of the N-methyl-D-aspartate response by anti-depressant sigma receptor ligands. Eur. J. Pharmacol., 240, 319 - 323.
2. BERGERON, R., DE MONTIGNY, C. & DEBONNEL, G. (1995). Biphasic effects of sigma ligands on the neuronal response to N-methyl-D-aspartate. Naunyn-Schmiedeberg's Arch. Pharmacol., 351, 252 - 260.
3. BOOTH, R.G., WYRICK, S.D., BALDESSARINI, R.J., KULA, N.S., MYERS, A.M. & MAILMAN, R.B. (1993). A new sigma-like receptor recognized by novel phenylaminotetralins: ligand binding and functional studies. Mol. Pharmacol., 44, 1232 - 1239.
4. 1 receptors. Mol. Neuropharmacol., 3, 117 - 126.
5. BOWEN, W.D., MOSES, E.L., TOLENTINO, P.J. & WALKER, J.M. (1990). Metabolites of haloperidol display preferential activity at sigma receptors compared to dopamine D2 receptors. Eur. J. Pharmacol., 177, 111 - 118.
6. BOWEN, W.D., VILNER, B.J., LEE, K.S., HE, X.S., DE COSTA, B.R & WEINBERGER, D.R. (1995). A haloperidol-insensitive binding site for sigma-active aryl ethylene diamine-related compounds: a novel sigma receptor subtype? Soc. Neurosci. Abstr., 21, 219.6, 526.
7. BOWEN, W.D., WALKER, J.M., DE COSTA, B.R., WU, R., TOLENTINO, P.J., FINN, D., ROTHMAN, R.B. & RICE, K.C. (1992). Characterization of the enantiomers of cis-N-methyl-N-[2-(3,4-dichlor-ophenyl) ethyl]-2-(1-pyrrolidinyl)cyclohexyl amine (BD-737 and BD-738): novel compounds with high affinity, selectivity and biological efficacy at sigma receptors. J. Pharmacol. Exp. Ther., 262, 32 - 40.
8. 1 binding sites in guinea pig brain. Eur. J. Pharmacol., 251, R1 - R2.
9. DE COSTA, B.R., HE, X.S., LINDERS, J.T.M., DOMINGUEZ, D., GU, Z.Q., WILLIAMS, W. & BOWEN, W.D. (1993). Synthesis and biological evaluation of conformationally restricted N-[2-(3,4-dichlorophenyl)ethyl-N-methyl-2(1-pyrrolidinyl)ethylamines as sigma receptor ligands 2. Piperazines, bicyclic amines bridged bicyclic amines and miscellaneous compounds. J. Med. Chem., 36, 2311 - 2320.
10. DE COSTA, B.R., RADESCA, L., DI PAOLO, L. & BOWEN, W.D. (1992). Synthesis, characterization and biological evaluation of a novel class of n-(arylethyl)-N-alkyl-2-(1-pyrrolidinyl)ethylamines: structural requirements and binding affinity at the sigma receptor. J. Med. Chem., 35, 38 - 47.
11. DE COSTA, B.R., RICE, K.C., BOWEN, W.D., THURKAUF, A., ROTHMAN, R.B., BAND, L., JACOBSON, A.E., RADESCA, L., CONTRERAS, P.C., GRAY, N.M., DALY, I., IYENGAR, S., FINN, D.T., VAZIRANI, S. & WALKER, J.M. (1990). Synthesis and evaluation of N-substituted cis-N-methyl-2- (1-pyrrolidinyl)cyclohexyla-mines as high affinity sigma-receptor ligands - identification of a new class of highly potent and selective sigma-receptor probes. J. Med. Chem., 33, 3100 - 3110.
12. DE COSTER, M.A., KLETTE, K.L., KNIGHT, E.S. & TORTELLA, F.C. (1995). Sigma receptor-mediated neuroprotection against glutamate toxicity in primary rat neuronal cultures. Brain Res., 671, 45 - 53.
13. FINK, K., GÖTHERT, M., MOLDERINGS, G. & SCHLICKER, E. (1989). N-methyl-D-aspartate (NMDA) receptor-mediated stimulation of noradrenaline release, but not release of other neurotransmitters, in the rat brain cortex - receptor location, characterization and desensitization. Naunyn-Schmiedeberg's Arch. Pharmacol., 339, 514 - 521.
14. FINK, K, BONISCH, H. & GÖTHERT, M. (1990a). Presynaptic NMDA receptors stimulate noradrenaline release in the cerebral cortex. Eur. J. Pharmacol., 185, 115 - 117.
15. FINK, K. & GÖTHERT, M. (1991). Ethanol inhibits the N-methyl-D-aspartate (NMDA)-induced attenuation of the NMDA-evoked noradrenaline release in the rat brain cortex: interaction with NMDA-induced desensitization. Naunyn-Schmiedeberg's Arch. Pharmacol., 344, 167 - 173.
16. FINK, K. & GÖTHERT, M. (1992). Presynaptic site of action underlying the ethanol-induced inhibition of noradrenaline release evoked by stimulation of N-methyl-D-aspartate receptors in rat cerebral cortex. Brain Res., 572, 27 - 32.
17. 2 ions on N-methyl-D-aspartate (NMDA)-induced noradrenaline release in vitro. Naunyn-Schmiedeberg's Arch. Pharmacol., 342, 53 - 60.
18. 3H]dopamine release from rat striatal slices by sigma receptor ligands. J. Pharmacol. Exp. Ther., 271, 212 - 219.
19. GONZALES-ALVEAR, G.M. & WERLING, L.L. (1995). Sigma receptor regulation of noradrenaline release from rat hippocampal slices. Brain Res., 673, 61 - 69.
20. GÖTHERT, M. & FINK, K. (1989). Inhibition of N-methyl-D-aspartate (NMDA)-induced and L-Glutamate-induced Noradrenaline and acetylcholine release in the rat brain by ethanol. Naunyn-Schmiedeberg's Arch. Pharmacol., 340, 516 - 521.
21. HE, X.S., BOWEN, W.D., LEE, K.S., WILLIAMS, W., WEINBERGER, D.R. & DE COSTA, B.R. (1993). Synthesis and binding characteristics of potential SPECT imaging agents for sigma1 and sigma2 binding sites. J. Med. Chem., 36, 566 - 572.
22. HELLEWELL, S.B. & BOWEN, W.D. (1990). A sigma-like binding site in rat pheochromocytoma (PC12) cells: decreased affinity for ( + )benzomorphans and lower molecular weight suggest a different sigma receptor form from that in guinea pig brain. Brain Res., 527, 244 - 253.
23. HOEHN, K. & WHITE, T.D. (1990). N-methyl-D-aspartate, kainate and quisqualate release endogenous adenosine from rat cortical slices. Neuroscience, 39, 441 - 450.
24. JAEN, J.C., CAPRATHE, B.W., PUGSLEY, TA., WISE, L.D. & AKUNNE, H. (1993). Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and σ receptors. J. Med. Chem., 36, 3929 - 3936.
25. JONES, S.M., SNELL, L.D. & JOHNSON, K.M. (1987). Phencyclidine selectively inhibits N-methyl-D-aspartate-induced hippocampal [3H]noradrenaline release. J. Pharmacol. Exp. Ther., 240, 492 - 4970.
26. KLEIN, M., COOPER, T.B. & MUSACCHIO, J.M. (1994). Effects of haloperidol and reduced haloperidol on binding to sigma sites. Eur. J. Pharmacol., 254, 239 - 248.
27. LESAGE, A.S., DE LOORE, K.L., PEETERS, L. & LEYSEN, J.E. (1995). Neuroprotective sigma ligands interfere with the glutamate-activated NOS pathways in hippocampal cell culture. Synapse, 20, 156 - 164.
28. LOCKHART, B.P., SOULARD, P., BENICOURT, C., PRIVAT, A. & JUNIEN, J.L. (1995). Distinct neuroprotective profiles for sigma ligands against N-methyl-D-aspartate (NMDA), and hypoxia-mediated neurotoxicity in neuronal culture toxicity studies. Brain Res., 675, 110 - 120.
29. 2+ concentration by presynaptic glutamate receptors in hippocampus. Br. J. Pharmacol., 113, 1439 - 1447.
30. MARTIN, W.R., EADES, C.G., THOMPSON, J.A., HUPPLER, R.E & GILBERT, P.E. (1976). The effects of morphine and nalorphine like drugs in the non dependent and morphine dependent chronic spinal dog. J. Pharmacol. Exp. Ther., 197, 517 - 532.
31. MARTIN, W.J., ROTH, J.S. & WALKER, J.M. (1992). The effects of sigma compounds on both NMDA- and non-NMDA-mediated neuronal activity in rat hippocampus. Soc. Neurosci. Abstr., 18, 16.6.
32. MATSUMOTO, R.R., BOWEN, W.D., TOM, M.A., VO, V.N., TRUONG, D.D. & DE COSTA, B.R. (1995). Characterization of two novel sigma ligands: antidystonic effects in rats suggest sigma receptor antagonism. Eur. J. Pharmacol., 280, 301 - 310.
33. MAURICE, T., HIRAMATSU, M., ITOH, J., KAMEYAMA, T., HASEGAWA, T. & NABESHIMA, T. (1994a). Behavioral evidence for a modulating role of sigma ligands in memory processes: I. attenuation of dizocilpine(MK-801-induced amnesia. Brain Res., 647, 44 - 56.
34. MAURICE, T., SU, T.P., PARISH, D.W. & PRIVAT, A. (1994b). PRE-084, a σ selective PCP derivative, attenuates MK-801-induced impairment of learning in mice. Pharmacol. Biochem. Behav., 49, 859 - 869.
35. 3H]norepinephrine release in the rat hippocampus: G-protein dependency. Naunyn-Schmiedeberg's Arch. Pharmacol., 346, 32 - 39.
36. 3 dorsal hippocampus. Br. J. Pharmacol., 112, 709 - 715.
37. MONNET, F.P., DEBONNEL, G., JUNIEN, J.L. & DE MONTIGNY, C. (1990). N-Methyl-D-aspartate-induced neuronal activation is selectively modulated by sigma-receptors. Eur. J. Pharmacol., 179, 441 - 445.
38. 3 dorsal hippocampus by sigma ligands. J. Pharmacol. Exp. Ther., 261, 123 - 130.
39. 3H]norepinephrine release evoked by NMDA in the rat hippocampus. Proc. Natl. Acad. Sci. U.S.A., 92, 3774 - 3778.
40. 3 receptor. J. Med. Chem., 37, 4109 - 4117.
41. NOWAK, L., BREGESTOVSKI, P., ASCHER, P., HERBERT, A. & PROCHIANTZ, A. (1984). Magnesium gates glutamate activated channels in mouse central neurones. Nature, 307, 462 - 465.
42. OKUYAMA, S., IMAGAWA, Y., OGAWA, S.I., ARAKI, H., AJIMA, A., TANAKA, M., MURAMATSU, M., NAKAZATO, A., YAMAGUCHI, K., YOSHIDA, M. & OTOMO, S. (1993). NE-100, a novel sigma receptor ligand: in vivo tests. Life Sci., 53, PL285 290.
43. OKUYAMA, S., IMAGAWA, Y., SAKAGAWA, T., NAKAZATO, A., YAMAGUCHI, K., KATOH, M., YAMADA, S., ARAKI, H. & OTOMO, S. (1994). NE-100, a novel sigma receptor ligand: effect on phencyclidine-induced behaviors in rats, dogs and monkeys. Life Sci., 55, PL133 138.
44. PONTECORVO, M.J., KARBON, E.W., GOODE, S., CLISSOLD, D.B., BORODSKY, S.A., PATCH, R.J. & FERKANY, J.W. (1991). Possible cerebroprotective and in vivo NMDA antagonist activities of sigma agents. Brain Res. Bull., 26, 461 465.
45. QUIRION, R., BOWEN, W.D., ITZHAK, Y., JUNIEN, J.L., MUSACCHIO, J.M., ROTHMAN, R.B., SU, T.P., TAM, S.W. & TAYLOR, D.P. (1992). Classification of sigma binding sites: a proposal. Trends Pharmacol. Sci., 13, 85 - 86.
46. ROMAN, F.J., PASCAUD, X., DUFFY, O. & JUNIEN, J.L. (1991). Modulation by neuropeptide Y and peptide YY of NMDA effects in hippocampal slices: Role of sigma receptors. In: NMDA Receptor Related Agents: Biochemistry, Pharmacology and Behavior, ed. Kameyama, T., Nabeshima, T. & Domino, E.F., pp. 211 - 218. Ann Arbor, MI: NPP Books.
47. 3H]noradrenaline release by phencyclidine is dependent on potassium concentration. Neurosci. Lett., 78, 333 337.
48. 3H]norepinephrine from hippocampal slices. Neuropharmacology, 33, 1367 - 1374.
49. SU, T.P. & JUNIEN, J.L. (1994). Sigma receptors in the central nervous system and the periphery. In Sigma Receptors, ed. Itzhak, Y. pp. 21 - 44. London: Academic Press.
50. 3H]haloperidol binding in guinea pig brain membranes. Proc. Natl. Acad. Sci. U.S.A., 81, 5618 - 5621.
51. WALKER, J.M., BOWEN, W.D., WALKER, F.O., MATSUMOTO, R.R., DE COSTA, B.R. & RICE, K.C. (1990). Sigma receptors: biology and function. Pharmacol. Rev., 42, 355 402.
52. 3H] toly)guanidine: a selective ligand that labels σ-type receptors for psychotomimetic opiates and antipsyehotic drugs. Proc. Natl. Acad. Sci. U.S.A., 83, 8784 8788.