N-alkyl substituted analogs of the σ receptor ligand BD1008 and traditional σ receptor ligands affect cocaine-induced convulsions and lethality in mice

European Journal of Pharmacology

Volumn 411, Issue 3, 2001, Pages 261-273

  Matsumoto, Rae R ^a   McCracken, Kari A ^a   Pouw, Buddy ^a   Miller, Jeffrey ^a   Bowen, Wayne D ^b   Williams, Wanda ^b   De Costa, Brian R ^b  

^a UNIVERSITY OF OKLAHOMA HEALTH SCIENCES CENTER   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

Author keywords

Receptor; Cocaine; Convulsion; Dystonia; Lethality; Red nucleus; Toxicity

Indexed keywords

1,2 DITOLYLGUANIDINE; 4 AMINOBUTYRIC ACID A RECEPTOR; ALPHA (4 FLUOROPHENYL) 4 (5 FLUORO 2 PYRIMIDINYL) 1 PIPERAZINEBUTANOL; BD 1052; BD 1060; BD 1067; COCAINE; DOPAMINE 2 RECEPTOR; GUANIDINE DERIVATIVE; HALOPERIDOL; N [2 (3,4 DICHLOROPHENYL)ETHYL] 2 (1 PYRROLIDINYL)ETHYLAMINE; N [2 (3,4 DICHLOROPHENYL)ETHYL] N ALLYL 2 (1 PYRROLIDINYL)ETHYLAMINE; N [2 (3,4 DICHLOROPHENYL)ETHYL] N ETHYL 2 (1 PYRROLIDINYL)ETHYLAMINE; N [2 (3,4 DICHLOROPHENYL)ETHYL] N METHYL 2 (1 PYRROLIDINYL)ETHYLAMINE; NALOXONE; OPIATE ANTAGONIST; PENTAZOCINE; REDUCED HALOPERIDOL; RIMCAZOLE; SEROTONIN 2 RECEPTOR; SIGMA 1 OPIATE RECEPTOR; SIGMA OPIATE RECEPTOR; SULPIRIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; COCAINE DEPENDENCE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CONVULSION; DRUG ANTAGONISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG STRUCTURE; GUINEA PIG; MALE; MOUSE; NEUROPROTECTION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; RAT; RECEPTOR AFFINITY;

ALKYLATION; ANIMALS; BEHAVIOR, ANIMAL; COCAINE; DOPAMINE UPTAKE INHIBITORS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; GUINEA PIGS; INJECTIONS, INTRAVENTRICULAR; LIGANDS; MALE; MICE; MICROINJECTIONS; PYRROLIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; RED NUCLEUS; SEIZURES;

EID: 0035847141     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0014-2999(00)00917-1     Document Type: Article

References (64)

1. Status update on the search for a "dopamine-sparing cocaine antagonist"
2. Clinical pharmacology and toxicology of cocaine
3. Interaction of sigma receptors with signal transduction pathways and effects of second messengers
4. Evidence for a multi-site model of the rat brain σ receptor
5. Metabolites of haloperidol display preferential activity at σ receptors compared to dopamine D-2 receptors
6. 3H]-(+)-Pentazocine: A potent and highly selective benzomorphan-based probe for sigma-1 receptors
7. Prevention of cocaine-induced convulsions and lethality in mice: Effectiveness of targeting different sites on the NMDA receptor complex
8. Intrasynaptosomal free calcium levels in rat forebrain synaptosomes: Modulation by sigma (σ) receptor ligands
9. Sigma receptors inhibit contractions of the guinea pig ileum longitudinal muscle/myenteric plexus preparation elicited by both electrical stimulation and exogenous serotonin
10. Focal stimulation of specific pathways in the rat hippocampus causes a reduction in radioligand binding to the haloperidol-sensitive sigma receptor
11. Structure-activity relationships and evolution of sigma receptor ligands (1976-present)
12. Synthesis, characterization, and biological evaluation of a novel class of N-(arylethyl-N-alkyl-2-(1-pyrrolidinyl)ethylamines: Structural requirements and binding affinity at the σ receptor
13. Model for estimating dopmaine transporter occupancy and subsequent increases in synaptic dopamine using positron emission tomography and carbon-11-labeled cocaine
14. 1 Receptors in rat striatum regulate NMDA-stimulated [3H]dopamine release via a presynaptic mechanism
15. 1-binding site
16. 2+ concentration
17. Rat liver and kidney contain high densities of sigma-1 and sigma-2 receptors. Characterization by ligand binding and photoaffinity labeling
18. 1) receptor signaling in rodent brain
19. Medications development at the National Institute on Drug Abuse: Focus on cocaine
20. 35S]GTPγS binding to intact SK-N-SH neuroblastoma cells but not SK-N-SH cell membrane preparations
21. 1 receptor
22. 2 Site-mediated inhibition of electrically-evoked guinea pig ileum longitudinal muscle/myenteric plexus contractions
23. 1 receptor regulates MK-801-induced memory deficits in mice
24. Effects of σ ligands on rat cerebellar Purkinje neuron firing: An iontophoretic study
25. 1 receptors reduce the convulsive and locomotor stimulatory effects of cocaine in mice
26. Drug specificity of pharmacological dystonia
27. Down-regulation of sigma receptors by chronic haloperidol
28. Characterization of two novel σ receptor ligands: Antidystonic effects in rats suggest σ receptor antagonism
29. 1 sites
30. Novel NMDA/glycine site antagonists attenuate cocaine-induced behavioral toxicity
31. Novel sigma ligands attenuate cocaine-induced toxicity and locomotor stimulation
32. Relationship between modulation of the cerebellorubrospinal system in the in vitro turtle brain and changes in motor behavior in rats: Effects of novel sigma ligands
33. 1 receptor by in vivo antisense oligodeoxynucleotide strategy in the mouse confirmed its implication in memory processes
34. Novel σ receptor ligands attenuate the locomotor stimulatory effects of cocaine
35. Two novel σ receptor ligands, BD1047 and LR172, attenuate cocaine-induced toxicity and locomotor activity
36. Selective σ ligands block stimulant effects of cocaine
37. 3H]-noradrenaline release in rat hippocampal slices
38. Intracellular sigma1 receptor modulates phospholipase C and protein kinase C activities in the brainstem
39. Ionotropic action of sigma receptor ligands in isolated cardiac myocytes from adult rats
40. BMY-14802 reversed the sigma receptor agonist-induced neck dystonia in rats
41. GABA receptor function and epilepsy
42. 1 receptor
43. Recent evidence for endogenous substance(s) for sigma receptors
44. Exon-intron structure, analysis of promoter region, and chromosomal localization of the human type 1 sigma receptor gene
45. A proposal for the classification of sigma binding sites
46. Effects of sigma ligands on mouse cerebellar cyclic guanosine monophosphate (cGMP) levels in vivo: Further evidence for a functional modulation of N-methyl-D-aspartate (NMDA) receptor complex-mediated events by sigma ligands
47. Cocaine-induced convulsions: Pharmacological antagonism at serotonergic, muscarinic and sigma receptors
48. Cocaine toxicity: Concurrent influence of dopaminergic, muscarinic and sigma receptors in mediating cocaine-induced lethality
49. Cloning and structural analysis of the cDNA and the gene encoding the murine type 1 sigma receptor
50. Cloning and functional characterization of a sigma receptor from rat brain
51. Cocaine binding at σ receptors
52. Brain concentrations of cocaine and benzoylecgonine in fatal cases
53. Endogenous ligands for sigma opioid receptors in the brain ("sigmaphin"): Evidence from binding assays
54. 3H]haloperidol binding in guinea pig brain membranes
55. Microinjection of sigma ligands into cranial nerve nuclei produces vacuous chewing in rats
56. Modulation of cellular calcium by sigma-2 receptors: Release from intracellular stores in human SK-N-SH neuroblastoma cells
57. Cytotoxic effects of sigma ligands: Sigma receptor-mediated alterations in cellular morphology and viability
58. Evidence for the role of haloperidol-sensitive σ-"opiate" receptors in the motor effects of antipsychotic drugs
59. Sigma receptors: Biology and function
60. Inhibition of cholinergic analgesia by (+)-opiates
61. 2 receptors in motor function
62. Effects of the selective sigma receptor ligand, 6-[6-(4-hydroxypiperidinyl)hexyloxy]-3-methyflavone (NPC 16377), on behavioral toxic effects of cocaine
63. Electrophysiological and binding studies on intact NCB-20 cells suggest presence of low affinity sigma receptors