Rimcazole analogs attenuate the convulsive effects of cocaine: Correlation with binding to sigma receptors rather than dopamine transporters

Neuropharmacology

Volumn 41, Issue 7, 2001, Pages 878-886

  Matsumoto, Rae R ^a   Hewett, Kizzy L ^a   Pouw, Buddy ^a   Bowen, Wayne D ^b   Husbands, Stephen M ^c   Cao, Jian Jing ^c   Newman, Amy Hauck ^c  

^a UNIVERSITY OF OKLAHOMA   (United States)

^b NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

Author keywords

receptor; Cocaine; Dopamine transporter; LR176; Rimcazole

Indexed keywords

9 [3 [3,5 DIMETHYL 4 (2 ISOTHIOCYANATOETHYL) 1 PIPERAZINYL]PROPYL]CARBAZOLE; [3 (3,5 DIMETHYL 1 PIPERAZINYL)PROPYL]DIPHENYLAMINE; [3 [3,5 DIMETHYL 4 (3 PHENYLPROPYL) 1 PIPERAZINYL]PROPYL]DIPHENYLAMINE; ANTICONVULSIVE AGENT; COCAINE; DOPAMINE TRANSPORTER; LR 176; N [2 (3,4 DICHLOROPHENYL)ETHYL] N METHYL 1 METHYL 2 (1 PYRROLIDINYL)ETHYLAMINE; RECEPTOR SUBTYPE; RIMCAZOLE; SH 1 57; SH 2 21; SH 3 24; SIGMA OPIATE RECEPTOR; SIGMA RECEPTOR LIGAND; UNCLASSIFIED DRUG;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANTICONVULSANT ACTIVITY; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; CONVULSION; DOSE RESPONSE; DOSE TIME EFFECT RELATION; DRUG MECHANISM; DRUG RECEPTOR BINDING; LOCOMOTION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SENSITIZATION; TOXICITY;

ANIMALS; ANTICONVULSANTS; BINDING SITES; CARBAZOLES; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; DOSE-RESPONSE RELATIONSHIP, DRUG; ETHYLAMINES; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; MICE; NERVE TISSUE PROTEINS; PYRROLIDINES; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, SIGMA; SEIZURES;

EID: 0034778556     PISSN: 00283908     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0028-3908(01)00116-2     Document Type: Article

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