Specific modulation of sigma binding sites by the anxiolytic drug opipramol

Journal of Neural Transmission

Volumn 110, Issue 10, 2003, Pages 1169-1179

  Holoubek, G ^a   Muller W E ^a,b  

^a GOETHE UNIVERSITY   (Germany)

^b 1 OG ^*  (Germany)

Author keywords

Antidepressants; Anxiolytics; Forced swimming test; Opipramol; Rats; Sigma binding sites; Subchronic treatment

Indexed keywords

ANTIDEPRESSANT AGENT; ANXIOLYTIC AGENT; CITALOPRAM; IMIPRAMINE; OPIPRAMOL; REBOXETINE; SIGMA OPIATE RECEPTOR;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DOWN REGULATION; DRUG ACTIVITY; DRUG POTENCY; MALE; NEUROCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; RAT; TRANQUILIZING ACTIVITY;

ADRENERGIC UPTAKE INHIBITORS; ANIMALS; ANTI-ANXIETY AGENTS; ANTIDEPRESSIVE AGENTS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BRAIN; CELL MEMBRANE; CITALOPRAM; IMIPRAMINE; MALE; MORPHOLINES; OPIPRAMOL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, ADRENERGIC, BETA; RECEPTORS, SEROTONIN, 5-HT2; RECEPTORS, SIGMA; SWIMMING;

EID: 0142091252     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00702-003-0019-5     Document Type: Article

References (31)

1. Akunne HC, Zoski KT, Whetzel SZ, Cordon JJ, Brandon RM, Roman F, Pugsley TA (2001) Neuropharmacological profile of a selective sigma ligand, igmesine: a potential antidepressant. Neuropharmacol 41: 138-149
2. Arfwidsson L, Arn L, Beskow J, Ottosson JO, Persson G (1971) A comparison between diazepam, dixyrazine, opipramol and placebo in anxiety states. Acta Psychiatr Scand [Suppl]: 19-32
3. Dostert P, Benedetti MS, Poggesi I (1997) Review of the pharmacokinetics and metabolism of reboxetine, a selective noradrenaline reuptake inhibitor. Eur Neuropsychopharmacol 7: S23-S35
4. Ericson H, Ross SB (1992) Subchronic treatment of rats with remoxipride fails to modify sigma binding sites in the brain. Eur J Pharmacol 226: 157-161
5. Faherty CJ, Harkin AJ, Leonard BE (1998) The functional sensitisation of sigma receptors following chronic selective serotonin reuptake inhibitor treatment. Eur J Pharmacol 346: 15-21
6. Ferris CD, Hirsch DJ, Brooks BP, Snowman AM, Snyder SH (1991) [3H]opipramol labels a novel binding site and sigma receptors in rat brain membranes. Mol Pharmacol 39: 199-204
7. Fredricson OK (1982) Kinetics of citalopram in test animals; drug exposure in safety studies. Prog Neuropsychopharmacol Biol Psychiatry 6: 297-309
8. Grosser HH, Ryan E (1965) Drug treatment of anxiety: a controlled study of opipramol and chlordiazepoxide. Br J Psychiatry 111: 134-141
9. Heading C (2001) Siramesine H Lundbeck. Curr Opin Invest Drugs 2: 266-270
10. Inoue A, Sugita S, Shoji H, Ichimoto H, Hide I, Nakata Y (2000) Repeated haloperidol treatment decreases sigma(1) receptor binding but does not affect its mRNA levels in the guinea pig or rat brain. Eur J Pharmacol 401: 307-316
11. Itzhak Y, Stein I (1991) Regulation of sigma receptors and responsiveness to guanine nucleotides following repeated exposure of rats to haloperidol: further evidence for multiple sigma binding sites. Brain Res 566: 166-172
12. Kizu A, Yoshida Y, Miyagishi T (1991) Rat cortical sigma receptors differentially regulated by pentazocine and haloperidol. J Neural Transm [Gen Sect] 83: 149-153
13. Klein M, Cooper TB, Musacchio JM (1994) Effects of haloperidol and reduced haloperidol on binding to sigma sites. Eur J Pharmacol 254: 239-248
14. Leonard BE (1997) The potential contribution of sigma receptors to antidepressant actions. In: Skolnick P (ed) A, Antidepressants - new pharmacological strategies. Humana Press, Totowa, pp 159-172
15. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ (1951) Protein measurement with the Folin phenol reagent. J Biol Chem 193: 265-275
16. 1 Receptor subtype is involved in the relief of behavioral despair in the mouse forced swimming test. Eur J Pharmacol 312: 267-271
17. McCann DJ, Weissman AD, Su TP (1994) Sigma-1 and sigma-2 sites in rat brain: comparison of regional, ontogenetic, and subcellular patterns. Synapse 17: 182-189
18. Möller HJ, Volz HP, Reimann IW, Stoll KD (2001) Opipramol for the treatment of generalized anxiety disorder: a placebo-controlled trial including an alprazolam-treated group. J Clin Psychopharmacol 21: 59-65
19. Müller WE, Siebert B (1998) Opipramol im Vergleich zu anderen Therapeutika - Neue pharmakologische Daten. Fortschr Neurol Psychiatr 66: S9-S16
20. Müller WE, Siebert B (1999) Effects of opipramol, a sigma ligand with antidepressant and anxiolytic properties. Pharmacopsychiatry 32: 198
21. Narita N, Hashimoto K, Tomitaka S, Minabe Y (1996) Interactions of selective serotonin reuptake inhibitors with subtypes of σ receptors in rat brain. Eur J Pharmacol 307: 117-119
22. Rajotte P, Bordeleau JM, Tetreault L, Doucet P, Rajotte E (1966) A double-blind comparative study of opipramol and amitriptyline in neurotic and endogenous depressions. Can Psychiatr Assoc J 11: S68
23. 2 dopamine receptors and σ/haloperidol binding sites in rat brain. Mol Neuropharmacol 1: 17-22
24. 2-ligand Lu 28-179 has potent anxiolytic-like effects in rodents. J Pharmacol Exp Ther 238: 1323-1332
25. Shirayama Y, Nishikawa T, Umino A, Takahashi K (1993) p-chlorophenylalanine-reversible reduction of sigma binding sites by chronic imipramine treatment in rat brain. Eur J Pharmacol 237: 117-126
26. Shirayama Y, Takahashi K, Nishikawa T (1997) Uncompetitive inhibition of [3H]1,3-di-otolyl-guanidine-defined sigma binding sites by desipramine, propranolol and alprenolol in rat brain. Eur J Pharmacol 331: 319-323
27. Takebayashi M, Hayashi T, Su TP (2002) Nerve growth factor-induced neurite sprouting in PC12 cells involves σ-1 receptors: implications for antidepressants. J Phamacol Exp Ther 303: 1227-1237
28. Theobald W, Büch O, Morpurgo C, Stenger EG, Kunz HA, Wilhelm G (1964) Vergleichende pharmakologische Untersuchungen mit Tofranil, Pertofran und Insidon. Arch Int Pharmacodyn Ther 148: 560-596
29. Urani A, Roman FJ, Phan VL, Su TP, Maurice T (2001) The antidepressant-like effect induced by sigma(1)-receptor agonists and neuroactive steroids in mice submitted to the forced swimming test. J Pharmacol Exp Ther 298: 1269-1279
30. Weissman AD, De Souza EB (1991) Chronic treatment of rats with the specific sigma ligand D-pentazocine fails to modulate dopamine D2 and sigma binding in brain. Eur J Pharmacol 195: 163-165
31. 1 receptor mRNA in rat brain by a putative atypical antipsychotic and sigma receptor ligand. Neurosci Lett 282: 169-172