메뉴 건너뛰기




Volumn 30, Issue 6, 2009, Pages 864-874

Dystrophic neurites in TgCRND8 and Tg2576 mice mimic human pathological brain aging

Author keywords

Alpha internexin; Dystrophic neurites; Hyperphosphorylated tau; Neurofilament; Pathological aging; Preclinical Alzheimer's disease; Tg2576; TgCRND8

Indexed keywords

ALPHA INTERNEXIN; AMYLOID BETA PROTEIN; TAU PROTEIN;

EID: 65249085666     PISSN: 01974580     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neurobiolaging.2007.09.003     Document Type: Article
Times cited : (41)

References (42)
  • 1
    • 0036946621 scopus 로고    scopus 로고
    • Morphologically distinct plaque types differentially affect dendritic structure and organization in the early and late stages of Alzheimer's disease
    • Adlard P.A., and Vickers J.C. Morphologically distinct plaque types differentially affect dendritic structure and organization in the early and late stages of Alzheimer's disease. Acta Neuropathol. 103 (2002) 377-383
    • (2002) Acta Neuropathol. , vol.103 , pp. 377-383
    • Adlard, P.A.1    Vickers, J.C.2
  • 2
    • 0030003487 scopus 로고    scopus 로고
    • Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein
    • Akiyama H., Schwab C., Kondo H., Mori H., Kametani F., Ikeda K., and McGeer P.L. Granules in glial cells of patients with Alzheimer's disease are immunopositive for C-terminal sequences of β-amyloid protein. Neurosci. Lett. 206 (1996) 169-172
    • (1996) Neurosci. Lett. , vol.206 , pp. 169-172
    • Akiyama, H.1    Schwab, C.2    Kondo, H.3    Mori, H.4    Kametani, F.5    Ikeda, K.6    McGeer, P.L.7
  • 3
    • 0033557386 scopus 로고    scopus 로고
    • Occurrence of the diffuse amyloid β-protein (Aβ) deposits with numerous Aβ-containing glial cells in the cerebral cortex of patients with Alzheimer's disease
    • Akiyama H., Hiroshi M., Saido T., Kondo H., Ikeda K., and McGeer P.L. Occurrence of the diffuse amyloid β-protein (Aβ) deposits with numerous Aβ-containing glial cells in the cerebral cortex of patients with Alzheimer's disease. Glia 25 (1999) 324-331
    • (1999) Glia , vol.25 , pp. 324-331
    • Akiyama, H.1    Hiroshi, M.2    Saido, T.3    Kondo, H.4    Ikeda, K.5    McGeer, P.L.6
  • 4
    • 2442483898 scopus 로고    scopus 로고
    • Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease
    • Bergamaschini L., Rossi E., Storini C., Pizzimenti S., Distaso M., Perego C., Luigi A., Vergani C., and De Simoni M.G. Peripheral treatment with enoxaparin, a low molecular weight heparin, reduces plaques and beta-amyloid accumulation in a mouse model of Alzheimer's disease. J. Neurosci. 24 (2004) 4181-4186
    • (2004) J. Neurosci. , vol.24 , pp. 4181-4186
    • Bergamaschini, L.1    Rossi, E.2    Storini, C.3    Pizzimenti, S.4    Distaso, M.5    Perego, C.6    Luigi, A.7    Vergani, C.8    De Simoni, M.G.9
  • 6
    • 34248399631 scopus 로고    scopus 로고
    • Combined biomarkers for early Alzheimer's disease diagnosis
    • Borroni B., Premi E., Di Luca M., and Padovani A. Combined biomarkers for early Alzheimer's disease diagnosis. Curr. Med. Chem. 14 (2007) 1171-1178
    • (2007) Curr. Med. Chem. , vol.14 , pp. 1171-1178
    • Borroni, B.1    Premi, E.2    Di Luca, M.3    Padovani, A.4
  • 7
    • 1642578930 scopus 로고    scopus 로고
    • Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1
    • Boutajangout A., Authelet M., Blanchard V., Touchet N., Tremp G., Pradier L., and Brion J.-P. Characterisation of cytoskeletal abnormalities in mice transgenic for wild-type human tau and familial Alzheimer's disease mutants of APP and presenilin-1. Neurobiol. Dis. 15 (2004) 47-60
    • (2004) Neurobiol. Dis. , vol.15 , pp. 47-60
    • Boutajangout, A.1    Authelet, M.2    Blanchard, V.3    Touchet, N.4    Tremp, G.5    Pradier, L.6    Brion, J.-P.7
  • 8
    • 0025863618 scopus 로고
    • Neuropathological staging of Alzheimer-related changes
    • Braak H., and Braak E. Neuropathological staging of Alzheimer-related changes. Acta Neuropathol. 82 (1991) 239-259
    • (1991) Acta Neuropathol. , vol.82 , pp. 239-259
    • Braak, H.1    Braak, E.2
  • 9
    • 4344565054 scopus 로고    scopus 로고
    • Morphological characterization of thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance
    • Bussière T., Bard F., Barbour B., Grajeda H., Guido T., Khan K., Schenk D., Games D., Seubert P., and Buttini M. Morphological characterization of thioflavin-S-positive amyloid plaques in transgenic Alzheimer mice and effect of passive Abeta immunotherapy on their clearance. Am. J. Pathol. 165 (2004) 987-995
    • (2004) Am. J. Pathol. , vol.165 , pp. 987-995
    • Bussière, T.1    Bard, F.2    Barbour, B.3    Grajeda, H.4    Guido, T.5    Khan, K.6    Schenk, D.7    Games, D.8    Seubert, P.9    Buttini, M.10
  • 11
    • 0033990169 scopus 로고    scopus 로고
    • Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms
    • Czech C., Tremp G., and Pradier L. Presenilins and Alzheimer's disease: biological functions and pathogenic mechanisms. Prog. Neurobiol. 60 (2000) 363-384
    • (2000) Prog. Neurobiol. , vol.60 , pp. 363-384
    • Czech, C.1    Tremp, G.2    Pradier, L.3
  • 12
    • 2342653632 scopus 로고    scopus 로고
    • Alzheimer pathology disorganized cortico-cortical circuitry: direct evidence from a transgenic animal model
    • Delatour B., Blanchard V., Pradier L., and Duyckaerts C. Alzheimer pathology disorganized cortico-cortical circuitry: direct evidence from a transgenic animal model. Neurobiol. Dis. 16 (2004) 41-47
    • (2004) Neurobiol. Dis. , vol.16 , pp. 41-47
    • Delatour, B.1    Blanchard, V.2    Pradier, L.3    Duyckaerts, C.4
  • 14
    • 0033066239 scopus 로고    scopus 로고
    • Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease
    • Dickson T.C., King C.E., McCormack G.H., and Vickers J.C. Neurochemical diversity of dystrophic neurites in the early and late stages of Alzheimer's disease. Exp. Neurol. 156 (1999) 100-110
    • (1999) Exp. Neurol. , vol.156 , pp. 100-110
    • Dickson, T.C.1    King, C.E.2    McCormack, G.H.3    Vickers, J.C.4
  • 15
    • 0033740733 scopus 로고    scopus 로고
    • Sequence of cellular changes following localized axotomy to cortical neurons in glia-free cultures
    • Dickson T.C., Adlard P.A., and Vickers J.C. Sequence of cellular changes following localized axotomy to cortical neurons in glia-free cultures. J. Neurotrauma 17 (2000) 1095-1103
    • (2000) J. Neurotrauma , vol.17 , pp. 1095-1103
    • Dickson, T.C.1    Adlard, P.A.2    Vickers, J.C.3
  • 16
    • 15944382705 scopus 로고    scopus 로고
    • Novel Alzheimer's disease pathology reflects variable neuronal vulnerability and demonstrates the role of b-amyloid plaques in neurodegeneration
    • Dickson T.C., Chuckowree J.A., Chuah M.I., West A.K., and Vickers J.C. Novel Alzheimer's disease pathology reflects variable neuronal vulnerability and demonstrates the role of b-amyloid plaques in neurodegeneration. Neurobiol. Dis. 18 (2005) 286-295
    • (2005) Neurobiol. Dis. , vol.18 , pp. 286-295
    • Dickson, T.C.1    Chuckowree, J.A.2    Chuah, M.I.3    West, A.K.4    Vickers, J.C.5
  • 19
    • 1042265187 scopus 로고    scopus 로고
    • Neuropathology and pathogenesis of encephalitis following amyloid-β immunization in Alzheimer's disease
    • Ferrer I., Rovira M.B., Sanchez Guerra M.L., Rey M.J., and Costa-Jussa F. Neuropathology and pathogenesis of encephalitis following amyloid-β immunization in Alzheimer's disease. Brain Pathol. 14 (2004) 11-20
    • (2004) Brain Pathol. , vol.14 , pp. 11-20
    • Ferrer, I.1    Rovira, M.B.2    Sanchez Guerra, M.L.3    Rey, M.J.4    Costa-Jussa, F.5
  • 20
    • 0141596079 scopus 로고    scopus 로고
    • Transgenic mouse models of Alzheimer's disease: phenotype and application
    • Higgins G.A., and Jacobsen H. Transgenic mouse models of Alzheimer's disease: phenotype and application. Behav. Pharmacol. 14 (2003) 419-428
    • (2003) Behav. Pharmacol. , vol.14 , pp. 419-428
    • Higgins, G.A.1    Jacobsen, H.2
  • 22
    • 0031593784 scopus 로고    scopus 로고
    • Aβ associated neuropil changes: correlation with neuronal loss and dementia
    • Knowles R.B., Gomez-Isla T., and Hyman B.T. Aβ associated neuropil changes: correlation with neuronal loss and dementia. J. Neuropathol. Exp. Neurol. 57 (1998) 1122-1130
    • (1998) J. Neuropathol. Exp. Neurol. , vol.57 , pp. 1122-1130
    • Knowles, R.B.1    Gomez-Isla, T.2    Hyman, B.T.3
  • 23
    • 0042334542 scopus 로고    scopus 로고
    • Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes
    • Kurt M.A., Davies D.C., Kidd M., Duff K., and Howlett D.R. Hyperphosphorylated tau and paired helical filament-like structures in the brains of mice carrying mutant amyloid precursor protein and mutant presenilin-1 transgenes. Neurobiol. Dis. 14 (2003) 89-97
    • (2003) Neurobiol. Dis. , vol.14 , pp. 89-97
    • Kurt, M.A.1    Davies, D.C.2    Kidd, M.3    Duff, K.4    Howlett, D.R.5
  • 25
    • 0027745766 scopus 로고
    • An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease
    • Masliah E., Mallory M., Hansen L., Alford M., DeTeresa R., and Terry R. An antibody against phosphorylated neurofilaments identifies a subset of damaged association axons in Alzheimer's disease. Am. J. Pathol. 142 (1993) 871-881
    • (1993) Am. J. Pathol. , vol.142 , pp. 871-881
    • Masliah, E.1    Mallory, M.2    Hansen, L.3    Alford, M.4    DeTeresa, R.5    Terry, R.6
  • 26
    • 0035057591 scopus 로고    scopus 로고
    • Neurofibrillary pathology in transgenic mice overexpressing V717F β-amyloid precursor protein
    • Masliah E., Sisk A., Mallory M., and Games D. Neurofibrillary pathology in transgenic mice overexpressing V717F β-amyloid precursor protein. J. Neuropathol. Exp. Neurol. 60 (2001) 357-368
    • (2001) J. Neuropathol. Exp. Neurol. , vol.60 , pp. 357-368
    • Masliah, E.1    Sisk, A.2    Mallory, M.3    Games, D.4
  • 27
    • 0032890340 scopus 로고    scopus 로고
    • Microtubule-associated protein-2 in the hypothalamo-neurohypophysial system: low-molecular-weight microtubule-associated protein-2 in pituitary astrocytes
    • Matsunaga W., Miyata S., Hashimoto Y., Lin S.H., Nakashima T., Kiyohara T., and Matsumoto T. Microtubule-associated protein-2 in the hypothalamo-neurohypophysial system: low-molecular-weight microtubule-associated protein-2 in pituitary astrocytes. Neuroscience 88 (1999) 1289-1297
    • (1999) Neuroscience , vol.88 , pp. 1289-1297
    • Matsunaga, W.1    Miyata, S.2    Hashimoto, Y.3    Lin, S.H.4    Nakashima, T.5    Kiyohara, T.6    Matsumoto, T.7
  • 29
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease
    • Mirra S.S., Heyman A., McKeel D., Sumi S.M., Brownlee L.M., Vogel F.S., van Belle G., and Berg L. The consortium to establish a registry for Alzheimer's disease (CERAD). Part II. Standardization of the neuropathological assessment of Alzheimer's disease. Neurology 41 (1991) 479-486
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Brownlee, L.M.5    Vogel, F.S.6    van Belle, G.7    Berg, L.8
  • 30
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report
    • Nicoll J.A.R., Wilkinson D., Holmes C., Steart P., Markham H., and Weller R.O. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report. Nat. Med. 9 (2003) 448-452
    • (2003) Nat. Med. , vol.9 , pp. 448-452
    • Nicoll, J.A.R.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6
  • 31
    • 7744243271 scopus 로고    scopus 로고
    • Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease
    • Noda-Saita K., Terai K., Iwai A., Tsukamoto M., Shitaka Y., Kawabata S., Okada M., and Yamaguchi T. Exclusive association and simultaneous appearance of congophilic plaques and AT8-positive dystrophic neurites in Tg2576 mice suggest a mechanism of senile plaque formation and progression of neuritic dystrophy in Alzheimer's disease. Acta Neuropathol. 108 (2004) 435-442
    • (2004) Acta Neuropathol. , vol.108 , pp. 435-442
    • Noda-Saita, K.1    Terai, K.2    Iwai, A.3    Tsukamoto, M.4    Shitaka, Y.5    Kawabata, S.6    Okada, M.7    Yamaguchi, T.8
  • 32
    • 4043167747 scopus 로고    scopus 로고
    • Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome
    • Oddo S., Billings L., Kesslak J.P., Cribbs D.H., and LaFerla F.M. Aβ immunotherapy leads to clearance of early, but not late, hyperphosphorylated tau aggregates via the proteasome. Neuron 43 (2004) 321-332
    • (2004) Neuron , vol.43 , pp. 321-332
    • Oddo, S.1    Billings, L.2    Kesslak, J.P.3    Cribbs, D.H.4    LaFerla, F.M.5
  • 34
    • 34248525053 scopus 로고    scopus 로고
    • Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein
    • Porzig R., Singer D., and Hoffmann R. Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein. Biochem. Biophys. Res. Commun. 358 (2007) 644-649
    • (2007) Biochem. Biophys. Res. Commun. , vol.358 , pp. 644-649
    • Porzig, R.1    Singer, D.2    Hoffmann, R.3
  • 35
    • 0032989712 scopus 로고    scopus 로고
    • Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease
    • Price J.L., and Morris J.C. Tangles and plaques in nondemented aging and "preclinical" Alzheimer's disease. Ann. Neurol. 45 (1999) 358-368
    • (1999) Ann. Neurol. , vol.45 , pp. 358-368
    • Price, J.L.1    Morris, J.C.2
  • 36
    • 0028301184 scopus 로고
    • Cathespin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein
    • Savage M.J., Iqbal M., Loh T., Trusko S.P., Scott R., and Siman R. Cathespin G: localization in human cerebral cortex and generation of amyloidogenic fragments from the beta-amyloid precursor protein. Neuroscience 60 (1994) 607-619
    • (1994) Neuroscience , vol.60 , pp. 607-619
    • Savage, M.J.1    Iqbal, M.2    Loh, T.3    Trusko, S.P.4    Scott, R.5    Siman, R.6
  • 38
    • 2942611429 scopus 로고    scopus 로고
    • Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease
    • Schwab C., Hosokawa M., and McGeer P.L. Transgenic mice overexpressing amyloid beta protein are an incomplete model of Alzheimer disease. Exp. Neurol. 188 (2004) 52-64
    • (2004) Exp. Neurol. , vol.188 , pp. 52-64
    • Schwab, C.1    Hosokawa, M.2    McGeer, P.L.3
  • 39
    • 0030580439 scopus 로고    scopus 로고
    • Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments
    • Su J.H., Cummings B.J., and Cotman C.W. Plaque biogenesis in brain aging and Alzheimer's disease. I. Progressive changes in phosphorylation states of paired helical filaments and neurofilaments. Brain Res. 739 (1996) 79-87
    • (1996) Brain Res. , vol.739 , pp. 79-87
    • Su, J.H.1    Cummings, B.J.2    Cotman, C.W.3
  • 40
    • 0031716440 scopus 로고    scopus 로고
    • Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites
    • Su J.H., Cummings B.J., and Cotman C.W. Plaque biogenesis in brain aging and Alzheimer's disease. II. Progressive transformation and developmental sequence of dystrophic neurites. Acta Neuropathol. 96 (1998) 463-471
    • (1998) Acta Neuropathol. , vol.96 , pp. 463-471
    • Su, J.H.1    Cummings, B.J.2    Cotman, C.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.