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Volumn 7, Issue , 2012, Pages 35-60

The life and death of epithelia during inflammation: Lessons learned from the gut

Author keywords

Apoptosis; Differentiation; Homeostasis; Inflammatory bowel diseases; Proliferation

Indexed keywords

BETA CATENIN; BETA INTERFERON; BONE MORPHOGENETIC PROTEIN; GAMMA INTERFERON; GLYCOGEN SYNTHASE KINASE 3; I KAPPA B KINASE BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERCELLULAR ADHESION MOLECULE 1 ANTIBODY; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 17; INTERLEUKIN 22; INTERLEUKIN 6; JANUS KINASE; LEUCINE RICH REPEAT CONTAINING G PROTEIN COUPLED RECEPTOR 5; NOGGIN; NOTCH RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PLATELET DERIVED GROWTH FACTOR; PROTEIN P42; PROTEIN P44; PROTEIN SERINE THREONINE KINASE; SONIC HEDGEHOG PROTEIN; STAT3 PROTEIN; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOPHYSIN; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; WNT PROTEIN;

EID: 84856940669     PISSN: 15534006     EISSN: 15534014     Source Type: Book Series    
DOI: 10.1146/annurev-pathol-011811-120905     Document Type: Review
Times cited : (118)

References (156)
  • 2
    • 39749092525 scopus 로고    scopus 로고
    • Current View: Intestinal Stem Cells and Signaling
    • DOI 10.1053/j.gastro.2008.01.079, PII S0016508508001856
    • Scoville DH, Sato T, He X.C., Li L. 2008. Current view: intestinal stem cells and signaling. Gastroenterology 134:849-64 (Pubitemid 351312767)
    • (2008) Gastroenterology , vol.134 , Issue.3 , pp. 849-864
    • Scoville, D.H.1    Sato, T.2    He, X.C.3    Li, L.4
  • 4
    • 79551686425 scopus 로고    scopus 로고
    • Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro
    • Spence JR, Mayhew CN, Rankin SA, Kuhar MF, Vallance JE, et al. 2010. Directed differentiation of human pluripotent stem cells into intestinal tissue in vitro. Nature 470:105-9
    • (2010) Nature , vol.470 , pp. 105-9
    • Spence, J.R.1    Mayhew, C.N.2    Rankin, S.A.3    Kuhar, M.F.4    Vallance, J.E.5
  • 6
    • 75749146169 scopus 로고    scopus 로고
    • Coexistence of quiescent and active adult stem cells in mammals
    • Li L, CleversH. 2010. Coexistence of quiescent and active adult stem cells in mammals. Science 327:542-45
    • (2010) Science , vol.327 , pp. 542-45
    • Li, L.1    Clevers, H.2
  • 7
    • 33847755702 scopus 로고    scopus 로고
    • WNT signaling in the normal intestine and colorectal cancer
    • DOI 10.2741/2076
    • de Lau W, Barker N, Clevers H. 2007. WNT signaling in the normal intestine and colorectal cancer. Front. Biosci. 12:471-91 (Pubitemid 46852800)
    • (2007) Frontiers in Bioscience , vol.12 , Issue.2 , pp. 471-491
    • De Lau, W.1    Barker, N.2    Clevers, H.3
  • 8
    • 58949101489 scopus 로고    scopus 로고
    • Intestinal stem cells in mammals and Drosophila
    • Casali A, Batlle E. 2009. Intestinal stem cells in mammals and Drosophila. Cell Stem Cell 4:124-27
    • (2009) Cell Stem Cell , vol.4 , pp. 124-27
    • Casali, A.1    Batlle, E.2
  • 9
    • 33646182727 scopus 로고    scopus 로고
    • Organizing cell renewal in the intestine: Stem cells, signals and combinatorial control
    • Crosnier C, Stamataki D, Lewis J. 2006. Organizing cell renewal in the intestine: stem cells, signals and combinatorial control. Nat. Rev. Genet. 7:349-59
    • (2006) Nat. Rev. Genet , vol.7 , pp. 349-59
    • Crosnier, C.1    Stamataki, D.2    Lewis, J.3
  • 10
    • 77956934167 scopus 로고    scopus 로고
    • The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation
    • Rezza A, Skah S, Roche C, Nadjar J, Samarut J, Plateroti M. 2010. The overexpression of the putative gut stem cell marker Musashi-1 induces tumorigenesis through Wnt and Notch activation. J. Cell Sci. 123:3256-65
    • (2010) J. Cell Sci. , vol.123 , pp. 3256-65
    • Rezza, A.1    Skah, S.2    Roche, C.3    Nadjar, J.4    Samarut, J.5    Plateroti, M.6
  • 11
    • 79959187704 scopus 로고    scopus 로고
    • Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors
    • van Es JH, de Geest N, van de Born M, Clevers H, Hassan BA. 2010. Intestinal stem cells lacking the Math1 tumour suppressor are refractory to Notch inhibitors. Nat. Commun. 1:18
    • (2010) Nat. Commun. , vol.1 , pp. 18
    • Van Es, J.H.1    De Geest, N.2    Van De Born, M.3    Clevers, H.4    Hassan, B.A.5
  • 12
    • 67349123408 scopus 로고    scopus 로고
    • Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
    • Sato T, Vries RG, Snippert HJ, van de Wetering M, Barker N, et al. 2009. Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche. Nature 459:262-65
    • (2009) Nature , vol.459 , pp. 262-65
    • Sato, T.1    Vries, R.G.2    Snippert, H.J.3    Van De Wetering, M.4    Barker, N.5
  • 13
    • 78751644734 scopus 로고    scopus 로고
    • Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts
    • Sato T, van Es JH, Snippert HJ, Stange DE, Vries RG, et al. 2011. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. Nature 469:415-18
    • (2011) Nature , vol.469 , pp. 415-18
    • Sato, T.1    Van Es, J.H.2    Snippert, H.J.3    Stange, D.E.4    Vries, R.G.5
  • 14
    • 67349157318 scopus 로고    scopus 로고
    • Sustained in vitro intestinal epithelial culture within aWnt-dependent stem cell niche
    • Ootani A, Li X, Sangiorgi E, Ho QT, Ueno H, et al. 2009. Sustained in vitro intestinal epithelial culture within aWnt-dependent stem cell niche. Nat. Med. 15:701-6
    • (2009) Nat. Med , vol.15 , pp. 701-6
    • Ootani, A.1    Li, X.2    Sangiorgi, E.3    Ho, Q.T.4    Ueno, H.5
  • 15
    • 31144474775 scopus 로고    scopus 로고
    • Colonic subepithelial myofibroblasts in mucosal inflammation and repair: Contribution of bone marrow-derived stem cells to the gut regenerative response
    • DOI 10.1007/s00535-005-1727-4
    • Andoh A, Bamba S, Fujiyama Y, Brittan M, Wright NA. 2005. Colonic subepithelial myofibroblasts in mucosal inflammation and repair: contribution of bonemarrow-derived stem cells to the gut regenerative response. J. Gastroenterol. 40:1089-99 (Pubitemid 43124835)
    • (2005) Journal of Gastroenterology , vol.40 , Issue.12 , pp. 1089-1099
    • Andoh, A.1    Bamba, S.2    Fujiyama, Y.3    Brittan, M.4    Wright, N.A.5
  • 16
    • 0033916281 scopus 로고    scopus 로고
    • Hedgehog signals regulate multiple aspects of gastrointestinal development
    • Ramalho-Santos M, Melton DA, McMahon AP. 2000. Hedgehog signals regulate multiple aspects of gastrointestinal development. Development 127:2763-72 (Pubitemid 30426822)
    • (2000) Development , vol.127 , Issue.12 , pp. 2763-2772
    • Ramalho-Santos, M.1    Melton, D.A.2    McMahon, A.P.3
  • 17
    • 13944259054 scopus 로고    scopus 로고
    • Epithelial hedgehog signals pattern the intestinal crypt-villus axis
    • DOI 10.1242/dev.01576
    • Madison BB, Braunstein K, Kuizon E, Portman K, Qiao XT, Gumucio DL. 2005. Epithelial hedgehog signals pattern the intestinal crypt-villus axis. Development 132:279-89 (Pubitemid 40268278)
    • (2005) Development , vol.132 , Issue.2 , pp. 279-289
    • Madison, B.B.1    Braunstein, K.2    Kuizon, E.3    Portman, K.4    Qiao, X.T.5    Gumucio, D.L.6
  • 18
    • 0033832891 scopus 로고    scopus 로고
    • Abnormal gastrointestinal development in PDGFA and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis
    • Karlsson L, Lindahl P, Heath JK, Betsholtz C. 2000. Abnormal gastrointestinal development in PDGFA and PDGFR-α deficient mice implicates a novel mesenchymal structure with putative instructive properties in villus morphogenesis. Development 127:3457-66
    • (2000) Development , vol.127 , pp. 3457-66
    • Karlsson, L.1    Lindahl, P.2    Heath, J.K.3    Betsholtz, C.4
  • 20
    • 17144373679 scopus 로고    scopus 로고
    • Differences in the effects of age on intestinal proliferation, crypt-fission and apoptosis on the small intestine and the colon of the rat
    • DOI 10.1111/j.0959-9673.2005.00422.x
    • Mandir N, FitzGerald AJ, Goodlad RA. 2005. Differences in the effects of age on intestinal proliferation, crypt fission and apoptosis on the small intestine and the colon of the rat. Int. J. Exp. Pathol. 86:125-30 (Pubitemid 40523813)
    • (2005) International Journal of Experimental Pathology , vol.86 , Issue.2 , pp. 125-130
    • Mandir, N.1    FitzGerald, A.J.2    Goodlad, R.A.3
  • 21
    • 0021854656 scopus 로고
    • Whole population cell kinetics and postnatal development of the mouse intestinal epithelium
    • DOI 10.1002/ar.1092110408
    • Cheng H, Bjerknes M. 1985. Whole population cell kinetics and postnatal development of the mouse intestinal epithelium. Anat. Rec. 211:420-26 (Pubitemid 15081136)
    • (1985) Anatomical Record , vol.211 , Issue.4 , pp. 420-426
    • Cheng, H.1    Bjerknes, M.2
  • 23
    • 0023901132 scopus 로고
    • Altered controls of proliferation in proximal small intestine of the senescent rat
    • Holt PR, Yeh KY, Kotler DP. 1988. Altered controls of proliferation in proximal small intestine of the senescent rat. Proc. Natl. Acad. Sci. USA 85:2771-75
    • (1988) Proc. Natl. Acad. Sci. USA , vol.85 , pp. 2771-75
    • Holt, P.R.1    Yeh, K.Y.2    Kotler, D.P.3
  • 24
    • 19444373939 scopus 로고    scopus 로고
    • Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: Ulcerative colitis shows specific p53- and EGFR expression alterations
    • DOI 10.1007/s10350-004-0831-5
    • Sipos F, Molnar B, Zagoni T, Berczi L, Tulassay Z. 2005. Growth in epithelial cell proliferation and apoptosis correlates specifically to the inflammation activity of inflammatory bowel diseases: ulcerative colitis shows specific p53- and EGFR expression alterations. Dis. Colon Rectum 48:775-86 (Pubitemid 40880726)
    • (2005) Diseases of the Colon and Rectum , vol.48 , Issue.4 , pp. 775-786
    • Sipos, F.1    Molnar, B.2    Zagoni, T.3    Berczi, L.4    Tulassay, Z.5
  • 25
    • 0019443626 scopus 로고
    • Rate and pattern of epithelial cell proliferation in ulcerative colitis
    • Serafini EP, Kirk AP, Chambers TJ. 1981. Rate and pattern of epithelial cell proliferation in ulcerative colitis. Gut 22:648-52 (Pubitemid 11018268)
    • (1981) Gut , vol.22 , Issue.8 , pp. 648-652
    • Serafini, E.P.1    Kirk, A.P.2    Chambers, T.J.3
  • 26
    • 0032433425 scopus 로고    scopus 로고
    • Increased cell proliferation characterizes Crohn's disease
    • Noffsinger A, Unger B, Fenoglio-Preiser CM. 1998. Increased cell proliferation characterizes Crohn's disease. Mod. Pathol. 11:1198-203 (Pubitemid 29009330)
    • (1998) Modern Pathology , vol.11 , Issue.12 , pp. 1198-1203
    • Noffsinger, A.1    Unger, B.2    Fenoglio-Preiser, C.M.3
  • 28
    • 33646801637 scopus 로고    scopus 로고
    • Regulation of apoptosis during homeostasis and disease in the intestinal epithelium
    • Edelblum KL, Yan F, Yamaoka T, Polk DB. 2006. Regulation of apoptosis during homeostasis and disease in the intestinal epithelium. Inflamm. Bowel Dis. 12:413-24
    • (2006) Inflamm. Bowel Dis , vol.12 , pp. 413-24
    • Edelblum, K.L.1    Yan, F.2    Yamaoka, T.3    Polk, D.B.4
  • 29
    • 67650330166 scopus 로고    scopus 로고
    • Carcinogenesis in IBD: Potential targets for the prevention of colorectal cancer
    • Feagins LA, Souza RF, Spechler SJ. 2009. Carcinogenesis in IBD: potential targets for the prevention of colorectal cancer. Nat. Rev. Gastroenterol. Hepatol. 6:297-305
    • (2009) Nat. Rev. Gastroenterol. Hepatol , vol.6 , pp. 297-305
    • Feagins, L.A.1    Souza, R.F.2    Spechler, S.J.3
  • 32
    • 77949937466 scopus 로고    scopus 로고
    • Interferon-γ regulates intestinal epithelial homeostasis through converging α-catenin signaling pathways
    • Nava P, Koch S, Laukoetter MG, Lee WY, Kolegraff K, et al. 2010. Interferon-γ regulates intestinal epithelial homeostasis through converging α-catenin signaling pathways. Immunity 32:392-402
    • (2010) Immunity , vol.32 , pp. 392-402
    • Nava, P.1    Koch, S.2    Laukoetter, M.G.3    Lee, W.Y.4    Kolegraff, K.5
  • 33
    • 67349279221 scopus 로고    scopus 로고
    • The effects of mechanical forces on intestinal physiology and pathology
    • Gayer CP, Basson MD. 2009. The effects of mechanical forces on intestinal physiology and pathology. Cell Signal. 21:1237-44
    • (2009) Cell Signal , vol.21 , pp. 1237-44
    • Gayer, C.P.1    Basson, M.D.2
  • 35
    • 0015527848 scopus 로고
    • Rectal biopsy in inflammatory bowel disease
    • Morson BC. 1972. Rectal biopsy in inflammatory bowel disease. N. Engl. J. Med. 287:1337-39
    • (1972) N. Engl. J. Med , vol.287 , pp. 1337-39
    • Morson, B.C.1
  • 37
    • 70350437264 scopus 로고    scopus 로고
    • α-Defensins in enteric innate immunity: Functional Paneth cell α-defensins in mouse colonic lumen
    • Mastroianni JR, Ouellette AJ. 2009. α-Defensins in enteric innate immunity: functional Paneth cell α-defensins in mouse colonic lumen. J. Biol. Chem. 284:27848-56
    • (2009) J. Biol. Chem , vol.284 , pp. 27848-56
    • Mastroianni, J.R.1    Ouellette, A.J.2
  • 38
    • 16844382886 scopus 로고    scopus 로고
    • Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease
    • DOI 10.1189/jlb.0904543
    • Wehkamp J, Schmid M, Fellermann K, Stange EF. 2005. Defensin deficiency, intestinal microbes, and the clinical phenotypes of Crohn's disease. J. Leukoc. Biol. 77:460-65 (Pubitemid 40489521)
    • (2005) Journal of Leukocyte Biology , vol.77 , Issue.4 , pp. 460-465
    • Wehkamp, J.1    Schmid, M.2    Fellermann, K.3    Stange, E.F.4
  • 39
    • 0018413057 scopus 로고
    • The Paneth cell
    • Sandow MJ, Whitehead R. 1979. The Paneth cell. Gut 20:420-31 (Pubitemid 9212792)
    • (1979) Gut , vol.20 , Issue.5 , pp. 420-431
    • Sandow, M.J.1    Whitehead, R.2
  • 40
    • 58549085968 scopus 로고    scopus 로고
    • Proposal of a new hypothesis on the development of colorectal epithelial neoplasia: Nonspecific inflammation-colorectal Paneth cell metaplasia-colorectal epithelial neoplasia
    • Wada R. 2009. Proposal of a new hypothesis on the development of colorectal epithelial neoplasia: nonspecific inflammation-colorectal Paneth cell metaplasia-colorectal epithelial neoplasia. Digestion 79(Suppl. 1):9-12
    • (2009) Digestion , vol.79 , Issue.SUPPL. 1 , pp. 9-12
    • Wada, R.1
  • 41
    • 67649988997 scopus 로고    scopus 로고
    • The role of stromal stem cells in tissue regeneration and wound repair
    • Stappenbeck TS, Miyoshi H. 2009. The role of stromal stem cells in tissue regeneration and wound repair. Science 324:1666-69
    • (2009) Science , vol.324 , pp. 1666-69
    • Stappenbeck, T.S.1    Miyoshi, H.2
  • 44
    • 65549086537 scopus 로고    scopus 로고
    • Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine
    • Fre S, Pallavi SK, Huyghe M, Lae M, Janssen KP, et al. 2009. Notch and Wnt signals cooperatively control cell proliferation and tumorigenesis in the intestine. Proc. Natl. Acad. Sci. USA 106:6309-14
    • (2009) Proc. Natl. Acad. Sci. USA , vol.106 , pp. 6309-14
    • Fre, S.1    Pallavi, S.K.2    Huyghe, M.3    Lae, M.4    Janssen, K.P.5
  • 45
    • 34547643983 scopus 로고    scopus 로고
    • Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth and metastasis of human colon carcinoma
    • DOI 10.2353/ajpath.2006.060653
    • Kitadai Y, Sasaki T, Kuwai T, Nakamura T, Bucana CD, Fidler IJ. 2006. Targeting the expression of platelet-derived growth factor receptor by reactive stroma inhibits growth andmetastasis of human colon carcinoma. Am. J. Pathol. 169:2054-65 (Pubitemid 351181965)
    • (2006) American Journal of Pathology , vol.169 , Issue.6 , pp. 2054-2065
    • Kitadai, Y.1    Sasaki, T.2    Kuwai, T.3    Nakamura, T.4    Bucana, C.D.5    Fidler, I.J.6
  • 46
    • 39149088615 scopus 로고    scopus 로고
    • Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation
    • DOI 10.1038/sj.onc.1210720, PII 1210720
    • Beppu H, Mwizerwa ON, Beppu Y, Dattwyler MP, Lauwers GY, et al. 2008. Stromal inactivation of BMPRII leads to colorectal epithelial overgrowth and polyp formation. Oncogene 27:1063-70 (Pubitemid 351253183)
    • (2008) Oncogene , vol.27 , Issue.8 , pp. 1063-1070
    • Beppu, H.1    Mwizerwa, O.N.2    Beppu, Y.3    Dattwyler, M.P.4    Lauwers, G.Y.5    Bloch, K.D.6    Goldstein, A.M.7
  • 47
    • 78049469952 scopus 로고    scopus 로고
    • Loss of Indian hedgehog activates multiple aspects of a wound healing response in themouse intestine
    • Van Dop WA, Heijmans J, Buller NV, Snoek SA, Rosekrans SL, et al. 2010. Loss of Indian hedgehog activates multiple aspects of a wound healing response in themouse intestine. Gastroenterology 139:1665-76
    • (2010) Gastroenterology , vol.139 , pp. 1665-76
    • Van Dop, W.A.1    Heijmans, J.2    Buller, N.V.3    Snoek, S.A.4    Rosekrans, S.L.5
  • 48
    • 0038121795 scopus 로고    scopus 로고
    • Bone morphogenetic protein-7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats
    • DOI 10.1002/jcp.10275
    • Maric I, Poljak L, Zoricic S, Bobinac D, Bosukonda D, et al. 2003. Bone morphogenetic protein 7 reduces the severity of colon tissue damage and accelerates the healing of inflammatory bowel disease in rats. J. Cell Physiol. 196:258-64 (Pubitemid 36775872)
    • (2003) Journal of Cellular Physiology , vol.196 , Issue.2 , pp. 258-264
    • Maric, I.1    Poljak, L.2    Zoricic, S.3    Bobinac, D.4    Bosukonda, D.5    Sampath, K.T.6    Vukicevic, S.7
  • 49
    • 54349125596 scopus 로고    scopus 로고
    • Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease
    • Burke JP, FerranteM, Dejaegher K, Watson RW, DochertyNG, et al. 2008. Transcriptomic analysis of intestinal fibrosis-associated gene expression in response to medical therapy in Crohn's disease. Inflamm. Bowel Dis. 14:1197-204
    • (2008) Inflamm. Bowel Dis , vol.14 , pp. 1197-204
    • Burke, J.P.1    Ferrante, M.2    Dejaegher, K.3    Watson, R.W.4    Docherty, N.G.5
  • 51
    • 78650077745 scopus 로고    scopus 로고
    • Expression profiling ofWnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells
    • Hughes KR, Sablitzky F, Mahida YR. 2011. Expression profiling ofWnt family of genes in normal and inflammatory bowel disease primary human intestinal myofibroblasts and normal human colonic crypt epithelial cells. Inflamm. Bowel Dis. 17:213-20
    • (2011) Inflamm. Bowel Dis. , vol.17 , pp. 213-20
    • Hughes, K.R.1    Sablitzky, F.2    Mahida, Y.R.3
  • 52
    • 23244448347 scopus 로고    scopus 로고
    • Expression pattern of Wnt signaling components in the adult intestine
    • DOI 10.1016/j.gastro.2005.06.007, PII S0016508505011054
    • Gregorieff A, Pinto D, Begthel H, Destree O, Kielman M, Clevers H. 2005. Expression pattern of Wnt signaling components in the adult intestine. Gastroenterology 129:626-38 (Pubitemid 41096648)
    • (2005) Gastroenterology , vol.129 , Issue.2 , pp. 626-638
    • Gregorieff, A.1    Pinto, D.2    Begthel, H.3    Destree, O.4    Kielman, M.5    Clevers, H.6
  • 53
    • 77956138914 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase signaling mediates α-catenin activation in intestinal epithelial stem and progenitor cells in colitis
    • Lee G, Goretsky T, Managlia E, Dirisina R, Singh AP, et al. 2010. Phosphoinositide 3-kinase signaling mediates α-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology 139:869-81
    • (2010) Gastroenterology , vol.139 , pp. 869-81
    • Lee, G.1    Goretsky, T.2    Managlia, E.3    Dirisina, R.4    Singh, A.P.5
  • 54
    • 73449139396 scopus 로고    scopus 로고
    • The NF-κB/AKT-dependent induction of Wnt signaling in colon cancer cells by macrophages and IL-1α
    • Kaler P, Godasi BN, Augenlicht L, Klampfer L. 2009. The NF-κB/AKT-dependent induction of Wnt signaling in colon cancer cells by macrophages and IL-1α. Cancer Microenviron. 2:69-80
    • (2009) Cancer Microenviron , vol.2 , pp. 69-80
    • Kaler, P.1    Godasi, B.N.2    Augenlicht, L.3    Klampfer, L.4
  • 56
    • 0031897632 scopus 로고    scopus 로고
    • NF-κB and rel proteins: Evolutionarily conserved mediators of immune responses
    • DOI 10.1146/annurev.immunol.16.1.225
    • Ghosh S, May MJ, Kopp EB. 1998. NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16:225-60 (Pubitemid 28183365)
    • (1998) Annual Review of Immunology , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 58
    • 33745853832 scopus 로고    scopus 로고
    • Epithelial cell IκB-kinase β has an important protective role in Clostridium difficile toxin A-induced mucosal injury
    • Chae S, Eckmann L, Miyamoto Y, Pothoulakis C, Karin M, Kagnoff MF. 2006. Epithelial cell IκB kinase has an important protective role in Clostridium difficile toxin A-induced mucosal injury. J. Immunol. 177:1214-20 (Pubitemid 44036626)
    • (2006) Journal of Immunology , vol.177 , Issue.2 , pp. 1214-1220
    • Chae, S.1    Eckmann, L.2    Miyamoto, Y.3    Pothoulakis, C.4    Karin, M.5    Kagnoff, M.F.6
  • 60
    • 73949105149 scopus 로고    scopus 로고
    • Epithelial NF-κB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation
    • Tang Y, Clayburgh DR, Mittal N, Goretsky T, Dirisina R, et al. 2010. Epithelial NF-κB enhances transmucosal fluid movement by altering tight junction protein composition after T cell activation. Am. J. Pathol. 176:158-67
    • (2010) Am. J. Pathol. , vol.176 , pp. 158-67
    • Tang, Y.1    Clayburgh, D.R.2    Mittal, N.3    Goretsky, T.4    Dirisina, R.5
  • 62
    • 77949841924 scopus 로고    scopus 로고
    • Distinct effects of p38 deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease
    • Otsuka M, Kang YJ, Ren J, Jiang H, Wang Y, et al. 2010. Distinct effects of p38 deletion in myeloid lineage and gut epithelia in mouse models of inflammatory bowel disease. Gastroenterology 138: 1255-65
    • (2010) Gastroenterology , vol.138 , pp. 1255-65
    • Otsuka, M.1    Kang, Y.J.2    Ren, J.3    Jiang, H.4    Wang, Y.5
  • 63
    • 39849098748 scopus 로고    scopus 로고
    • Role of the JNK signal transduction pathway in inflammatory bowel disease
    • DOI 10.3748/wjg.14.200
    • Roy PK, Rashid F, Bragg J, Ibdah JA. 2008. Role of the JNKsignal transduction pathway in inflammatory bowel disease. World J. Gastroenterol. 14:200-2 (Pubitemid 351314299)
    • (2008) World Journal of Gastroenterology , vol.14 , Issue.2 , pp. 200-202
    • Roy, P.K.1    Rashid, F.2    Bragg, J.3    Ibdah, J.A.4
  • 65
    • 58649101347 scopus 로고    scopus 로고
    • Gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis
    • Bollrath J, Phesse TJ, von Burstin VA, Putoczki T, Bennecke M, et al. 2009. gp130-mediated Stat3 activation in enterocytes regulates cell survival and cell-cycle progression during colitis-associated tumorigenesis. Cancer Cell 15:91-102
    • (2009) Cancer Cell , vol.15 , pp. 91-102
    • Bollrath, J.1    Phesse, T.J.2    Von Burstin, V.A.3    Putoczki, T.4    Bennecke, M.5
  • 66
    • 58649108302 scopus 로고    scopus 로고
    • IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer
    • Grivennikov S, Karin E, Terzic J, Mucida D, Yu GY, et al. 2009. IL-6 and Stat3 are required for survival of intestinal epithelial cells and development of colitis-associated cancer. Cancer Cell 15:103-13
    • (2009) Cancer Cell , vol.15 , pp. 103-13
    • Grivennikov, S.1    Karin, E.2    Terzic, J.3    Mucida, D.4    Yu, G.Y.5
  • 67
    • 0033034365 scopus 로고    scopus 로고
    • Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of stat3 in macrophages and neutrophils
    • DOI 10.1016/S1074-7613(00)80005-9
    • Takeda K, Clausen BE, Kaisho T, Tsujimura T, Terada N, et al. 1999. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity 10:39-49 (Pubitemid 29077382)
    • (1999) Immunity , vol.10 , Issue.1 , pp. 39-49
    • Takeda, K.1    Clausen, B.E.2    Kaisho, T.3    Tsujimura, T.4    Terada, N.5    Forster, I.6    Akira, S.7
  • 69
    • 77955587900 scopus 로고    scopus 로고
    • Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream ofWnt/c-Myc signaling
    • Ashton GH, Morton JP, Myant K, Phesse TJ, Ridgway RA, et al. 2010. Focal adhesion kinase is required for intestinal regeneration and tumorigenesis downstream ofWnt/c-Myc signaling. Dev. Cell 19: 259-69
    • (2010) Dev. Cell , vol.19 , pp. 259-69
    • Ashton, G.H.1    Morton, J.P.2    Myant, K.3    Phesse, T.J.4    Ridgway, R.A.5
  • 70
    • 47049116663 scopus 로고    scopus 로고
    • Activated macrophages promote Wnt signalling through tumour necrosis factor in gastric tumour cells
    • Oguma K, Oshima H, Aoki M, Uchio R, Naka K, et al. 2008. Activated macrophages promote Wnt signalling through tumour necrosis factor in gastric tumour cells. EMBO J. 27:1671-81
    • (2008) EMBO J , vol.27 , pp. 1671-81
    • Oguma, K.1    Oshima, H.2    Aoki, M.3    Uchio, R.4    Naka, K.5
  • 71
    • 72149109797 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade
    • Ng SS, Mahmoudi T, Danenberg E, Bejaoui I, de Lau W, et al. 2009. Phosphatidylinositol 3-kinase signaling does not activate the wnt cascade. J. Biol. Chem. 284:35308-13
    • (2009) J. Biol. Chem , vol.284 , pp. 35308-13
    • Ng, S.S.1    Mahmoudi, T.2    Danenberg, E.3    Bejaoui, I.4    De Lau, W.5
  • 72
    • 78650484935 scopus 로고    scopus 로고
    • Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes
    • Taelman VF, Dobrowolski R, Plouhinec JL, Fuentealba LC, Vorwald PP, et al. 2010. Wnt signaling requires sequestration of glycogen synthase kinase 3 inside multivesicular endosomes. Cell 143: 1136-48
    • (2010) Cell , vol.143 , pp. 1136-48
    • Taelman, V.F.1    Dobrowolski, R.2    Plouhinec, J.L.3    Fuentealba, L.C.4    Vorwald, P.P.5
  • 73
    • 74249107095 scopus 로고    scopus 로고
    • GSK3is involved in JNK2-mediatedα-catenin inhibition
    • Hu D, Bi X, Fang W, Han A, YangW. 2009. GSK3is involved in JNK2-mediatedα-catenin inhibition. PLoS ONE 4:e6640
    • (2009) PLoS ONE , vol.4
    • Hu, D.1    Bi, X.2    Fang, W.3    Han, A.4    Yang, W.5
  • 74
    • 57349124420 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/α-catenin signaling through GSK3 pathway
    • Hu D, Fang W, Han A, Gallagher L, Davis RJ, et al. 2008. c-Jun N-terminal kinase 1 interacts with and negatively regulates Wnt/α-catenin signaling through GSK3 pathway. Carcinogenesis 29:2317-24
    • (2008) Carcinogenesis , vol.29 , pp. 2317-24
    • Hu, D.1    Fang, W.2    Han, A.3    Gallagher, L.4    Davis, R.J.5
  • 77
    • 0034612636 scopus 로고    scopus 로고
    • Requirement for glycogen synthase kinase-3β in cell survival and NF-κB activation
    • DOI 10.1038/35017574
    • Hoeflich KP, Luo J, Rubie EA, Tsao MS, Jin O, Woodgett JR. 2000. Requirement for glycogen synthase kinase-3in cell survival and NF-κB activation. Nature 406:86-90 (Pubitemid 30460216)
    • (2000) Nature , vol.406 , Issue.6791 , pp. 86-90
    • Hoeflich, K.P.1    Luo, J.2    Rubie, E.A.3    Tsao, M.-S.4    Jin, O.5    Woodgett, J.R.6
  • 78
    • 4544341116 scopus 로고    scopus 로고
    • Genetic deletion of glycogen synthase kinase-3β abrogates activation of IκBα kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor
    • DOI 10.1074/jbc.M403449200
    • Takada Y, Fang X, JamaluddinMS, Boyd DD, Aggarwal BB. 2004. Genetic deletion of glycogen synthase kinase 3abrogates activation of IκBkinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J. Biol. Chem. 279:39541-54 (Pubitemid 39258221)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.38 , pp. 39541-39554
    • Takada, Y.1    Fang, X.2    Jamaluddin, Md.S.3    Boyd, D.D.4    Aggarwal, B.B.5
  • 79
    • 23944497169 scopus 로고    scopus 로고
    • Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-κB activation but not GSK3β activity
    • DOI 10.1007/s10495-005-2943-3
    • Bhattacharya S, Ray RM, Johnson LR. 2005. Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-κB activation but not GSK3activity. Apoptosis 10:759-76 (Pubitemid 41187075)
    • (2005) Apoptosis , vol.10 , Issue.4 , pp. 759-776
    • Bhattacharya, S.1    Ray, R.M.2    Johnson, L.R.3
  • 80
  • 82
    • 24644478136 scopus 로고    scopus 로고
    • Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development
    • DOI 10.1038/nature03914
    • Nateri AS, Spencer-Dene B, Behrens A. 2005. Interaction of phosphorylated c-Jun with TCF4 regulates intestinal cancer development. Nature 437:281-85 (Pubitemid 41294493)
    • (2005) Nature , vol.437 , Issue.7056 , pp. 281-285
    • Nateri, A.S.1    Spencer-Dene, B.2    Behrens, A.3
  • 83
    • 67650507032 scopus 로고    scopus 로고
    • JNK signallingmodulates intestinal homeostasis and tumourigenesis in mice
    • Sancho R, Nateri AS, de Vinuesa AG, Aguilera C, Nye E, et al. 2009. JNK signallingmodulates intestinal homeostasis and tumourigenesis in mice. EMBO J. 28:1843-54
    • (2009) EMBO J , vol.28 , pp. 1843-54
    • Sancho, R.1    Nateri, A.S.2    De Vinuesa, A.G.3    Aguilera, C.4    Nye, E.5
  • 84
    • 77549083560 scopus 로고    scopus 로고
    • Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer
    • Grivennikov SI, Karin M. 2010. Dangerous liaisons: STAT3 and NF-κB collaboration and crosstalk in cancer. Cytokine Growth Factor Rev. 21:11-19
    • (2010) Cytokine Growth Factor Rev. , vol.21 , pp. 11-19
    • Grivennikov, S.I.1    Karin, M.2
  • 86
    • 22844448786 scopus 로고    scopus 로고
    • Crosstalk between NF-κB and α-catenin pathways in bacterial-colonized intestinal epithelial cells
    • Sun J, Hobert ME, Duan Y, Rao AS, He TC, et al. 2005. Crosstalk between NF-κB and α-catenin pathways in bacterial-colonized intestinal epithelial cells. Am. J. Physiol. Gastrointest. Liver Physiol. 289: 129-37
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol , vol.289 , pp. 129-37
    • Sun, J.1    Hobert, M.E.2    Duan, Y.3    Rao, A.S.4    He, T.C.5
  • 87
    • 69249124129 scopus 로고    scopus 로고
    • Functional cross-talk betweenα-catenin andNF-κB signaling pathways in colonic crypts of mice in response to progastrin
    • Umar S, Sarkar S, Wang Y, Singh P. 2009. Functional cross-talk betweenα-catenin andNF-κB signaling pathways in colonic crypts of mice in response to progastrin. J. Biol. Chem. 284:22274-84
    • (2009) J. Biol. Chem , vol.284 , pp. 22274-84
    • Umar, S.1    Sarkar, S.2    Wang, Y.3    Singh, P.4
  • 88
    • 44349132270 scopus 로고    scopus 로고
    • Epithelial-cell recognition of commensal bacteria and maintenance of immune homeostasis in the gut
    • DOI 10.1038/nri2316, PII NRI2316
    • ArtisD. 2008. Epithelial-cell recognition of commensal bacteria andmaintenance of immunehomeostasis in the gut. Nat. Rev. Immunol. 8:411-20 (Pubitemid 351733416)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.6 , pp. 411-420
    • Artis, D.1
  • 89
    • 70049090007 scopus 로고    scopus 로고
    • The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses
    • Strober W. 2009. The multifaceted influence of the mucosal microflora on mucosal dendritic cell responses. Immunity 31:377-88
    • (2009) Immunity , vol.31 , pp. 377-88
    • Strober, W.1
  • 90
    • 70049099845 scopus 로고    scopus 로고
    • Immune responses to the microbiota at the intestinal mucosal surface
    • Duerkop BA, Vaishnava S, Hooper LV. 2009. Immune responses to the microbiota at the intestinal mucosal surface. Immunity 31:368-76
    • (2009) Immunity , vol.31 , pp. 368-76
    • Duerkop, B.A.1    Vaishnava, S.2    Hooper, L.V.3
  • 91
    • 75649093343 scopus 로고    scopus 로고
    • Toll-like receptor signalling in the intestinal epithelium: How bacterial recognition shapes intestinal function
    • Abreu MT. 2010. Toll-like receptor signalling in the intestinal epithelium: how bacterial recognition shapes intestinal function. Nat. Rev. Immunol. 10:131-44
    • (2010) Nat. Rev. Immunol. , vol.10 , pp. 131-44
    • Abreu, M.T.1
  • 92
    • 35549003579 scopus 로고    scopus 로고
    • Regulation of Interferon-γ During Innate and Adaptive Immune Responses
    • DOI 10.1016/S0065-2776(07)96002-2, PII S0065277607960022
    • Schoenborn JR, Wilson CB. 2007. Regulation of interferon-γ during innate and adaptive immune responses. Adv. Immunol. 96:41-101 (Pubitemid 350018717)
    • (2007) Advances in Immunology , vol.96 , pp. 41-101
    • Schoenborn, J.R.1    Wilson, C.B.2
  • 93
    • 0842266786 scopus 로고    scopus 로고
    • Interferon-γ: An overview of signals, mechanisms and functions
    • DOI 10.1189/jlb.0603252
    • Schroder K, Hertzog PJ, Ravasi T, Hume DA. 2004. Interferon-γ: an overview of signals, mechanisms and functions. J. Leukoc. Biol. 75:163-89 (Pubitemid 38174573)
    • (2004) Journal of Leukocyte Biology , vol.75 , Issue.2 , pp. 163-189
    • Schroder, K.1    Hertzog, P.J.2    Ravasi, T.3    Hume, D.A.4
  • 94
    • 0023908566 scopus 로고
    • Defective in vitro interferon production and elevated serum immunoreactive thymosin 4 levels in patients with inflammatory bowel disease
    • Mutchnick MG, Lee HH, Hollander DI, Haynes GD, Chua DC. 1988. Defective in vitro interferon production and elevated serum immunoreactive thymosin 4 levels in patients with inflammatory bowel disease. Clin. Immunol. Immunopathol. 47:84-92
    • (1988) Clin. Immunol. Immunopathol , vol.47 , pp. 84-92
    • Mutchnick, M.G.1    Lee, H.H.2    Hollander, D.I.3    Haynes, G.D.4    Chua, D.C.5
  • 96
    • 0027436376 scopus 로고
    • Cytokine modulation of intestinal epithelial cell restitution: Central role of transforming growth factor β
    • Dignass AU, Podolsky DK. 1993. Cytokine modulation of intestinal epithelial cell restitution: central role of transforming growth factor?. Gastroenterology 105:1323-32 (Pubitemid 23315306)
    • (1993) Gastroenterology , vol.105 , Issue.5 , pp. 1323-1332
    • Dignass, A.U.1    Podolsky, D.K.2
  • 99
    • 33645233839 scopus 로고    scopus 로고
    • The significance of interferon-α-triggered internalization of tight-junction proteins in inflammatory bowel disease
    • Chiba H, Kojima T, Osanai M, Sawada N. 2006. The significance of interferon-α-triggered internalization of tight-junction proteins in inflammatory bowel disease. Sci. Signal Transduct. Knowl. Environ. 2006:pe1
    • (2006) Sci. Signal Transduct. Knowl. Environ , vol.2006
    • Chiba, H.1    Kojima, T.2    Osanai, M.3    Sawada, N.4
  • 100
    • 0031808795 scopus 로고    scopus 로고
    • Effects of interferon γ on growth, apoptosis, and MHC class II expression of immature rat intestinal crypt (IEC-6) cells
    • DOI 10.1002/(SICI)1097-4652(199807)176:1<120::AID-JCP14>3.0.CO;2-B
    • Ruemmele FM, Gurbindo C, Mansour AM, Marchand R, Levy E, Seidman EG. 1998. Effects of interferon on growth, apoptosis, and MHC class II expression of immature rat intestinal crypt (IEC-6) cells. J. Cell Physiol. 176:120-26 (Pubitemid 28277202)
    • (1998) Journal of Cellular Physiology , vol.176 , Issue.1 , pp. 120-126
    • Ruemmele, F.M.1    Gurbindo, C.2    Mansour, A.M.3    Marchand, R.4    Levy, E.5    Seidman, E.G.6
  • 101
    • 40549113336 scopus 로고    scopus 로고
    • Mucosal IL-10 and TGF-β play crucial roles in preventing LPS-driven, IFN-γ-mediated epithelial damage in human colon explants
    • DOI 10.1172/JCI32140
    • Jarry A, Bossard C, Bou-Hanna C, Masson D, Espaze E, et al. 2008. Mucosal IL-10 and TGF-sβ play crucial roles in preventing LPS-driven, IFN-γ-mediated epithelial damage in human colon explants. J. Clin. Investig. 118:1132-42 (Pubitemid 351364620)
    • (2008) Journal of Clinical Investigation , vol.118 , Issue.3 , pp. 1132-1142
    • Jarry, A.1    Bossard, C.2    Bou-Hanna, C.3    Masson, D.4    Espaze, E.5    Denis, M.G.6    Laboisse, C.L.7
  • 103
    • 84883577100 scopus 로고    scopus 로고
    • The first decade of biologic TNF antagonists in clinical practice: Lessons learned, unresolved issues and future directions
    • Sfikakis PP. 2010. The first decade of biologic TNF antagonists in clinical practice: lessons learned, unresolved issues and future directions. Curr. Dir. Autoimmun. 11:180-210
    • (2010) Curr. Dir. Autoimmun , vol.11 , pp. 180-210
    • Sfikakis, P.P.1
  • 104
    • 0037377183 scopus 로고    scopus 로고
    • Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms
    • Corredor J, Yan F, Shen CC, Tong W, John SK, et al. 2003. Tumor necrosis factor regulates intestinal epithelial cell migration by receptor-dependent mechanisms. Am. J. Physiol. Cell Physiol. 284: 953-61
    • (2003) Am. J. Physiol. Cell Physiol , vol.284 , pp. 953-61
    • Corredor, J.1    Yan, F.2    Shen, C.C.3    Tong, W.4    John, S.K.5
  • 106
    • 77957278004 scopus 로고    scopus 로고
    • Cytoskeletal regulation of epithelial barrier function during inflammation
    • Ivanov AI, Parkos CA, Nusrat A. 2010. Cytoskeletal regulation of epithelial barrier function during inflammation. Am. J. Pathol. 177:512-24
    • (2010) Am. J. Pathol. , vol.177 , pp. 512-24
    • Ivanov, A.I.1    Parkos, C.A.2    Nusrat, A.3
  • 107
    • 0032854183 scopus 로고    scopus 로고
    • Synergistic effects of interferon γ and tumour necrosis factor α on T84 cell function
    • Fish SM, Proujansky R, Reenstra WW. 1999. Synergistic effects of interferon and tumour necrosis factor on T84 cell function. Gut 45:191-98 (Pubitemid 29333767)
    • (1999) Gut , vol.45 , Issue.2 , pp. 191-198
    • Fish, S.M.1    Proujansky, R.2    Reenstra, W.W.3
  • 108
    • 33749466490 scopus 로고    scopus 로고
    • IFN-γ-Induced TNFR2 Expression Is Required for TNF-Dependent Intestinal Epithelial Barrier Dysfunction
    • DOI 10.1053/j.gastro.2006.08.022, PII S0016508506017616
    • Wang F, Schwarz BT, Graham WV, Wang Y, Su L, et al. 2006. IFN-γ-induced TNFR2 expression is required for TNF-dependent intestinal epithelial barrier dysfunction. Gastroenterology 131:1153-63 (Pubitemid 44515106)
    • (2006) Gastroenterology , vol.131 , Issue.4 , pp. 1153-1163
    • Wang, F.1    Schwarz, B.T.2    Graham, W.V.3    Wang, Y.4    Su, L.5    Clayburgh, D.R.6    Abraham, C.7    Turner, J.R.8
  • 109
    • 0028062982 scopus 로고
    • Regulation of intestinal epithelial barrier function by TGF-β1: Evidence for its role in abrogating the effect of a T cell cytokine
    • Planchon SM, Martins CA, Guerrant RL, Roche JK. 1994. Regulation of intestinal epithelial barrier function by TGF-β1. Evidence for its role in abrogating the effect of a T cell cytokine. J. Immunol. 153:5730-39 (Pubitemid 24377709)
    • (1994) Journal of Immunology , vol.153 , Issue.12 , pp. 5730-5739
    • Planchon, S.M.1    Martins, C.A.P.2    Guerrant, R.L.3    Roche, J.K.4
  • 110
    • 0031011849 scopus 로고    scopus 로고
    • Interleukin 10 prevents cytokine-induced disruption of T84 monolayer barrier integrity and limits chloride secretion
    • DOI 10.1016/S0016-5085(97)70090-8
    • Madsen KL, Lewis SA, Tavernini MM, Hibbard J, Fedorak RN. 1997. Interleukin 10 prevents cytokineinduced disruption of T84 monolayer barrier integrity and limits chloride secretion. Gastroenterology 113:151-59 (Pubitemid 27281769)
    • (1997) Gastroenterology , vol.113 , Issue.1 , pp. 151-159
    • Madsen, K.L.1    Lewis, S.A.2    Tavernini, M.M.3    Hibbard, J.4    Fedorak, R.N.5
  • 112
    • 77953537389 scopus 로고    scopus 로고
    • Th17 cytokines and the gut mucosal barrier
    • Blaschitz C, Raffatellu M. 2010. Th17 cytokines and the gut mucosal barrier. J. Clin. Immunol. 30:196-203
    • (2010) J. Clin. Immunol. , vol.30 , pp. 196-203
    • Blaschitz, C.1    Raffatellu, M.2
  • 113
    • 77950349016 scopus 로고    scopus 로고
    • Th17 and regulatoryTcells in mediating and restraining inflammation
    • Littman DR, Rudensky AY. 2010. Th17 and regulatoryTcells in mediating and restraining inflammation. Cell 140:845-58
    • (2010) Cell , vol.140 , pp. 845-58
    • Littman, D.R.1    Rudensky, A.Y.2
  • 114
    • 65549099573 scopus 로고    scopus 로고
    • Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine
    • Raffatellu M, George MD, Akiyama Y, Hornsby MJ, Nuccio SP, et al. 2009. Lipocalin-2 resistance confers an advantage to Salmonella enterica serotype Typhimurium for growth and survival in the inflamed intestine. Cell Host Microbe 5:476-86
    • (2009) Cell Host Microbe , vol.5 , pp. 476-86
    • Raffatellu, M.1    George, M.D.2    Akiyama, Y.3    Hornsby, M.J.4    Nuccio, S.P.5
  • 115
    • 0034128634 scopus 로고    scopus 로고
    • Claudins regulate the intestinal barrier in response to immune mediators
    • Kinugasa T, Sakaguchi T, Gu X, Reinecker HC. 2000. Claudins regulate the intestinal barrier in response to immune mediators. Gastroenterology 118:1001-11 (Pubitemid 30346975)
    • (2000) Gastroenterology , vol.118 , Issue.6 , pp. 1001-1011
    • Kinugasa, T.1    Sakaguchi, T.2    Gu, X.3    Reinecker, H.4
  • 116
    • 67650474246 scopus 로고    scopus 로고
    • STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing
    • Pickert G, Neufert C, Leppkes M, Zheng Y, Wittkopf N, et al. 2009. STAT3 links IL-22 signaling in intestinal epithelial cells to mucosal wound healing. J. Exp. Med. 206:1465-72
    • (2009) J. Exp. Med , vol.206 , pp. 1465-72
    • Pickert, G.1    Neufert, C.2    Leppkes, M.3    Zheng, Y.4    Wittkopf, N.5
  • 117
    • 33645829078 scopus 로고    scopus 로고
    • IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration
    • Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst ST, et al. 2006. IL-22 is increased in active Crohn's disease and promotes proinflammatory gene expression and intestinal epithelial cell migration. Am. J. Physiol. Gastrointest. Liver Physiol. 290:827-38
    • (2006) Am. J. Physiol. Gastrointest. Liver Physiol , vol.290 , pp. 827-38
    • Brand, S.1    Beigel, F.2    Olszak, T.3    Zitzmann, K.4    Eichhorst, S.T.5
  • 118
    • 42649089790 scopus 로고    scopus 로고
    • Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators
    • DOI 10.1038/nri2294, PII NRI2294
    • Serhan CN, Chiang N, Van Dyke TE. 2008. Resolving inflammation: dual anti-inflammatory and proresolution lipid mediators. Nat. Rev. Immunol. 8:349-61 (Pubitemid 351595216)
    • (2008) Nature Reviews Immunology , vol.8 , Issue.5 , pp. 349-361
    • Serhan, C.N.1    Chiang, N.2    Van Dyke, T.E.3
  • 119
    • 77954218503 scopus 로고    scopus 로고
    • Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists
    • Dufton N, Perretti M. 2010. Therapeutic anti-inflammatory potential of formyl-peptide receptor agonists. Pharmacol. Ther. 127:175-88
    • (2010) Pharmacol. Ther. , vol.127 , pp. 175-88
    • Dufton, N.1    Perretti, M.2
  • 121
    • 40049099793 scopus 로고    scopus 로고
    • Formyl peptide receptor 1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42
    • BabbinBA, Jesaitis AJ, Ivanov AI, Kelly D, LaukoetterM, et al. 2007. Formyl peptide receptor 1 activation enhances intestinal epithelial cell restitution through phosphatidylinositol 3-kinase-dependent activation of Rac1 and Cdc42. J. Immunol. 179:8112-21
    • (2007) J. Immunol , vol.179 , pp. 8112-21
    • Babbin, B.A.1    Jesaitis, A.J.2    Ivanov, A.I.3    Kelly, D.4    Laukoetter, M.5
  • 122
    • 35248868413 scopus 로고    scopus 로고
    • Resolvin E1 promotes mucosal surface clearance of neutrophils: A new paradigm for inflammatory resolution
    • DOI 10.1096/fj.07-8473com
    • Campbell EL, Louis NA, Tomassetti SE, Canny GO, Arita M, et al. 2007. Resolvin E1 promotes mucosal surface clearance of neutrophils: a new paradigm for inflammatory resolution. FASEB J. 21:3162-70 (Pubitemid 47565535)
    • (2007) FASEB Journal , vol.21 , Issue.12 , pp. 3162-3170
    • Campbell, E.L.1    Louis, N.A.2    Tomassetti, S.E.3    Canny, G.O.4    Arita, M.5    Serhan, C.N.6    Colgan, S.P.7
  • 123
    • 77956293963 scopus 로고    scopus 로고
    • Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification
    • Campbell EL, MacManus CF, Kominsky DJ, Keely S, Glover LE, et al. 2010. Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxification. Proc. Natl. Acad. Sci. USA 107:14298-303
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 14298-303
    • Campbell, E.L.1    MacManus, C.F.2    Kominsky, D.J.3    Keely, S.4    Glover, L.E.5
  • 126
    • 60749125436 scopus 로고    scopus 로고
    • Epidermal homeostasis: A balancing act of stem cells in the skin
    • Blanpain C, Fuchs E. 2009. Epidermal homeostasis: a balancing act of stem cells in the skin. Nat. Rev. Mol. Cell Biol. 10:207-17
    • (2009) Nat. Rev. Mol. Cell Biol , vol.10 , pp. 207-17
    • Blanpain, C.1    Fuchs, E.2
  • 128
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. 1995. Inhibition of glycogen synthase kinase 3 by insulin mediated by protein kinase B. Nature 378:785-89 (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 130
    • 77955997469 scopus 로고    scopus 로고
    • Nuclear IKKis an adaptor protein for IκBubiquitination and degradation in UV-induced NF-κB activation
    • Tsuchiya Y, Asano T, Nakayama K, Kato T Jr, Karin M, Kamata H. 2010. Nuclear IKKis an adaptor protein for IκBubiquitination and degradation in UV-induced NF-κB activation. Mol. Cell 39:570-82
    • (2010) Mol. Cell , vol.39 , pp. 570-82
    • Tsuchiya, Y.1    Asano, T.2    Nakayama, K.3    Kato Jr., T.4    Karin, M.5    Kamata, H.6
  • 131
    • 33947631511 scopus 로고    scopus 로고
    • IL-1β causes an increase in intestinal epithelial tight junction permeability
    • Al-Sadi RM, Ma TY. 2007. IL-1αcauses an increase in intestinal epithelial tight junction permeability. J. Immunol. 178:4641-49 (Pubitemid 46492417)
    • (2007) Journal of Immunology , vol.178 , Issue.7 , pp. 4641-4649
    • Al-Sadi, R.M.1    Ma, T.Y.2
  • 132
    • 0028566861 scopus 로고
    • Caco-2 cells express type i interleukin-1 receptors: Ligand binding enhances proliferation
    • Varilek GW, Neil GA, Bishop WP. 1994. Caco-2 cells express type I interleukin-1 receptors: Ligand binding enhances proliferation. Am. J. Physiol. Gastrointest. Liver Physiol. 267:1101-7
    • (1994) Am. J. Physiol. Gastrointest. Liver Physiol , vol.267 , pp. 1101-7
    • Varilek, G.W.1    Neil, G.A.2    Bishop, W.P.3
  • 133
    • 0034776379 scopus 로고    scopus 로고
    • Interleukin 2 modulates ion secretion and cell proliferation in cultured human small intestinal enterocytes
    • DOI 10.1136/gut.49.5.636
    • O'Loughlin EV, Pang GP, Noltorp R, Koina C, Batey R, Clancy R. 2001. Interleukin 2 modulates ion secretion and cell proliferation in cultured human small intestinal enterocytes. Gut 49:636-43 (Pubitemid 32989199)
    • (2001) Gut , vol.49 , Issue.5 , pp. 636-643
    • O'Loughlin, E.V.1    Pang, G.P.2    Noltorp, R.3    Koina, C.4    Batey, R.5    Clancy, R.6
  • 135
    • 0029955709 scopus 로고    scopus 로고
    • Interleukin 2 modulates intestinal epithelial cell function in vitro
    • Dignass AU, Podolsky DK. 1996. Interleukin 2 modulates intestinal epithelial cell function in vitro. Exp. Cell Res. 225:422-29
    • (1996) Exp. Cell Res , vol.225 , pp. 422-29
    • Dignass, A.U.1    Podolsky, D.K.2
  • 137
    • 0025145163 scopus 로고
    • Synergistic effect of IL-4 and IFN-γ on the expression of polymeric Ig receptor (secretory component) and IgA binding by human epithelial cells
    • Phillips JO, EversonMP, Moldoveanu Z, Lue C, Mestecky J. 1990. Synergistic effect of IL-4 and IFN-γ on the expression of polymeric Ig receptor (secretory component) and IgA binding by human epithelial cells. J. Immunol. 145:1740-44 (Pubitemid 20336738)
    • (1990) Journal of Immunology , vol.145 , Issue.6 , pp. 1740-1744
    • Phillips, J.O.1    Everson, M.P.2    Moldoveanu, Z.3    Lue, C.4    Mestecky, J.5
  • 138
    • 0030018523 scopus 로고    scopus 로고
    • IL-4 enhances IEC-6 intestinal epithelial cell proliferation yet has no effect on IL-6 secretion
    • McGee DW, Vitkus SJ. 1996. IL-4 enhances IEC-6 intestinal epithelial cell proliferation yet has no effect on IL-6 secretion. Clin. Exp. Immunol. 105:274-77 (Pubitemid 26246945)
    • (1996) Clinical and Experimental Immunology , vol.105 , Issue.2 , pp. 274-277
    • Mcgee, D.W.1    Vitkus, S.J.D.2
  • 139
    • 0034599429 scopus 로고    scopus 로고
    • Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells
    • DOI 10.1016/S0304-3835(99)00401-2, PII S0304383599004012
    • Schneider MR, Hoeflich A, Fischer JR, Wolf E, Sordat B, Lahm H. 2000. Interleukin-6 stimulates clonogenic growth of primary and metastatic human colon carcinoma cells. Cancer Lett. 151:31-38 (Pubitemid 30155582)
    • (2000) Cancer Letters , vol.151 , Issue.1 , pp. 31-38
    • Schneider, M.R.1    Hoeflich, A.2    Fischer, J.R.3    Wolf, E.4    Sordat, B.5    Lahm, H.6
  • 140
    • 77149154988 scopus 로고    scopus 로고
    • Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice
    • Jin X, Zimmers TA, Zhang Z, Pierce RH, Koniaris LG. Interleukin-6 is an important in vivo inhibitor of intestinal epithelial cell death in mice. Gut 59:186-96
    • Gut , vol.59 , pp. 186-96
    • Jin, X.1    Zimmers, T.A.2    Zhang, Z.3    Pierce, R.H.4    Koniaris, L.G.5
  • 141
    • 2142679042 scopus 로고    scopus 로고
    • Interleukin-8 stimulates the migration of human colonic epithelial cells in vitro
    • DOI 10.1042/CS19980351
    • Wilson AJ, Byron K, Gibson PR. 1999. Interleukin-8 stimulates themigration of human colonic epithelial cells in vitro. Clin. Sci. 97:385-90 (Pubitemid 29425336)
    • (1999) Clinical Science , vol.97 , Issue.3 , pp. 385-390
    • Wilson, A.J.1    Byron, K.2    Gibson, P.R.3
  • 142
    • 0037405740 scopus 로고    scopus 로고
    • Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells
    • Ma D, Wolvers D, Stanisz AM, Bienenstock J. 2003. Interleukin-10 and nerve growth factor have reciprocal upregulatory effects on intestinal epithelial cells. Am. J. Physiol. Regul. Integr. Comp. Physiol. 284:1323-29
    • (2003) Am. J. Physiol. Regul. Integr. Comp. Physiol , vol.284 , pp. 1323-29
    • Ma, D.1    Wolvers, D.2    Stanisz, A.M.3    Bienenstock, J.4
  • 143
    • 0029747033 scopus 로고    scopus 로고
    • Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation
    • Peterson RL, Bozza MM, Dorner AJ. 1996. Interleukin-11 induces intestinal epithelial cell growth arrest through effects on retinoblastoma protein phosphorylation. Am. J. Pathol. 149:895-902 (Pubitemid 26334173)
    • (1996) American Journal of Pathology , vol.149 , Issue.3 , pp. 895-902
    • Peterson, R.L.1    Bozza, M.M.2    Dorner, A.J.3
  • 144
    • 0030006884 scopus 로고    scopus 로고
    • Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation
    • Orazi A, Du X, Yang Z, Kashai M, Williams DA. 1996. Interleukin-11 prevents apoptosis and accelerates recovery of small intestinal mucosa in mice treated with combined chemotherapy and radiation. Lab. Investig. 75:33-42 (Pubitemid 26250271)
    • (1996) Laboratory Investigation , vol.75 , Issue.1 , pp. 33-42
    • Orazi, A.1    Du, X.2    Yang, Z.3    Kashai, M.4    Williams, D.A.5
  • 145
    • 0029561579 scopus 로고
    • Effects of IL-11 on the growth of intestinal epithelial cells in vitro
    • Booth C, Potten CS. 1995. Effects of IL-11 on the growth of intestinal epithelial cells in vitro. Cell Prolif. 28:581-94 (Pubitemid 26018248)
    • (1995) Cell Proliferation , vol.28 , Issue.11 , pp. 581-594
    • Booth, C.1    Potten, C.S.2
  • 147
    • 77949317183 scopus 로고    scopus 로고
    • IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
    • Inoue S, Unsinger J, Davis CG, Muenzer JT, Ferguson TA, et al. IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis. J. Immunol. 184:1401-9
    • J. Immunol , vol.184 , pp. 1401-9
    • Inoue, S.1    Unsinger, J.2    Davis, C.G.3    Muenzer, J.T.4    Ferguson, T.A.5
  • 149
    • 26444433211 scopus 로고    scopus 로고
    • Interleukin-17 is a potent immuno-modulator and regulator of normal human intestinal epithelial cell growth
    • DOI 10.1016/j.bbrc.2005.09.075, PII S0006291X05021042
    • Schwartz S, Beaulieu JF, Ruemmele FM. 2005. Interleukin-17 is a potent immuno-modulator and regulator of normal human intestinal epithelial cell growth. Biochem. Biophys. Res. Commun. 337:505-9 (Pubitemid 41429313)
    • (2005) Biochemical and Biophysical Research Communications , vol.337 , Issue.2 , pp. 505-509
    • Schwartz, S.1    Beaulieu, J.F.2    Ruemmele, F.M.3
  • 151
    • 68849124464 scopus 로고    scopus 로고
    • The role of the novel Th17 cytokine IL-26 in intestinal inflammation
    • Dambacher J, Beigel F, Zitzmann K, De Toni EN, Goke B, et al. 2009. The role of the novel Th17 cytokine IL-26 in intestinal inflammation. Gut 58:1207-17
    • (2009) Gut , vol.58 , pp. 1207-17
    • Dambacher, J.1    Beigel, F.2    Zitzmann, K.3    De Toni, E.N.4    Goke, B.5
  • 152
    • 34548128025 scopus 로고    scopus 로고
    • Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease
    • DOI 10.1136/gut.2006.118679
    • Dambacher J, Beigel F, Seiderer J, Haller D, Goke B, et al. 2007. Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. Gut 56:1257-65 (Pubitemid 47300428)
    • (2007) Gut , vol.56 , Issue.9 , pp. 1257-1265
    • Dambacher, J.1    Beigel, F.2    Seiderer, J.3    Haller, D.4    Goke, B.5    Auernhammer, C.J.6    Brand, S.7
  • 153
    • 0024553788 scopus 로고
    • Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers
    • Madara JL, Stafford J. 1989. Interferon-γdirectly affects barrier function of cultured intestinal epithelial monolayers. J. Clin. Investig. 83:724-27 (Pubitemid 19061198)
    • (1989) Journal of Clinical Investigation , vol.83 , Issue.2 , pp. 724-727
    • Madara, J.L.1    Stafford, J.2
  • 154
    • 27444432552 scopus 로고    scopus 로고
    • IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression
    • Brand S, Beigel F, Olszak T, Zitzmann K, Eichhorst ST, et al. 2005. IL-28A and IL-29 mediate antiproliferative and antiviral signals in intestinal epithelial cells and murine CMV infection increases colonic IL-28A expression. Am. J. Physiol. Gastrointest. Liver Physiol. 289:960-68
    • (2005) Am. J. Physiol. Gastrointest. Liver Physiol , vol.289 , pp. 960-68
    • Brand, S.1    Beigel, F.2    Olszak, T.3    Zitzmann, K.4    Eichhorst, S.T.5
  • 156
    • 13244298599 scopus 로고    scopus 로고
    • Interferon-γ and tumor necrosis factor-α synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression
    • Wang F, Graham WV, Wang Y, Witkowski ED, Schwarz BT, Turner JR. 2005. Interferon-γand tumor necrosis factor synergize to induce intestinal epithelial barrier dysfunction by up-regulating myosin light chain kinase expression. Am. J. Pathol. 166:409-19 (Pubitemid 40189038)
    • (2005) American Journal of Pathology , vol.166 , Issue.2 , pp. 409-419
    • Wang, F.1    Graham, W.V.2    Wang, Y.3    Witkowski, E.D.4    Schwarz, B.T.5    Turner, J.R.6


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