메뉴 건너뛰기




Volumn 10, Issue 4, 2005, Pages 759-776

Decreased apoptosis in polyamine depleted IEC-6 cells depends on Akt-mediated NF-κB activation but not GSK3β activity

Author keywords

Akt; DFMO; GSK 3 ; IEC 6 cells; LY294002; NF B; Polyamines

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CASPASE 3; CASPASE 9; ENZYME INHIBITOR; GLYCOGEN SYNTHASE KINASE 3BETA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LITHIUM CHLORIDE; POLYAMINE; PROTEIN BAD; PROTEIN KINASE B; SERINE;

EID: 23944497169     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10495-005-2943-3     Document Type: Article
Times cited : (34)

References (60)
  • 1
    • 0034641918 scopus 로고    scopus 로고
    • The biochemistry of apoptosis
    • Hengartner MO. The biochemistry of apoptosis. Nature 2000; 407: 770-776.
    • (2000) Nature , vol.407 , pp. 770-776
    • Hengartner, M.O.1
  • 2
    • 0034641980 scopus 로고    scopus 로고
    • Apoptosis in development
    • Meier P, Finch A, Evan G. Apoptosis in development. Nature 2000; 407: 796-801.
    • (2000) Nature , vol.407 , pp. 796-801
    • Meier, P.1    Finch, A.2    Evan, G.3
  • 3
    • 0026731996 scopus 로고
    • The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice
    • Potten CS. The significance of spontaneous and induced apoptosis in the gastrointestinal tract of mice. Cancer Metastasis Rev 1992; 11: 179-195.
    • (1992) Cancer Metastasis Rev , vol.11 , pp. 179-195
    • Potten, C.S.1
  • 4
    • 0030472432 scopus 로고    scopus 로고
    • Apoptosis and gastrointestinal pharmacology
    • Pritchard DM, Watson AJ. Apoptosis and gastrointestinal pharmacology. Pharmacol Ther 1996; 72: 149-169.
    • (1996) Pharmacol Ther , vol.72 , pp. 149-169
    • Pritchard, D.M.1    Watson, A.J.2
  • 5
  • 6
    • 0028800002 scopus 로고
    • Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells
    • Tobias KE, Kahana C. Exposure to ornithine results in excessive accumulation of putrescine and apoptotic cell death in ornithine decarboxylase overproducing mouse myeloma cells. Cell Growth Differ 1995; 10: 1279-1285.
    • (1995) Cell Growth Differ , vol.10 , pp. 1279-1285
    • Tobias, K.E.1    Kahana, C.2
  • 7
    • 0142213140 scopus 로고    scopus 로고
    • Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells
    • Bhattacharya S, Ray M, Viar MJ, Johnson LR. Polyamines are required for activation of c-Jun NH2-terminal kinase and apoptosis in response to TNF-alpha in IEC-6 cells. Am J Physiol Gastrointest Liver Physiol. 2003; 285: G980-991.
    • (2003) Am J Physiol Gastrointest Liver Physiol , vol.285
    • Bhattacharya, S.1    Ray, M.2    Viar, M.J.3    Johnson, L.R.4
  • 8
    • 1342322887 scopus 로고    scopus 로고
    • Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2
    • Bhattacharya S, Ray RM, Johnson LR. Prevention of TNF-alpha-induced apoptosis in polyamine-depleted IEC-6 cells is mediated through the activation of ERK1/2. Am J Physiol Gastrointest Liver Physiol 2004; 286: G479-G490.
    • (2004) Am J Physiol Gastrointest Liver Physiol , vol.286
    • Bhattacharya, S.1    Ray, R.M.2    Johnson, L.R.3
  • 10
    • 2542451727 scopus 로고    scopus 로고
    • Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion
    • Zhang HM, Rao JN, Guo X, et al.. Akt kinase activation blocks apoptosis in intestinal epithelial cells by inhibiting caspase-3 after polyamine depletion. J Biol Chem 2004; 279: 22539-47.
    • (2004) J Biol Chem , vol.279 , pp. 22539-22547
    • Zhang, H.M.1    Rao, J.N.2    Guo, X.3
  • 11
    • 0026095665 scopus 로고
    • A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region
    • Bellacosa A, Testa J, Staal S, Tsichlis P. A retroviral oncogene, akt, encoding a serine-threonine kinase containing an SH2-like region. Science 1991; 254: 274-277.
    • (1991) Science , vol.254 , pp. 274-277
    • Bellacosa, A.1    Testa, J.2    Staal, S.3    Tsichlis, P.4
  • 12
    • 0037205048 scopus 로고    scopus 로고
    • The phosphoinositide 3-kinase pathway
    • Cantley LC. The phosphoinositide 3-kinase pathway. Science 2002; 296: 1655-1657.
    • (2002) Science , vol.296 , pp. 1655-1657
    • Cantley, L.C.1
  • 13
    • 0031127305 scopus 로고    scopus 로고
    • Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha
    • Alessi DR, James SR, Downes CP, et al. Characterization of a 3-phosphoinositide-dependent protein kinase which phosphorylates and activates protein kinase B alpha. Curr Biol 1997; 7: 261-269.
    • (1997) Curr Biol , vol.7 , pp. 261-269
    • Alessi, D.R.1    James, S.R.2    Downes, C.P.3
  • 14
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PKD connection: More than just a road tp PKB
    • Vanhaesebroeck B, Alessi DR. The PI3K-PKD connection: more than just a road tp PKB. Biochem J 2000; 346: 561-576.
    • (2000) Biochem J , vol.346 , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 15
    • 0036333737 scopus 로고    scopus 로고
    • Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B
    • Scheid MP, Marignani PA, Wooggett Jr. Multiple phosphoinositide 3-kinase-dependent steps in activation of protein kinase B. Mol Cell Biol 2002; 22: 6247-6260.
    • (2002) Mol Cell Biol , vol.22 , pp. 6247-6260
    • Scheid, M.P.1    Marignani, P.A.2    Wooggett, Jr.3
  • 16
    • 0031053586 scopus 로고    scopus 로고
    • Regulation of neuronal survival by the serine-threonine protein kinase Akt
    • Dudek H, Datta SR, Franke TF, et al. Regulation of neuronal survival by the serine-threonine protein kinase Akt. Science 1997; 275: 661-665.
    • (1997) Science , vol.275 , pp. 661-665
    • Dudek, H.1    Datta, S.R.2    Franke, T.F.3
  • 17
    • 0033568294 scopus 로고    scopus 로고
    • Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli
    • Goswami R, Kilkus J, Dawson SA, Dawson G. Overexpression of Akt (protein kinase B) confers protection against apoptosis and prevents formation of ceramide in response to pro-apoptotic stimuli. J Neurosci Res 1999; 57: 884-893.
    • (1999) J Neurosci Res , vol.57 , pp. 884-893
    • Goswami, R.1    Kilkus, J.2    Dawson, S.A.3    Dawson, G.4
  • 18
    • 0030904561 scopus 로고    scopus 로고
    • The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal
    • Kennedy SG, Wagner AJ, Conzen SD, et al. The PI 3-kinase/Akt signaling pathway delivers an anti-apoptotic signal. Genes Dev 1997; 11: 701-713.
    • (1997) Genes Dev , vol.11 , pp. 701-713
    • Kennedy, S.G.1    Wagner, A.J.2    Conzen, S.D.3
  • 19
    • 0031034574 scopus 로고    scopus 로고
    • Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylmositol 3-kinase, and Akt
    • Kulik G, Klippel A, Weber MJ. Antiapoptotic signalling by the insulin-like growth factor I receptor, phosphatidylmositol 3-kinase, and Akt. Mol Cell Biol 1997; 17: 1595-1606.
    • (1997) Mol Cell Biol , vol.17 , pp. 1595-1606
    • Kulik, G.1    Klippel, A.2    Weber, M.J.3
  • 20
    • 0034201965 scopus 로고    scopus 로고
    • Alpha5 beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylnositol 3-kinase and protein kinase B-dependent pathway
    • Lee JW, Juliano RL. alpha5 beta1 integrin protects intestinal epithelial cells from apoptosis through a phosphatidylnositol 3-kinase and protein kinase B-dependent pathway. Mol Biol Cell 2000; 11: 1973-1987.
    • (2000) Mol Biol Cell , vol.11 , pp. 1973-1987
    • Lee, J.W.1    Juliano, R.L.2
  • 21
    • 0033522927 scopus 로고    scopus 로고
    • Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner
    • Fujio Y, Walsh K. Akt mediates cytoprotection of endothelial cells by vascular endothelial growth factor in an anchorage-dependent manner. J Biol Chem 1999; 274: 16349-16354.
    • (1999) J Biol Chem , vol.274 , pp. 16349-16354
    • Fujio, Y.1    Walsh, K.2
  • 22
    • 0033964671 scopus 로고    scopus 로고
    • Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells
    • Hermann C, Assmus B, Urbich C, Zeiher AM, Dimmeler S. Insulin-mediated stimulation of protein kinase Akt: A potent survival signaling cascade for endothelial cells. Arterioscler Thromb Vasc Biol 2000; 20: 402-409.
    • (2000) Arterioscler Thromb Vasc Biol , vol.20 , pp. 402-409
    • Hermann, C.1    Assmus, B.2    Urbich, C.3    Zeiher, A.M.4    Dimmeler, S.5
  • 23
    • 0033582929 scopus 로고    scopus 로고
    • Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor
    • Brunet A, Bonni A, Zigmond MJ, et al. Akt promotes cell survival by phosphorylating and inhibiting a Forkhead transcription factor. Cell 1999; 96: 857-868.
    • (1999) Cell , vol.96 , pp. 857-868
    • Brunet, A.1    Bonni, A.2    Zigmond, M.J.3
  • 24
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997; 91: 231-241.
    • (1997) Cell , vol.91 , pp. 231-241
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 25
    • 1842333237 scopus 로고    scopus 로고
    • Interleukin-3 -induced phosphorylation of BAD through the protein kinase Akt
    • del Peso L, Gonzalez-Garcia M, Page C, Herrera R, Nunez G. Interleukin-3 -induced phosphorylation of BAD through the protein kinase Akt. Science 1997; 278: 687-689.
    • (1997) Science , vol.278 , pp. 687-689
    • Del Peso, L.1    Gonzalez-Garcia, M.2    Page, C.3    Herrera, R.4    Nunez, G.5
  • 26
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone MH, Roy N, Stennick HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-1321.
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1    Roy, N.2    Stennick, H.R.3
  • 27
    • 0035980060 scopus 로고    scopus 로고
    • Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis
    • Masuyama N, Oishi K, Mori Y, Ueno T, Takahama Y, Gotoh Y. Akt inhibits the orphan nuclear receptor Nur77 and T-cell apoptosis. J Biol Chem 2001; 276: 32799-32805.
    • (2001) J Biol Chem , vol.276 , pp. 32799-32805
    • Masuyama, N.1    Oishi, K.2    Mori, Y.3    Ueno, T.4    Takahama, Y.5    Gotoh, Y.6
  • 28
    • 0033517189 scopus 로고    scopus 로고
    • NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase
    • Ozes ON, Mayo LD, Gustin JA, Pfeffer SR, Pfeffer LM, Donner DB. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature 1999; 401: 82-85.
    • (1999) Nature , vol.401 , pp. 82-85
    • Ozes, O.N.1    Mayo, L.D.2    Gustin, J.A.3    Pfeffer, S.R.4    Pfeffer, L.M.5    Donner, D.B.6
  • 29
    • 0032493729 scopus 로고    scopus 로고
    • Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway
    • Pap M, Cooper GM. Role of glycogen synthase kinase-3 in the phosphatidylinositol 3-Kinase/Akt cell survival pathway. J Biol Chem 1998; 273: 19929-19932.
    • (1998) J Biol Chem , vol.273 , pp. 19929-19932
    • Pap, M.1    Cooper, G.M.2
  • 30
    • 0033517190 scopus 로고    scopus 로고
    • NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling
    • Romashkova JA, Makarov SS. NF-kappaB is a target of AKT in anti-apoptotic PDGF signalling. Nature 1999; 401: 86-90.
    • (1999) Nature , vol.401 , pp. 86-90
    • Romashkova, J.A.1    Makarov, S.S.2
  • 31
    • 0032808154 scopus 로고    scopus 로고
    • Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria
    • Kennedy SG, Kandel ES, Cross TK, Hay N. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol Cell Biol 1999; 19: 5800-5810.
    • (1999) Mol Cell Biol , vol.19 , pp. 5800-5810
    • Kennedy, S.G.1    Kandel, E.S.2    Cross, T.K.3    Hay, N.4
  • 32
    • 0034983918 scopus 로고    scopus 로고
    • Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase
    • Gottlob K, Majewski N, Kennedy S, Kandel E, Robey RB, Hay N. Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase. Genes Dev 2001; 15: 1406-1418.
    • (2001) Genes Dev , vol.15 , pp. 1406-1418
    • Gottlob, K.1    Majewski, N.2    Kennedy, S.3    Kandel, E.4    Robey, R.B.5    Hay, N.6
  • 33
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings, BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-789.
    • (1995) Nature , vol.378 , pp. 785-789
    • Cross, D.A.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 34
    • 0029874138 scopus 로고    scopus 로고
    • The NF-kappa B and I kappa B proteins: New discoveries and insights
    • Baldwin AS Jr. The NF-kappa B and I kappa B proteins: New discoveries and insights. Annu Rev Immunol 1996; 14: 649-683.
    • (1996) Annu Rev Immunol , vol.14 , pp. 649-683
    • Baldwin Jr., A.S.1
  • 35
    • 0034084163 scopus 로고    scopus 로고
    • Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity
    • Karin M, Ben-Neriah Y. Phosphorylation meets ubiquitination: The control of NF-[kappa]B activity. Annu Rev Immunol 2000; 16: 621-63.
    • (2000) Annu Rev Immunol , vol.16 , pp. 621-663
    • Karin, M.1    Ben-Neriah, Y.2
  • 36
    • 0034668149 scopus 로고    scopus 로고
    • Nuclear factor-kappa B, cancer, and apoptosis
    • Bours V, Bentires-Alj M, Hellin AC, et al. Nuclear factor-kappa B, cancer, and apoptosis. Biochem Pharmacol 2000; 60: 1085-1089.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1085-1089
    • Bours, V.1    Bentires-Alj, M.2    Hellin, A.C.3
  • 38
    • 0035824608 scopus 로고    scopus 로고
    • Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells
    • Pfeffer LM, Yang CH, Murti A, et al.. Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells. J Biol Chem 2001; 276: 45909-45913.
    • (2001) J Biol Chem , vol.276 , pp. 45909-45913
    • Pfeffer, L.M.1    Yang, C.H.2    Murti, A.3
  • 39
    • 0032575752 scopus 로고    scopus 로고
    • Mitochondria and apoptosis
    • Green DR, Reed JC. Mitochondria and apoptosis. Science 1998; 281: 1309-1312.
    • (1998) Science , vol.281 , pp. 1309-1312
    • Green, D.R.1    Reed, J.C.2
  • 40
    • 0034068601 scopus 로고    scopus 로고
    • Mitochondrial control of cell death
    • Kroemer G, Reed JC. Mitochondrial control of cell death. Nat Med 2000; 6: 513-519.
    • (2000) Nat Med , vol.6 , pp. 513-519
    • Kroemer, G.1    Reed, J.C.2
  • 41
    • 0032588317 scopus 로고    scopus 로고
    • NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
    • Wang CY, Guttridge DC, Mayo MW, Baldwin AS, Jr. NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol Cell Biol 1999; 19: 5923-5929.
    • (1999) Mol Cell Biol , vol.19 , pp. 5923-5929
    • Wang, C.Y.1    Guttridge, D.C.2    Mayo, M.W.3    Baldwin Jr., A.S.4
  • 42
    • 1242316958 scopus 로고    scopus 로고
    • JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD
    • Yu C, Minemoto Y, Zhang J, et al. JNK suppresses apoptosis via phosphorylation of the proapoptotic Bcl-2 family protein BAD. Mol Cell 2004; 13: 329-40.
    • (2004) Mol Cell , vol.13 , pp. 329-340
    • Yu, C.1    Minemoto, Y.2    Zhang, J.3
  • 43
    • 0030584088 scopus 로고    scopus 로고
    • Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L)
    • Zha J, Harada H, Yang E, Jockel J, Korsmeyer SJ. Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14-3-3 not BCL-X(L). Cell 1996; 87: 619-628.
    • (1996) Cell , vol.87 , pp. 619-628
    • Zha, J.1    Harada, H.2    Yang, E.3    Jockel, J.4    Korsmeyer, S.J.5
  • 44
    • 0033558215 scopus 로고    scopus 로고
    • The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis
    • Zong WX, Edelstein LC, Chen C, Bash J, Gelinas C. The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis. Genes Dev 1999; 13: 382-387.
    • (1999) Genes Dev , vol.13 , pp. 382-387
    • Zong, W.X.1    Edelstein, L.C.2    Chen, C.3    Bash, J.4    Gelinas, C.5
  • 45
    • 0036080433 scopus 로고    scopus 로고
    • Polyamine depletion prevents camptothecin-mduced apoptosis by inhibiting the release of cytochrome c
    • Yuan Q, Ray RM, Johnson LR. Polyamine depletion prevents camptothecin-mduced apoptosis by inhibiting the release of cytochrome c. Am J Physiol Cell Physiol 2002; 282: C1290-1297.
    • (2002) Am J Physiol Cell Physiol , vol.282
    • Yuan, Q.1    Ray, R.M.2    Johnson, L.R.3
  • 46
    • 0018394382 scopus 로고
    • Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria
    • Quaroni A, Wands J, Trelstad RL, Isselbacher KJ. Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria. J Cell Biol 1979; 80: 248-265.
    • (1979) J Cell Biol , vol.80 , pp. 248-265
    • Quaroni, A.1    Wands, J.2    Trelstad, R.L.3    Isselbacher, K.J.4
  • 47
    • 0036307626 scopus 로고    scopus 로고
    • RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion
    • Ray RM, Patel A, Viar MJ, et al. RhoA inactivation inhibits cell migration but does not mediate the effects of polyamine depletion. Gastroenterology 2002; 123: 196-205.
    • (2002) Gastroenterology , vol.123 , pp. 196-205
    • Ray, R.M.1    Patel, A.2    Viar, M.J.3
  • 48
    • 0242664588 scopus 로고    scopus 로고
    • Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418
    • Bhat R, Xue Y, Berg S, et al. Structural insights and biological effects of glycogen synthase kinase 3-specific inhibitor AR-A014418. J Biol Chem 2003; 278: 45937-45945.
    • (2003) J Biol Chem , vol.278 , pp. 45937-45945
    • Bhat, R.1    Xue, Y.2    Berg, S.3
  • 49
    • 85047692700 scopus 로고    scopus 로고
    • Glycogen synthase kinase-3b mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore
    • Juhaszova M, Zoroz DB, Kim SH, et al. Glycogen synthase kinase-3b mediates convergence of protection signaling to inhibit the mitochondrial permeability transition pore. J Clin Invest 2004; 113: 1535-1549.
    • (2004) J Clin Invest , vol.113 , pp. 1535-1549
    • Juhaszova, M.1    Zoroz, D.B.2    Kim, S.H.3
  • 50
    • 1942486873 scopus 로고    scopus 로고
    • NF-kappa B-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion
    • Zou T, Rao JN, Guo X, et al. NF-kappa B-mediated IAP expression induces resistance of intestinal epithelial cells to apoptosis after polyamine depletion. Am J Physiol Cell Physiol 2004; 286: C1009-18.
    • (2004) Am J Physiol Cell Physiol , vol.286
    • Zou, T.1    Rao, J.N.2    Guo, X.3
  • 51
    • 0032752063 scopus 로고    scopus 로고
    • Cellular survival: A play in three Akts
    • Datta SR, Brunet A, Greenberg ME. Cellular survival: A play in three Akts Genes Dev 1999; 13: 2905-2927.
    • (1999) Genes Dev , vol.13 , pp. 2905-2927
    • Datta, S.R.1    Brunet, A.2    Greenberg, M.E.3
  • 52
    • 0032515027 scopus 로고    scopus 로고
    • Regulation of cell death protease caspase-9 by phosphorylation
    • Cardone MH, Roy N, Stennicke HR, et al. Regulation of cell death protease caspase-9 by phosphorylation. Science 1998; 282: 1318-1321.
    • (1998) Science , vol.282 , pp. 1318-1321
    • Cardone, M.H.1    Roy, N.2    Stennicke, H.R.3
  • 54
    • 0032484019 scopus 로고    scopus 로고
    • CREB is a regulatory target for the protein kinase Akt/PKB
    • Du K, Montminy M. CREB is a regulatory target for the protein kinase Akt/PKB. J Biol Chem 1998; 273: 32377-32379.
    • (1998) J Biol Chem , vol.273 , pp. 32377-32379
    • Du, K.1    Montminy, M.2
  • 55
    • 0035133227 scopus 로고    scopus 로고
    • Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1
    • Kim AH, Khursigara G, Sun X, Franke TF, Chao MV. Akt phosphorylates and negatively regulates apoptosis signal-regulating kinase 1. Mol Cell Biol 2001; 21: 893-901.
    • (2001) Mol Cell Biol , vol.21 , pp. 893-901
    • Kim, A.H.1    Khursigara, G.2    Sun, X.3    Franke, T.F.4    Chao, M.V.5
  • 56
    • 0035379555 scopus 로고    scopus 로고
    • Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38
    • Madrid LV, Mayo MW, Reuther JY, Baldwin AS Jr. Akt stimulates the transactivation potential of the RelA/p65 Subunit of NF-kappa B through utilization of the Ikappa B kinase and activation of the mitogen-activated protein kinase p38. J Biol Chem 2001; 276: 18934-18940.
    • (2001) J Biol Chem , vol.276 , pp. 18934-18940
    • Madrid, L.V.1    Mayo, M.W.2    Reuther, J.Y.3    Baldwin Jr., A.S.4
  • 57
    • 0028809209 scopus 로고
    • Bad, a heterodimeric partner for Brl-XL and Bcl-2, displaces Bax and promotes cell death
    • Yang E, Zha J, Jockel J, Boise LM, Thompson, CB, Korsmeyer, SJ. Bad, a heterodimeric partner for Brl-XL and Bcl-2, displaces Bax and promotes cell death. Cell 1995; 80: 285-291.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.M.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 58
    • 0037119405 scopus 로고    scopus 로고
    • Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells
    • Yuan ZQ, Feldman RI, Sun M, et al. Inhibition of JNK by cellular stress- and tumor necrosis factor alpha-induced AKT2 through activation of the NF kappa B pathway in human epithelial Cells. J Biol Chem 2002; 277: 29973-29982.
    • (2002) J Biol Chem , vol.277 , pp. 29973-29982
    • Yuan, Z.Q.1    Feldman, R.I.2    Sun, M.3
  • 59
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinositide 3-kinases
    • Vanhaesebroeck B, Waterfield M. Signaling by distinct classes of phosphoinositide 3-kinases. Exp Cell Res 1999; 253: 239-254.
    • (1999) Exp Cell Res , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.2
  • 60
    • 0037037374 scopus 로고    scopus 로고
    • A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis
    • Schmidt M, Hovelmann S, Beckers TL. A novel form of constitutively active farnesylated Akt1 prevents mammary epithelial cells from anoikis and suppresses chemotherapy-induced apoptosis. British Journal of Cancer 2002; 87: 924-932.
    • (2002) British Journal of Cancer , vol.87 , pp. 924-932
    • Schmidt, M.1    Hovelmann, S.2    Beckers, T.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.