Constitutive expression of IL-18 and IL-18R in differentiated IEC-6 cells: Effect of TNF-α and IFN-γ treatment

Journal of Interferon and Cytokine Research

Volumn 28, Issue 5, 2008, Pages 287-296

  Kolinska, Jirina ^a   Lisa, Vera ^a   Clark, Jessica A ^b,c   Kozakova, Hana ^d   Zakostelecka, Marie ^a   Khailova, Ludmila ^b   Sinkora, Marek ^d   Kitanovicova, Andrea ^d   Dvorak, Bohuslav ^b  

^a INSTITUTE OF PHYSIOLOGY   (Czech Republic)

^b UNIVERSITY OF ARIZONA COLLEGE OF MEDICINE   (United States)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d INSTITUTE OF MICROBIOLOGY   (Czech Republic)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 18; INTERLEUKIN 18 RECEPTOR; INTERLEUKIN 18 RECEPTOR ALPHA; INTERLEUKIN 18 RECEPTOR BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MEMBRANE ENZYME; MESSENGER RNA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRUSH BORDER; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVITY; EXTRACELLULAR MATRIX; FLOW CYTOMETRY; GENE EXPRESSION; INFLAMMATION; INTESTINE EPITHELIUM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; RAT; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; BIOLOGICAL MARKERS; CASPASE 1; CELL COUNT; CELL DIFFERENTIATION; CELL LINE; CELL MEMBRANE; CHEMOKINE CCL2; CULTURE MEDIA; EPITHELIAL CELLS; GENE EXPRESSION REGULATION; INTERFERON-GAMMA; INTERLEUKIN-18; INTERLEUKIN-18 RECEPTOR ALPHA SUBUNIT; INTERLEUKIN-18 RECEPTOR BETA SUBUNIT; INTESTINES; RATS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TUMOR NECROSIS FACTOR-ALPHA;

RATTUS;

EID: 44249091188     PISSN: 10799907     EISSN: None     Source Type: Journal    
DOI: 10.1089/jir.2006.0130     Document Type: Article

References (57)

1. Azam T, Novick D, Bufler P, Yoon DY, Rubinstein M, Dinarello CA, Kim SH. 2003. Identification of a critical Ig-like domain in IL-18 receptor alpha and characterization of a functional IL-18 receptor complex. J Immunol 171:6574-6580.
2. Breese EJ, Michie CA, Nicholls SW, Murch SH, Williams CB, Domizio P, Walker-Smith JA, MacDonald TT. 1994. Tumor necrosis factor alpha-producing cells in the intestinal mucosa of children with inflammatory bowel disease. Gastroenterology 106:1455-1466.
3. 2 induce IL-18 and IL-18R beta expression in cardiomyocytes via NF-kappa B activation. Biochem Biophys Res Commun 303:1152-1158.
4. Chavez AM, Morin MJ, Unno N, Fink MP, Hodin RA. 1999. Acquired interferon gamma responsiveness during Caco-2 cell differentiation: effects on iNOS gene expression. Gut 44:659-665.
5. Choi C, Park JY, Lee J, Lim JH, Shin EC, Ahn YS, Kim CH, Kim SJ, Kim JD, Choi IS, Choi IH. 1999. Fas ligand and Fas are expressed constitutively in human astrocytes and the expression increases with IL-1, IL-6, TNF-alpha, or IFN-gamma. J Immunol 162:1889-1895.
6. Clark JA, Lane RH, Maclennan NK, Holubec H, Dvorakova K, Halpern MD, Williams CS, Payne CM, Dvorak B. 2005. Epidermal growth factor reduces intestinal apoptosis in an experimental model of necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 288:G755-762.
7. Dahlqvist A. 1964. Method for assay of intestinal disaccharidases. Anal Biochem 7:18-25.
8. Eaton AD, Xu D, Garside P. 2003. Administration of exogenous interleukin-18 and interleukin-12 prevents the induction of oral tolerance. Immunology 108:196-203.
9. Fantuzzi G, Reed DA, Dinarello CA. 1999. IL-12-induced IFN-gamma is dependent on caspase-1 processing of the IL-18 precursor. J Clin Invest 104:761-767.
10. Fish SM, Proujansky R, Reenstra WW. 1999. Synergistic effects of interferon gamma and tumour necrosis factor alpha on T84 cell function. Gut 45:191-198.
11. Gardella S, Andrei C, Costigliolo S, Poggi A, Zocchi MR, Rubartelli A. 1999. Interleukin-18 synthesis and secretion by dendritic cells are modulated by interaction with antigen-specific T cells. J Leukoc Biol 66:237-241.
12. Goodrich ME, McGee DW. 1998. Regulation of mucosal B cell immunoglobulin secretion by intestinal epithelial cell-derived cytokines. Cytokine 10:948-955.
13. Gu Y, Kuida K, Tsutsui H, Ku G, Hsiao K, Fleming MA, Hayashi N, Higashino K, Okamura H, Nakanishi K, Kurimoto M, Tanimoto T, Flavell RA, Sato V, Harding MW, Livingston DJ, Su MS. 1997. Activation of interferon-gamma inducing factor mediated by interleukin-1beta converting enzyme. Science 275:206-209.
14. Halpern MD, Clark JA, Saunders TA, Doelle SM, Hosseini DM, Stagner AM, Dvorak B. 2006. Reduction of experimental necrotizing enterocolitis with anti-TNF-α. Am J Physiol Gastrointest Liver Physiol 290:G757-764.
15. Halpern MD, Holubec H, Dominguez JA, Meza YG, Williams CS, Ruth MC, McCuskey RS, Dvorak B. 2003. Hepatic inflammatory mediators contribute to intestinal damage in necrotizing enterocolitis. Am J Physiol Gastrointest Liver Physiol 284:G695-702.
16. Halpern MD, Holubec H, Dominguez JA, Williams CS, Meza YG, McWilliam DL, Payne CM, McCuskey RS, Besselsen DG, Dvorak B. 2002. Up-regulation of IL-18 and IL-12 in the ileum of neonatal rats with necrotizing enterocolitis. Pediatr Res 51:733-739.
17. He Y, Chu SH, Walker WA. 1993. Nucleotide supplements alter proliferation and differentiation of cultured human (Caco-2) and rat (IEC-6) intestinal epithelial cells. J Nutr 123:1017-1027.
18. Hong TP, Andersen NA, Nielsen K, Karlsen AE, Fantuzzi G, Eizirik DL, Dinarello CA, Mandrup-Poulsen T. 2000. Interleukin-18 mRNA, but not interleukin-18 receptor mRNA, is constitutively expressed in islet beta-cells and up-regulated by interferon-gamma. Eur Cytokine Netw 11:193-205.
19. Kaiser GC, Polk DB. 1997. Tumor necrosis factor alpha regulates proliferation in a mouse intestinal cell line. Gastroenterology 112:1231-1240.
20. Kalina U, Koyama N, Hosoda T, Nuernberger H, Sato K, Hoelzer D, Herweck F, Manigold T, Singer MV, Rossol S, Bocker U. 2002. Enhanced production of IL-18 in butyrate-treated intestinal epithelium by stimulation of the proximal promoter region. Eur J Immunol 32:2635-2643.
21. Kim SH, Reznikov LL, Stuyt RJ, Selzman CH, Fantuzzi G, Hoshino T, Young HA, Dinarello CA. 2001. Functional reconstitution and regulation of IL-18 activity by the IL-18R beta chain. J Immunol 166:148-154.
22. Kolinska J, Kraml J. 1972. Separation and characterization of sucroseisomaltase and of glucoamylase of rat intestine. Biochim Biophys Acta 284:235-247.
23. Kraml J, Kolinska J, Ellederova D, Hirsova D. 1972. β-Glucosidase (phlorizin hydrolase) activity of the lactase fraction isolated from the small intestinal mucosa of infant rats, and the relationship between β-glucosidases and β-galactosidases. Biochim Biophys Acta 258:520-530.
24. Maerten P, Shen C, Colpaert S, Liu Z, Bullens DA, van Assche G, Penninckx F, Geboes K, Vanham G, Rutgeerts P, Ceuppens JL. 2004. Involvement of interleukin 18 in Crohn's disease: evidence from in vitro analysis of human gut inflammatory cells and from experimental colitis models. Clin Exp Immunol 135:310-317.
25. Melnikov VY, Ecder T, Fantuzzi G, Siegmund B, Lucia MS, Dinarello CA, Schrier RW, Edelstein CL. 2001. Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. J Clin Invest 107:1145-1152.
26. Menon RK, Shaufl A, Yu JH, Stephan DA, Friday RP. 2001. Identification and characterization of a novel transcript of the murine growth hormone receptor gene exhibiting development- and tissue-specific expression. Mol Cell Endocrinol 172:135-146.
27. Nagatsu T, Hino M, Fuyamada H, Hayakawa T, Sakakibara S. 1976. New chromogenic substrates for X-prolyl dipeptidyl-aminopeptidase. Anal Biochem 74:466-476.
28. Nakanishi K, Yoshimoto T, Tsutsui H, Okamura H. 2001. Interleukin-18 is a unique cytokine that stimulates both Th1 and Th2 responses depending on its cytokine milieu. Cytokine Growth Factor Rev 12:53-72.
29. Niessner M, Volk BA. 1995. Altered Th1/Th2 cytokine profiles in the intestinal mucosa of patients with inflammatory bowel disease as assessed by quantitative reversed transcribed polymerase chain reaction (RT-PCR). Clin Exp Immunol 101:428-435.
30. Okamura H, Nagata K, Komatsu T, Tanimoto T, Nukata Y, Tanabe F, Akita K, Torigoe K, Okura T, Fukuda S, Kurimoto M. 1995a. A novel costimulatory factor for gamma interferon induction found in the livers of mice causes endotoxic shock. Infect Immun 63:3966-7392.
31. Okamura H, Tsutsi H, Komatsu T, Yutsudo M, Hakura A, Tanimoto T, Torigoe K, Okura T, Nukada Y, Hattori K, et al. 1995b. Cloning of a new cytokine that induces IFN-gamma production by T cells. Nature 378:88-91.
32. Okazawa A, Kanai T, Nakamaru K, Sato T, Inoue N, Ogata H, Iwao Y, Ikeda M, Kawamura T, Makita S, Uraushihara K, Okamoto R, Yamazaki M, Kurimoto M, Ishii H, Watanabe M, Hibi T. 2004. Human intestinal epithelial cell-derived interleukin (IL)-18, along with IL-2, IL-7 and IL-15, is a potent synergistic factor for the proliferation of intraepithelial lymphocytes. Clin Exp Immunol 136:269-276.
33. Pages F, Berger A, Lebel-Binay S, Zinzindohoue F, Danel C, Piqueras B, Carriere O, Thiounn N, Cugnenc PH, Fridman WH. 2000. Proinflammatory and antitumor properties of interleukin-18 in the gastrointestinal tract. Immunol Lett 75:9-14.
34. Pham TD, MacLennan NK, Chiu CT, Laksana GS, Hsu JL, Lane RH. 2003. Uteroplacental insufficiency increases apoptosis and alters p53 gene methylation in the full-term IUGR rat kidney. Am J Physiol Regul Integr Comp Physiol 285:R962-970.
35. Pizarro TT, Michie MH, Bentz M, Woraratanadharm J, Smith MF Jr, Foley E, Moskaluk CA, Bickston SJ, Cominelli F. 1999. IL-18, a novel immunoregulatory cytokine, is up-regulated in Crohn's disease: expression and localization in intestinal mucosal cells. J Immunol 162:6829-6835.
36. + human blood mononuclear cells. J Clin Invest 101:711-721.
37. Quaroni A, Wands J, Trelstad RL, Isselbacher KJ. 1979. Epithelioid cell cultures from rat small intestine. Characterization by morphologic and immunologic criteria. J Cell Biol 80:248-265.
38. Reuter BK, Pizarro TT. 2004. Commentary: the role of the IL-18 system and other members of the IL-1R/TLR superfamily in innate mucosal immunity and the pathogenesis of inflammatory bowel disease: friend or foe? Eur J Immunol 34:2347-2355.
39. Ruemmele FM, Dionne S, Levy E, Seidman EG. 1999. TNFalpha-induced IEC-6 cell apoptosis requires activation of ICE caspases whereas complete inhibition of the caspase cascade leads to necrotic cell death. Biochem Biophys Res Commun 260:159-166.
40. Sartor RB. 1994. Cytokines in intestinal inflammation: pathophysiological and clinical considerations. Gastroenterology 106:533-539.
41. Semino C, Angelini G, Poggi A, Rubartelli A. 2005. NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1. Blood 106:609-616.
42. Siegmund B, Fantuzzi G, Rieder F, Gamboni-Robertson F, Lehr HA, Hartmann G, Dinarello CA, Endres S, Eigler A. 2001. Neutralization of interleukin-18 reduces severity in murine colitis and intestinal IFN-gamma and TNF-alpha production. Am J Physiol Regul Integr Comp Physiol 281:R1264-1273.
43. Sinkora M, Sinkorova J, Cimburek Z, Holtmeier W. 2007. Two groups of porcine TCRgammadelta+ thymocytes behave and diverge differently. J Immunol 178:711-719.
44. Sinkora M, Sinkorova J, Holtmeier W. 2005. Development of gammadelta thymocyte subsets during prenatal and postnatal ontogeny. Immunology 115:544-555.
45. Snoeck V, Goddeeris B, Cox E. 2005. The role of enterocytes in the intestinal barrier function and antigen uptake. Microbes Infect 7:997-1004.
46. Stadnyk AW. 2002. Intestinal epithelial cells as a source of inflammatory cytokines and chemokines. Can J Gastroenterol 16:241-246.
47. Stoll S, Muller G, Kurimoto M, Saloga J, Tanimoto T, Yamauchi H, Okamura H, Knop J, Enk AH. 1997. Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes. J Immunol 159:298-302.
48. Strand ML, Wahlgren A, Svechnikov K, Zetterstrom C, Setchell BP, Soder O. 2005. Interleukin-18 is expressed in rat testis and may promote germ cell growth. Mol Cell Endocrinol 240:64-73.
49. Takeuchi M, Nishizaki Y, Sano O, Ohta T, Ikeda M, Kurimoto M. 1997. Immunohistochemical and immuno-electron-microscopic detection of interferon-gamma-inducing factor ("interleukin-18") in mouse intestinal epithelial cells. Cell Tissue Res 289:499-503.
50. Tamura T, Ueda S, Yoshida M, Matsuzaki M, Mohri H, Okubo T. 1996. Interferon-gamma induces Ice gene expression and enhances cellular susceptibility to apoptosis in the U937 leukemia cell line. Biochem Biophys Res Commun 229:21-26.
51. Thompson GA, Meister A. 1976. Hydrolysis and transfer reactions catalyzed by gamma-glutamyl transpeptidase: evidence for separate substrate sites and for high affinity of L-cystine. Biochem Biophys Res Commun 71:32-36.
52. Torigoe K, Ushio S, Okura T, Kobayashi S, Taniai M, Kunikata T, Murakami T, Sanou O, Kojima H, Fujii M, Ohta T, Ikeda M, Ikegami H, Kurimoto M. 1997. Purification and characterization of the human interleukin-18 receptor. J Biol Chem 272:25737-25742.
53. Tsutsui H, Kayagaki N, Kuida K, Nakano H, Hayashi N, Takeda K, Matsui K, Kashiwamura S, Hada T, Akira S, Yagita H, Okamura H, Nakanishi K. 1999. Caspase-1-independent, Fas/Fas ligand-mediated IL-18 secretion from macrophages causes acute liver injury in mice. Immunity 11:359-367.
54. Udagawa N, Horwood NJ, Elliott J, Mackay A, Owens J, Okamura H, Kurimoto M, Chambers TJ, Martin TJ, Gillespie MT. 1997. Interleukin-18 (interferon-gamma-inducing factor) is produced by osteoblasts and acts via granulocyte/macrophage colony-stimulating factor and not via interferon-gamma to inhibit osteoclast formation. J Exp Med 185:1005-1012.
55. Vallee S, Laforest S, Fouchier F, Montero MP, Penel C, Champion S. 2004. Cytokine-induced upregulation of NF-kappaB, IL-8, and ICAM-1 is dependent on colonic cell polarity: implication for PKCdelta. Exp Cell Res 297:165-185.
56. Wood SR, Zhao Q, Smith LH, Daniels CK. 2003. Altered morphology in cultured rat intestinal epithelial IEC-6 cells is associated with alkaline phosphatase expression. Tissue Cell 35:47-58.
57. Ziambaras T, Rubin DC, Perlmutter DH. 1996. Regulation of sucraseisomaltase gene expression in human intestinal epithelial cells by inflammatory cytokines. J Biol Chem 271:1237-1242.