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Volumn 138, Issue 4, 2010, Pages

Distinct Effects of p38α Deletion in Myeloid Lineage and Gut Epithelia in Mouse Models of Inflammatory Bowel Disease

Author keywords

Colitis; Knockout Mice; p38

Indexed keywords

4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; DEXTRAN SULFATE; DIBENZAZEPINE DERIVATIVE; MITOGEN ACTIVATED PROTEIN KINASE 11; MITOGEN ACTIVATED PROTEIN KINASE 12; MITOGEN ACTIVATED PROTEIN KINASE 13; MITOGEN ACTIVATED PROTEIN KINASE 14; TRINITROBENZENESULFONIC ACID; IMIDAZOLE DERIVATIVE; PYRIDINE DERIVATIVE; SECRETASE;

EID: 77949841924     PISSN: 00165085     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.gastro.2010.01.005     Document Type: Article
Times cited : (92)

References (35)
  • 1
    • 33947546191 scopus 로고    scopus 로고
    • Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940-2000
    • Loftus C.G., Loftus Jr. E.V., Harmsen W.S., et al. Update on the incidence and prevalence of Crohn's disease and ulcerative colitis in Olmsted County, Minnesota, 1940-2000. Inflamm Bowel Dis 13 (2007) 254-261
    • (2007) Inflamm Bowel Dis , vol.13 , pp. 254-261
    • Loftus, C.G.1    Loftus Jr., E.V.2    Harmsen, W.S.3
  • 2
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • Podolsky D.K. Inflammatory bowel disease. N Engl J Med 347 (2002) 417-429
    • (2002) N Engl J Med , vol.347 , pp. 417-429
    • Podolsky, D.K.1
  • 3
    • 34547176642 scopus 로고    scopus 로고
    • Unravelling the pathogenesis of inflammatory bowel disease
    • Xavier R.J., and Podolsky D.K. Unravelling the pathogenesis of inflammatory bowel disease. Nature 448 (2007) 427-434
    • (2007) Nature , vol.448 , pp. 427-434
    • Xavier, R.J.1    Podolsky, D.K.2
  • 4
    • 33847381116 scopus 로고    scopus 로고
    • The fundamental basis of inflammatory bowel disease
    • Strober W., Fuss I., and Mannon P. The fundamental basis of inflammatory bowel disease. J Clin Invest 117 (2007) 514-521
    • (2007) J Clin Invest , vol.117 , pp. 514-521
    • Strober, W.1    Fuss, I.2    Mannon, P.3
  • 5
    • 0038337828 scopus 로고    scopus 로고
    • Targeting enteric bacteria in treatment of inflammatory bowel diseases: why, how, and when
    • Sartor R.B. Targeting enteric bacteria in treatment of inflammatory bowel diseases: why, how, and when. Curr Opin Gastroenterol 19 (2003) 358-365
    • (2003) Curr Opin Gastroenterol , vol.19 , pp. 358-365
    • Sartor, R.B.1
  • 6
    • 33745679123 scopus 로고    scopus 로고
    • Targeting signal transduction as a strategy to treat inflammatory diseases
    • O'Neill L.A. Targeting signal transduction as a strategy to treat inflammatory diseases. Nat Rev Drug Discov 5 (2006) 549-563
    • (2006) Nat Rev Drug Discov , vol.5 , pp. 549-563
    • O'Neill, L.A.1
  • 7
    • 0027936755 scopus 로고
    • A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells
    • Han J., Lee J.-D., Bibbs L., et al. A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells. Science 265 (1994) 808-811
    • (1994) Science , vol.265 , pp. 808-811
    • Han, J.1    Lee, J.-D.2    Bibbs, L.3
  • 8
    • 0142026209 scopus 로고    scopus 로고
    • p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases
    • Kumar S., Boehm J., and Lee J.C. p38 MAP kinases: key signalling molecules as therapeutic targets for inflammatory diseases. Nat Rev Drug Discov 2 (2003) 717-726
    • (2003) Nat Rev Drug Discov , vol.2 , pp. 717-726
    • Kumar, S.1    Boehm, J.2    Lee, J.C.3
  • 9
    • 0037093877 scopus 로고    scopus 로고
    • p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease
    • Waetzig G.H., Seegert D., Rosenstiel P., et al. p38 mitogen-activated protein kinase is activated and linked to TNF-alpha signaling in inflammatory bowel disease. J Immunol 168 (2002) 5342-5351
    • (2002) J Immunol , vol.168 , pp. 5342-5351
    • Waetzig, G.H.1    Seegert, D.2    Rosenstiel, P.3
  • 10
    • 0042845960 scopus 로고    scopus 로고
    • Review article: mitogen-activated protein kinases in chronic intestinal inflammation-targeting ancient pathways to treat modern diseases
    • Waetzig G.H., and Schreiber S. Review article: mitogen-activated protein kinases in chronic intestinal inflammation-targeting ancient pathways to treat modern diseases. Aliment Pharmacol Ther 18 (2003) 17-32
    • (2003) Aliment Pharmacol Ther , vol.18 , pp. 17-32
    • Waetzig, G.H.1    Schreiber, S.2
  • 11
    • 0036142395 scopus 로고    scopus 로고
    • Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease
    • Hommes D., van den B.B., Plasse T., et al. Inhibition of stress-activated MAP kinases induces clinical improvement in moderate to severe Crohn's disease. Gastroenterology 122 (2002) 7-14
    • (2002) Gastroenterology , vol.122 , pp. 7-14
    • Hommes, D.1    van den, B.B.2    Plasse, T.3
  • 12
    • 33644756429 scopus 로고    scopus 로고
    • Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial
    • Schreiber S., Feagan B., D'Haens G., et al. Oral p38 mitogen-activated protein kinase inhibition with BIRB 796 for active Crohn's disease: a randomized, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 4 (2006) 325-334
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 325-334
    • Schreiber, S.1    Feagan, B.2    D'Haens, G.3
  • 13
    • 17644405863 scopus 로고    scopus 로고
    • Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease
    • Hollenbach E., Vieth M., Roessner A., et al. Inhibition of RICK/nuclear factor-kappaB and p38 signaling attenuates the inflammatory response in a murine model of Crohn disease. J Biol Chem 280 (2005) 14981-14988
    • (2005) J Biol Chem , vol.280 , pp. 14981-14988
    • Hollenbach, E.1    Vieth, M.2    Roessner, A.3
  • 14
    • 9444228220 scopus 로고    scopus 로고
    • Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease
    • Hollenbach E., Neumann M., Vieth M., et al. Inhibition of p38 MAP kinase- and RICK/NF-kappaB-signaling suppresses inflammatory bowel disease. FASEB J 18 (2004) 1550-1552
    • (2004) FASEB J , vol.18 , pp. 1550-1552
    • Hollenbach, E.1    Neumann, M.2    Vieth, M.3
  • 15
    • 0036278884 scopus 로고    scopus 로고
    • Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis
    • ten Hove T., van den Blink B., Pronk I., et al. Dichotomal role of inhibition of p38 MAPK with SB 203580 in experimental colitis. Gut 50 (2002) 507-512
    • (2002) Gut , vol.50 , pp. 507-512
    • ten Hove, T.1    van den Blink, B.2    Pronk, I.3
  • 16
    • 33748164488 scopus 로고    scopus 로고
    • No evidence for an involvement of the p38 and JNK mitogen-activated protein in inflammatory bowel diseases
    • Malamut G., Cabane C., Dubuquoy L., et al. No evidence for an involvement of the p38 and JNK mitogen-activated protein in inflammatory bowel diseases. Dig Dis Sci 51 (2006) 1443-1453
    • (2006) Dig Dis Sci , vol.51 , pp. 1443-1453
    • Malamut, G.1    Cabane, C.2    Dubuquoy, L.3
  • 17
    • 44449100233 scopus 로고    scopus 로고
    • Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation
    • Kang Y.J., Chen J., Otsuka M., et al. Macrophage deletion of p38alpha partially impairs lipopolysaccharide-induced cellular activation. J Immunol 180 (2008) 5075-5082
    • (2008) J Immunol , vol.180 , pp. 5075-5082
    • Kang, Y.J.1    Chen, J.2    Otsuka, M.3
  • 18
    • 33947100032 scopus 로고    scopus 로고
    • Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation
    • Perdiguero E., Ruiz-Bonilla V., Gresh L., et al. Genetic analysis of p38 MAP kinases in myogenesis: fundamental role of p38alpha in abrogating myoblast proliferation. EMBO J 26 (2007) 1245-1256
    • (2007) EMBO J , vol.26 , pp. 1245-1256
    • Perdiguero, E.1    Ruiz-Bonilla, V.2    Gresh, L.3
  • 19
    • 50049122380 scopus 로고    scopus 로고
    • The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression
    • Kim C., Sano Y., Todorova K., et al. The kinase p38 alpha serves cell type-specific inflammatory functions in skin injury and coordinates pro- and anti-inflammatory gene expression. Nat Immunol 9 (2008) 1019-1027
    • (2008) Nat Immunol , vol.9 , pp. 1019-1027
    • Kim, C.1    Sano, Y.2    Todorova, K.3
  • 20
    • 0014509786 scopus 로고
    • Cell proliferation in gastrointestinal disease
    • Lipkin M. Cell proliferation in gastrointestinal disease. Natl Cancer Inst Monogr 30 (1969) 199-207
    • (1969) Natl Cancer Inst Monogr , vol.30 , pp. 199-207
    • Lipkin, M.1
  • 21
    • 0014059909 scopus 로고
    • Patterns of cell proliferation in gastrointestinal disease
    • Bell B., Deschner E., Almy T.P., et al. Patterns of cell proliferation in gastrointestinal disease. Dis Colon Rectum 10 (1967) 107-111
    • (1967) Dis Colon Rectum , vol.10 , pp. 107-111
    • Bell, B.1    Deschner, E.2    Almy, T.P.3
  • 22
    • 18844383961 scopus 로고    scopus 로고
    • p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes
    • Engel F.B., Schebesta M., Duong M.T., et al. p38 MAP kinase inhibition enables proliferation of adult mammalian cardiomyocytes. Genes Dev 19 (2005) 1175-1187
    • (2005) Genes Dev , vol.19 , pp. 1175-1187
    • Engel, F.B.1    Schebesta, M.2    Duong, M.T.3
  • 23
    • 34249334506 scopus 로고    scopus 로고
    • p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway
    • Hui L., Bakiri L., Mairhorfer A., et al. p38alpha suppresses normal and cancer cell proliferation by antagonizing the JNK-c-Jun pathway. Nat Genet 39 (2007) 741-749
    • (2007) Nat Genet , vol.39 , pp. 741-749
    • Hui, L.1    Bakiri, L.2    Mairhorfer, A.3
  • 24
    • 34249807348 scopus 로고    scopus 로고
    • p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation
    • Ventura J.J., Tenbaum S., Perdiguero E., et al. p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation. Nat Genet 39 (2007) 750-758
    • (2007) Nat Genet , vol.39 , pp. 750-758
    • Ventura, J.J.1    Tenbaum, S.2    Perdiguero, E.3
  • 25
    • 0037031856 scopus 로고    scopus 로고
    • Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine
    • Madison B.B., Dunbar L., Qiao X.T., et al. Cis elements of the villin gene control expression in restricted domains of the vertical (crypt) and horizontal (duodenum, cecum) axes of the intestine. J Biol Chem 277 (2002) 33275-33283
    • (2002) J Biol Chem , vol.277 , pp. 33275-33283
    • Madison, B.B.1    Dunbar, L.2    Qiao, X.T.3
  • 26
    • 0026081411 scopus 로고
    • Functional biology of intestinal goblet cells
    • Specian R.D., and Oliver M.G. Functional biology of intestinal goblet cells. Am J Physiol 260 (1991) C183-C193
    • (1991) Am J Physiol , vol.260
    • Specian, R.D.1    Oliver, M.G.2
  • 27
    • 0029836444 scopus 로고    scopus 로고
    • Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice
    • Neurath M.F., Pettersson S., Meyer zum Buschenfelde K.H., et al. Local administration of antisense phosphorothioate oligonucleotides to the p65 subunit of NF-kappa B abrogates established experimental colitis in mice. Nat Med 2 (1996) 998-1004
    • (1996) Nat Med , vol.2 , pp. 998-1004
    • Neurath, M.F.1    Pettersson, S.2    Meyer zum Buschenfelde, K.H.3
  • 28
    • 20544460148 scopus 로고    scopus 로고
    • Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells
    • van Es J.H., van Gijn M.E., Riccio O., et al. Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature 435 (2005) 959-963
    • (2005) Nature , vol.435 , pp. 959-963
    • van Es, J.H.1    van Gijn, M.E.2    Riccio, O.3
  • 29
    • 20544447734 scopus 로고    scopus 로고
    • Notch signals control the fate of immature progenitor cells in the intestine
    • Fre S., Huyghe M., Mourikis P., et al. Notch signals control the fate of immature progenitor cells in the intestine. Nature 435 (2005) 964-968
    • (2005) Nature , vol.435 , pp. 964-968
    • Fre, S.1    Huyghe, M.2    Mourikis, P.3
  • 30
    • 18544404101 scopus 로고    scopus 로고
    • Control of endodermal endocrine development by Hes-1
    • Jensen J., Pedersen E.E., Galante P., et al. Control of endodermal endocrine development by Hes-1. Nat Genet 24 (2000) 36-44
    • (2000) Nat Genet , vol.24 , pp. 36-44
    • Jensen, J.1    Pedersen, E.E.2    Galante, P.3
  • 31
    • 0035824487 scopus 로고    scopus 로고
    • Requirement of Math1 for secretory cell lineage commitment in the mouse intestine
    • Yang Q., Bermingham N.A., Finegold M.J., et al. Requirement of Math1 for secretory cell lineage commitment in the mouse intestine. Science 294 (2001) 2155-2158
    • (2001) Science , vol.294 , pp. 2155-2158
    • Yang, Q.1    Bermingham, N.A.2    Finegold, M.J.3
  • 32
    • 0033591344 scopus 로고    scopus 로고
    • Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase
    • Mikkola I., Bruun J.A., Bjorkoy G., et al. Phosphorylation of the transactivation domain of Pax6 by extracellular signal-regulated kinase and p38 mitogen-activated protein kinase. J Biol Chem 274 (1999) 15115-15126
    • (1999) J Biol Chem , vol.274 , pp. 15115-15126
    • Mikkola, I.1    Bruun, J.A.2    Bjorkoy, G.3
  • 33
    • 4043088499 scopus 로고    scopus 로고
    • IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer
    • Greten F.R., Eckmann L., Greten T.F., et al. IKKbeta links inflammation and tumorigenesis in a mouse model of colitis-associated cancer. Cell 118 (2004) 285-296
    • (2004) Cell , vol.118 , pp. 285-296
    • Greten, F.R.1    Eckmann, L.2    Greten, T.F.3
  • 34
    • 54449091097 scopus 로고    scopus 로고
    • Opposing functions of IKKbeta during acute and chronic intestinal inflammation
    • Eckmann L., Nebelsiek T., Fingerle A.A., et al. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A 105 (2008) 15058-15063
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 15058-15063
    • Eckmann, L.1    Nebelsiek, T.2    Fingerle, A.A.3
  • 35
    • 43249106330 scopus 로고    scopus 로고
    • Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation
    • Thornton T.M., Pedraza-Alva G., Deng B., et al. Phosphorylation by p38 MAPK as an alternative pathway for GSK3beta inactivation. Science 320 (2008) 667-670
    • (2008) Science , vol.320 , pp. 667-670
    • Thornton, T.M.1    Pedraza-Alva, G.2    Deng, B.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.