CD4+CD28- T cell expansion in granulomatosis with polyangiitis (Wegener's) is driven by latent cytomegalovirus infection and is associated with an increased risk of infection and mortality

Arthritis and Rheumatism

Volumn 63, Issue 7, 2011, Pages 2127-2137

  Morgan, Matthew D ^a,b   Pachnio, Annette ^a,b   Begum, Jusnara ^a,b   Roberts, David ^a,b   Rasmussen, Niels ^c   Neil, Desley A H ^a   Bajema, Ingeborg ^d   Savage, Caroline O S ^a,b   Moss, Paul A ^a   Harper, Lorraine ^a  

^a UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^b GLAXOSMITHKLINE   (United Kingdom)

^c STATENS SERUM INSTITUT   (Denmark)

^d LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; IMMUNOGLOBULIN G;

ADULT; AGED; ANCA ASSOCIATED VASCULITIS; ARTICLE; CD4+ T LYMPHOCYTE; CELL EXPANSION; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOMEGALOVIRUS INFECTION; FEMALE; GLOMERULUS FILTRATION RATE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOGLOBULIN BLOOD LEVEL; IMMUNOHISTOCHEMISTRY; INFECTION RISK; KIDNEY BIOPSY; LYMPHOCYTE PROLIFERATION; MALE; MORTALITY; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK FACTOR; WEGENER GRANULOMATOSIS;

ADULT; AGED; ANTIGENS, CD28; CD4-POSITIVE T-LYMPHOCYTES; CYTOMEGALOVIRUS; CYTOMEGALOVIRUS INFECTIONS; FEMALE; HUMANS; MALE; MIDDLE AGED; WEGENER GRANULOMATOSIS;

EID: 79959818390     PISSN: 00043591     EISSN: 15290131     Source Type: Journal    
DOI: 10.1002/art.30366     Document Type: Article

References (25)

1. Morgan MD, Harper L, Williams J, Savage C,. Anti-neutrophil cytoplasm-associated glomerulonephritis. J Am Soc Nephrol 2006; 17: 1224-34. (Pubitemid 43673402)
2. + effector memory T cells in Wegener's granulomatosis. Kidney Int 2006; 70: 938-47. (Pubitemid 44285972)
3. Popa ER, Stegeman CA, Bos NA, Kallenberg CG, Tervaert JW,. Differential B- and T-cell activation in Wegener's granulomatosis. J Allergy Clin Immunol 1999; 103: 885-94. (Pubitemid 29297593)
4. Schlesier M, Kaspar T, Gutfleisch J, Wolff-Vorbeck G, Peter H,. Activated CD4+ and CD8+ T-cell subsets in Wegener's granulomatosis. Rheumatol Int 1995; 14: 213-9.
5. Giscombe R, Nityanand S, Lewin N, Grunewald J, Lefvert A,. Expanded T cell populations in patients with Wegener's granulomatosis: characteristics and correlates with disease activity. J Clin Immunol 1998; 18: 404-13. (Pubitemid 28565218)
6. Moosig F, Csernok E, Wang G, Gross W,. Costimulatory molecules in Wegener's granulomatosis (WG): lack of expression of CD28 and preferential up-regulation of its ligands B7-1 (CD80) and B7-2 (CD86) on T cells. Clin Exp Immunol 1998; 114: 113-8. (Pubitemid 28442822)
7. Lamprecht P, Mueller A, Gross WL,. CD28- T cells display features of effector memory T cells in Wegener's granulomatosis [letter]. Kidney Int 2004; 65: 1113.
8. - T-cells are a major source of interferon Î and tumour necrosis factor α in Wegener's granulomatosis. Am J Pathol 2002; 160: 1717-24. (Pubitemid 34525651)
9. Hooper M, Kallas EG, Coffin D, Campbell D, Evans TG, Looney RJ,. Cytomegalovirus seropositivity is associated with the expansion of CD4+CD28- and CD8+CD28- T cells in rheumatoid arthritis. J Rheumatol 1999; 26: 1452-7. (Pubitemid 29317864)
10. Jayne DR, Gaskin G, Rasmussen N, Abramowicz D, Ferrario F, Guillevin L, et al. Randomized trial of plasma exchange or high-dosage methylprednisolone as adjunctive therapy for severe renal vasculitis. J Am Soc Nephrol 2007; 18: 2180-8. (Pubitemid 47041083)
11. De Groot K, Harper L, Jayne DR, Flores Suarez LF, Gregorini G, Gross WL, et al. Pulse versus daily oral cyclophosphamide for induction of remission in antineutrophil cytoplasmic antibody-associated vasculitis: a randomized trial. Ann Intern Med 2009; 150: 670-80.
12. Jayne D, Rasmussen N, Andrassy K, Bacon P, Tervaert JW, Dadoniene J, et al. A randomized trial of maintenance therapy for vasculitis associated with antineutrophil cytoplasmic autoantibodies. N Engl J Med 2003; 349: 36-44. (Pubitemid 36765101)
13. De Groot K, Rasmussen N, Bacon PA, Tervaert JW, Feighery C, Gregorini G, et al, for the European Vasculitis Study Group. Randomized trial of cyclophosphamide versus methotrexate for induction of remission in early systemic antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Rheum 2005; 52: 2461-9. (Pubitemid 41117433)
14. Moins-Teisserenc H, Busson M, Scieux C, Bajzik V, Cayuela JM, Clave E, et al. Patterns of cytomegalovirus reactivation are associated with distinct evolutive profiles of immune reconstitution after allogeneic hematopoietic stem cell transplantation. J Infect Dis 2008; 198: 818-26.
15. Serriari N, Gondois-Rey F, Guillaume Y, Remmerswaal E, Pastor S, Messal N, et al. B and T lymphocyte attenuator is highly expressed on CMV-specific T cells during infection and regulates their function. J Immunol 2010; 185: 3140-8.
16. + T-cell repertoire. J Virol 2007; 81: 7759-65. (Pubitemid 47047862)
17. Little MA, Nightingale P, Verburgh CA, Hauser T, De Groot K, Savage C, et al. Early mortality in systemic vasculitis: relative contribution of adverse events and active vasculitis. Ann Rheum Dis 2009; 69: 1036-43.
18. +, cytomegalovirus-specific T cell subset after recovery of primary cytomegalovirus infection. J Immunol 2004; 173: 1834-41. (Pubitemid 38971617)
19. Vogt S, Iking-Konert C, Hug F, Andrassy K, Hansch GM,. Shortening of telomeres: evidence for replicative senescence of T cells derived from patients with Wegener's granulomatosis. Kidney Int 2003; 63: 2144-51. (Pubitemid 36605825)
20. Thewissen M, Somers V, Venken K, Linsen L, Van Paassen P, Geusens P, et al. Analyses of immunosenescent markers in patients with autoimmune disease. Clin Immunol 2007; 123: 209-18. (Pubitemid 46590073)
21. + T cells in living kidney transplant patients with long-term allograft acceptance. Hum Immunol 2001; 62: 1335-45. (Pubitemid 33116971)
22. - T cells. Virology 2009; 398: 158-67.
23. - T-cells and in granulomatous lesions between localized and generalized Wegener's granulomatosis. Clin Immunol 2003; 108: 1-7. (Pubitemid 36809210)
24. Lamprecht P, Moosig F, Csernok E, Seitzer U, Schnabel A, Mueller A, et al. CD28 negative T-cells are enriched in granulomatous lesions of the respiratory tract in Wegener's granulomatosis. Thorax 2001; 56: 751-7. (Pubitemid 32917543)
25. null T cells in autoimmune disease: pathogenic features and decreased susceptibility to immunoregulation. J Immunol 2007; 179: 6514-23.