The number of cytomegalovirus-specific CD4+ T cells is markedly expanded in patients with B-cell chronic lymphocytic leukemia and determines the total CD4+ T-cell repertoire

Blood

Volumn 116, Issue 16, 2010, Pages 2968-2974

  Pourgheysari, Batoul ^a,b   Bruton, Rachel ^a   Parry, Helen ^a   Billingham, Lucinda ^a   Fegan, Chris ^c   Murray, Jim ^d   Moss, Paul ^a,d  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b SHAHREKORD UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^d University Hospitals National Health Service Foundation Trust   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CD27 ANTIGEN; CD28 ANTIGEN; CD45RO ANTIGEN; CHEMOKINE RECEPTOR CCR7; CHLORAMBUCIL; FLUDARABINE;

ADULT; AGED; ARTICLE; B CELL LEUKEMIA; CANCER CHEMOTHERAPY; CANCER STAGING; CANCER SURVIVAL; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CELL COUNT; CELL EXPANSION; CELL SPECIFICITY; CHRONIC LYMPHATIC LEUKEMIA; CONTROLLED STUDY; CYTOMEGALOVIRUS; FEMALE; HUMAN; IMMUNE RESPONSE; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION;

EID: 77958167920     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2009-12-257147     Document Type: Article

References (24)

1. Wadhwa P, Morrison VA. Infectious complications of chronic lymphocytic leukemia. Semin Oncol. 2006;33(2):240-249.
2. Ben-Bassat I, Many A, Modan M, Peretz C, Ramot B. Serum immunoglobulins in chronic lymphocytic leukemia. Am J Med Sci. 1979;278(1):4-9. (Pubitemid 10242764)
3. Sampalo A, Navas G, Medina F, Segundo C, Cámara C, Brieva JA. Chronic lymphocytic leukemia B cells inhibit spontaneous Ig production by autologous bone marrow cells: role of CD95-CD95L interaction. Blood. 2000;96(9):3168-3174.
4. Ravandi F, O'Brien S. Immune defects in patients with chronic lymphocytic leukemia. Cancer Immunol Immunother. 2006;55(2):197-209. (Pubitemid 41682592)
5. Hamblin AD, Hamblin TJ. The immunodeficiency of chronic lymphocytic leukaemia. Br Med Bull. 2008;87:49-62.
6. Johnston PB, Kay NE. Pathogenesis of impaired cellular immune function in CLL. In: Chronic Lymphocytic Leukemia: Molecular Genetics, Biology, Diagnosis and Management. Faguet GB, ed. Totowa, NJ: Humana Press; 2004:109-121.
7. Catovsky D, Lauria F, Matutes E, et al. Increase in T gamma lymphocytes in B-cell chronic lymphocytic leukaemia. II. Correlation with clinical stage and findings in B-prolymphocytic leukaemia. Br J Haematol. 1981;47(4):539-44.
8. Whelan CA, Willoughby R, McCann SR. T-cell function in chronic lymphocytic leukaemia. Br J Haematol. 1982;50(1):111-21. (Pubitemid 12168673)
9. Gorgun G, Holderried TA, Zahrieh D, Neuberg D, Gribben JG. Chronic lymphocytic leukaemia cells induce changes in gene expression of CD4 and CD8 T cells. J. Clin Invest. 2005;115(7):1797-805.
10. Gillespie GM, Wills MR, Appay V, et al. Functional heterogeneity and high frequencies of cytomegalovirus-specific CD8(+) T lymphocytes in healthy seropositive donors. J Virol. 2000;74(17):8140-50.
11. Harari A, Zimmerli SC, Pantaleo G. Cytomegalovirus (CMV)-specific cellular immune responses. Hum Immunol. 2004;65(5):500-6. (Pubitemid 38686774)
12. Mackus WJ, Frakking FN, Grummels A, et al. Expansion of CMV-specific CD8 + CD45RA + CD27- T cells in B-cell chronic lymphocytic leukemia. Blood. 2003;102:1057-1063.
13. Hooper M, Kallas EG, Coffin D, Campbell D, Evans TG, Looney RJ. Cytomegalovirus seropositivity is associated with the expansion of CD4+CD28- and CD8+CD28- T cells in rheumatoid arthritis. J Rheumatol. 1999;26(7):1452-7.
14. Pourgheysari B, Khan N, Best D, Bruton R, Nayak L, Moss PA. The cytomegalovirus-specific CD4+ T-cell response expands with age and markedly alters the CD4+ T-cell repertoire. J Virol. 2007;81:7759-7765.
15. Fletcher JM, Vukmanovic-Stejic M, Dunne PJ, et al. Cytomegalovirus- specific CD4+ T cells in healthy carriers are continuously driven to replicative exhaustion. J Immunol. 2005;175(12):8218-25.
16. Waldrop SL, Davis KA, Maino VC, Picker LJ. Normal human CD4+ memory T cells display broad heterogeneity in their activation threshold for cytokine synthesis. J Immunol. 1998;161(10):5284-95.
17. Frolova EA, Richards SJ, Jones RA, et al. Immunophenotypic and DNA genotypic analysis of T-cell and NK-cell subpopulations in patients with B-cell chronic lymphocytic leukaemia (B-CLL). Leuk Lymphoma. 1995;16(3-4):307-18.
18. Ramsay AG, Johnson AJ, Lee AM, et al. Chronic lymphocytic leukaemia cells show impaired immunological synapse formation that can be reversed with an immunomodulating drug. J Clin Invest. 2008;118(7):2427-2433.
19. Serrano D, Monteiro J, Allen SL, et al. Clonal expansion within the CD4+CD57+ and CD8+CD57+ T cell subsets in chronic lymphocytic leukemia. J Immunol. 1997;158(3):1482-9.
20. Porakishvili N, Kardava L, Jewell AP, et al. Cytotoxic CD4+ T cells in patients with B cell chronic lymphocytic leukemia kill via a perforin-mediated pathway. Haematologica. 2004;89(4):435-43.
21. Katrinakis G, Kyriakou D, Alexandrakis M, Sakellariou D, Foudoulakis A, Eliopoulos GD. Evidence for involvement of activated CD8+/HLA-DR+ cells in the pathogenesis of neutropenia in patients with B-cell chronic lymphocytic leukaemia. Eur J Haematol. 1995;55(1):33-41.
22. Cwynarski K, Ainsworth J, Cobbold M, et al. Direct visualization of cytomegalovirus-specific T-cell reconstitution after allogeneic stem cell transplantation. Blood. 2001;97(5):1232-40.
23. Hillmen P, Skotnicki AB, Robak T, et al. Alemtuzumab compared with chlorambucil as first-line therapy for chronic lymphocytic leukemia. J Clin Oncol. 2007;25:5616-5623.
24. Chidrawar S, Khan N, Wei W, et al. Cytomegalo-virus-seropositivity has a profound influence on the magnitude of major lymphoid subsets within healthy individuals. Clin Exp Immunol. 2009;155(3):423-32.