메뉴 건너뛰기




Volumn 9, Issue 4, 2010, Pages 478-489

Thiazolidinedione treatment and constitutive-PPARγ activation induces ectopic adipogenesis and promotes age-related thymic involution

Author keywords

Aging; Bone marrow adipocytes; Insulin; Kgf; Mesenchymal; T cells

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; CALVASCULIN; HYBRID PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; ROSIGLITAZONE; T LYMPHOCYTE RECEPTOR; LIGAND; LYMPHOCYTE ANTIGEN RECEPTOR;

EID: 77955652947     PISSN: 14749718     EISSN: 14749726     Source Type: Journal    
DOI: 10.1111/j.1474-9726.2010.00574.x     Document Type: Article
Times cited : (31)

References (60)
  • 1
    • 0035496231 scopus 로고    scopus 로고
    • Lymphostromal interactions in thymic development and function
    • Anderson G, Jenkinson EJ (2001) Lymphostromal interactions in thymic development and function. Nat. Rev. Immunol. 1, 31-40.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 31-40
    • Anderson, G.1    Jenkinson, E.J.2
  • 2
    • 46949110881 scopus 로고    scopus 로고
    • Reversal of age-associated thymic atrophy: treatments, delivery, and side effects
    • Aspinall R, Mitchell W (2008) Reversal of age-associated thymic atrophy: treatments, delivery, and side effects. Exp. Gerontol. 43, 700-705.
    • (2008) Exp. Gerontol. , vol.43 , pp. 700-705
    • Aspinall, R.1    Mitchell, W.2
  • 3
    • 34250212481 scopus 로고    scopus 로고
    • Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from
    • Bhandoola A, von Boehmer H, Petrie HT, Zúñiga-Pflücker JC (2007) Commitment and developmental potential of extrathymic and intrathymic T cell precursors: plenty to choose from. Immunity 26, 678-689.
    • (2007) Immunity , vol.26 , pp. 678-689
    • Bhandoola, A.1    von Boehmer, H.2    Petrie, H.T.3    Zúñiga-Pflücker, J.C.4
  • 4
    • 0031726324 scopus 로고    scopus 로고
    • Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment
    • von Boehmer H, Aifantis I, Azogui O, Feinberg J, Saint-Ruf C, Zober C, Garcia C, Buer J (1998) Crucial function of the pre-T-cell receptor (TCR) in TCR beta selection, TCR beta allelic exclusion and alpha beta versus gamma delta lineage commitment. Immunol. Rev. 165, 111-119.
    • (1998) Immunol. Rev. , vol.165 , pp. 111-119
    • von Boehmer, H.1    Aifantis, I.2    Azogui, O.3    Feinberg, J.4    Saint-Ruf, C.5    Zober, C.6    Garcia, C.7    Buer, J.8
  • 5
    • 0030964085 scopus 로고    scopus 로고
    • Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase
    • Camp HS, Tafuri SR (1997) Regulation of peroxisome proliferator-activated receptor gamma activity by mitogen-activated protein kinase. J. Biol. Chem. 272, 10811-10816.
    • (1997) J. Biol. Chem. , vol.272 , pp. 10811-10816
    • Camp, H.S.1    Tafuri, S.R.2
  • 6
    • 0032894240 scopus 로고    scopus 로고
    • c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity
    • Camp HS, Tafuri SR, Left T (1999) c-Jun N-terminal kinase phosphorylates peroxisome proliferator-activated receptor-gamma1 and negatively regulates its transcriptional activity. Endocrinology 140, 392-397.
    • (1999) Endocrinology , vol.140 , pp. 392-397
    • Camp, H.S.1    Tafuri, S.R.2    Left, T.3
  • 7
    • 36549062401 scopus 로고    scopus 로고
    • Impact of niche aging on thymic regeneration and immune reconstitution
    • Chidgey A, Dudakov J, Seach N, Boyd R (2007) Impact of niche aging on thymic regeneration and immune reconstitution. Semin. Immunol. 19, 331-340.
    • (2007) Semin. Immunol. , vol.19 , pp. 331-340
    • Chidgey, A.1    Dudakov, J.2    Seach, N.3    Boyd, R.4
  • 8
    • 54249149973 scopus 로고    scopus 로고
    • Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span
    • Dixit VD (2008) Adipose-immune interactions during obesity and caloric restriction: reciprocal mechanisms regulating immunity and health span. J. Leukoc. Biol. 84, 882-892.
    • (2008) J. Leukoc. Biol. , vol.84 , pp. 882-892
    • Dixit, V.D.1
  • 10
    • 0031439111 scopus 로고    scopus 로고
    • p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha
    • Dowell P, Ishmael JE, Avram D, Peterson VJ, Nevrivy DJ, Leid M (1997) p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha. J. Biol. Chem. 272, 33435-33443.
    • (1997) J. Biol. Chem. , vol.272 , pp. 33435-33443
    • Dowell, P.1    Ishmael, J.E.2    Avram, D.3    Peterson, V.J.4    Nevrivy, D.J.5    Leid, M.6
  • 11
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • Evans R, Barish GD, Wang YX (2004) PPARs and the complex journey to obesity. Nat. Med. 10, 1-7.
    • (2004) Nat. Med. , vol.10 , pp. 1-7
    • Evans, R.1    Barish, G.D.2    Wang, Y.X.3
  • 16
    • 35348874911 scopus 로고    scopus 로고
    • Developmental origin of fat: tracking obesity to its source
    • Gesta S, Tseng YH, Kahn CR (2007) Developmental origin of fat: tracking obesity to its source. Cell 131, 242-256.
    • (2007) Cell , vol.131 , pp. 242-256
    • Gesta, S.1    Tseng, Y.H.2    Kahn, C.R.3
  • 17
    • 0034234237 scopus 로고    scopus 로고
    • CBP/p300 in cell growth, transformation, and development
    • Goodman RH, Smolik S (2000) CBP/p300 in cell growth, transformation, and development. Genes Dev. 14, 1553-1577.
    • (2000) Genes Dev , vol.14 , pp. 1553-1577
    • Goodman, R.H.1    Smolik, S.2
  • 22
    • 34648832073 scopus 로고    scopus 로고
    • Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials
    • Lago RM, Singh PP, Nesto RW (2007) Congestive heart failure and cardiovascular death in patients with prediabetes and type 2 diabetes given thiazolidinediones: a meta-analysis of randomised clinical trials. Lancet 370, 1129-1136.
    • (2007) Lancet , vol.370 , pp. 1129-1136
    • Lago, R.M.1    Singh, P.P.2    Nesto, R.W.3
  • 23
    • 46749115113 scopus 로고    scopus 로고
    • PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease
    • Landreth G, Jiang Q, Mandrekar S, Heneka M (2008) PPARgamma agonists as therapeutics for the treatment of Alzheimer's disease. Neurotherapeutics 5, 481-489.
    • (2008) Neurotherapeutics , vol.5 , pp. 481-489
    • Landreth, G.1    Jiang, Q.2    Mandrekar, S.3    Heneka, M.4
  • 24
    • 1142275269 scopus 로고    scopus 로고
    • Age-related changes in lymphocyte development and function
    • Linton PJ, Dorshkind K (2004) Age-related changes in lymphocyte development and function. Nat. Immunol. 5, 133-139.
    • (2004) Nat. Immunol. , vol.5 , pp. 133-139
    • Linton, P.J.1    Dorshkind, K.2
  • 25
    • 58149468801 scopus 로고    scopus 로고
    • Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis
    • Lu FP, Lin KP, Kuo HK (2009) Diabetes and the risk of multi-system aging phenotypes: a systematic review and meta-analysis. PLoS ONE 4, e4144.
    • (2009) PLoS ONE , vol.4
    • Lu, F.P.1    Lin, K.P.2    Kuo, H.K.3
  • 28
    • 34548864933 scopus 로고    scopus 로고
    • PPARs in calorie restricted and genetically long-lived mice
    • Masternak MM, Bartke A (2007) PPARs in calorie restricted and genetically long-lived mice. PPAR Res. 2007, 1-7.
    • (2007) PPAR Res , vol.2007 , pp. 1-7
    • Masternak, M.M.1    Bartke, A.2
  • 30
    • 0030035583 scopus 로고    scopus 로고
    • The aging immune system: primer and prospectus
    • Miller RA (1996) The aging immune system: primer and prospectus. Science 273, 70-74.
    • (1996) Science , vol.273 , pp. 70-74
    • Miller, R.A.1
  • 31
    • 47849086589 scopus 로고    scopus 로고
    • Diabetes and aging: epidemiologic overview
    • Morley JE (2008) Diabetes and aging: epidemiologic overview. Clin. Geriatr. Med. 24, 395-405.
    • (2008) Clin. Geriatr. Med. , vol.24 , pp. 395-405
    • Morley, J.E.1
  • 35
    • 84867789950 scopus 로고    scopus 로고
    • National Institute on Aging, National Institutes of Health. Publication No. 07-6134, March 2007
    • National Institute on Aging, National Institutes of Health. Publication No. 07-6134, March 2007.
  • 36
    • 67650504733 scopus 로고    scopus 로고
    • Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment
    • Naveiras O, Nardi V, Wenzel PL, Hauschka PV, Fahey F, Daley GQ (2009) Bone-marrow adipocytes as negative regulators of the haematopoietic microenvironment. Nature 460, 259-263.
    • (2009) Nature , vol.460 , pp. 259-263
    • Naveiras, O.1    Nardi, V.2    Wenzel, P.L.3    Hauschka, P.V.4    Fahey, F.5    Daley, G.Q.6
  • 39
    • 0027251463 scopus 로고
    • The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments
    • Pannetier C, Cochet M, Darche S, Casrouge A, Zöller M, Kourilsky P (1993) The sizes of the CDR3 hypervariable regions of the murine T-cell receptor beta chains vary as a function of the recombined germ-line segments. Proc. Natl Acad. Sci. USA 90, 4319-4323.
    • (1993) Proc. Natl Acad. Sci. USA , vol.90 , pp. 4319-4323
    • Pannetier, C.1    Cochet, M.2    Darche, S.3    Casrouge, A.4    Zöller, M.5    Kourilsky, P.6
  • 41
    • 33846877211 scopus 로고    scopus 로고
    • Maintenance of adiponectin attenuates insulin resistance induced by dietary conjugated linoleic acid in mice
    • Purushotham A, Wendel AA, Liu LF, Belury MA (2007) Maintenance of adiponectin attenuates insulin resistance induced by dietary conjugated linoleic acid in mice. J. Lipid Res. 48, 444-452.
    • (2007) J. Lipid Res. , vol.48 , pp. 444-452
    • Purushotham, A.1    Wendel, A.A.2    Liu, L.F.3    Belury, M.A.4
  • 43
    • 0029995670 scopus 로고    scopus 로고
    • Thiazolidinediones in the treatment of insulin resistance and type II diabetes
    • Saltiel AR, Olefsky JM (1996) Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45, 1661-1669.
    • (1996) Diabetes , vol.45 , pp. 1661-1669
    • Saltiel, A.R.1    Olefsky, J.M.2
  • 47
    • 0034847431 scopus 로고    scopus 로고
    • Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs)
    • Sporn MB, Suh N, Mangelsdorf DJ (2001) Prospects for prevention and treatment of cancer with selective PPARgamma modulators (SPARMs). Trends Mol. Med. 7, 395-400.
    • (2001) Trends Mol. Med. , vol.7 , pp. 395-400
    • Sporn, M.B.1    Suh, N.2    Mangelsdorf, D.J.3
  • 48
    • 23644456172 scopus 로고    scopus 로고
    • Therapeutic roles of peroxisome proliferator-activated receptor agonists
    • Staels B, Fruchart JC (2005) Therapeutic roles of peroxisome proliferator-activated receptor agonists. Diabetes 54, 2460-2470.
    • (2005) Diabetes , vol.54 , pp. 2460-2470
    • Staels, B.1    Fruchart, J.C.2
  • 49
    • 23044433753 scopus 로고    scopus 로고
    • Homeostasis and the age-associated defect of CD4 T cells
    • Swain S, Clise-Dwyer K, Haynes L (2005) Homeostasis and the age-associated defect of CD4 T cells. Semin. Immunol. 17, 370-377.
    • (2005) Semin. Immunol. , vol.17 , pp. 370-377
    • Swain, S.1    Clise-Dwyer, K.2    Haynes, L.3
  • 50
    • 20344371900 scopus 로고    scopus 로고
    • Insights into thymic aging and regeneration
    • Taub DD, Longo DL (2005) Insights into thymic aging and regeneration. Immunol. Rev. 205, 72-93.
    • (2005) Immunol. Rev. , vol.205 , pp. 72-93
    • Taub, D.D.1    Longo, D.L.2
  • 51
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: the diverse biology of PPARgamma
    • Tontonoz P, Spiegelman BM (2008) Fat and beyond: the diverse biology of PPARgamma. Annu. Rev. Biochem. 77, 289-312.
    • (2008) Annu. Rev. Biochem. , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 52
    • 36849034568 scopus 로고    scopus 로고
    • PPAR-gamma regulates osteoclastogenesis in mice
    • Wan Y, Chong LW, Evans RM (2007) PPAR-gamma regulates osteoclastogenesis in mice. Nat. Med. 13, 1496-1503.
    • (2007) Nat. Med. , vol.13 , pp. 1496-1503
    • Wan, Y.1    Chong, L.W.2    Evans, R.M.3
  • 53
    • 38049059518 scopus 로고    scopus 로고
    • Forecasting the obesity epidemic in the aging U S. population
    • Wang YC, Colditz GA, Kuntz KM (2007) Forecasting the obesity epidemic in the aging U.S. population. Obesity 15, 2855-2865.
    • (2007) Obesity , vol.15 , pp. 2855-2865
    • Wang, Y.C.1    Colditz, G.A.2    Kuntz, K.M.3
  • 54
    • 41149170727 scopus 로고    scopus 로고
    • Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus
    • Yager EJ, Ahmed M, Lanzer K, Randall TD, Woodland DL, Blackman MA (2008) Age-associated decline in T cell repertoire diversity leads to holes in the repertoire and impaired immunity to influenza virus. J. Exp. Med. 205, 711-723.
    • (2008) J. Exp. Med. , vol.205 , pp. 711-723
    • Yager, E.J.1    Ahmed, M.2    Lanzer, K.3    Randall, T.D.4    Woodland, D.L.5    Blackman, M.A.6
  • 56
    • 67149098203 scopus 로고    scopus 로고
    • Axin expression in thymic stromal cells contributes to agerelated increase in thymic adiposity and associated with reduced thymopoiesis independently of ghrelin signaling
    • Yang H, Youm YH, Rim JS, Galbán CJ, Vandanmagsar B, Dixit VD (2009b) Axin expression in thymic stromal cells contributes to agerelated increase in thymic adiposity and associated with reduced thymopoiesis independently of ghrelin signaling. J. Leukoc. Biol. 85, 928-938.
    • (2009) J. Leukoc. Biol. , vol.85 , pp. 928-938
    • Yang, H.1    Youm, Y.H.2    Rim, J.S.3    Galbán, C.J.4    Vandanmagsar, B.5    Dixit, V.D.6
  • 57
    • 70349231092 scopus 로고    scopus 로고
    • Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution
    • Yang H, Youm YH, Dixit VD (2009c) Inhibition of thymic adipogenesis by caloric restriction is coupled with reduction in age-related thymic involution. J. Immunol. 183, 3040-3052.
    • (2009) J. Immunol. , vol.183 , pp. 3040-3052
    • Yang, H.1    Youm, Y.H.2    Dixit, V.D.3
  • 58
    • 19244365650 scopus 로고    scopus 로고
    • Thiazolidinediones
    • Yki-Järvinen H (2004) Thiazolidinediones. N. Engl. J. Med. 351, 1106-1118.
    • (2004) N. Engl. J. Med , vol.351 , pp. 1106-1118
    • Yki-Järvinen, H.1
  • 59
    • 65449128145 scopus 로고    scopus 로고
    • Deficient Ghrelin receptor mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity
    • Youm YH, Yang H, Sun Y, Smith RG, Manley NR, Dixit VD (2009) Deficient Ghrelin receptor mediated signaling compromises thymic stromal cell microenvironment by accelerating thymic adiposity. J. Biol. Chem. 284, 7068-7077.
    • (2009) J. Biol. Chem. , vol.284 , pp. 7068-7077
    • Youm, Y.H.1    Yang, H.2    Sun, Y.3    Smith, R.G.4    Manley, N.R.5    Dixit, V.D.6
  • 60
    • 67650996754 scopus 로고    scopus 로고
    • Biomarkers for epithelial-mesenchymal transitions
    • Zeisberg M, Neilson EG (2009) Biomarkers for epithelial-mesenchymal transitions. J. Clin. Invest. 119, 1429-1437.
    • (2009) J. Clin. Invest. , vol.119 , pp. 1429-1437
    • Zeisberg, M.1    Neilson, E.G.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.