Age-related immune dysfunction in health and in human immunodeficiency virus (HIV) disease: Association of age and HIV infection with naive CD8+ cell depletion, reduced expression of CD28 on CD8+ cells, and reduced thymic volumes

Journal of Infectious Diseases

Volumn 187, Issue 12, 2003, Pages 1924-1933

  Kalayjian, Robert C ^a,b,p   Landay, Alan ^c   Pollard, Richard B ^d   Taub, Dennis D ^f   Gross, Barry H ^j   Francis, Isaac R ^j   Sevin, Anne ^k   Pu, Minya ^k   Spritzler, John ^k   Chernoff, Miriam ^k,l   Namkung, Ann ⁱ   Fox, Lawrence ^h   Martinez, Ana ^h   Waterman, Karen ^m   Fiscus, Susan A ⁿ   Sha, Beverly ^c   Johnson, Debra ^e   Slater, Stanley ^g   Rousseau, Frank ^o   Lederman, Michael M ^b  

^a METROHEALTH MEDICAL CENTER   (United States)

^b CASE WESTERN RESERVE UNIVERSITY   (United States)

^c RUSH MEDICAL COLLEGE   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^f NATIONAL INSTITUTE ON AGING   (United States)

^g National Institute of Aging   (United States)

^h NATIONAL INSTITUTES OF HEALTH   (United States)

ⁱ SOCIAL AND SCIENTIFIC SYSTEMS INC   (United States)

^j UNIVERSITY OF MICHIGAN   (United States)

^k HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^l MASSACHUSETTS GENERAL HOSPITAL   (United States)

^m UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

ⁿ UNIVERSITY OF NORTH CAROLINA   (United States)

^o Triangle Pharmaceuticals   (United States)

^p Div of Infectious Diseases   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

CD28 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4;

ADULT; AGE; ANTIGEN EXPRESSION; APOPTOSIS; ARTICLE; CELL COUNT; CONTROLLED STUDY; CORRELATION ANALYSIS; DELAYED HYPERSENSITIVITY; DISEASE ASSOCIATION; FEMALE; HEALTH; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE DEFICIENCY; IMMUNITY; LYMPHOCYTE PROLIFERATION; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; THYMUS;

ADOLESCENT; ADULT; AGED; AGING; ANTIGENS, CD28; CD8-POSITIVE T-LYMPHOCYTES; CROSS-SECTIONAL STUDIES; DISEASE PROGRESSION; FEMALE; GENE EXPRESSION REGULATION; HIV INFECTIONS; HIV-1; HUMANS; MALE; MIDDLE AGED; PHENOTYPE; THYMUS GLAND;

EID: 0038577099     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/375372     Document Type: Article

References (47)

1. Rosenberg PS, Goedert JJ, Bigger RJ. Effect of age at seroconversion on the natural AIDS incubation distribution. AIDS 1994;8:803-10.
2. Blatt SP, McCarthy WF, Bucko-Krasnicka B, et al. Multivariate models for predicting progression to AIDS and survival in human immunodeficiency virus-infected persons. J Infect Dis 1995;171:837-44.
3. Darby SC, Ewart DW, Giangrande PLF, Spooner RJD, Rizza CR. Importance of age at infection with HIV-1 for survival and development of AIDS in UK haemophilia population. Lancet 1996;347:1573-9.
4. Fordyce DJ, Singh TP, Nash D, Gallagher B, Forlenza S. Survival rates in NYC in the era of combination ART. J Acquir Immune Defic Syndr 2002;30:111-8.
5. Egger M, May M, Chene G, et al. Prognosis of H1V-1 infected patients starting highly active antiretroviral therapy: a collaborative analysis of prospective studies. Lancet 2002;360:119-28.
6. Chene G, May M, Costaglola D, et al. Prognosis of HIV-1 infected drug naive patients starting potent antiretroviral therapy: ART Cohort Collaboration [abstract TuOrB1140]. In: Program and abstracts of the 14th International AIDS Conference (Barcelona, Spain). Vol 1. Stockholm: International AIDS Society, 2002:370.
7. + T cell subsets in human peripheral blood. Mech Ageing Dev 1992;63:57-68.
8. Xu X, Beckman I, Ahern M, Bradley J. A comprehensive analysis of peripheral blood lymphocytes in healthy aged humans by flow cytometry. Immunol Cell Biol 1993;71:549-57.
9. + T cells provides new insights on immunodeficiency in aging. Blood 2000;95:2860-8.
10. Rabin R, Roederer M, Madonado Y, Petru A, Herzenberg LA, Herzenberg LA. Altered representation of naive and memory CD8 T cell subsets in HIV-infected children. J Clin Invest 1995;95:2054-60.
11. Roederer M, Dubs JG, Anderson MT, Raju PA, Herzenberg LA, Herzenberg LA. CD8 naive T cell counts decrease progressively in HIV-infected adults. J Clin Invest 1995;95:2061-6.
12. DePaoi P, Battistin S, Santini GF. Age-related changes in human lymphocyte subsets: progressive reduction of the CD4 CD45R (suppressor inducer) population. Clin Immunol Immunopathol 1988;48:290-6.
13. Sansoni P, Cossarizza A, Brianti V, et al. Lymphocyte subsets and natural killer cell activity in healthy old people and centenarians. Blood 1993;82:2767-73.
14. Mahalingam M, Peakman M, Davies ET, Pozniak A, McManus TJ, Vergani D. T cell activation and disease severity in HIV infection. Clin Exp Immunol 1993;93:337-43.
15. + cell levels. The Multicenter AIDS Cohort Study Group. J Infect Dis 1994;170:775-81.
16. Giorgi JV, Lyles R, Matud JL, et al. Predictive value of immunologic and virologic markers after long or short duration of HIV-1 infection. J Acquir Immune Defic Syndr 2002;29:346-55.
17. Aggarwal S, Gupta S. Increased apoptosis of T cell subsets in aging humans: altered expression of Fas (CD95), Fas ligand, Bcl-s and Bax. J Immunol 1998;160:1627-37.
18. McCloskey TW, Oyaizu N, Kaplan M, Pahwa S. Expression of the Fas antigen in patients infected with human immunodeficiency virus. Cytometry 1995;22:111-4.
19. Baumler CB, Bohler T, Herr I, Benner A, Krammer PH, Debatin K-M. Activation of the CD95 (APO/Fas) system in T cells from human immunodeficiency virus type-1-infected children. Blood 1996;88:1741-6.
20. + T cells in healthy ageing people, including centenarians. Immunology 1996;88:501-7.
21. + T lymphocytes during HIV-1 infection. J Acquir Immune Defic Syndr 1994;7:245-53.
22. Brinchmann JE, Dobloug JH, Heger BH, Haaheim LL, Sannes M, Egeland T. Expression of costimulatory molecule CD28 on T cells in human immunodeficiency virus type 1 infection: functional and clinical correlations. J Infect Dis 1994;169:730-8.
23. Phelouzat M-A, Arbogast A, Laforge T, Quadri RA, Proust JJ. Excessive apoptosis of mature T lymphocytes is a characteristic feature of human immune senescence. Mech Ageing Dev 1996;88:25-8.
24. Aggarwa S, Gollapundi S, Gupta S. Increased TNF-α-induced apoptosis in lymphocytes from aged humans: changes in TNF-α receptor expression and activation of caspases. J Immunol 1999;162:2154-61.
25. Meyaard L, Otto SA, Jonker RR, Mijnster MJ, Keet RPM, Miedema F. Programmed death of T cells in HIV-1 infection. Science 1992;257:217-9.
26. + T cells from human immunodeficiency virus-infected asymptomatic individuals. J Exp Med 1992;175:331-40.
27. Lane HC, Masur H, Edgar LC, Whalen G, Rook AH, Fauci AS. Abnormalities of B-cell activation and immunoregulation in patients with acquired immunodeficiency syndrome. N Engl J Med 1983;309:453-8.
28. Miller RA. The aging immune system: primer and prospectus. Science 1996;273:63-7.
29. Thoman ML, Weigle WO. The cellular and subcellular bases of immunosenescence. Adv Immunol 1989;46:221-61.
30. Ullum H, Lepri AC, Aladdin H, et al. Natural immunity and HIV disease progression. AIDS 1999;13:557-63.
31. Murasko DM, Weiner P, Kaye D. Decline in mitogen induced proliferation of lymphocytes with increasing age. Clin Exp Immunol 1987;70:440-8.
32. Hessen MT, Kaye D, Murasko DM. Heterogenous effects of exogenous lymphokines on lymphoproliferation of elderly subjects. Mech Ageing Dev 1991;58:61-73.
33. Lederman MM, Connick E, Landay A, et al. Immunologic responses associated with 12 weeks of combination antiretroviral therapy consisting of zidovudine, lamivudine, and ritonavir: results of AIDS Clinical Trials Group Protocol 315. J Infect Dis 1998;78:70-9.
34. Roberts-Thomson IC, Whittingham S, Youngchaiynd U, Mackay IR. Ageing, immune response, and mortality. Lancet 1974;2:368-71.
35. Viard J-P, Mocroft A, Chiesi A, et al. Influence of age on CD4 cell recovery in human immunodeficiency virus-infected patients receiving highly active antiretroviral therapy: evidence from the EuroSIDA study. J Infect Dis 2001;183:1290-4.
36. Teixeira L, Valdez H, McCune JM, et al. Poor CD4 T cell restoration after suppression of HIV-1 replication may reflect lower thymic function. AIDS 2001;15:1749-56.
37. The Adult AIDS Clinical Trials Group immunology consensus methods. Available at: http://aactg.s-3.com/immmeth.htm. Accessed on: 13 September 2002.
38. Sokal JE. Measurement of delayed skin-test responses. N Engl J Med 1975;293:501-2.
39. McCune JM, Loftus R, Schmidt DK, et al. High prevalence of thymic tissue in adults with human immunodeficiency virus-1 infection. J Clin Invest 1998;101:2301-8.
40. Lighthart GJ, Corgerand JX, Fournier C, et al. Admission criteria for immunogeriatric studies in man: the Senieur protocol. Mech Ageing Dev 1984;28:47-55.
41. Valdez H, Smith K, Landay A, et al. Response to immunization with recall and neoantigens after prolonged administration of a protease inhibitor-containing regimen. AIDS 2000;14:11-21.
42. + cell counts [abstract LbOr09]. In: Program supplement of the 14th International AIDS Conference (Barcelona, Spain). Stockholm: International AIDS Society, 2002:22.
43. Algere ML, Fauwirth KA, Thompson CB. T-cell regulation by CD28 and CTLA-4. Nat Rev Immunol 2001;1:220-8.
44. Grossman Z, So AE, Victorino RMM. CD4 cell depletion, immune activation and viral load in HIV infection: from correlation to causal relationships [abstract ThPpA2132]. In: Program and abstracts of the International AIDS Conference (Barcelona, Spain). Vol 2. Stockholm: International AIDS Society, 2002:354.
45. Ostrowski MA, Justement SJ, Catanzaro A, et al. Expression of chemokine receptors CXCR4 and CCR5 in HIV-1 infected and uninfected individuals. J Immunol 1998;161:3195-201.
46. Smith KY, Valdez H, Landay A, et al. Thymic size and lymphocyte restoration in patients with human immunodeficiency virus infection after 48 weeks of zidovudine, lamivudine, and ritonavir therapy. ACTG 375 Protocol Team. J Infect Dis 2000;181:141-7.
47. Napolitano LA, Lo JC, Gotway MB, et al. Increased thymic mass and circulating naive CD4 T cells in HIV-1 infected adults treated with growth hormone. AIDS 2002;16:1103-11.