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Volumn 176, Issue 12, 2006, Pages 7371-7378

Estrogen induces thymic atrophy by eliminating early thymic progenitors and inhibiting proliferation of β-selected thymocytes

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; CD4 ANTIGEN; CD8 ANTIGEN; ESTRADIOL; ESTROGEN; FLT3 LIGAND; RAG1 PROTEIN; STEM CELL FACTOR; T LYMPHOCYTE RECEPTOR;

EID: 33744927395     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: 10.4049/jimmunol.176.12.7371     Document Type: Article
Times cited : (116)

References (50)
  • 2
    • 0020056406 scopus 로고
    • Dihydrotestosterone and estradiol deplete corticosensitive thymocytes lacking in receptors for these hormones
    • Barr, I. G., B. A. Khalid, P. Pearce, B. H. Toh, P. F. Bartlett, R. G. Scollay, and J. W. Funder. 1982. Dihydrotestosterone and estradiol deplete corticosensitive thymocytes lacking in receptors for these hormones. J. Immunol. 128: 2825-2828.
    • (1982) J. Immunol. , vol.128 , pp. 2825-2828
    • Barr, I.G.1    Khalid, B.A.2    Pearce, P.3    Toh, B.H.4    Bartlett, P.F.5    Scollay, R.G.6    Funder, J.W.7
  • 3
    • 0024537460 scopus 로고
    • Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy
    • Utsuyama, M., and K. Hirokawa. 1989. Hypertrophy of the thymus and restoration of immune functions in mice and rats by gonadectomy. Mech. Ageing Dev. 47: 175-185.
    • (1989) Mech. Ageing Dev. , vol.47 , pp. 175-185
    • Utsuyama, M.1    Hirokawa, K.2
  • 4
    • 0028036930 scopus 로고
    • The thymus in pregnancy: The interplay of neural, endocrine and immune influences
    • Clarke, A. G., and M. D. Kendall. 1994. The thymus in pregnancy: the interplay of neural, endocrine and immune influences. Immunol. Today 15: 545-551.
    • (1994) Immunol. Today , vol.15 , pp. 545-551
    • Clarke, A.G.1    Kendall, M.D.2
  • 5
    • 0024852512 scopus 로고
    • Histological changes in the thymus during mouse pregnancy
    • Clarke, A. G., and M. D. Kendall. 1989. Histological changes in the thymus during mouse pregnancy. Thymus 14: 65-78.
    • (1989) Thymus , vol.14 , pp. 65-78
    • Clarke, A.G.1    Kendall, M.D.2
  • 7
    • 1542287265 scopus 로고    scopus 로고
    • Regulatory T cells mediate maternal tolerance to the fetus
    • Aluvihare, V. R., M. Kallikourdis, and A. G. Betz. 2004. Regulatory T cells mediate maternal tolerance to the fetus. Nat. Immunol. 5: 266-271.
    • (2004) Nat. Immunol. , vol.5 , pp. 266-271
    • Aluvihare, V.R.1    Kallikourdis, M.2    Betz, A.G.3
  • 9
    • 0027153201 scopus 로고
    • - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression
    • - triple-negative adult mouse thymocytes defined by CD44 and CD25 expression. J. Immunol. 150: 4244-4252.
    • (1993) J. Immunol. , vol.150 , pp. 4244-4252
    • Godfrey, D.I.1    Kennedy, J.2    Suda, T.3    Zlotnik, A.4
  • 10
    • 0033178512 scopus 로고    scopus 로고
    • Control of early thymocyte development by the pre-T cell receptor complex: A receptor without a ligand?
    • Wiest, D. L., M. A. Berger, and M. Carleton. 1999. Control of early thymocyte development by the pre-T cell receptor complex: a receptor without a ligand? Semin. Immunol. 11: 251-262.
    • (1999) Semin. Immunol. , vol.11 , pp. 251-262
    • Wiest, D.L.1    Berger, M.A.2    Carleton, M.3
  • 11
    • 0028201339 scopus 로고
    • Selective events in T cell development
    • Robey, E., and B. J. Fowlkes. 1994. Selective events in T cell development. Annu. Rev. Immunol. 12: 675-705.
    • (1994) Annu. Rev. Immunol. , vol.12 , pp. 675-705
    • Robey, E.1    Fowlkes, B.J.2
  • 12
    • 0035962678 scopus 로고    scopus 로고
    • Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus
    • Okasha, S. A., S. Ryu, Y. Do, R. J. McKallip, M. Nagarkatti, and P. S. Nagarkatti. 2001. Evidence for estradiol-induced apoptosis and dysregulated T cell maturation in the thymus. Toxicology 163: 49-62.
    • (2001) Toxicology , vol.163 , pp. 49-62
    • Okasha, S.A.1    Ryu, S.2    Do, Y.3    McKallip, R.J.4    Nagarkatti, M.5    Nagarkatti, P.S.6
  • 13
    • 0036850414 scopus 로고    scopus 로고
    • Role of death receptor pathway in estradiol-induced T-cell apoptosis in vivo
    • Do, Y., S. Ryu, M. Nagarkatti, and P. S. Nagarkatti. 2002. Role of death receptor pathway in estradiol-induced T-cell apoptosis in vivo. Toxicol. Sci. 70: 63-72.
    • (2002) Toxicol. Sci. , vol.70 , pp. 63-72
    • Do, Y.1    Ryu, S.2    Nagarkatti, M.3    Nagarkatti, P.S.4
  • 14
    • 0031723485 scopus 로고    scopus 로고
    • Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7, 8-tetrachlorodibenzo- p-dioxin
    • Staples, J. E., N. C. Fiore, D. E. Frazier, Jr., T. A. Gasiewicz, and A. E. Silverstone. 1998. Overexpression of the anti-apoptotic oncogene, bcl-2, in the thymus does not prevent thymic atrophy induced by estradiol or 2,3,7, 8-tetrachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 151: 200-210.
    • (1998) Toxicol. Appl. Pharmacol. , vol.151 , pp. 200-210
    • Staples, J.E.1    Fiore, N.C.2    Frazier Jr., D.E.3    Gasiewicz, T.A.4    Silverstone, A.E.5
  • 16
    • 0034879612 scopus 로고    scopus 로고
    • Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen
    • Medina, K. L., K. P. Garrett, L. F. Thompson, M. I. Rossi, K. J. Payne, and P. W. Kincade. 2001. Identification of very early lymphoid precursors in bone marrow and their regulation by estrogen. Nat. Immunol. 2: 718-724.
    • (2001) Nat. Immunol. , vol.2 , pp. 718-724
    • Medina, K.L.1    Garrett, K.P.2    Thompson, L.F.3    Rossi, M.I.4    Payne, K.J.5    Kincade, P.W.6
  • 17
    • 0028176508 scopus 로고
    • Dexamethasone, β-estradiol, and 2,3,7,8-tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets
    • Silverstone, A. E., D. E. Frazier, Jr., N. C. Fiore, J. A. Soults, and T. A. Gasiewicz. 1994. Dexamethasone, β-estradiol, and 2,3,7,8- tetrachlorodibenzo-p-dioxin elicit thymic atrophy through different cellular targets. Toxicol. Appl. Pharmacol. 126: 248-259.
    • (1994) Toxicol. Appl. Pharmacol. , vol.126 , pp. 248-259
    • Silverstone, A.E.1    Frazier Jr., D.E.2    Fiore, N.C.3    Soults, J.A.4    Gasiewicz, T.A.5
  • 18
    • 0034457436 scopus 로고    scopus 로고
    • Role of estrogen receptor a in hematopoietic stem cell development and B lymphocyte maturation in the male mouse
    • Thurmond, T. S., F. G. Murante, J. E. Staples, A. E. Silverstone, K. S. Korach, and T. A. Gasiewicz. 2000. Role of estrogen receptor a in hematopoietic stem cell development and B lymphocyte maturation in the male mouse. Endocrinology 141: 2309-2318.
    • (2000) Endocrinology , vol.141 , pp. 2309-2318
    • Thurmond, T.S.1    Murante, F.G.2    Staples, J.E.3    Silverstone, A.E.4    Korach, K.S.5    Gasiewicz, T.A.6
  • 19
    • 0035353179 scopus 로고    scopus 로고
    • Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators
    • Kouro, T., K. L. Medina, K. Oritani, and P. W. Kincade. 2001. Characteristics of early murine B-lymphocyte precursors and their direct sensitivity to negative regulators. Blood 97: 2708-2715.
    • (2001) Blood , vol.97 , pp. 2708-2715
    • Kouro, T.1    Medina, K.L.2    Oritani, K.3    Kincade, P.W.4
  • 20
    • 0034654329 scopus 로고    scopus 로고
    • Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors
    • Medina, K. L., A. Strasser, and P. W. Kincade. 2000. Estrogen influences the differentiation, proliferation, and survival of early B-lineage precursors. Blood 95: 2059-2067.
    • (2000) Blood , vol.95 , pp. 2059-2067
    • Medina, K.L.1    Strasser, A.2    Kincade, P.W.3
  • 21
    • 0036311982 scopus 로고    scopus 로고
    • Molecular characterization of the mouse involuted thymus: Aberrations in expression of transcription regulators in thymocyte and epithelial compartments
    • Ortman, C. L., K. A. Dittmar, P. L. Witte, and P. T. Le. 2002. Molecular characterization of the mouse involuted thymus: aberrations in expression of transcription regulators in thymocyte and epithelial compartments. Int. Immunol. 14: 813-822.
    • (2002) Int. Immunol. , vol.14 , pp. 813-822
    • Ortman, C.L.1    Dittmar, K.A.2    Witte, P.L.3    Le, P.T.4
  • 22
    • 0036607528 scopus 로고    scopus 로고
    • Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3
    • Anderson, M. K., G. Hernandez-Hoyos, C. J. Dionne, A. M. Arias, D. Chen, and E. V. Rothenberg. 2002. Definition of regulatory network elements for T cell development by perturbation analysis with PU.1 and GATA-3. Dev. Biol. 246: 103-121.
    • (2002) Dev. Biol. , vol.246 , pp. 103-121
    • Anderson, M.K.1    Hernandez-Hoyos, G.2    Dionne, C.J.3    Arias, A.M.4    Chen, D.5    Rothenberg, E.V.6
  • 23
    • 0028276002 scopus 로고
    • Pregnancy-related steroids are potential negative regulators of B lymphopoiesis
    • Medina, K. L., and P. W. Kincade. 1994. Pregnancy-related steroids are potential negative regulators of B lymphopoiesis. Proc. Natl. Acad. Sci. USA 91: 5382-5386.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 5382-5386
    • Medina, K.L.1    Kincade, P.W.2
  • 24
    • 0035253377 scopus 로고    scopus 로고
    • Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains
    • Bebo, B. F., Jr., A. Fyfe-Johnson, K. Adlard, A. G. Beam, A. A. Vandenbark, and H. Offner. 2001. Low-dose estrogen therapy ameliorates experimental autoimmune encephalomyelitis in two different inbred mouse strains. J. Immunol. 166: 2080-2089.
    • (2001) J. Immunol. , vol.166 , pp. 2080-2089
    • Bebo Jr., B.F.1    Fyfe-Johnson, A.2    Adlard, K.3    Beam, A.G.4    Vandenbark, A.A.5    Offner, H.6
  • 25
    • 0026507212 scopus 로고
    • Estrogen administration activates extrathymic T cell differentiation in the liver
    • Okuyama, R., T. Abo, S. Seki, T. Ohteki, K. Sugiura, A. Kusumi, and K. Kumagai. 1992. Estrogen administration activates extrathymic T cell differentiation in the liver. J. Exp. Med. 175: 661-669.
    • (1992) J. Exp. Med. , vol.175 , pp. 661-669
    • Okuyama, R.1    Abo, T.2    Seki, S.3    Ohteki, T.4    Sugiura, K.5    Kusumi, A.6    Kumagai, K.7
  • 26
    • 0024379772 scopus 로고
    • Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation: Effects of 17 β-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor
    • Screpanti, I., S. Morrone, D. Meco, A. Santoni, A. Gulino, R. Paolini, A. Crisanti, B. J. Mathieson, and L. Frati. 1989. Steroid sensitivity of thymocyte subpopulations during intrathymic differentiation: effects of 17 β-estradiol and dexamethasone on subsets expressing T cell antigen receptor or IL-2 receptor. J. Immunol. 142: 3378-3383.
    • (1989) J. Immunol. , vol.142 , pp. 3378-3383
    • Screpanti, I.1    Morrone, S.2    Meco, D.3    Santoni, A.4    Gulino, A.5    Paolini, R.6    Crisanti, A.7    Mathieson, B.J.8    Frati, L.9
  • 27
    • 4644329449 scopus 로고    scopus 로고
    • Circulating hematopoietic progenitors with T lineage potential
    • Schwarz, B. A., and A. Bhandoola. 2004. Circulating hematopoietic progenitors with T lineage potential. Nat. Immunol. 5: 953-960.
    • (2004) Nat. Immunol. , vol.5 , pp. 953-960
    • Schwarz, B.A.1    Bhandoola, A.2
  • 28
    • 0141449952 scopus 로고    scopus 로고
    • Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice
    • Porritt, H. E., K. Gordon, and H. T. Petrie. 2003. Kinetics of steady-state differentiation and mapping of intrathymic-signaling environments by stem cell transplantation in nonirradiated mice. J. Exp. Med. 198: 957-962.
    • (2003) J. Exp. Med. , vol.198 , pp. 957-962
    • Porritt, H.E.1    Gordon, K.2    Petrie, H.T.3
  • 29
    • 0035477668 scopus 로고    scopus 로고
    • Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus
    • Wilson, A., H. R. MacDonald, and F. Radtke. 2001. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J. Exp. Med. 194: 1003-1012.
    • (2001) J. Exp. Med. , vol.194 , pp. 1003-1012
    • Wilson, A.1    MacDonald, H.R.2    Radtke, F.3
  • 31
    • 0034772446 scopus 로고    scopus 로고
    • Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation
    • Vasseur, F., A. Le Campion, and C. Penit. 2001. Scheduled kinetics of cell proliferation and phenotypic changes during immature thymocyte generation. Eur. J. Immunol. 31: 3038-3047.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3038-3047
    • Vasseur, F.1    Le Campion, A.2    Penit, C.3
  • 33
    • 1842737707 scopus 로고    scopus 로고
    • Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals
    • Huang, Y. H., D. Li, A. Winoto, and E. A. Robey. 2004. Distinct transcriptional programs in thymocytes responding to T cell receptor, Notch, and positive selection signals. Proc. Natl. Acad. Sci. USA 101: 4936-4941.
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 4936-4941
    • Huang, Y.H.1    Li, D.2    Winoto, A.3    Robey, E.A.4
  • 38
    • 0031587826 scopus 로고    scopus 로고
    • Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice
    • Akashi, K., M. Kondo, U. von Freeden-Jeffry, R. Murray, and I. L. Weissman. 1997. Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89: 1033-1041.
    • (1997) Cell , vol.89 , pp. 1033-1041
    • Akashi, K.1    Kondo, M.2    Von Freeden-Jeffry, U.3    Murray, R.4    Weissman, I.L.5
  • 40
    • 0035910060 scopus 로고    scopus 로고
    • Age and stage dependency of estrogen receptor expression by lymphocyte precursors
    • Igarashi, H., T. Kouro, T. Yokota, P. C. Comp, and P. W. Kincade. 2001. Age and stage dependency of estrogen receptor expression by lymphocyte precursors. Proc. Natl. Acad. Sci. USA 98: 15131-15136.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 15131-15136
    • Igarashi, H.1    Kouro, T.2    Yokota, T.3    Comp, P.C.4    Kincade, P.W.5
  • 41
    • 0026698311 scopus 로고
    • Localization of estrogen receptors and estrogen receptor-mRNA in female mouse thymus
    • Kawashima, I., K. Seiki, K. Sakabe, S. Ihara, A. Akatsuka, and Y. Katsumata. 1992. Localization of estrogen receptors and estrogen receptor-mRNA in female mouse thymus. Thymus 20: 115-121.
    • (1992) Thymus , vol.20 , pp. 115-121
    • Kawashima, I.1    Seiki, K.2    Sakabe, K.3    Ihara, S.4    Akatsuka, A.5    Katsumata, Y.6
  • 43
    • 0032826488 scopus 로고    scopus 로고
    • Estrogen receptor α is necessary in thymic development and estradiol-induced thymic alterations
    • Staples, J. E., T. A. Gasiewicz, N. C. Fiore, D. B. Lubahn, K. S. Korach, and A. E. Silverstone. 1999. Estrogen receptor α is necessary in thymic development and estradiol-induced thymic alterations. J. Immunol. 163: 4168-4174.
    • (1999) J. Immunol. , vol.163 , pp. 4168-4174
    • Staples, J.E.1    Gasiewicz, T.A.2    Fiore, N.C.3    Lubahn, D.B.4    Korach, K.S.5    Silverstone, A.E.6
  • 44
    • 0034049874 scopus 로고    scopus 로고
    • Glucocorticoids in T cell development and function
    • Ashwell, J. D., F. W. Lu, and M. S. Vacchio. 2000. Glucocorticoids in T cell development and function. Annu. Rev. Immunol. 18: 309-345.
    • (2000) Annu. Rev. Immunol. , vol.18 , pp. 309-345
    • Ashwell, J.D.1    Lu, F.W.2    Vacchio, M.S.3
  • 45
    • 0034599099 scopus 로고    scopus 로고
    • Supraphysiological level of estrogen exposure in vivo increases lymphoid cell death in mice
    • Zajchowski, S., and L. Hoffman-Goetz. 2000. Supraphysiological level of estrogen exposure in vivo increases lymphoid cell death in mice. Life Sci. 66: 1451-1459.
    • (2000) Life Sci. , vol.66 , pp. 1451-1459
    • Zajchowski, S.1    Hoffman-Goetz, L.2
  • 46
    • 4544326176 scopus 로고    scopus 로고
    • Evidence for the Notch signaling pathway on the role of estrogen in angiogenesis
    • Soares, R., G. Balogh, S. Guo, F. Gartner, J. Russo, and F. Schmitt. 2004. Evidence for the Notch signaling pathway on the role of estrogen in angiogenesis. Mol. Endocrinol. 18: 2333-2343.
    • (2004) Mol. Endocrinol. , vol.18 , pp. 2333-2343
    • Soares, R.1    Balogh, G.2    Guo, S.3    Gartner, F.4    Russo, J.5    Schmitt, F.6
  • 48
    • 0027331409 scopus 로고
    • Suppression of B lymphopoiesis during normal pregnancy
    • Medina, K. L., G. Smithson, and P. W. Kincade. 1993. Suppression of B lymphopoiesis during normal pregnancy. J. Exp. Med. 178: 1507-1515.
    • (1993) J. Exp. Med. , vol.178 , pp. 1507-1515
    • Medina, K.L.1    Smithson, G.2    Kincade, P.W.3
  • 49
    • 0019462005 scopus 로고
    • Thymic involution in pregnant mice. I. Characterization of the remaining thymocyte subpopulations
    • Phuc, L. H., M. Papiernik, S. Berrih, and D. Duval. 1981. Thymic involution in pregnant mice. I. Characterization of the remaining thymocyte subpopulations. Clin. Exp. Immunol. 44: 247-252.
    • (1981) Clin. Exp. Immunol. , vol.44 , pp. 247-252
    • Phuc, L.H.1    Papiernik, M.2    Berrih, S.3    Duval, D.4
  • 50
    • 0032781755 scopus 로고    scopus 로고
    • Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus
    • Ostensen, M. 1999. Sex hormones and pregnancy in rheumatoid arthritis and systemic lupus erythematosus. Ann. NY Acad. Sci. 876: 131-143.
    • (1999) Ann. NY Acad. Sci. , vol.876 , pp. 131-143
    • Ostensen, M.1


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