Immune aging and rheumatoid arthritis

Rheumatic Disease Clinics of North America

Volumn 36, Issue 2, 2010, Pages 297-310

  Goronzy, Jorg J ^a   Shao, Lan ^a   Weyand, Cornelia M ^a  

^a STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Aging; Autoimmunity; Immunosenescence; Rheumatoid arthritis; Telomere

Indexed keywords

ALEMTUZUMAB; CD28 ANTIGEN; HLA DR ANTIGEN; MITOGEN ACTIVATED PROTEIN KINASE; T LYMPHOCYTE RECEPTOR; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE; TUMOR NECROSIS FACTOR INHIBITOR;

AGE DISTRIBUTION; AGED; AGING; AUTOIMMUNITY; CELLULAR IMMUNITY; COMORBIDITY; DNA DAMAGE; DNA SEQUENCE; GENETIC PREDISPOSITION; GENETIC RISK; GENETIC TRANSCRIPTION; HUMAN; IMMUNOCOMPETENCE; IMMUNOLOGICAL TOLERANCE; IMMUNOPATHOGENESIS; INNATE IMMUNITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; T LYMPHOCYTE ACTIVATION;

AGING; ARTHRITIS, RHEUMATOID; HUMANS; IMMUNE SYSTEM; RISK FACTORS; TELOMERE;

EID: 77953234191     PISSN: 0889857X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.rdc.2010.03.001     Document Type: Review

References (83)

1. Kokkonen H., Soderstrom I., Rocklov J., et al. Up-regulation of cytokines and chemokines predates the onset of rheumatoid arthritis. Arthritis Rheum 2010, 62(2):383-391.
2. Weyand C.M., Goronzy J.J. Pathogenesis of rheumatoid arthritis. Med Clin North Am 1997, 81(1):29-55.
3. Goronzy J.J., Weyand C.M. Developments in the scientific understanding of rheumatoid arthritis. Arthritis Res Ther 2009, 11(5):249.
4. Doran M.F., Pond G.R., Crowson C.S., et al. Trends in incidence and mortality in rheumatoid arthritis in Rochester, Minnesota, over a forty-year period. Arthritis Rheum 2002, 46(3):625-631.
5. Goronzy J.J., Weyand C.M. Rheumatoid arthritis. Immunol Rev 2005, 204:55-73.
6. Larbi A., Fulop T., Pawelec G. Immune receptor signaling, aging and autoimmunity. Adv Exp Med Biol 2008, 640:312-324.
7. Weyand C.M., Goronzy J.J. Giant-cell arteritis and polymyalgia rheumatica. Ann Intern Med 2003, 139(6):505-515.
8. Weyand C.M., Goronzy J.J. Medium- and large-vessel vasculitis. N Engl J Med 2003, 349(2):160-169.
9. Moulias R., Proust J., Wang A., et al. Age-related increase in autoantibodies. Lancet 1984, 1(8386):1128-1129.
10. Grubeck-Loebenstein B., Wick G. The aging of the immune system. Adv Immunol 2002, 80:243-284.
11. Weng N.P. Aging of the immune system: how much can the adaptive immune system adapt?. Immunity 2006, 24(5):495-499.
12. Targonski P.V., Jacobson R.M., Poland G.A. Immunosenescence: role and measurement in influenza vaccine response among the elderly. Vaccine 2007, 25(16):3066-3069.
13. Jefferson T., Rivetti D., Rivetti A., et al. Efficacy and effectiveness of influenza vaccines in elderly people: a systematic review. Lancet 2005, 366(9492):1165-1174.
14. Nichol K.L., Nordin J.D., Nelson D.B., et al. Effectiveness of influenza vaccine in the community-dwelling elderly. N Engl J Med 2007, 357(14):1373-1381.
15. Donahue J.G., Choo P.W., Manson J.E., et al. The incidence of herpes zoster. Arch Intern Med 1995, 155(15):1605-1609.
16. Arvin A. Aging, immunity, and the varicella-zoster virus. N Engl J Med 2005, 352(22):2266-2267.
17. Thompson W.W., Shay D.K., Weintraub E., et al. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003, 289(2):179-186.
18. Looney R.J., Hasan M.S., Coffin D., et al. Hepatitis B immunization of healthy elderly adults: relationship between naive CD4 + T-cells and primary immune response and evaluation of GM-CSF as an adjuvant. J Clin Immunol 2001, 21(1):30-36.
19. Goronzy J.J., Weyand C.M. T-cell development and receptor diversity during aging. Curr Opin Immunol 2005, 17(5):468-475.
20. Naylor K., Li G., Vallejo A.N., et al. The influence of age on T-cell generation and TCR diversity. J Immunol 2005, 174(11):7446-7452.
21. Gomez C.R., Boehmer E.D., Kovacs E.J. The aging innate immune system. Curr Opin Immunol 2005, 17(5):457-462.
22. Niessner A., Weyand C.M. Dendritic cells in atherosclerotic disease. Clin Immunol 2010, 134(1):25-32.
23. Weyand C.M., Younge B.R., Goronzy J.J. T-cells in arteritis and atherosclerosis. Curr Opin Lipidol 2008, 19(5):469-477.
24. Hakim F.T., Memon S.A., Cepeda R., et al. Age-dependent incidence, time course, and consequences of thymic renewal in adults. J Clin Invest 2005, 115(4):930-939.
25. Czesnikiewicz-Guzik M., Lee W.W., Cui D., et al. T-cell subset-specific susceptibility to aging. Clin Immunol 2008, 127(1):107-118.
26. Nikolich-Zugich J. Ageing and life-long maintenance of T-cell subsets in the face of latent persistent infections. Nat Rev Immunol 2008, 8(7):512-522.
27. Hodes R.J., Hathcock K.S., Weng N.P. Telomeres in T- and B-cells. Nat Rev Immunol 2002, 2(9):699-706.
28. Jendro M.C., Ganten T., Matteson E.L., et al. Emergence of oligoclonal T-cell populations following therapeutic T-cell depletion in rheumatoid arthritis. Arthritis Rheum 1995, 38(9):1242-1251.
29. Brett S., Baxter G., Cooper H., et al. Repopulation of blood lymphocyte sub-populations in rheumatoid arthritis patients treated with the depleting humanized monoclonal antibody, CAMPATH-1H. Immunology 1996, 88(1):13-19.
30. Lorenzi A.R., Clarke A.M., Wooldridge T., et al. Morbidity and mortality in rheumatoid arthritis patients with prolonged therapy-induced lymphopenia: twelve-year outcomes. Arthritis Rheum 2008, 58(2):370-375.
31. Jones J.L., Phuah C.L., Cox A.L., et al. IL-21 drives secondary autoimmunity in patients with multiple sclerosis, following therapeutic lymphocyte depletion with alemtuzumab (Campath-1H). J Clin Invest 2009, 119(7):2052-2061.
32. Koetz K., Bryl E., Spickschen K., et al. T-cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A 2000, 97(16):9203-9208.
33. Kong F.K., Chen C.L., Six A., et al. T-cell receptor gene deletion circles identify recent thymic emigrants in the peripheral T-cell pool. Proc Natl Acad Sci U S A 1999, 96(4):1536-1540.
34. Douek D.C., McFarland R.D., Keiser P.H., et al. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396(6712):690-695.
35. van den Dool C., de Boer R.J. The effects of age, thymectomy, and HIV Infection on alpha and beta TCR excision circles in naive T-cells. J Immunol 2006, 177(7):4391-4401.
36. Ponchel F., Morgan A.W., Bingham S.J., et al. Dysregulated lymphocyte proliferation and differentiation in patients with rheumatoid arthritis. Blood 2002, 100(13):4550-4556.
37. Hazenberg M.D., Otto S.A., Cohen Stuart J.W., et al. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T-cell population in HIV-1 infection. Nat Med 2000, 6(9):1036-1042.
38. Hazenberg M.D., Borghans J.A., de Boer R.J., et al. Thymic output: a bad TREC record. Nat Immunol 2003, 4(2):97-99.
39. Andrews N.P., Fujii H., Goronzy J.J., et al. Telomeres and immunological diseases of aging. Gerontology 2009, [Epub ahead of print].
40. Vallejo A., Nestel A.R., Schirmer M., et al. Aging-related deficiency of CD28 expression in CD4+ T cells is associated with the loss of gene specific nuclear factor binding activity. J Biol Chem 1998, 273:8119-8129.
41. Effros R.B., Dagarag M., Spaulding C., et al. The role of CD8 + T-cell replicative senescence in human aging. Immunol Rev 2005, 205:147-157.
42. Schmidt D., Goronzy J.J., Weyand C.M. CD4 + CD7-CD28-T cells are expanded in rheumatoid arthritis and are characterized by autoreactivity. J Clin Invest 1996, 97(9):2027-2037.
43. Schmidt D., Martens P.B., Weyand C.M., et al. The repertoire of CD4 + CD28-T cells in rheumatoid arthritis. Mol Med 1996, 2(5):608-618.
44. Wagner U.G., Koetz K., Weyand C.M., et al. Perturbation of the T-cell repertoire in rheumatoid arthritis. Proc Natl Acad Sci U S A 1998, 95(24):14447-14452.
45. Thewissen M., Somers V., Venken K., et al. Analyses of immunosenescent markers in patients with autoimmune disease. Clin Immunol 2007, 123(2):209-218.
46. Schönland S.O., Lopez C., Widmann T., et al. Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc Natl Acad Sci U S A 2003, 100(23):13471-13476.
47. Shao L., Fujii H., Colmegna I., et al. Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J Exp Med 2009, 206(6):1435-1449.
48. Goronzy J.J., Matteson E.L., Fulbright J.W., et al. Prognostic markers of radiographic progression in early rheumatoid arthritis. Arthritis Rheum 2004, 50(1):43-54.
49. Martens P.B., Goronzy J.J., Schaid D., et al. Expansion of unusual CD4 + T-cells in severe rheumatoid arthritis. Arthritis Rheum 1997, 40(6):1106-1114.
50. Bryl E., Vallejo A.N., Weyand C.M., et al. Down-regulation of CD28 expression by TNF-alpha. J Immunol 2001, 167(6):3231-3238.
51. Bryl E., Vallejo A.N., Matteson E.L., et al. Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis. Arthritis Rheum 2005, 52(10):2996-3003.
52. Warrington K.J., Vallejo A.N., Weyand C.M., et al. CD28 loss in senescent CD4 + T-cells: reversal by interleukin-12 stimulation. Blood 2003, 101(9):3543-3549.
53. Chapman A., Stewart S.J., Nepom G.T., et al. CD11b+CD28-CD4+ human T-cells: activation requirements and association with HLA-DR alleles. J Immunol 1996, 157(11):4771-4780.
54. Waase I., Kayser C., Carlson P.J., et al. Oligoclonal T-cell proliferation in patients with rheumatoid arthritis and their unaffected siblings. Arthritis Rheum 1996, 39(6):904-913.
55. van Leeuwen E.M., Remmerswaal E.B., Vossen M.T., et al. Emergence of a CD4+CD28- granzyme B+, cytomegalovirus-specific T-cell subset after recovery of primary cytomegalovirus infection. J Immunol 2004, 173(3):1834-1841.
56. Palm W., de Lange T. How shelterin protects mammalian telomeres. Annu Rev Genet 2008, 42:301-334.
57. Weyand C.M., Fujii H., Shao L., et al. Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol 2009, 5(10):583-588.
58. Fujii H., Shao L., Colmegna I., et al. Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A 2009, 106(11):4360-4365.
59. Colmegna I., Diaz-Borjon A., Fujii H., et al. Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Arthritis Rheum 2008, 58(4):990-1000.
60. Lavin M.F., Kozlov S., Gueven N., et al. Atm and cellular response to DNA damage. Adv Exp Med Biol 2005, 570:457-476.
61. King C., Ilic A., Koelsch K., et al. Homeostatic expansion of T-cells during immune insufficiency generates autoimmunity. Cell 2004, 117(2):265-277.
62. Crisa L., Mordes J.P., Rossini A.A. Autoimmune diabetes mellitus in the BB rat. Diabetes Metab Rev 1992, 8(1):4-37.
63. Glant T.T., Finnegan A., Mikecz K. Proteoglycan-induced arthritis: immune regulation, cellular mechanisms, and genetics. Crit Rev Immunol 2003, 23(3):199-250.
64. Goronzy J.J., Weyand C.M. Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity-catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther 2003, 5(5):225-234.
65. Goronzy J.J., Weyand C.M. Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis. Trends Immunol 2001, 22(5):251-255.
66. Cope A.P. T-cells in rheumatoid arthritis. Arthritis Res Ther 2008, 10(Suppl 1):S1.
67. Singh K., Colmegna I., He X., et al. Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritis. J Immunol 2008, 180(3):1971-1978.
68. Sawai H., Park Y.W., Roberson J., et al. T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis. Arthritis Rheum 2005, 52(5):1392-1401.
69. Davila E., Kang Y.M., Park Y.W., et al. Cell-based immunotherapy with suppressor CD8 + T-cells in rheumatoid arthritis. J Immunol 2005, 174(11):7292-7301.
70. Sawai H., Park Y.W., He X., et al. Fractalkine mediates T-cell dependent proliferation of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum 2007, 56(10):3215-3225.
71. Goronzy J.J., Henel G., Sawai H., et al. Costimulatory pathways in rheumatoid synovitis and T-cell senescence. Ann N Y Acad Sci 2005, 1062:182-194.
72. Singh K., Deshpande P., Pryshchep S., et al. ERK-dependent T-cell receptor threshold calibration in rheumatoid arthritis. J Immunol 2009, 183(12):8258-8267.
73. Warrington K.J., Kent P.D., Frye R.L., et al. Rheumatoid arthritis is an independent risk factor for multivessel coronary artery disease: a case control study. Arthritis Res Ther 2005, 7(5):R984-R991.
74. Crowson C.S., Liang K.P., Therneau T.M., et al. Could accelerated aging explain the excess mortality in patients with seropositive rheumatoid arthritis?. Arthritis Rheum 2010, 62(2):378-382.
75. Liuzzo G., Kopecky S.L., Frye R.L., et al. Perturbation of the T-cell repertoire in patients with unstable angina. Circulation 1999, 100(21):2135-2139.
76. Liuzzo G., Vallejo A.N., Kopecky S.L., et al. Molecular fingerprint of interferon-gamma signaling in unstable angina. Circulation 2001, 103(11):1509-1514.
77. Nakajima T., Schulte S., Warrington K.J., et al. T-cell mediated lysis of endothelial cells in acute coronary syndromes. Circulation 2002, 105(5):570-575.
78. Niessner A., Sato K., Chaikof E.L., et al. Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha. Circulation 2006, 114(23):2482-2489.
79. Sato K., Niessner A., Kopecky S.L., et al. TRAIL-expressing T-cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. J Exp Med 2006, 203(1):239-250.
80. Pryshchep S., Sato K., Goronzy J.J., et al. T-cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome. Circ Res 2006, 98(9):1168-1176.
81. Liuzzo G., Goronzy J.J., Yang H., et al. Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation 2000, 101(25):2883-2888.
82. Pryshchep S., Goronzy J.J., Parashar S., et al. Insufficient deactivation of the protein tyrosine kinase Lck amplifies T-cell responsiveness in acute coronary syndrome. Circ Res 2010, 106:769-778.
83. Pasceri V., Yeh E.T. A tale of two diseases: atherosclerosis and rheumatoid arthritis. Circulation 1999, 100(21):2124-2126.