Premature ageing of the immune system underlies immunodeficiency in ataxia telangiectasia

Clinical Immunology

Volumn 140, Issue 1, 2011, Pages 26-36

  Exley, Andrew Robert ^a   Buckenham, Samantha ^a   Hodges, Elizabeth ^b   Hallam, Robert ^a   Byrd, Phil ^c   Last, James ^c   Trinder, Claire ^a   Harris, Susan ^b   Screaton, Nicholas ^a   Williams, Anthony P ^d   Taylor, A Malcolm R ^c   Shneerson, John M ^a  

^a St John s Innovation Centre   (United Kingdom)

^b UNIVERSITY HOSPITAL SOUTHAMPTON NHS FOUNDATION TRUST   (United Kingdom)

^c UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^d UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

Author keywords

Ataxia telangiectasia; ATM kinase; Immune ageing; Naive T cells; Pneumococcal antibodies; T cell receptor

Indexed keywords

ATM PROTEIN; PNEUMOCOCCUS VACCINE; T LYMPHOCYTE RECEPTOR;

ADULT; ANTIBODY RESPONSE; ARTICLE; ATAXIA TELANGIECTASIA; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE SEVERITY; DNA REPAIR; ENZYME ACTIVITY; FEMALE; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE SYSTEM; IMMUNOMODULATION; MALE; NUCLEOTIDE SEQUENCE; PREMATURE AGING; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIA; THYMUS; TREATMENT RESPONSE;

ADULT; AGING; ATAXIA TELANGIECTASIA; CD4-POSITIVE T-LYMPHOCYTES; CELL COUNT; CELL CYCLE PROTEINS; CELL SEPARATION; DNA-BINDING PROTEINS; FEMALE; FLOW CYTOMETRY; HUMANS; MALE; PROTEIN-SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEINS;

EID: 79958772323     PISSN: 15216616     EISSN: 15217035     Source Type: Journal    
DOI: 10.1016/j.clim.2011.03.007     Document Type: Article

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