메뉴 건너뛰기




Volumn 39, Issue 1, 2012, Pages 80-96

Mutational determinants of epigenetic instablity in myeloid malignancies

Author keywords

[No Author keywords available]

Indexed keywords

DNA METHYLTRANSFERASE; HISTONE DEMETHYLASE; HISTONE METHYLTRANSFERASE; POLYCOMB GROUP PROTEIN; UNTRANSLATED RNA;

EID: 84856405146     PISSN: 00937754     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.seminoncol.2011.11.006     Document Type: Article
Times cited : (8)

References (125)
  • 1
    • 33847065486 scopus 로고    scopus 로고
    • The Epigenomics of Cancer
    • DOI 10.1016/j.cell.2007.01.029, PII S0092867407001274
    • P.A. Jones, S.B. Baylin The epigenomics of cancer Cell 128 2007 683 692 (Pubitemid 46273572)
    • (2007) Cell , vol.128 , Issue.4 , pp. 683-692
    • Jones, P.A.1    Baylin, S.B.2
  • 2
    • 36949012730 scopus 로고    scopus 로고
    • Chromatin structure and DNA double-strand break responses in cancer progression and therapy
    • DOI 10.1038/sj.onc.1210874, PII 1210874
    • J.A. Downs Chromatin structure and DNA double-strand break responses in cancer progression and therapy Oncogene 26 2007 7765 7772 (Pubitemid 350242456)
    • (2007) Oncogene , vol.26 , Issue.56 , pp. 7765-7772
    • Downs, J.A.1
  • 3
    • 56549108407 scopus 로고    scopus 로고
    • Epigenetic regulation of centromeric chromatin: Old dogs, new tricks?
    • DOI 10.1038/nrg2466, PII NRG2466
    • R.C. Allshire, G.H. Karpen Epigenetic regulation of centromeric chromatin: old dogs, new tricks? Nat Rev Genet 9 2008 923 937 (Pubitemid 50329068)
    • (2008) Nature Reviews Genetics , vol.9 , Issue.12 , pp. 923-937
    • Allshire, R.C.1    Karpen, G.H.2
  • 4
    • 35348868573 scopus 로고    scopus 로고
    • Epigenetic regulation of normal and malignant hematopoiesis
    • DOI 10.1038/sj.onc.1210755, PII 1210755
    • K.L. Rice, I. Hormaeche, J.D. Licht Epigenetic regulation of normal and malignant hematopoiesis Oncogene 26 2007 6697 6714 (Pubitemid 47585096)
    • (2007) Oncogene , vol.26 , Issue.47 , pp. 6697-6714
    • Rice, K.L.1    Hormaeche, I.2    Licht, J.D.3
  • 5
    • 77950529126 scopus 로고    scopus 로고
    • Epigenetic changes in the myelodysplastic syndrome
    • J.P. Issa Epigenetic changes in the myelodysplastic syndrome Hematol Oncol Clin North Am 24 2010 317 330
    • (2010) Hematol Oncol Clin North Am , vol.24 , pp. 317-330
    • Issa, J.P.1
  • 7
    • 0242624636 scopus 로고    scopus 로고
    • Epigenetic targets in hematopoietic malignancies
    • R. Claus, M. Lubbert Epigenetic targets in hematopoietic malignancies Oncogene 22 2003 6489 6496 (Pubitemid 37372329)
    • (2003) Oncogene , vol.22 , Issue.43 , pp. 6489-6496
    • Claus, R.1    Lubbert, M.2
  • 8
    • 67349255210 scopus 로고    scopus 로고
    • CpG islands'a rough guide'
    • R.S. Illingworth, A.P. Bird CpG islands'a rough guide' FEBS Lett 583 2009 1713 1720
    • (2009) FEBS Lett , vol.583 , pp. 1713-1720
    • Illingworth, R.S.1    Bird, A.P.2
  • 9
    • 77249170184 scopus 로고    scopus 로고
    • Establishing, maintaining and modifying DNA methylation patterns in plants and animals
    • J.A. Law, S.E. Jacobsen Establishing, maintaining and modifying DNA methylation patterns in plants and animals Nat Rev Genet 11 2010 204 220
    • (2010) Nat Rev Genet , vol.11 , pp. 204-220
    • Law, J.A.1    Jacobsen, S.E.2
  • 10
    • 0033615717 scopus 로고    scopus 로고
    • DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development
    • DOI 10.1016/S0092-8674(00)81656-6
    • M. Okano, D.W. Bell, D.A. Haber, E. Li DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development Cell 99 1999 247 257 (Pubitemid 29519904)
    • (1999) Cell , vol.99 , Issue.3 , pp. 247-257
    • Okano, M.1    Bell, D.W.2    Haber, D.A.3    Li, E.4
  • 11
    • 9144256125 scopus 로고    scopus 로고
    • The Dnmt1 DNA-(cytosine-C5)-methyltransferase methylates DNA processively with high preference for hemimethylated target sites
    • DOI 10.1074/jbc.M403427200
    • A. Hermann, R. Goyal, A. Jeltsch The Dnmt1 DNA-(cytosine-C5)- methyltransferase methylates DNA processively with high preference for hemimethylated target sites J Biol Chem 279 2004 48350 48359 (Pubitemid 39540991)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.46 , pp. 48350-48359
    • Hermann, A.1    Goyal, R.2    Jeltsch, A.3
  • 12
    • 0033564902 scopus 로고    scopus 로고
    • DNA methylation
    • R. Singal, G.D. Ginder DNA methylation Blood 93 1999 4059 4070 (Pubitemid 29279247)
    • (1999) Blood , vol.93 , Issue.12 , pp. 4059-4070
    • Singal, R.1    Ginder, G.D.2
  • 13
    • 67349240804 scopus 로고    scopus 로고
    • Metabolic defects provide a spark for the epigenetic switch in cancer
    • M.J. Hitchler, F.E. Domann Metabolic defects provide a spark for the epigenetic switch in cancer Free Radic Biol Med 47 2009 115 127
    • (2009) Free Radic Biol Med , vol.47 , pp. 115-127
    • Hitchler, M.J.1    Domann, F.E.2
  • 14
    • 34249982046 scopus 로고    scopus 로고
    • Gene silencing by DNA methylation in haematological malignancies
    • DOI 10.1111/j.1365-2141.2007.06604.x
    • J. Boultwood, J.S. Wainscoat Gene silencing by DNA methylation in haematological malignancies Br J Haematol 138 2007 3 11 (Pubitemid 46889779)
    • (2007) British Journal of Haematology , vol.138 , Issue.1 , pp. 3-11
    • Boultwood, J.1    Wainscoat, J.S.2
  • 15
    • 0037068353 scopus 로고    scopus 로고
    • DNA methylation in cancer: Too much, but also too little
    • DOI 10.1038/sj.onc.1205651
    • M. Ehrlich DNA methylation in cancer: too much, but also too little Oncogene 21 2002 5400 5413 (Pubitemid 34983477)
    • (2002) Oncogene , vol.21 , pp. 5400-5413
    • Ehrlich, M.1
  • 16
    • 34249076321 scopus 로고    scopus 로고
    • The regulation of genes and genomes by small RNAs
    • DOI 10.1242/dev.002006
    • V. Ambros, X. Chen The regulation of genes and genomes by small RNAs Development 134 2007 1635 1641 (Pubitemid 46796561)
    • (2007) Development , vol.134 , Issue.9 , pp. 1635-1641
    • Ambros, V.1    Chen, X.2
  • 17
    • 0032480226 scopus 로고    scopus 로고
    • DNA hypomethylation leads to elevated mutation rates
    • DOI 10.1038/25779
    • R.Z. Chen, U. Pettersson, C. Beard, L. Jackson-Grusby, R. Jaenisch DNA hypomethylation leads to elevated mutation rates Nature 395 1998 89 93 (Pubitemid 28420236)
    • (1998) Nature , vol.395 , Issue.6697 , pp. 89-93
    • Chen, R.Z.1    Pettersson, U.2    Beard, C.3    Jackson-Grusby, L.4    Jaenisch, R.5
  • 18
    • 60849089645 scopus 로고    scopus 로고
    • Aberrant DNA methylation is a dominant mechanism in MDS progression to AML
    • Y. Jiang, A. Dunbar, L.P. Gondek Aberrant DNA methylation is a dominant mechanism in MDS progression to AML Blood 113 2009 1315 1325
    • (2009) Blood , vol.113 , pp. 1315-1325
    • Jiang, Y.1    Dunbar, A.2    Gondek, L.P.3
  • 19
    • 70350720044 scopus 로고    scopus 로고
    • MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation
    • M.E. Figueroa, L. Skrabanek, Y. Li MDS and secondary AML display unique patterns and abundance of aberrant DNA methylation Blood 114 2009 3448 3458
    • (2009) Blood , vol.114 , pp. 3448-3458
    • Figueroa, M.E.1    Skrabanek, L.2    Li, Y.3
  • 21
    • 77956095231 scopus 로고    scopus 로고
    • Active DNA demethylation: Many roads lead to Rome
    • S.C. Wu, Y. Zhang Active DNA demethylation: many roads lead to Rome Nat Rev Mol Cell Biol 11 2010 607 620
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 607-620
    • Wu, S.C.1    Zhang, Y.2
  • 22
    • 40749119323 scopus 로고    scopus 로고
    • Base excision repair dysfunction in a subgroup of patients with myelodysplastic syndrome
    • DOI 10.1038/sj.leu.2405055, PII 2405055
    • A.M. Jankowska, L.P. Gondek, H. Szpurka, Z.P. Nearman, R.V. Tiu, J.P. Maciejewski Base excision repair dysfunction in a subgroup of patients with myelodysplastic syndrome Leukemia 22 2008 551 558 (Pubitemid 351386725)
    • (2008) Leukemia , vol.22 , Issue.3 , pp. 551-558
    • Jankowska, A.M.1    Gondek, L.P.2    Szpurka, H.3    Nearman, Z.P.4    Tiu, R.V.5    Maciejewski, J.P.6
  • 23
    • 0029001483 scopus 로고
    • DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase
    • P.W. Turk, A. Laayoun, S.S. Smith, S.A. Weitzman DNA adduct 8-hydroxyl-2'-deoxyguanosine (8-hydroxyguanine) affects function of human DNA methyltransferase Carcinogenesis 16 1995 1253 1255
    • (1995) Carcinogenesis , vol.16 , pp. 1253-1255
    • Turk, P.W.1    Laayoun, A.2    Smith, S.S.3    Weitzman, S.A.4
  • 24
    • 0028173309 scopus 로고
    • 5-Methylcytosine attack by free radicals arising from bromotrichloromethane in a model system: Structures of reaction products
    • G.D. Castro, C.J. Stamato, J.A. Castro 5-Methylcytosine attack by free radicals arising from bromotrichloromethane in a model system: structures of reaction products Free Radic Biol Med 17 1994 419 428
    • (1994) Free Radic Biol Med , vol.17 , pp. 419-428
    • Castro, G.D.1    Stamato, C.J.2    Castro, J.A.3
  • 25
    • 66149146320 scopus 로고    scopus 로고
    • Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by the MLL fusion partner TET1
    • M. Tahiliani, K.P. Koh, Y. Shen Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by the MLL fusion partner TET1 Science 324 2009 930 935
    • (2009) Science , vol.324 , pp. 930-935
    • Tahiliani, M.1    Koh, K.P.2    Shen, Y.3
  • 26
    • 66149123748 scopus 로고    scopus 로고
    • The nuclear DNA base 5-hydroxymethylcytosine is present in purkinje neurons and the brain
    • S. Kriaucionis, N. Heintz The nuclear DNA base 5-hydroxymethylcytosine is present in purkinje neurons and the brain Science 324 2009 929 930
    • (2009) Science , vol.324 , pp. 929-930
    • Kriaucionis, S.1    Heintz, N.2
  • 27
    • 78650175023 scopus 로고    scopus 로고
    • Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2
    • M. Ko, Y. Huang, A. Jankowska Impaired hydroxylation of 5-methylcytosine in myeloid cancers with mutant TET2 Nature 468 2010 839 843
    • (2010) Nature , vol.468 , pp. 839-843
    • Ko, M.1    Huang, Y.2    Jankowska, A.3
  • 28
    • 77956189495 scopus 로고    scopus 로고
    • Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification
    • S. Ito, A.C. D'Alessio, O.V. Taranova, K. Hong, L.C. Sowers, Y. Zhang Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification Nature 466 2010 1129 1133
    • (2010) Nature , vol.466 , pp. 1129-1133
    • Ito, S.1    D'Alessio, A.C.2    Taranova, O.V.3    Hong, K.4    Sowers, L.C.5    Zhang, Y.6
  • 29
    • 33947532026 scopus 로고    scopus 로고
    • Histone acetyltransferase complexes: One size doesn't fit all
    • DOI 10.1038/nrm2145, PII NRM2145
    • K.K. Lee, J.L. Workman Histone acetyltransferase complexes: one size doesn't fit all Nat Rev Mol Cell Biol 8 2007 284 295 (Pubitemid 46474661)
    • (2007) Nature Reviews Molecular Cell Biology , vol.8 , Issue.4 , pp. 284-295
    • Lee, K.K.1    Workman, J.L.2
  • 32
    • 0035839136 scopus 로고    scopus 로고
    • Translating the histone code
    • DOI 10.1126/science.1063127
    • T. Jenuwein, C.D. Allis Translating the histone code Science 293 2001 1074 1080 (Pubitemid 32758077)
    • (2001) Science , vol.293 , Issue.5532 , pp. 1074-1080
    • Jenuwein, T.1    Allis, C.D.2
  • 34
    • 0141816710 scopus 로고    scopus 로고
    • AML with 11q23/MLL abnormalities as defined by the WHO classification: Incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases
    • DOI 10.1182/blood-2003-02-0434
    • C. Schoch, S. Schnittger, M. Klaus, W. Kern, W. Hiddemann, T. Haferlach AML with 11q23/MLL abnormalities as defined by the WHO classification: incidence, partner chromosomes, FAB subtype, age distribution, and prognostic impact in an unselected series of 1897 cytogenetically analyzed AML cases Blood 102 2003 2395 2402 (Pubitemid 37193575)
    • (2003) Blood , vol.102 , Issue.7 , pp. 2395-2402
    • Schoch, C.1    Schnittger, S.2    Klaus, M.3    Kern, W.4    Hiddemann, W.5    Haferlach, T.6
  • 37
    • 33747455678 scopus 로고    scopus 로고
    • JmjC-domain-containing proteins and histone demethylation
    • DOI 10.1038/nrg1945, PII NRG1945
    • R.J. Klose, E.M. Kallin, Y. Zhang JmjC-domain-containing proteins and histone demethylation Nat Rev Genet 7 2006 715 727 (Pubitemid 44260007)
    • (2006) Nature Reviews Genetics , vol.7 , Issue.9 , pp. 715-727
    • Klose, R.J.1    Kallin, E.M.2    Zhang, Y.3
  • 38
    • 67349203626 scopus 로고    scopus 로고
    • Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer
    • G. van Haaften, G.L. Dalgliesh, H. Davies Somatic mutations of the histone H3K27 demethylase gene UTX in human cancer Nat Genet 41 2009 521 523
    • (2009) Nat Genet , vol.41 , pp. 521-523
    • Van Haaften, G.1    Dalgliesh, G.L.2    Davies, H.3
  • 39
    • 77956636685 scopus 로고    scopus 로고
    • Epigenetic regulation of cancer growth by histone demethylases
    • S. Lim, E. Metzger, R. Schule, J. Kirfel, R. Buettner Epigenetic regulation of cancer growth by histone demethylases Int J Cancer 127 2010 1991 1998
    • (2010) Int J Cancer , vol.127 , pp. 1991-1998
    • Lim, S.1    Metzger, E.2    Schule, R.3    Kirfel, J.4    Buettner, R.5
  • 40
    • 0035962648 scopus 로고    scopus 로고
    • Chromatin silencing and activation by Polycomb and trithorax group proteins
    • DOI 10.1038/sj.onc.1204330
    • T. Mahmoudi, C.P. Verrijzer Chromatin silencing and activation by polycomb and trithorax group proteins Oncogene 20 2001 3055 3066 (Pubitemid 32553560)
    • (2001) Oncogene , vol.20 , pp. 3055-3066
    • Mahmoudi, T.1    Verrijzer, C.P.2
  • 41
    • 84856266598 scopus 로고    scopus 로고
    • MicroRNA-101 is down-regulated in PV and et granulocytes and its decrease is associated with over-expression of histone methyltransferase in EZH2 in MPN patients
    • S. Swierczek, D. Yoon, K. Hickman, J.T. Prchal MicroRNA-101 is down-regulated in PV and ET granulocytes and its decrease is associated with over-expression of histone methyltransferase in EZH2 in MPN patients Blood (ASH Annual Meeting Abstracts) 116 2010 1989
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 1989
    • Swierczek, S.1    Yoon, D.2    Hickman, K.3    Prchal, J.T.4
  • 42
    • 34249692139 scopus 로고    scopus 로고
    • The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia
    • DOI 10.1182/blood-2006-12-065599
    • M. Mohty, A.S. Yong, R.M. Szydlo, J.F. Apperley The polycomb group BMI1 gene is a molecular marker for predicting prognosis of chronic myeloid leukemia Blood 110 2007 380 383 (Pubitemid 47026858)
    • (2007) Blood , vol.110 , Issue.1 , pp. 380-383
    • Mohty, M.1    Yong, A.S.M.2    Szydlo, R.M.3    Apperley, J.F.4    Melo, J.V.5
  • 45
    • 78751557893 scopus 로고    scopus 로고
    • Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations
    • D.T. Starczynowski, R. Morin, A. McPherson Genome-wide identification of human microRNAs located in leukemia-associated genomic alterations Blood 117 2011 595 607
    • (2011) Blood , vol.117 , pp. 595-607
    • Starczynowski, D.T.1    Morin, R.2    McPherson, A.3
  • 46
    • 73849121794 scopus 로고    scopus 로고
    • Identification of MiR-145 and MiR-146a as mediators of the 5q- syndrome phenotype
    • D.T. Starczynowski, F. Kuchenbauer, B. Argiropoulos Identification of MiR-145 and MiR-146a as mediators of the 5q- syndrome phenotype Nat Med 16 2010 49 58
    • (2010) Nat Med , vol.16 , pp. 49-58
    • Starczynowski, D.T.1    Kuchenbauer, F.2    Argiropoulos, B.3
  • 48
    • 73949118737 scopus 로고    scopus 로고
    • MicroRNA 29b functions in acute myeloid leukemia
    • R. Garzon, C.E. Heaphy, V. Havelange MicroRNA 29b functions in acute myeloid leukemia Blood 114 2009 5331 5341
    • (2009) Blood , vol.114 , pp. 5331-5341
    • Garzon, R.1    Heaphy, C.E.2    Havelange, V.3
  • 49
    • 50649087954 scopus 로고    scopus 로고
    • Genomic instability in myeloid malignancies: Increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair
    • A. Sallmyr, J. Fan, F.V. Rassool Genomic instability in myeloid malignancies: increased reactive oxygen species (ROS), DNA double strand breaks (DSBs) and error-prone repair Cancer Lett 270 2008 1 9
    • (2008) Cancer Lett , vol.270 , pp. 1-9
    • Sallmyr, A.1    Fan, J.2    Rassool, F.V.3
  • 51
    • 77950990572 scopus 로고    scopus 로고
    • Copy neutral loss of heterozygosity: A novel chromosomal lesion in myeloid malignancies
    • C.L. O'Keefe, M.A. McDevitt, J.P. Maciejewski Copy neutral loss of heterozygosity: a novel chromosomal lesion in myeloid malignancies Blood 115 2010 2731 2739
    • (2010) Blood , vol.115 , pp. 2731-2739
    • O'Keefe, C.L.1    McDevitt, M.A.2    MacIejewski, J.P.3
  • 55
    • 4043181214 scopus 로고    scopus 로고
    • Cancer genes and the pathways they control
    • DOI 10.1038/nm1087
    • B. Vogelstein, K.W. Kinzler Cancer genes and the pathways they control Nat Med 10 2004 789 799 (Pubitemid 39070849)
    • (2004) Nature Medicine , vol.10 , Issue.8 , pp. 789-799
    • Vogelstein, B.1    Kinzler, K.W.2
  • 56
    • 78649906060 scopus 로고    scopus 로고
    • DNMT3A mutations in acute myeloid leukemia
    • T.J. Ley, L. Ding, M.J. Walter DNMT3A mutations in acute myeloid leukemia N Engl J Med 363 2010 2424 2433
    • (2010) N Engl J Med , vol.363 , pp. 2424-2433
    • Ley, T.J.1    Ding, L.2    Walter, M.J.3
  • 57
    • 77954089584 scopus 로고    scopus 로고
    • Array-based genomic resequencing of human leukemia
    • Y. Yamashita, J. Yuan, I. Suetake Array-based genomic resequencing of human leukemia Oncogene 29 2010 3723 3731
    • (2010) Oncogene , vol.29 , pp. 3723-3731
    • Yamashita, Y.1    Yuan, J.2    Suetake, I.3
  • 58
    • 79960216183 scopus 로고    scopus 로고
    • Recurrent DNMT3A mutations in patients with myelodysplastic syndrome
    • M.J. Walter, D. Shen, J. Shao Recurrent DNMT3A mutations in patients with myelodysplastic syndrome Blood (ASH Annual Meeting Abstracts) 116 2010 608
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 608
    • Walter, M.J.1    Shen, D.2    Shao, J.3
  • 59
    • 80053135096 scopus 로고    scopus 로고
    • Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulationUTX, EZH2 and DNMT3A
    • A.M. Jankowska, H. Makishima, R.V. Tiu Mutational spectrum analysis of chronic myelomonocytic leukemia includes genes associated with epigenetic regulationUTX, EZH2 and DNMT3A Blood 118 2011 3932 3941
    • (2011) Blood , vol.118 , pp. 3932-3941
    • Jankowska, A.M.1    Makishima, H.2    Tiu, R.V.3
  • 60
    • 77952140672 scopus 로고    scopus 로고
    • Clinical response and MiR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine
    • W. Blum, R. Garzon, R.B. Klisovic Clinical response and MiR-29b predictive significance in older AML patients treated with a 10-day schedule of decitabine Proc Natl Acad Sci U S A 107 2010 7473 7478
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 7473-7478
    • Blum, W.1    Garzon, R.2    Klisovic, R.B.3
  • 61
    • 66849124925 scopus 로고    scopus 로고
    • Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia
    • V. Gelsi-Boyer, V. Trouplin, J. Adelaide Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia Br J Haematol 145 2009 788 800
    • (2009) Br J Haematol , vol.145 , pp. 788-800
    • Gelsi-Boyer, V.1    Trouplin, V.2    Adelaide, J.3
  • 62
    • 75749124332 scopus 로고    scopus 로고
    • Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin
    • R.D. Morin, N.A. Johnson, T.M. Severson Somatic mutations altering EZH2 (Tyr641) in follicular and diffuse large B-cell lymphomas of germinal-center origin Nat Genet 42 2010 181 185
    • (2010) Nat Genet , vol.42 , pp. 181-185
    • Morin, R.D.1    Johnson, N.A.2    Severson, T.M.3
  • 63
    • 77955087290 scopus 로고    scopus 로고
    • Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes
    • G. Nikoloski, S.M. Langemeijer, R.P. Kuiper Somatic mutations of the histone methyltransferase gene EZH2 in myelodysplastic syndromes Nat Genet 42 2010 665 667
    • (2010) Nat Genet , vol.42 , pp. 665-667
    • Nikoloski, G.1    Langemeijer, S.M.2    Kuiper, R.P.3
  • 64
    • 77955085750 scopus 로고    scopus 로고
    • Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders
    • T. Ernst, A.J. Chase, J. Score Inactivating mutations of the histone methyltransferase gene EZH2 in myeloid disorders Nat Genet 42 2010 722 726
    • (2010) Nat Genet , vol.42 , pp. 722-726
    • Ernst, T.1    Chase, A.J.2    Score, J.3
  • 65
    • 77957987676 scopus 로고    scopus 로고
    • Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies
    • 10.1038/leu.2010.167 Epub ahead of print 19 August 2010
    • H. Makishima, A. Jankowska, R.V. Tiu Novel homo- and hemizygous mutations in EZH2 in myeloid malignancies Leukemia 2010 10.1038/leu.2010.167 Epub ahead of print 19 August 2010
    • (2010) Leukemia
    • Makishima, H.1    Jankowska, A.2    Tiu, R.V.3
  • 66
    • 79956145260 scopus 로고    scopus 로고
    • Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: Relation to adverse epigenetic alteration and poor prognostic scoring
    • F. Xu, X. Li, L. Wu Overexpression of the EZH2, RING1 and BMI1 genes is common in myelodysplastic syndromes: relation to adverse epigenetic alteration and poor prognostic scoring Ann Hematol 90 2011 643 653
    • (2011) Ann Hematol , vol.90 , pp. 643-653
    • Xu, F.1    Li, X.2    Wu, L.3
  • 69
    • 47549105128 scopus 로고    scopus 로고
    • Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3
    • DOI 10.1101/gad.1673508
    • G.L. Sen, D.E. Webster, D.I. Barragan, H.Y. Chang, P.A. Khavari Control of differentiation in a self-renewing mammalian tissue by the histone demethylase JMJD3 Genes Dev 22 2008 1865 1870 (Pubitemid 352008635)
    • (2008) Genes and Development , vol.22 , Issue.14 , pp. 1865-1870
    • Sen, G.L.1    Webster, D.E.2    Barragan, D.I.3    Chang, H.Y.4    Khavari, P.A.5
  • 71
    • 54049105351 scopus 로고    scopus 로고
    • + cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival
    • + cells from patients with low-risk myelodysplastic syndromes reveals cryptic copy number alterations and predicts overall and leukemia-free survival Blood 112 2008 3412 3424
    • (2008) Blood , vol.112 , pp. 3412-3424
    • Starczynowski, D.T.1    Vercauteren, S.2    Telenius, A.3
  • 73
    • 84856377388 scopus 로고    scopus 로고
    • Genome-wide analysis reveals frequent inactivating mutations of acetyltransferase genes in B-cell lymphoma
    • L. Pasqualucci, D. Dominguez-Sola, A. Chiarenza Genome-wide analysis reveals frequent inactivating mutations of acetyltransferase genes in B-cell lymphoma Blood (ASH Annual Meeting Abstracts) 116 2010 474
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 474
    • Pasqualucci, L.1    Dominguez-Sola, D.2    Chiarenza, A.3
  • 75
    • 84856390113 scopus 로고    scopus 로고
    • Targeted next-generation sequencing (NGS) enables a broad screening of 95 molecular mutations in a one-step approach and detects recurrent mutations in AML with a normal karyotype in MYH11 and NOTCH1
    • A. Kohlmann, V. Grossmann, H.U. Klein Targeted next-generation sequencing (NGS) enables a broad screening of 95 molecular mutations in a one-step approach and detects recurrent mutations in AML with a normal karyotype in MYH11 and NOTCH1 Blood (ASH Annual Meeting Abstracts) 116 2010 175
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 175
    • Kohlmann, A.1    Grossmann, V.2    Klein, H.U.3
  • 76
    • 33745842538 scopus 로고    scopus 로고
    • Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor
    • Y.S. Cho, E.J. Kim, U.H. Park, H.S. Sin, S.J. Um Additional sex comb-like 1 (ASXL1), in cooperation with SRC-1, acts as a ligand-dependent coactivator for retinoic acid receptor J Biol Chem 281 2006 17588 17598
    • (2006) J Biol Chem , vol.281 , pp. 17588-17598
    • Cho, Y.S.1    Kim, E.J.2    Park, U.H.3    Sin, H.S.4    Um, S.J.5
  • 77
    • 77958591628 scopus 로고    scopus 로고
    • ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia
    • V. Gelsi-Boyer, V. Trouplin, J. Roquain ASXL1 mutation is associated with poor prognosis and acute transformation in chronic myelomonocytic leukaemia Br J Haematol 151 2010 365 375
    • (2010) Br J Haematol , vol.151 , pp. 365-375
    • Gelsi-Boyer, V.1    Trouplin, V.2    Roquain, J.3
  • 78
    • 70450239681 scopus 로고    scopus 로고
    • Mutations of ASXL1 gene in myeloproliferative neoplasms
    • N. Carbuccia, A. Murati, V. Trouplin Mutations of ASXL1 gene in myeloproliferative neoplasms Leukemia 23 2009 2183 2186
    • (2009) Leukemia , vol.23 , pp. 2183-2186
    • Carbuccia, N.1    Murati, A.2    Trouplin, V.3
  • 79
    • 77954583280 scopus 로고    scopus 로고
    • Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia
    • J. Boultwood, J. Perry, A. Pellagatti Frequent mutation of the polycomb-associated gene ASXL1 in the myelodysplastic syndromes and in acute myeloid leukemia Leukemia 24 2010 1139 1145
    • (2010) Leukemia , vol.24 , pp. 1139-1145
    • Boultwood, J.1    Perry, J.2    Pellagatti, A.3
  • 80
    • 76749084667 scopus 로고    scopus 로고
    • Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias
    • N. Carbuccia, V. Trouplin, V. Gelsi-Boyer Mutual exclusion of ASXL1 and NPM1 mutations in a series of acute myeloid leukemias Leukemia 24 2010 469 473
    • (2010) Leukemia , vol.24 , pp. 469-473
    • Carbuccia, N.1    Trouplin, V.2    Gelsi-Boyer, V.3
  • 81
    • 77954583280 scopus 로고    scopus 로고
    • High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression
    • J. Boultwood, J. Perry, R. Zaman High-density single nucleotide polymorphism array analysis and ASXL1 gene mutation screening in chronic myeloid leukemia during disease progression Leukemia 24 2010 1139 1145
    • (2010) Leukemia , vol.24 , pp. 1139-1145
    • Boultwood, J.1    Perry, J.2    Zaman, R.3
  • 82
    • 74949143986 scopus 로고    scopus 로고
    • Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia
    • C.L. Fisher, N. Pineault, C. Brookes Loss-of-function additional sex combs like 1 mutations disrupt hematopoiesis but do not cause severe myelodysplasia or leukemia Blood 115 2010 38 46
    • (2010) Blood , vol.115 , pp. 38-46
    • Fisher, C.L.1    Pineault, N.2    Brookes, C.3
  • 84
    • 77950299929 scopus 로고    scopus 로고
    • PHF6 mutations in T-cell acute lymphoblastic leukemia
    • P. Van Vlierberghe, T. Palomero, H. Khiabanian PHF6 mutations in T-cell acute lymphoblastic leukemia Nat Genet 42 2010 338 342
    • (2010) Nat Genet , vol.42 , pp. 338-342
    • Van Vlierberghe, P.1    Palomero, T.2    Khiabanian, H.3
  • 85
    • 78651299314 scopus 로고    scopus 로고
    • PHF6 mutations in adult acute myeloid leukemia
    • P. Van Vlierberghe, J. Patel, O. Abdel-Wahab PHF6 mutations in adult acute myeloid leukemia Leukemia 25 2011 130 134
    • (2011) Leukemia , vol.25 , pp. 130-134
    • Van Vlierberghe, P.1    Patel, J.2    Abdel-Wahab, O.3
  • 86
    • 66249137734 scopus 로고    scopus 로고
    • Mutation in TET2 in myeloid cancers
    • F. Delhommeau, S. Dupont, V. Della Mutation in TET2 in myeloid cancers N Engl J Med 360 2009 2289 2301
    • (2009) N Engl J Med , vol.360 , pp. 2289-2301
    • Delhommeau, F.1    Dupont, S.2    Della, V.3
  • 87
    • 67649876132 scopus 로고    scopus 로고
    • Acquired mutations in TET2 are common in myelodysplastic syndromes
    • S.M. Langemeijer, R.P. Kuiper, M. Berends Acquired mutations in TET2 are common in myelodysplastic syndromes Nat Genet 41 2009 838 842
    • (2009) Nat Genet , vol.41 , pp. 838-842
    • Langemeijer, S.M.1    Kuiper, R.P.2    Berends, M.3
  • 88
    • 67650588639 scopus 로고    scopus 로고
    • Loss of heterozygosity 4q42 and TET2 mutations associated with myelodysplatic/myeloproliferative neoplasms
    • A.M. Jankowska, H. Szpurka, R.V. Tiu Loss of heterozygosity 4q42 and TET2 mutations associated with myelodysplatic/myeloproliferative neoplasms Blood 113 2009 6403 6410
    • (2009) Blood , vol.113 , pp. 6403-6410
    • Jankowska, A.M.1    Szpurka, H.2    Tiu, R.V.3
  • 89
    • 67349124376 scopus 로고    scopus 로고
    • TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis
    • A. Tefferi, A. Pardanani, K.H. Lim TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis Leukemia 23 2009 905 911
    • (2009) Leukemia , vol.23 , pp. 905-911
    • Tefferi, A.1    Pardanani, A.2    Lim, K.H.3
  • 90
    • 79951951235 scopus 로고    scopus 로고
    • TET genes: New players in DNA demethylation and important determinants for stemness
    • F. Mohr, K. Dohner, C. Buske, V.P. Rawat TET genes: new players in DNA demethylation and important determinants for stemness Exp Hematol 39 2011 272 281
    • (2011) Exp Hematol , vol.39 , pp. 272-281
    • Mohr, F.1    Dohner, K.2    Buske, C.3    Rawat, V.P.4
  • 91
    • 67651065502 scopus 로고    scopus 로고
    • Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies
    • O. Abdel-Wahab, A. Mullally, C. Hedvat Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies Blood 114 2009 144 147
    • (2009) Blood , vol.114 , pp. 144-147
    • Abdel-Wahab, O.1    Mullally, A.2    Hedvat, C.3
  • 92
    • 78650019179 scopus 로고    scopus 로고
    • Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation
    • M.E. Figueroa, O. Abdel-Wahab, C. Lu Leukemic IDH1 and IDH2 mutations result in a hypermethylation phenotype, disrupt TET2 function, and impair hematopoietic differentiation Cancer Cell 18 2010 553 567
    • (2010) Cancer Cell , vol.18 , pp. 553-567
    • Figueroa, M.E.1    Abdel-Wahab, O.2    Lu, C.3
  • 93
    • 77953485589 scopus 로고    scopus 로고
    • Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations
    • Y. Sugimoto, H. Muramatsu, H. Makishima Spectrum of molecular defects in juvenile myelomonocytic leukaemia includes ASXL1 mutations Br J Haematol 150 2010 83 87
    • (2010) Br J Haematol , vol.150 , pp. 83-87
    • Sugimoto, Y.1    Muramatsu, H.2    Makishima, H.3
  • 94
    • 78349249756 scopus 로고    scopus 로고
    • Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia
    • B. Perez, O. Kosmider, B. Cassinat Genetic typing of CBL, ASXL1, RUNX1, TET2 and JAK2 in juvenile myelomonocytic leukaemia reveals a genetic profile distinct from chronic myelomonocytic leukaemia Br J Haematol 151 2010 460 468
    • (2010) Br J Haematol , vol.151 , pp. 460-468
    • Perez, B.1    Kosmider, O.2    Cassinat, B.3
  • 95
    • 77952424259 scopus 로고    scopus 로고
    • Molecular alterations of the IDH1 gene in AML: A Children's Oncology Group and Southwest Oncology Group study
    • P.A. Ho, T.A. Alonzo, K.J. Kopecky Molecular alterations of the IDH1 gene in AML: a Children's Oncology Group and Southwest Oncology Group study Leukemia 24 2010 909 913
    • (2010) Leukemia , vol.24 , pp. 909-913
    • Ho, P.A.1    Alonzo, T.A.2    Kopecky, K.J.3
  • 96
    • 52949127312 scopus 로고    scopus 로고
    • An integrated genomic analysis of human glioblastoma multiforme
    • D.W. Parsons, S. Jones, X. Zhang An integrated genomic analysis of human glioblastoma multiforme Science 321 2008 1807 1812
    • (2008) Science , vol.321 , pp. 1807-1812
    • Parsons, D.W.1    Jones, S.2    Zhang, X.3
  • 97
    • 70149093912 scopus 로고    scopus 로고
    • Recurring mutations found by sequencing an acute myeloid leukemia genome
    • E.R. Mardis, L. Ding, D.J. Dooling Recurring mutations found by sequencing an acute myeloid leukemia genome N Engl J Med 361 2009 1058 1066
    • (2009) N Engl J Med , vol.361 , pp. 1058-1066
    • Mardis, E.R.1    Ding, L.2    Dooling, D.J.3
  • 98
    • 77649305610 scopus 로고    scopus 로고
    • The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate
    • P.S. Ward, J. Patel, D.R. Wise The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate Cancer Cell 17 2010 225 234
    • (2010) Cancer Cell , vol.17 , pp. 225-234
    • Ward, P.S.1    Patel, J.2    Wise, D.R.3
  • 99
    • 77149134353 scopus 로고    scopus 로고
    • Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations
    • S. Gross, R.A. Cairns, M.D. Minden Cancer-associated metabolite 2-hydroxyglutarate accumulates in acute myelogenous leukemia with isocitrate dehydrogenase 1 and 2 mutations J Exp Med 207 2010 339 344
    • (2010) J Exp Med , vol.207 , pp. 339-344
    • Gross, S.1    Cairns, R.A.2    Minden, M.D.3
  • 100
    • 77950968519 scopus 로고    scopus 로고
    • Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation
    • W.C. Chou, H.A. Hou, C.Y. Chen Distinct clinical and biologic characteristics in adult acute myeloid leukemia bearing the isocitrate dehydrogenase 1 mutation Blood 115 2010 2749 2754
    • (2010) Blood , vol.115 , pp. 2749-2754
    • Chou, W.C.1    Hou, H.A.2    Chen, C.Y.3
  • 101
    • 77952536841 scopus 로고    scopus 로고
    • IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: A Cancer and Leukemia Group B study
    • G. Marcucci, K. Maharry, Y.Z. Wu IDH1 and IDH2 gene mutations identify novel molecular subsets within de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study J Clin Oncol 28 2010 2348 2355
    • (2010) J Clin Oncol , vol.28 , pp. 2348-2355
    • Marcucci, G.1    Maharry, K.2    Wu, Y.Z.3
  • 102
    • 77955907891 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication
    • P. Paschka, R.F. Schlenk, V.I. Gaidzik IDH1 and IDH2 mutations are frequent genetic alterations in acute myeloid leukemia and confer adverse prognosis in cytogenetically normal acute myeloid leukemia with NPM1 mutation without FLT3 internal tandem duplication J Clin Oncol 28 2010 3636 3643
    • (2010) J Clin Oncol , vol.28 , pp. 3636-3643
    • Paschka, P.1    Schlenk, R.F.2    Gaidzik, V.I.3
  • 103
    • 77954658823 scopus 로고    scopus 로고
    • IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis
    • A. Tefferi, T.L. Lasho, O. Abdel-Wahab IDH1 and IDH2 mutation studies in 1473 patients with chronic-, fibrotic- or blast-phase essential thrombocythemia, polycythemia vera or myelofibrosis Leukemia 24 2010 1302 1309
    • (2010) Leukemia , vol.24 , pp. 1302-1309
    • Tefferi, A.1    Lasho, T.L.2    Abdel-Wahab, O.3
  • 104
    • 77952481300 scopus 로고    scopus 로고
    • Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP Rs11554137 is an adverse prognostic factor
    • K. Wagner, F. Damm, G. Gohring Impact of IDH1 R132 mutations and an IDH1 single nucleotide polymorphism in cytogenetically normal acute myeloid leukemia: SNP Rs11554137 is an adverse prognostic factor J Clin Oncol 28 2010 2356 2364
    • (2010) J Clin Oncol , vol.28 , pp. 2356-2364
    • Wagner, K.1    Damm, F.2    Gohring, G.3
  • 105
    • 72049125350 scopus 로고    scopus 로고
    • Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
    • L. Dang, D.W. White, S. Gross Cancer-associated IDH1 mutations produce 2-hydroxyglutarate Nature 462 2009 739 744
    • (2009) Nature , vol.462 , pp. 739-744
    • Dang, L.1    White, D.W.2    Gross, S.3
  • 106
    • 70349975711 scopus 로고    scopus 로고
    • JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin
    • M.A. Dawson, A.J. Bannister, B. Gottgens JAK2 phosphorylates histone H3Y41 and excludes HP1alpha from chromatin Nature 461 2009 819 822
    • (2009) Nature , vol.461 , pp. 819-822
    • Dawson, M.A.1    Bannister, A.J.2    Gottgens, B.3
  • 107
    • 84856286617 scopus 로고    scopus 로고
    • Mutations of EZH2 in myeloproliferative neoplasms with myelofibrosis: Correlation with molecular and clinical data
    • F. Stegelmann, R.F. Schlenk, M. Griesshammer Mutations of EZH2 in myeloproliferative neoplasms with myelofibrosis: correlation with molecular and clinical data Blood (ASH Annual Meeting Abstracts) 116 2010 4111
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 4111
    • Stegelmann, F.1    Schlenk, R.F.2    Griesshammer, M.3
  • 108
    • 79955810336 scopus 로고    scopus 로고
    • Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance
    • V. Grossmann, A. Kohlmann, C. Eder Molecular profiling of chronic myelomonocytic leukemia reveals diverse mutations in >80% of patients with TET2 and EZH2 being of high prognostic relevance Leukemia 25 2011 877 879
    • (2011) Leukemia , vol.25 , pp. 877-879
    • Grossmann, V.1    Kohlmann, A.2    Eder, C.3
  • 109
    • 79951865273 scopus 로고    scopus 로고
    • Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms
    • O. Abdel-Wahab, A. Pardanani, J. Patel Concomitant analysis of EZH2 and ASXL1 mutations in myelofibrosis, chronic myelomonocytic leukemia and blast-phase myeloproliferative neoplasms Blood (ASH Annual Meeting Abstracts) 116 2010 3070
    • (2010) Blood (ASH Annual Meeting Abstracts) , vol.116 , pp. 3070
    • Abdel-Wahab, O.1    Pardanani, A.2    Patel, J.3
  • 110
    • 76549109434 scopus 로고    scopus 로고
    • Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias
    • O. Abdel-Wahab, T. Manshouri, J. Patel Genetic analysis of transforming events that convert chronic myeloproliferative neoplasms to leukemias Cancer Res 70 2010 447 452
    • (2010) Cancer Res , vol.70 , pp. 447-452
    • Abdel-Wahab, O.1    Manshouri, T.2    Patel, J.3
  • 111
    • 77953616961 scopus 로고    scopus 로고
    • Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations
    • H. Szpurka, A.M. Jankowska, H. Makishima Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations Leuk Res 34 2010 969 973
    • (2010) Leuk Res , vol.34 , pp. 969-973
    • Szpurka, H.1    Jankowska, A.M.2    Makishima, H.3
  • 112
    • 77955081371 scopus 로고    scopus 로고
    • Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias
    • J. Rocquain, N. Carbuccia, V. Trouplin Combined mutations of ASXL1, CBL, FLT3, IDH1, IDH2, JAK2, KRAS, NPM1, NRAS, RUNX1, TET2 and WT1 genes in myelodysplastic syndromes and acute myeloid leukemias BMC Cancer 10 2010 401
    • (2010) BMC Cancer , vol.10 , pp. 401
    • Rocquain, J.1    Carbuccia, N.2    Trouplin, V.3
  • 113
    • 78549279199 scopus 로고    scopus 로고
    • Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations
    • W.C. Chou, H.H. Huang, H.A. Hou Distinct clinical and biological features of de novo acute myeloid leukemia with additional sex comb-like 1 (ASXL1) mutations Blood 116 2010 4086 4094
    • (2010) Blood , vol.116 , pp. 4086-4094
    • Chou, W.C.1    Huang, H.H.2    Hou, H.A.3
  • 114
    • 67349145955 scopus 로고    scopus 로고
    • Frequent TET2 mutations in systemic mastocytosis: Clinical, KITD816V and FIP1L1-PDGFRA correlates
    • A. Tefferi, R.L. Levine, K.H. Lim Frequent TET2 mutations in systemic mastocytosis: clinical, KITD816V and FIP1L1-PDGFRA correlates Leukemia 23 2009 900 904
    • (2009) Leukemia , vol.23 , pp. 900-904
    • Tefferi, A.1    Levine, R.L.2    Lim, K.H.3
  • 115
    • 67650924270 scopus 로고    scopus 로고
    • Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML
    • A. Tefferi, K.H. Lim, O. Abdel-Wahab Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS/MPN and AML Leukemia 23 2009 1343 1345
    • (2009) Leukemia , vol.23 , pp. 1343-1345
    • Tefferi, A.1    Lim, K.H.2    Abdel-Wahab, O.3
  • 116
    • 70350438115 scopus 로고    scopus 로고
    • TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs)
    • O. Kosmider, V. Gelsi-Boyer, M. Cheok TET2 mutation is an independent favorable prognostic factor in myelodysplastic syndromes (MDSs) Blood 114 2009 3285 3291
    • (2009) Blood , vol.114 , pp. 3285-3291
    • Kosmider, O.1    Gelsi-Boyer, V.2    Cheok, M.3
  • 117
    • 73149094518 scopus 로고    scopus 로고
    • TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia
    • O. Kosmider, V. Gelsi-Boyer, M. Ciudad TET2 gene mutation is a frequent and adverse event in chronic myelomonocytic leukemia Haematologica 94 2009 1676 1681
    • (2009) Haematologica , vol.94 , pp. 1676-1681
    • Kosmider, O.1    Gelsi-Boyer, V.2    Ciudad, M.3
  • 118
    • 70149101696 scopus 로고    scopus 로고
    • Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms
    • C. Saint-Martin, G. Leroy, F. Delhommeau Analysis of the ten-eleven translocation 2 (TET2) gene in familial myeloproliferative neoplasms Blood 114 2009 1628 1632
    • (2009) Blood , vol.114 , pp. 1628-1632
    • Saint-Martin, C.1    Leroy, G.2    Delhommeau, F.3
  • 119
    • 77949732119 scopus 로고    scopus 로고
    • Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis
    • J. Flach, F. Dicker, S. Schnittger, A. Kohlmann, T. Haferlach, C. Haferlach Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis Haematologica 95 2010 518 519
    • (2010) Haematologica , vol.95 , pp. 518-519
    • Flach, J.1    Dicker, F.2    Schnittger, S.3    Kohlmann, A.4    Haferlach, T.5    Haferlach, C.6
  • 120
    • 77950382457 scopus 로고    scopus 로고
    • Mutations of an E3 Ubiquitin Ligase C-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia
    • H. Muramatsu, H. Makishima, A.M. Jankowska Mutations of an E3 Ubiquitin Ligase C-Cbl but not TET2 mutations are pathogenic in juvenile myelomonocytic leukemia Blood 115 2010 1969 1975
    • (2010) Blood , vol.115 , pp. 1969-1975
    • Muramatsu, H.1    Makishima, H.2    Jankowska, A.M.3
  • 121
    • 77956513784 scopus 로고    scopus 로고
    • Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission
    • O. Nibourel, O. Kosmider, M. Cheok Incidence and prognostic value of TET2 alterations in de novo acute myeloid leukemia achieving complete remission Blood 116 2010 1132 1135
    • (2010) Blood , vol.116 , pp. 1132-1135
    • Nibourel, O.1    Kosmider, O.2    Cheok, M.3
  • 122
    • 77956237515 scopus 로고    scopus 로고
    • Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia (CMML) by detecting frequent alterations in TET2, CBL, RAS and RUNX1
    • A. Kohlmann, V. Grossmann, H.-U. Klein Next-generation sequencing technology reveals a characteristic pattern of molecular mutations in 72.8% of chronic myelomonocytic leukemia (CMML) by detecting frequent alterations in TET2, CBL, RAS and RUNX1 J Clin Oncol 28 2010 3858 3865
    • (2010) J Clin Oncol , vol.28 , pp. 3858-3865
    • Kohlmann, A.1    Grossmann, V.2    Klein, H.-U.3
  • 123
    • 78149454504 scopus 로고    scopus 로고
    • Next-generation sequencing of the TET2 gene in 355 MDS patients reveals low abundance mutant clones with early origins, but indicates no definite prognostic value
    • A.E. Smith, A. Mahamedali, A. Kulasekararaj Next-generation sequencing of the TET2 gene in 355 MDS patients reveals low abundance mutant clones with early origins, but indicates no definite prognostic value Blood 116 2010 3923 3932
    • (2010) Blood , vol.116 , pp. 3923-3932
    • Smith, A.E.1    Mahamedali, A.2    Kulasekararaj, A.3
  • 124
    • 77952426827 scopus 로고    scopus 로고
    • Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms
    • O. Kosmider, V. Gelsi-Boyer, L. Slama Mutations of IDH1 and IDH2 genes in early and accelerated phases of myelodysplastic syndromes and MDS/myeloproliferative neoplasms Leukemia 24 2010 1094 1096
    • (2010) Leukemia , vol.24 , pp. 1094-1096
    • Kosmider, O.1    Gelsi-Boyer, V.2    Slama, L.3
  • 125
    • 77957192661 scopus 로고    scopus 로고
    • Acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: Prevalence and prognostic value
    • S. Abbas, S. Lugthart, F.G. Kavelaars acquired mutations in the genes encoding IDH1 and IDH2 both are recurrent aberrations in acute myeloid leukemia: prevalence and prognostic value Blood 116 2010 2122 2126
    • (2010) Blood , vol.116 , pp. 2122-2126
    • Abbas, S.1    Lugthart, S.2    Kavelaars, F.G.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.