Integrated, genome-wide screening for hypomethylated oncogenes in salivary gland adenoid cystic carcinoma

Clinical Cancer Research

Volumn 17, Issue 13, 2011, Pages 4320-4330

  Shao, Chunbo ^a   Sun, Wenyue ^a   Tan, Marietta ^a   Glazer, Chad A ^a   Bhan, Sheetal ^a   Zhong, Xiaoli ^a   Fakhry, Carole ^a   Sharma, Rajni ^a   Westra, William H ^a   Hoque, Mohammad O ^a   Moskaluk, Christopher A ^c   Sidransky, David ^a   Califano, Joseph A ^a,b   Ha, Patrick K ^a,b  

^a DEPARTMENT OF PATHOLOGY   (United States)

^b GREATER BALTIMORE MEDICAL CENTER   (United States)

^c UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 AZA 2' DEOXYCYTIDINE; AQUAPORIN 1; CANCER TESTIS ANTIGEN; CANCER TESTIS ANTIGEN 2; MESSENGER RNA; TRICHOSTATIN A; UNCLASSIFIED DRUG;

ADENOID CYSTIC CARCINOMA; ADULT; AGED; AQP1 GENE; ARTICLE; BEX1 GENE; C1QR1 GENE; CANCER CELL CULTURE; CANCER INVASION; CANCER RECURRENCE; CANCER STAGING; CELL PROLIFERATION; CELL STRAIN; CERC1 GENE; CLINICAL ARTICLE; COLONY FORMATION; CONTROLLED STUDY; CPG ISLAND; CTAG2 GENE; DNA METHYLATION; DYNLT3 GENE; EPIGENETICS; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENE OVEREXPRESSION; GENE SEQUENCE; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; METASTASIS; MICROARRAY ANALYSIS; ONCOGENE; P53AIP1 GENE; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SALIVARY GLAND CARCINOMA; TDRD12 GENE; TRANSCRIPTION REGULATION; TUMOR LOCALIZATION; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; ANTIMETABOLITES, ANTINEOPLASTIC; AQUAPORIN 1; AZACITIDINE; CARCINOMA, ADENOID CYSTIC; CELL LINE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTIDINE TRIPHOSPHATE; DNA METHYLATION; EPIGENOMICS; FEMALE; GENE EXPRESSION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENETIC TESTING; GENOME-WIDE ASSOCIATION STUDY; HUMANS; MALE; MIDDLE AGED; ONCOGENES; SALIVARY GLAND NEOPLASMS; UP-REGULATION;

EID: 79960339184     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-2992     Document Type: Article

References (45)

1. Dodd RL, Slevin NJ. Salivary gland adenoid cystic carcinoma: a review of chemotherapy and molecular therapies. Oral Oncol 2006;42:759-69. (Pubitemid 44307768)
2. Fordice J, Kershaw C, El-Naggar A, Goepfert H. Adenoid cystic carcinoma of the head and neck: predictors of morbidity and mortality. Arch Otolaryngol Head Neck Surg 1999;125:149-52. (Pubitemid 29085262)
3. Garden AS, Weber RS, Morrison WH, Ang KK, Peters LJ. The influence of positive margins and nerve invasion in adenoid cystic carcinoma of the head and neck treated with surgery and radiation. Int J Radiat Oncol Biol Phys 1995;32:619-26.
4. Herman JG, Baylin SB. Gene silencing in cancer in association with promoter hypermethylation. N Engl J Med 2003;349:2042-54. (Pubitemid 37448928)
5. Uchida D, Begum NM, Almofti A, Kawamata H, Yoshida H, Sato M. Frequent downregulation of 14-3-3 sigma protein and hypermethylation of 14-3-3 sigma gene in salivary gland adenoid cystic carcinoma. Br J Cancer 2004;91:1131-8. (Pubitemid 39336252)
6. Maruya S, Kurotaki H, Shimoyama N, Kaimori M, Shinkawa H, Yagihashi S. Expression of p16 protein and hypermethylation status of its promoter gene in adenoid cystic carcinoma of the head and neck. ORL J Otorhinolaryngol Relat Spec 2003;65:26-32. (Pubitemid 36302450)
7. Maruya S, Kurotaki H, Wada R, Saku T, Shinkawa H, Yagihashi S. Promoter methylation and protein expression of the E-cadherin gene in the clinicopathologic assessment of adenoid cystic carcinoma. Mod Pathol 2004;17:637-45. (Pubitemid 38715485)
8. Li J, El-Naggar A, Mao L. Promoter methylation of p16INK4a, RASSF1A, and DAPK is frequent in salivary adenoid cystic carcinoma. Cancer 2005;104:771-6.
9. Zhang CY, Mao L, Li L, Tian Z, Zhou XJ, Zhang ZY, et al. Promoter methylation as a common mechanism for inactivating E-cadherin in human salivary gland adenoid cystic carcinoma. Cancer 2007;110:87-95. (Pubitemid 46992031)
10. Williams MD, Chakravarti N, Kies MS, Maruya S, Myers JN, Haviland JC, et al. Implications of methylation patterns of cancer genes in salivary gland tumors. Clin Cancer Res 2006;12:7353-8. (Pubitemid 46095408)
11. Durr ML, Mydlarz WK, Shao C, Zahurak ML, Chuang AY, Hoque MO, et al. Quantitative methylation profiles for multiple tumor suppressor gene promoters in salivary gland tumors. PLoS One 2010;5:e10828.
12. Yamashita K, Upadhyay S, Osada M, Hoque MO, Xiao Y, Mori M, et al. Pharmacologic unmasking of epigenetically silenced tumor suppressor genes in esophageal squamous cell carcinoma. Cancer Cell 2002;2:485-95. (Pubitemid 41043953)
13. Hoque MO, Kim MS, Ostrow KL, Liu J, Wisman GB, Park HL, et al. Genome-wide promoter analysis uncovers portions of the cancer methylome. Cancer Res 2008;68:2661-70. (Pubitemid 351556263)
14. Phuchareon J, Ohta Y, Woo JM, Eisele DW, Tetsu O. Genetic profiling reveals cross-contamination and misidentification of 6 adenoid cystic carcinoma cell lines: ACC2, ACC3, ACCM, ACCNS, ACCS and CAC2. PLoS One 2009;4:e6040.
15. Glazer CA, Smith IM, Ochs MF, Begum S, Westra W, Chang SS, et al. Integrative discovery of epigenetically derepressed cancer testis antigens in NSCLC. PLoS One 2009;4:e8189.
16. Smith IM, Glazer CA, Mithani SK, Ochs MF, Sun W, Bhan S, et al. Coordinated activation of candidate proto-oncogenes and cancer testes antigens via promoter demethylation in head and neck cancer and lung cancer. PLoS One 2009;4:e4961.
17. Shao C, Bai W, Junn JC, Uemura M, Hennessey PT, Zaboli D, et al. Evaluation of MYB promoter methylation in salivary adenoid cystic carcinoma. Oral Oncol 2011;47:251-5.
18. Chopra DP, Xue-Hu I, Bacchetti S, Gupta J. Extended abstract: unlimited life span of human diploid normal epithelial cells. Radiat Oncol Investig 1995;3:363-7. (Pubitemid 126680367)
19. Tomlins SA, Rhodes DR, Perner S, Dhanasekaran SM, Mehra R, Sun XW, et al. Recurrent fusion of TMPRSS2 and ETS transcription factor genes in prostate cancer. Science 2005;310:644-8. (Pubitemid 41528150)
20. Li LC, Dahiya R. MethPrimer: designing primers for methylation PCRs. Bioinformatics 2002;18:1427-31. (Pubitemid 35414532)
21. Kim MS, Yamashita K, Baek JH, Park HL, Carvalho AL, Osada M, et al. N-methyl-D-aspartate receptor type 2B is epigenetically inactivated and exhibits tumor-suppressive activity in human esophageal cancer. Cancer Res 2006;66:3409-18.
22. Hoque MO, Soria JC, Woo J, Lee T, Lee J, Jang SJ, et al. Aquaporin 1 is overexpressed in lung cancer and stimulates NIH-3T3 cell proliferation and anchorage-independent growth. Am J Pathol 2006;168:1345-53.
23. Lee JY, Park AK, Lee KM, Park SK, Han S, Han W, et al. Candidate gene approach evaluates association between innate immunity genes and breast cancer risk in Korean women. Carcinogenesis 2009;30:1528-31.
24. Vaughan HA, Svobodova S, Macgregor D, Sturrock S, Jungbluth AA, Browning J, et al. Immunohistochemical and molecular analysis of human melanomas for expression of the human cancer-testis antigens NY-ESO-1 and LAGE-1. Clin Cancer Res 2004;10:8396-404. (Pubitemid 40053402)
25. Mashino K, Sadanaga N, Tanaka F, Yamaguchi H, Nagashima H, Inoue H, et al. Expression of multiple cancer-testis antigen genes in gastrointestinal and breast carcinomas. Br J Cancer 2001;85:713-20. (Pubitemid 32929470)
26. Sharma P, Gnjatic S, Jungbluth AA, Williamson B, Herr H, Stockert E, et al. Frequency of NY-ESO-1 and LAGE-1 expression in bladder cancer and evidence of a new NY-ESO-1 T-cell epitope in a patient with bladder cancer. Cancer Immun 2003;3:19.
27. Fossa A, Alsoe L, Crameri R, Funderud S, Gaudernack G, Smeland EB. Serological cloning of cancer/testis antigens expressed in prostate cancer using cDNA phage surface display. Cancer Immunol Immunother 2004;53:431-8. (Pubitemid 38657256)
28. Nakamura Y. Isolation of p53-target genes and their functional analysis. Cancer Sci 2004;95:7-11. (Pubitemid 38208400)
29. Yamashita S, Chujo M, Miyawaki M, Tokuishi K, Anami K, Yamamoto S, et al. Combination of p53AIP1 and survivin expression is a powerful prognostic marker in non-small cell lung cancer. J Exp Clin Cancer Res 2009;28:22.
30. Foltz G, Ryu GY, Yoon JG, Nelson T, Fahey J, Frakes A, et al. Genome-wide analysis of epigenetic silencing identifies BEX1 and BEX2 as candidate tumor suppressor genes in malignant glioma. Cancer Res 2006;66:6665-74. (Pubitemid 44085623)
31. Verkman AS, Hara-Chikuma M, Papadopoulos MC. Aquaporins-new players in cancer biology. J Mol Med 2008;86:523-9.
32. Mazal PR, Susani M, Wrba F, Haitel A. Diagnostic significance of aquaporin-1 in liver tumors. Hum Pathol 2005;36:1226-31. (Pubitemid 41540400)
33. McCoy E, Sontheimer H. Expression and function of water channels (aquaporins) in migrating malignant astrocytes. Glia 2007;55:1034-43. (Pubitemid 47066743)
34. Guan B, Zhu D, Dong Z, Yang Z. [Expression and distribution of aquaporin 1 in laryngeal carcinoma]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2007;21:269-72.
35. Chen Y, Tachibana O, Oda M, Xu R, Hamada J, Yamashita J, et al. Increased expression of aquaporin 1 in human hemangioblastomas and its correlation with cyst formation. J Neurooncol 2006;80:219-25. (Pubitemid 44782898)
36. Longatti P, Basaldella L, Orvieto E, Dei Tos A, Martinuzzi A. Aquaporin (s) expression in choroid plexus tumours. Pediatr Neurosurg 2006;42:228-33. (Pubitemid 43787319)
37. Moon C, Soria JC, Jang SJ, Lee J, Obaidul Hoque M, Sibony M, et al. Involvement of aquaporins in colorectal carcinogenesis. Oncogene 2003;22:6699-703. (Pubitemid 37372210)
38. Endo M, Jain RK, Witwer B, Brown D. Water channel (aquaporin 1) expression and distribution in mammary carcinomas and glioblastomas. Microvasc Res 1999;58:89-98. (Pubitemid 29419934)
39. Papadopoulos MC, Saadoun S, Verkman AS. Aquaporins and cell migration. Pflugers Arch 2008;456:693-700. (Pubitemid 351692135)
40. Echevarria M, Munoz-Cabello AM, Sanchez-Silva R, Toledo-Aral JJ, Lopez-Barneo J. Development of cytosolic hypoxia and hypoxiainducible factor stabilization are facilitated by aquaporin-1 expression. J Biol Chem 2007;282:30207-15. (Pubitemid 350035297)
41. Risau W. Mechanisms of angiogenesis. Nature 1997;386:671-4. (Pubitemid 27193480)
42. Ferrara N, Davis-Smyth T. The biology of vascular endothelial growth factor. Endocr Rev 1997;18:4-25. (Pubitemid 27076453)
43. Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J 1999;13:9-22. (Pubitemid 29038270)
44. Sun W, Liu Y, Glazer CA, Shao C, Bhan S, Demokan S, et al. TKTL1 is activated by promoter hypomethylation and contributes to head and neck squamous cell carcinoma carcinogenesis through increased aerobic glycolysis and HIF1alpha stabilization. Clin Cancer Res 2010;16:857-66.
45. Huysseune S, Kienlen-Campard P, Hebert S, Tasiaux B, Leroy K, Devuyst O, et al. Epigenetic control of aquaporin 1 expression by the amyloid precursor protein. FASEB J 2009;23:4158-67.