Detection of viral DNA sequences in the cerebrospinal fluid of patients with multiple sclerosis

Journal of Medical Virology

Volumn 82, Issue 6, 2010, Pages 1051-1057

  Mancuso, Roberta ^a   Hernis, Ambra ^a   Cavarretta, Rosella ^a   Caputo, Domenico ^a   Calabrese, Elena ^a   Nemni, Raffaello ^a,b   Ferrante, Pasquale ^b   Delbue, Serena ^b   Clerici, Mario ^a,b  

^a IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Cerebrospinal fluid; EBV; HHV 6; JCV; Multiple sclerosis; VZV

Indexed keywords

VIRUS DNA;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN DAMAGE; CELL MIGRATION; CEREBROSPINAL FLUID; DNA SEQUENCE; EPSTEIN BARR VIRUS; FEMALE; HUMAN; HUMAN HERPESVIRUS 6; JC VIRUS; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VARICELLA ZOSTER VIRUS; VIRUS DETECTION;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; CEREBROSPINAL FLUID; DNA, VIRAL; FEMALE; HERPESVIRUS 3, HUMAN; HERPESVIRUS 4, HUMAN; HERPESVIRUS 6, HUMAN; HUMANS; JC VIRUS; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS; YOUNG ADULT;

HUMAN HERPESVIRUS 3; HUMAN HERPESVIRUS 4; HUMAN HERPESVIRUS 6; JC POLYOMAVIRUS;

EID: 77953497715     PISSN: 01466615     EISSN: 10969071     Source Type: Journal    
DOI: 10.1002/jmv.21764     Document Type: Article

References (48)

1. Alvarez-Lafuente R, García-Montojo M, De Las Heras V, Bartolomé M, Arroyo R. 2007. JC virus in cerebrospinal fluid samples of multiple sclerosis patients at the first demyelinating event. Mult Scler 13:590-595. (Pubitemid 46939524)
2. Alvarez-Lafuente R, García-Montojo M, De Las Heras V, Domínguez-Mozo MI, Bartolome M, Benito-Martin MS, Arroyo R. 2008. Herpesviruses and human endogenous retroviral sequences in the cerebrospinal fluid of multiple sclerosis patients. Mult Scler 14: 595-601. (Pubitemid 351954400)
3. Behzad-Behbahani A, Klapper PE, Vallely PJ, Cleator GM, Khoo SH. 2004. Detection of BK virus and JC virus DNA in urine samples from immunocompromised (HIV-infected) and immunocompetent (HIV-non-infected) patients using polymerase chain reaction and microplate hybridisation. J Clin Virol 29:224-229. (Pubitemid 38281212)
4. Blake K, Pillay D, Knowles W, Brown DW, Griffiths PD, Taylor B. 1992. JC virus associated meningoencephalitis in an immunocompetent girl. Arch Dis Child 67:956-957.
5. Bogdanovic G, Priftakis P, Hammarin AL, Söderström M, Samuelson A, Lewensohn-Fuchs I, Dalianis T. 1998. Detection of JC virus in cerebrospinal fluid (CSF) samples from patients with progressive multifocal leukoencephalopathy but not in CSF samples from patients with herpes simplex encephalitis, enteroviral meningitis, or multiple sclerosis. J Clin Microbiol 36:1137-1138. (Pubitemid 28146315)
6. Borghi E, Pagani E, Mancuso R, Delbue S, Valli M, Mazziotti R, Giordano L, Micheli R, Ferrante P. 2005. Detection of herpesvirus-6A in a case of subacute cerebellitis and myoclonic dystonia. JMed Virol 75:427-429. (Pubitemid 40175908)
7. Bossolasco S, Marenzi R, Dahl H, Vago L, Terreni MR, Broccolo F, Lazzarin A, Linde A, Cinque P. 1999. Human herpesvirus 6 in cerebrospinal fluid of patients infected with HIV: Frequency and clinical significance. J Neurol Neurosurg Psychiatry 67:789-792.
8. Buljevac D, van Doornum GJ, Flach HZ, Groen J, Osterhaus AD, Hop W, van Doorn PA, van der Meché FG, Hintzen RQ. 2005. Epstein-Barr virus and disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry 76:1377-1381.
9. Calabrese LH, Molloy ES, Huang D, Ransohoff RM. 2007. Progressive multifocal leukoencephalopathy in rheumatic diseases: Evolving clinical and pathologic patterns of disease. Arthritis Rheum 56:2116-2128.
10. Caserta MT, Hall CB, Schnabel K, McIntyre K, Long C, Costanzo M, Dewhurst S, Insel R, Epstein LG. 1994. Neuroinvasion and persistence of human herpesvirus 6 in children. J Infect Dis 170:1586-1589. (Pubitemid 24369923)
11. Delbue S, Sotgiu G, Fumagalli D, Valli M, Borghi E, Mancuso R, Marchioni E, Maserati R, Ferrante P. 2005. A case of a PML patient with four different JC virus TCR rearrangements in CSF, blood, serum and urine. J Neurovirol 11:51-57.
12. Delbue S, Branchetti E, Boldorini R, Vago L, Zerbi P, Veggiani C, Tremolada S, Ferrante P. 2008. Presence and expression of JCV early gene large T antigen in the brains of immunocompromised and immunocompetent individuals. J Med Virol 80:2147-2152.
13. Eggers C, Stellbrink HJ, Buhk T, Dörries K. 1999. Quantification of JC virus DNA in the cerebrospinal fluid of patients with human immunodeficiency virus-associated progressive multifocal leukoencephalopathy - A longitudinal study. J Infect Dis 180:1690-1694.
14. Elsner C, Dörries K. 1992. Evidence of human polyomavirus BK and JC infection in normal brain tissue. Virology 191:72-80.
15. Ferrante P, Omodeo-Zorini E, Caldarelli-Stefano R, Mediati M, Fainardi E, Granieri E, Caputo D. 1998. Detection of JC virus DNA in cerebrospinal fluid from multiple sclerosis patients. Mult Scler 4:49-54.
16. Focosi D, Kast RE, Maggi F, Ceccherini-Nelli L, Petrini M. 2009. JC virus DNA in healthy brain tissue: A challenge for progressive multifocal leukoencephalopathy diagnosis. Ann Neurol 65:230.
17. Franciotta D, Avolio C, Capello E, Lolli F, AINI. 2005. Consensus recommendations of the Italian Association for Neuroimmunology for immunochemical cerebrospinal fluid examination. J Neurol Sci 237:5-11.
18. Franciotta D, Bestetti A, Bergamaschi R, Piccolo G, Persico A, Cinque P. 2006. Failure to detect JC virus DNA in cerebrospinal fluid of multiple sclerosis patients. Mult Scler 12:674-675.
19. Goodman AD, Mock DJ, Powers JM, Baker JV, Blumberg BM. 2003. Human herpesvirus 6 genome and antigen in acute multiple sclerosis lesions. J Infect Dis 187:1365-1376.
20. Iacobaeus E, Ryschkewitsch C, Gravell M, Khademi M, Wallstrom E, Olsson T, Brundin L, Major E. 2008. Analysis of cerebrospinal fluid and cerebrospinal fluid cells from patients with multiple sclerosis for detection of JC virus DNA. Mult Scler 15:28-35.
21. Khalili K, White MK, Lublin F, Ferrante P, Berger JR. 2007. Reactivation of JC virus and development of PML in patients with multiple sclerosis. Neurology 68:985-990.
22. Kleinschmidt-DeMasters BK, Tyler KL. 2005. Progressive multifocal leukoencephalopathy complicating treatment with natalizumab and interferon beta-1a for multiple sclerosis. N Engl J Med 353:369-374.
23. Knox KK, Harrington DP, Carrigan DR. 1995. Fulminant human herpesvirus six encephalitis in a human immunodeficiency virus-infected infant. J Med Virol 45:288-292.
24. Koralnik IJ, Boden D, Mai VX, Lord CI, Letvin NL. 1999. JC virus DNA load in patients with and without progressive multifocal leukoencephalopathy. Neurology 52:253-260.
25. Koralnik IJ, Wüthrich C, Dang X, Rottnek M, Gurtman A, Simpson D, Morgello S. 2005. JC virus granule cell neuronopathy: A novel clinical syndrome distinct from progressive multifocal leukoencephalopathy. Ann Neurol 57:576-580.
26. Kuusisto H, Hyöty H, Kares S, Kinnunen E, Elovaara I. 2008. Human herpesvirus 6 and multiple sclerosis: A Finnish twin study. Mult Scler 14:54-58.
27. Langer-Gould A, Atlas SW, Green AJ, Bollen AW, Pelletier D. 2005. Progressive multifocal leukoencephalopathy in a patient treated with natalizumab. N Engl J Med 353:375-381.
28. Levin LI, Munger KL, Rubertone MV, Peck CA, Lennette ET, Spiegelman D, Ascherio A. 2003. Multiple sclerosis and Epstein-Barr virus. J Am Med Assoc 289:1533-1536.
29. Mancuso R, Delbue S, Borghi E, Pagani E, Calvo MG, Caputo D, Granieri E, Ferrante P. 2007. Increased prevalence of varicella zoster virus DNA in cerebrospinal fluid from patients with multiple sclerosis. J Med Virol 79:192-199.
30. McFarland HF, Jacobson S. 2006. Natalizumab and immune cells. Arch Neurol 63:1366-1367.
31. Mori M, Kurata H, Tajima M, Shimada H. 1991. JC virus detection by in situ hybridization in brain tissue from elderly patients. Ann Neurol 29:428-432.
32. Opsahl ML, Kennedy PG. 2005. Early and late HHV-6 gene transcripts in multiple sclerosis lesions and normal appearing white matter. Brain 128:516-527.
33. Ordoñez G, Pineda B, Garcia-Navarrete R, Sotelo J. 2004. Brief presence of varicella-zoster viral DNA in mononuclear cells during relapses of multiple sclerosis. Arch Neurol 61:529-532.
34. Perez-Liz G, Del Valle L, Gentilella A, Croul S, Khalili K. 2008. Detection of JC virus DNA fragments but not proteins in normal brain tissue. Ann Neurol 64:379-387.
35. Polman CH, Reingold SC, Edan G, Filippi M, Hartung HP, Kappos L, Lublin FD, Metz LM, McFarland HF, O'Connor PW, Sandberg-Wollheim M, Thompson AJ, Weinshenker BG, Wolinsky JS. 2005. Diagnostic criteria for multiple sclerosis: 2005 revisions to the "McDonald Criteria." Ann Neurol 58:840-846.
36. Rudick RA, Stuart WH, Calabresi PA, Confavreux C, Galetta SL, Radue EW, Lublin FD, Weinstock-Guttman B, Wynn DR, Lynn F, Panzara MA, Sandrock AW, SENTINEL Investigators. 2006. Natalizumab plus interferon beta-1a for relapsing multiple sclerosis. N Engl J Med 354:911-923.
37. Serafini B, Rosicarelli B, Franciotta D, Magliozzi R, Reynolds R, Cinque P, Andreoni L, Trivedi P, Salvetti M, Faggioni A, Aloisi F. 2007. Dysregulated Epstein-Barr virus infection in the multiple sclerosis brain. J Exp Med 204:2899-2912.
38. Sotelo J. 2007. On the viral hypothesis of multiple sclerosis: Participation of varicella-zoster virus. J Neurol Sci 262:113-116. (Pubitemid 47390907)
39. Stoner GL. 1991. Implications of progressive multifocal leukoencephalopathy and JC virus for the etiology of MS. Acta Neurol Scand 83:20-33.
40. Studahl M, Hagberg L, Rekabdar E, Bergström T. 2000. Herpesvirus DNA detection in cerebral spinal fluid: Differences in clinical presentation between alpha-, beta-, and gamma-herpesviruses. Scand J Infect Dis 32:237-248. (Pubitemid 30601327)
41. Stüve O, Marra CM, Bar-Or A, Niino M, Cravens PD, Cepok S, Frohman EM, Phillips JT, Arendt G, Jerome KR, Cook L, Grand'-Maison F, Hemmer B, Monson NL, Racke MK. 2006. Altered CD4+/CD8+ T-cell ratios in cerebrospinal fluid of natalizumab-treated patients with multiple sclerosis. Arch Neurol 63:1383-1387. (Pubitemid 44547548)
42. Sugaya N, Yoshikawa T, Miura M, Ishizuka T, Kawakami C, Asano Y. 2002. Influenza encephalopathy associated with infection with human herpesvirus 6 and/or human herpesvirus 7. Clin Infect Dis 34:461-466. (Pubitemid 34112266)
43. Sweet TM, Del Valle L, Khalili K. 2002. Molecular biology and immunoregulation of human neurotropic JC virus in CNS. J Cell Physiol 191:249-256. (Pubitemid 34462475)
44. Thacker EL, Mirzaei F, Ascherio A. 2006. Infectious mononucleosis and risk for multiple sclerosis: A meta-analysis. Ann Neurol 59:499-503. (Pubitemid 43358070)
45. Torkildsen Ø, Nyland H, Myrmel H, Myhr KM. 2008. Epstein-Barr virus reactivation and multiple sclerosis. Eur J Neurol 15:106-108.
46. Van Assche G, Van Ranst M, Sciot R, Dubois B, Vermeire S, Noman M, Verbeeck J, Geboes K, Robberecht W, Rutgeerts P. 2005. Progressive multifocal leukoencephalopathy after natalizumab therapy for Crohn's disease. N Engl J Med 353:362-368.
47. Yao K, Gagnon S, Akhyani N, Williams E, Fotheringham J, Frohman E, Stuve O, Monson N, Racke MK, Jacobson S. 2008. Reactivation of human herpesvirus-6 in natalizumab treated multiple sclerosis patients. PLoS ONE 3:e2028. (Pubitemid 352024769)
48. Yoshikawa T, Ihira M, Suzuki K, Suga S, Matsubara T, Furukawa S, Asano Y. 2000. Invasion by human herpesvirus 6 and human herpesvirus 7 of the central nervous system in patients with neurological signs and symptoms. Arch Dis Child 83:170-171. (Pubitemid 30670432)