Lead exposure suppressed ALAD transcription by increasing methylation level of the promoter CpG islands

Toxicology Letters

Volumn 203, Issue 1, 2011, Pages 48-53

  Li, Chunping ^a,b,c   Xu, Ming ^a,b   Wang, Sumeng ^a,b   Yang, Xiaolin ^c   Zhou, Shourong ^d   Zhang, Jingping ^c   Liu, Qizhan ^b   Sun, Yujie ^a,b  

^a Key Laboratory of Human Functional Genomics of Jiangsu Province   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c Wuxi Center for Disease Control and Prevention   (China)

^d Wuxi Center for Disease Prevention and Control   (China)

Author keywords

ALAD; DNA methylation; Epigenetics; Lead; Occupational exposure

Indexed keywords

LEAD;

ADULT; ALAD GENE; ARTICLE; BATTERY INDUSTRY; CONTROLLED STUDY; CPG ISLAND; DOWN REGULATION; EXPOSURE; FEMALE; GENE; GENETIC TRANSCRIPTION; HUMAN; HUMAN CELL; LEAD POISONING; MALE; METHYLATION; OUTCOME ASSESSMENT; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; RISK ASSESSMENT;

CASE-CONTROL STUDIES; CHI-SQUARE DISTRIBUTION; CHINA; CPG ISLANDS; DNA (CYTOSINE-5-)-METHYLTRANSFERASE; DNA METHYLATION; ELECTRIC POWER SUPPLIES; ENVIRONMENTAL POLLUTANTS; ENZYME REPRESSION; HEP G2 CELLS; HEPATOCYTES; HUMANS; LEAD; LEAD POISONING; LOGISTIC MODELS; OCCUPATIONAL EXPOSURE; ODDS RATIO; ORGANOMETALLIC COMPOUNDS; POLYMERASE CHAIN REACTION; PORPHOBILINOGEN SYNTHASE; PROMOTER REGIONS, GENETIC; RISK ASSESSMENT; RISK FACTORS; RNA, MESSENGER; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 79954726811     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.03.002     Document Type: Article

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