DNA integrity in plasma and serum of patients with malignant and benign diseases

Annals of the New York Academy of Sciences

Volumn 1137, Issue , 2008, Pages 162-170

  Holdenrieder, Stefan ^a   Burges, Alexander ^a   Reich, Oliver ^a   Spelsberg, Fritz W ^a   Stieber, Petra ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Cancer; Diagnosis; DNA; Integrity; Plasma; Serum

Indexed keywords

DNA MARKER;

ADULT; AGED; BENIGN TUMOR; BLOOD SAMPLING; CANCER DIAGNOSIS; CANCER PATIENT; CELL FREE SYSTEM; CONFERENCE PAPER; CONTROLLED STUDY; DIAGNOSTIC VALUE; DNA DETERMINATION; DNA ISOLATION; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MALIGNANT NEOPLASTIC DISEASE; REAL TIME POLYMERASE CHAIN REACTION; SENSITIVITY AND SPECIFICITY;

EID: 52249085870     PISSN: 00778923     EISSN: 17496632     Source Type: Book Series    
DOI: 10.1196/annals.1448.013     Document Type: Conference Paper

References (30)

1. Ziegler, A. et al. 2002. Circulating DNA: a new diagnostic gold mine? Cancer Treatment Rev. 28 : 255 271.
2. Shapiro, B. et al. 1983. Determination of circulating DNA levels in patients with benign or malignant gastrointestinal disease. Cancer 51 : 2116 2120.
3. Fournie, G.J. et al. 1995. Plasma DNA as a marker of cancerous cell death: investigations in patients suffering from lung cancer and in nude mice bearing human tumours. Cancer Lett. 91 : 221 227.
4. Holdenrieder, S. et al. 2001. Nucleosomes in serum of patients with benign and malignant diseases. Int. J. Cancer 95 : 114 120.
5. Jahr, S. et al. 2001. DNA fragments in the blood plasma of cancer patients: quantitations and evidence for their origin from apoptotic and necrotic cells. Cancer Res. 61 : 1659 1665.
6. Kuroi, K. et al. 2001. Clinical significance of plasma nucleosome levels in cancer patients. Int. J. Oncol. 19 : 143 148.
7. Sozzi, G. et al. 2003. Quantification of free circulating DNA as a diagnostic marker in lung cancer. J. Clin. Oncol. 21 : 3902 3908.
8. Gautschi, O. et al. 2004. Circulating deoxyribonucleic acid as prognostic marker in non-small-cell lung cancer patients undergoing chemotherapy. J. Clin. Oncol. 22 : 4157 4164.
9. Gormally, E. et al. 2004. Amount of DNA in plasma and cancer risk: a prospective study. Int. J. Cancer 111 : 746 749.
10. Herrera, L.J. et al. 2005. Quantitative analysis of circulating plasma DNA as a tumor marker in thoracic malignancies. Clin. Chem. 51 : 113 118.
11. Chiu, T.W. et al. 2006. Plasma cell-free DNA as an indicator of severity of injury in burn patients. Clin. Chem. Lab. Med. 44 : 13 17.
12. Zeerleder, S. et al. 2003. Elevated nucleosome levels in systemic inflammation and sepsis. Crit. Care Med. 31 : 1947 1951.
13. Lam, N.Y. et al. 2003. Time course of early and late changes in plasma DNA in trauma patients. Clin. Chem. 49 : 1286 1291.
14. Lam, N.Y. et al. 2006. Plasma DNA as a prognostic marker for stroke patients with negative neuroimaging within the first 24 h of symptom onset. Resuscitation 68 : 71 78.
15. Rainer, T.H. et al. 2006. Plasma beta-globin DNA as a prognostic marker in chest pain patients. Clin. Chim. Acta 368 : 110 113.
16. Holdenrieder, S. et al. 2006. Nucleosomal DNA fragments in autoimmune diseases. Ann. N. Y. Acad. Sci. 1075 : 318 327.
17. Anker, P. et al. 2003. Circulating nucleic acids in plasma and serum as a noninvasive investigation for cancer: time for large-scale clinical studies? Int. J. Cancer 103 : 149 152.
18. Stroun, M. et al. 1989. Neoplastic characteristics of the DNA found in the plasma of cancer patients. Oncology 46 : 318 322.
19. Baylin, S.B. 2005. DNA methylation and gene silencing in cancer. Nat. Clin. Pract. Oncol. 2 : S4 11.
20. Herman, J.G. & S.B. Baylin. 2003. Gene silencing in cancer in association with promoter hypermethylation. N. Engl. J. Med. 349 : 2042 2054.
21. Andriani, F. et al. 2004. Detecting lung cancer in plasma with the use of multiple genetic markers. Int. J. Cancer 108 : 91 96.
22. Fleischhacker, M. & B. Schmidt. 2007. Circulating nucleic acids (CNAs) and cancer-a survey. Biochim. Biophys. Acta 1775 : 181 232.
23. Wang, B.G. et al. 2003. Increased plasma DNA integrity in cancer patients. Cancer Res. 63 : 3966 3968.
24. Umetani, N. et al. 2006. Prediction of breast tumor progression by integrity of free circulating DNA in serum. J. Clin. Oncol. 24 : 4270 4276.
25. Umetani, N. et al. 2006. Increased integrity of free circulating DNA in sera of patients with colorectal or periampullary cancer: direct quantitative PCR for ALU repeats. Clin. Chem. 52 : 1062 1069.
26. Jiang, W.W. et al. 2006. Increased plasma DNA integrity index in head and neck cancer patients. Int. J. Cancer 119 : 2673 2676.
27. Hanley, R. et al. 2006. DNA integrity assay: a plasma-based screening tool for the detection of prostate cancer. Clin. Cancer Res. 12 : 4569 4574.
28. Boddy, J.L. et al. 2006. The role of cell-free DNA size distribution in the management of prostate cancer. Oncol. Res. 16 : 35 41.
29. Chang, H.W. et al. 2002. Assessment of plasma DNA levels, allelic imbalance, and CA 125 as diagnostic tests for cancer. J. Natl. Cancer Inst. 94 : 1697 1703.
30. Holdenrieder, S. et al. 2005. Cell-free DNA in serum and plasma: comparison of ELISA and quantitative PCR. Clin. Chem. 51 : 1544 1546.