Surprising repair activities of nonpolar analogs of 8-oxoG expose features of recognition and catalysis by base excision repair glycosylases

Journal of the American Chemical Society

Volumn 134, Issue 3, 2012, Pages 1653-1661

  McKibbin, Paige L ^a   Kobori, Akio ^b   Taniguchi, Yosuke ^b   Kool, Eric T ^b   David, Sheila S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BASE EXCISION REPAIRS; BASE PAIRS; CONFORMATIONAL PREFERENCES; DAMAGE RECOGNITION; GLYCOSYLASE; HIGH AFFINITY; LEAVING GROUPS; NON-POLAR; NUCLEOBASES; RELATIVE CONTRIBUTION; RELATIVE RATES; REMOVAL ACTIVITY; SUBSTITUTED INDOLES;

CATALYSIS; ENZYMES; FEATURE EXTRACTION; REPAIR; SUBSTRATES;

HYDROGEN BONDS;

8 HYDROXYGUANINE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; HOGG1 PROTEIN; INDOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CATALYSIS; CHEMICAL MODIFICATION; DNA DAMAGE; ENZYME STRUCTURE; EXCISION REPAIR; HYDROGEN BOND; PROTEIN FUNCTION;

DNA; DNA GLYCOSYLASES; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; GEOBACILLUS STEAROTHERMOPHILUS; GUANINE; HUMANS; MODELS, MOLECULAR;

EID: 84856242089     PISSN: 00027863     EISSN: 15205126     Source Type: Journal    
DOI: 10.1021/ja208510m     Document Type: Article

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