Probing the Requirements for Recognition and Catalysis in Fpg and MutY with Nonpolar Adenine Isosteres

Journal of the American Chemical Society

Volumn 125, Issue 52, 2003, Pages 16235-16242

  Francis, Anthony W ^a   Helquist, Sandra A ^b   Kool, Eric T ^b   David, Sheila S ^a  

^a UNIVERSITY OF UTAH   (United States)

^b STANFORD UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDITY; ALKALINITY; CATALYSIS; DNA; ESCHERICHIA COLI; HYDROGEN BONDS; MUTAGENESIS; REACTION KINETICS;

DEPURINATION;

ENZYMES;

4 METHYLBENZIMIDAZOLE BETA DEOXYNUCLEOSIDE; 8 HYDROXYDEOXYGUANOSINE; 8 OXO 7 HYDRODEOXYGUANOSINE; 8-OXO-7-HYDRODEOXYGUANOSINE; 9 METHYL 1H IMIDAZO[4,5 B]PYRIDINE BETA DEOXYNUCLEOSIDE; ADENINE; ADENINE DERIVATIVE; ADENINE GLYCOSYLASE; BENZIMIDAZOLE DERIVATIVE; DEOXYADENOSINE; DEOXYGUANOSINE; DNA; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE, E COLI; DNA GLYCOSYLASE MUTY; DNA GLYCOSYLTRANSFERASE; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE, E COLI; DRUG DERIVATIVE; ESCHERICHIA COLI PROTEIN; GENE PRODUCT; GLYCOSIDASE; IMIDAZOLE DERIVATIVE; NUCLEOSIDE DERIVATIVE; PURINE NUCLEOSIDE; UNCLASSIFIED DRUG;

ARTICLE; BASE MISPAIRING; BINDING AFFINITY; CATALYSIS; CHEMISTRY; DISSOCIATION; DNA REPAIR; ENZYME MECHANISM; ESCHERICHIA COLI; GENE MUTATION; HYDROGEN BOND; KINETICS; METABOLISM; MOLECULAR RECOGNITION; PH; STRUCTURE ACTIVITY RELATION;

ADENINE; BASE PAIR MISMATCH; CATALYSIS; DEOXYGUANOSINE; DNA; DNA GLYCOSYLASES; DNA REPAIR; DNA-FORMAMIDOPYRIMIDINE GLYCOSYLASE; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; IMIDAZOLES; KINETICS; N-GLYCOSYL HYDROLASES; PURINE NUCLEOSIDES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0346434114     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0374426     Document Type: Article

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