Specificity of human thymine DNA glycosylase depends on N-glycosidic bond stability

Journal of the American Chemical Society

Volumn 128, Issue 38, 2006, Pages 12510-12519

  Bennett, Matthew T ^a   Rodgers, M T ^b   Hebert, Alexander S ^c   Ruslander, Lindsay E ^c   Eisele, Leslie ^c   Drohat, Alexander C ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b WAYNE STATE UNIVERSITY   (United States)

^c WADSWORTH CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMICAL BONDS; DISSOCIATION; DNA; HYDROPHOBICITY; REACTION KINETICS;

BOND STABILITY; CYTOSINE; DNA GLYCOSYLASES; NUCLEOBASES;

ENZYMES;

5 BROMOCYTOSINE; 5 CHLOROURACIL DERIVATIVE; 5 HYDROXYCYTOSINE; CYTOSINE DERIVATIVE; FLUCYTOSINE; FLUOROURACIL; GUANINE; NUCLEIC ACID BASE; THYMINE; THYMINE DNA GLYCOSYLASE; UNCLASSIFIED DRUG; URACIL;

ARTICLE; BASE MISPAIRING; CHEMICAL BOND; CHEMICAL REACTION; ENERGY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME ANALYSIS; ENZYME KINETICS; ENZYME MECHANISM; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EXCISION REPAIR; HUMAN; HYDROPHOBICITY;

BINDING SITES; CYTOSINE; DNA; ELECTROSTATICS; GLYCOSIDES; HUMANS; HYDROLYSIS; KINETICS; LINEAR ENERGY TRANSFER; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; THERMODYNAMICS; THYMINE DNA GLYCOSYLASE; URACIL;

EID: 33749171576     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0634829     Document Type: Article

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