Profiling base excision repair glycosylases with synthesized transition state analogs

Bioorganic and Medicinal Chemistry Letters

Volumn 21, Issue 17, 2011, Pages 4969-4972

  Chu, Aurea M ^a   Fettinger, James C ^a   David, Sheila S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

8 Oxo 7,8 dihydro 2 deoxyguanosine; Base excision repair; DNA glycosylase; Fpg; hNEIL1; hOGG1; Nei; Pyrrolidine analogs; Transition state analogs

Indexed keywords

(HYDROXYMETHYL) PYRROLIDIN 3 OL; 1 BENZYL (HYDROXYMETHYL) PYRROLIDIN 3 OL; 2,6 DIAMINO 4 HYDROXY 5 FORMAMIDOPYRIMIDINE; 8 HYDROXYGUANINE; DNA BASE; DNA FORMAMIDOPYRIMIDINE GLYCOSYLASE; DNA GLYCOSYLTRANSFERASE; DOUBLE STRANDED DNA; HUMAN ENDONUCLEASE III ENZYME; HUMAN NEI LIKE GLYCOSYLASE; NUCLEOTIDE; PHOSPHORAMIDOUS ACID DERIVATIVE; PYRIMIDINE DERIVATIVE; PYRROLIDINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL BOND; CHEMICAL STRUCTURE; DEBENZYLATION; DNA MODIFICATION; DNA PROTEIN COMPLEX; DNA REPAIR; DNA SYNTHESIS; ELECTROPHORETIC MOBILITY; ENZYME MECHANISM; EXCISION REPAIR; MOLECULAR WEIGHT; OXIDATION; STEREOCHEMISTRY;

BASE SEQUENCE; BIOCATALYSIS; DNA GLYCOSYLASES; DNA REPAIR; HUMANS; PYRROLIDINES; SUBSTRATE SPECIFICITY;

BACTERIA (MICROORGANISMS);

EID: 80051788353     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.05.085     Document Type: Article

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