PKG is involved in testosterone-induced vasorelaxation of human umbilical artery

European Journal of Pharmacology

Volumn 640, Issue 1-3, 2010, Pages 94-101

  Cairrão, Elisa ^a,b   Santos Silva, António José ^a   Verde, Ignacio ^a  

^a UNIVERSITY OF BEIRA INTERIOR   (Portugal)

^b Centro Hospitalar da Cova da Beira   (Portugal)

Author keywords

ANP; Human umbilical artery; PKG; Potassium channel; Testosterone; Vasorelaxation

Indexed keywords

ATRIAL NATRIURETIC FACTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; GUANYLATE CYCLASE; HISTAMINE; NITROPRUSSIDE SODIUM; POTASSIUM CHANNEL; POTASSIUM CHLORIDE; SEROTONIN 5 RECEPTOR; TESTOSTERONE; CYCLIC GMP;

ARTICLE; CELL CULTURE; ELECTROPHYSIOLOGY; HUMAN; HUMAN CELL; POTASSIUM CURRENT; PRIORITY JOURNAL; UMBILICAL ARTERY; VASODILATATION; DRUG EFFECTS; ELECTRIC CONDUCTIVITY; ENZYMOLOGY; FEMALE; IN VITRO STUDY; METABOLISM; PATCH CLAMP TECHNIQUE; PREGNANCY; SMOOTH MUSCLE FIBER; VASCULARIZATION; VASOCONSTRICTION;

CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ELECTRIC CONDUCTIVITY; FEMALE; GUANYLATE CYCLASE; HUMANS; MYOCYTES, SMOOTH MUSCLE; PATCH-CLAMP TECHNIQUES; POTASSIUM CHANNELS; PREGNANCY; TESTOSTERONE; UMBILICAL ARTERIES; VASOCONSTRICTION; VASODILATION; IN VITRO TECHNIQUES;

EID: 77953807282     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.04.025     Document Type: Article

References (41)

1. Alvarez, E., Cairrao, E., Morgado, M., Morais, C., Verde, I., 2010. Testosterone and cholesterol vasodilation of rat aorta involves L-type calcium channel inhibition. Adv. Pharmacol. Sci., 10 p.
2. Armstead W.M. Role of ATP-sensitive K+ channels in cGMP-mediated pial artery vasodilation. Am. J. Physiol. 1996, 270:H423-426.
3. Bialecki R.A., Stinsonfisher C. KCa channel antagonists reduce NO donor-mediated relaxation of vascular and tracheal smooth muscle. Am. J. Physiol. 1995, 12:L152-L159.
4. Bychkov R., Gollasch M., Steinke T., Ried C., Luft F.C., Haller H. Calcium-activated potassium channels and nitrate-induced vasodilation in human coronary arteries. J. Pharmacol. Exp. Ther. 1998, 285:293-298.
5. Cairrao E., Alvarez E., Santos-Silva A.J., Verde I. Potassium channels are involved in testosterone-induced vasorelaxation of human umbilical artery. Naunyn Schmiedebergs Arch. Pharmacol. 2008, 376:375-383.
6. Cairrao E., Santos-Silva A.J., Alvarez E., Correia I., Verde I. Isolation and culture of human umbilical artery smooth muscle cells expressing functional calcium channels. In Vitro Cell Dev. Biol. Anim. 2009, 45:175-184.
7. Castro L.R.V., Verde I., Cooper D.M.F., Fischmeister R. Cyclic GMP compartmentation in rat cardiac myocytes. Circulation 2006, 113:2221-2228.
8. Chou T.M., Sudhir K., Hutchison S.J., Ko E., Amidon T.M., Collins P., Chatterjee K. Testosterone induces dilation of canine coronary conductance and resistance arteries in vivo. Circulation 1996, 94:2614-2619.
9. Deenadayalu V.P., White R.E., Stallone J.N., Gao X., Garcia A.J. Testosterone relaxes coronary arteries by opening the large-conductance, calcium-activated potassium channel. Am. J. Physiol. 2001, 281:H1720-1727.
10. Ding A.Q., Stallone J.N. Testosterone-induced relaxation of rat aorta is androgen structure specific and involves K+ channel activation. J. Appl. Physiol. 2001, 91:2742-2750.
11. Francis S.H., Corbin J.D. Structure and function of cyclic nucleotide-dependent protein kinases. Annu. Rev. Physiol. 1994, 56:237-272.
12. Gerulewicz-Vannini D., Camero Y., Salas J., Hernandez-Andrade E. High plasmatic androgen levels in women affected with pregnancy-induced hypertension. Rev. Invest. Clin. 2006, 58:228-233.
13. Hall J., Jones R.D., Jones T.H., Channer K.S., Peers C. Selective inhibition of L-type Ca2+ channels in A7r5 cells by physiological levels of testosterone. Endocrinology 2006, 147:2675-2680.
14. Honda H., Unemoto T., Kogo H. Different mechanisms for testosterone-induced relaxation of aorta between normotensive and spontaneously hypertensive rats. Hypertension 1999, 34:1232-1236.
15. Houslay M.D., Milligan G. Tailoring cAMP-signalling responses through isoforms multiplicity. Trends Biochem. Sci. 1997, 22:217-224.
16. Jones R.D., English K.M., Pugh P.J., Morice A.H., Jones T.H., Channer K.S. Pulmonary vasodilatory action of testosterone: evidence of a calcium antagonistic action. J. Cardiovasc. Pharmacol. 2002, 39:814-823.
17. Landgraf W., Ruth P., Keilbach A., May B., Welling A., Hofmann F. Cyclic GMP-dependent protein kinase and smooth muscle relaxation. J. Cardiovasc. Pharmacol. 1992, 20(Suppl 1):S18-22.
18. Malkin C.J., Jones R.D., Jones T.H., Channer K.S. Effect of testosterone on ex vivo vascular reactivity in man. Clin. Sci. (Lond.) 2006, 111:265-274.
19. Milesi V., Raingo J., Rebolledo A., Grassi de Gende A.O. Potassium channels in human umbilical artery cells. J. Soc. Gynecol. Investig. 2003, 10:339-346.
20. Montano L.M., Calixto E., Figueroa A., Flores-Soto E., Carbajal V., Perusquia M. Relaxation of androgens on rat thoracic aorta: testosterone concentration dependent agonist/antagonist L-type Ca2+ channel activity, and 5{beta}-dihydrotestosterone restricted to L-type Ca2+ channel antagonism. Endocrinology 2008.
21. Murphy J.G., Khalil R.A. Decreased [Ca2+]i during inhibition of coronary smooth muscle contraction by 17beta-estradiol, progesterone, and testosterone. J. Pharmacol. Exp. Ther. 1999, 291:44-52.
22. Otsuka K., Tanaka H., Horinouchi T., Koike K., Shigenobu K., Tanaka Y. Functional contribution of voltage-dependent and Ca2+ activated K+ (BK(Ca)) channels to the relaxation of guinea-pig aorta in response to natriuretic peptides. J. Smooth Muscle Res. 2002, 38:117-129.
23. Pasqualini J.R. Enzymes involved in the formation and transformation of steroid hormones in the fetal and placental compartments. J. Steroid. Biochem. Mol. Biol. 2005, 97:401-415.
24. Perusquia M., Villalon C.M. Possible role of Ca2+ channels in the vasodilating effect of 5-beta-dihydrotestosterone in rat aorta. Eur. J. Pharmacol. 1999, 371:169-178.
25. Perusquia M., Navarrete E., Gonzalez L., Villalon C.M. The modulatory role of androgens and progestins in the induction of vasorelaxation in human umbilical artery. Life Sci. 2007, 81:993-1002.
26. Piggott L.A., Hassell K.A., Berkova Z., Morris A.P., Silberbach M., Rich T.C. Natriuretic peptides and nitric oxide stimulate cGMP synthesis in different cellular compartments. J. Gen. Physiol. 2006, 128:3-14.
27. Rae J., Cooper K., Gates P., Watsky M. Low access resistance perforated patch recordings using amphotericin B. J. Neurosci. Meth. 1991, 37:15-26.
28. Rho E.H., Perkins W.J., Lorenz R.R., Warner D.O., Jones K.A. Differential effects of soluble and particulate guanylyl cyclase on Ca(2+) sensitivity in airway smooth muscle. J. Appl. Physiol. 2002, 92:257-263.
29. Robertson B.E., Schubert R., Hescheler J., Nelson M.T. cGMP-dependent protein kinase activates Ca-activated K channels in cerebral artery smooth muscle cells. Am. J. Physiol. 1993, 265:C299-303.
30. Salamalekis E., Bakas P., Vitoratos N., Eleptheriadis M., Creatsas G. Androgen levels in the third trimester of pregnancy in patients with preeclampsia. Eur. J. Obstet. Gynecol. Reprod. Biol. 2006, 126:16-19.
31. Santos-Silva A.J., Cairrão E., Morgado M., Álvarez E., Verde I. PDE4 and PDE5 regulate cyclic nucleotides relaxing effects in human umbilical arteries. Eur. J. Pharmacol. 2008, 582:102-109.
32. Tanaka Y., Aida M., Tanaka H., Shigenobu K., Toro L. Involvement of maxi-K(Ca) channel activation in atrial natriuretic peptide-induced vasorelaxation. Naunyn Schmiedebergs Arch. Pharmacol. 1998, 357:705-708.
33. Tanaka Y., Tang G., Takizawa K., Otsuka K., Eghbali M., Song M., Nishimaru K., Shigenobu K., Koike K., Stefani E., Toro L. Kv channels contribute to nitric oxide- and atrial natriuretic peptide-induced relaxation of a rat conduit artery. J. Pharmacol. Exp. Ther. 2006, 317:341-354.
34. Taniguchi J., Furukawa K.I., Shigekawa M. Maxi K+ channels are stimulated by cyclic guanosine monophosphate-dependent protein kinase in canine coronary artery smooth muscle cells. Pflugers Arch. 1993, 423:167-172.
35. Tep-areenan P., Kendall D.A., Randall M.D. Testosterone-induced vasorelaxation in the rat mesenteric arterial bed is mediated predominantly via potassium channels. Br. J. Pharmacol. 2002, 135:735-740.
36. Tep-areenan P., Kendall D.A., Randall M.D. Mechanisms of vasorelaxation to testosterone in the rat aorta. Eur. J. Pharmacol. 2003, 465:125-132.
37. Toyoshima H., Nasa Y., Hashizume Y., Koseki Y., Isayama Y., Kohsaka Y., Yamada T., Takeo S. Modulation of cAMP-mediated vasorelaxation by endothelial nitric oxide and basal cGMP in vascular smooth muscle. J. Cardiovasc. Pharmacol. 1998, 32:543-551.
38. Yildiz O., Seyrek M., Gul H., Un I., Yildirim V., Ozal E., Uzun M., Bolu E. Testosterone relaxes human internal mammary artery in vitro. J. Cardiovasc. Pharmacol. 2005, 45:580-585.
39. Yue P., Chatterjee K., Beale C., Poole-Wilson P.A., Collins P. Testosterone relaxes rabbit coronary arteries and aorta. Circulation 1995, 91:1154-1160.
40. Zhang Q., Moalem J., Tse J., Scholz P.M., Weiss H.R. Effects of natriuretic peptides on ventricular myocyte contraction and role of cyclic GMP signaling. Eur. J. Pharmacol. 2005, 510:209-215.
41. Zhao Y.J., Wang J., Rubin L.J., Yuan X.J. Inhibition of K(V) and K(Ca) channels antagonizes NO-induced relaxation in pulmonary artery. Am. J. Physiol. 1997, 272:H904-912.