Involvement of cyclic nucleotide-dependent protein kinases in cyclic AMP-mediated vasorelaxation

British Journal of Pharmacology

Volumn 122, Issue 1, 1997, Pages 158-164

  Eckly Michel, Anita ^a   Martin, Viviane ^a   Lugnier, Claire ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

Author keywords

Calcium; Cyclic AMP; Cyclic AMP dependent protein kinase; Cyclic GMP; Cyclic GMP dependent protein kinase; Isoprenaline; Phosphodiesterase; Vasorelaxation

Indexed keywords

5 (4 ACETAMIDOPHENYL) 2(1H) PYRAZINONE; BRONCHODILATING AGENT; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC GMP DEPENDENT PROTEIN KINASE; ISOPRENALINE; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; PHOSPHODIESTERASE INHIBITOR; ROLIPRAM; TRANSFERASE INHIBITOR;

ANIMAL TISSUE; AORTA; ARTICLE; DRUG INHIBITION; ISOLATED ARTERY; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE; VASODILATATION;

ADENOSINE TRIPHOSPHATE; ADRENERGIC BETA-AGONISTS; ANIMALS; AORTA; CALCIUM; CARDIOTONIC AGENTS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; CYCLIC GMP; CYCLIC GMP-DEPENDENT PROTEIN KINASES; ENDOTHELIUM, VASCULAR; ENZYME INHIBITORS; ISOPROTERENOL; ISOQUINOLINES; MALE; MUSCLE RELAXATION; MUSCLE, SMOOTH, VASCULAR; PHOSPHODIESTERASE INHIBITORS; PYRAZINES; PYRROLIDINONES; RATS; RATS, WISTAR; ROLIPRAM; SIGNAL TRANSDUCTION; SULFONAMIDES; THIONUCLEOTIDES;

EID: 0030871013     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0701339     Document Type: Article

References (35)

1. BARNETTE, M.S., GROUS, M., TORPHY, T.J. & ORMSBEE, H.S. (1990). Activation of cyclic AMP-dependent protein kinase during canine lower oesophageal sphincter relaxation. J. Pharmacol. Exp. Ther., 252, 1160-1166.
2. BEAVO, J.A., CONTI, M. & HEASLIP, R.J. (1994). Multiple cycle nucleotide phosphodiesterases. Mol. Pharmacol., 46, 399-405.
3. BIEL, M., ALTENHOFEN, W., HULLIN, R., LUDWIG, J., FREICHEL, M., FLOCKERRKI, V., DASCAL, N., KAUPP, U.B. & HOFMANN, F. (1993). Primary structure and functional expression of a cyclic nucleotide-gated channel from rabbit aorta. FEBS Lett., 329, 134-138.
4. BRADFORD, M.M. (1976). A rapid and sensitive method for the quantification of microgram quantities of proteins utilizing the principle of protein dye-binding. Anal. Biochem., 72, 248-254.
5. BUTT, E., VAN BEMMELEN, M., FISCHER, L, WALTER, U. & JASTORFF, B. (1990). Inhibition of cGMP-dependent protein kinase by (Rp)-guanosine 3′,5′-monophosphorothioates. FEBS Lett., 263, 47-50.
6. CHIJIWA, T., MISHIMA, A., HAGIWARA, M., SANO, M., HAYASHI, K., INOUE, T., NAITO, K., TOSSHIOKA, T. & HIDAKA, H. (1990). Inhibition of forskolin-induced outgrowth and protein phosphorylation by a newly synthesized selective inhibition of cyclic AMP-dependent protein kinase. N-[2-(p-bromocinnamylamino) ethyl]-5-isoquinolinesulfonamide (H-89), of PC 12D Pheochromocytoma cells. J. Biol. Chem., 265, 5267-5272.
7. COLBRAN, J.L., FRANCIS, S.H., LEACH, A.B., THOMAS, M.K., JIANG, H., MCALLISTER, L.M. & CORBIN, J.D. (1992). A phenylalanine in peptide substrate provides for selectivity between cGMP- and cAMP-dependent protein kinases. J. Biol. Chem., 267, 9589-9594.
8. CORRIU, C., ANDRE, P., SCHOTT, C., MICHEL, M. & STOCLET, J.-C. (1994). ANG II receptor expression and function during phenotypic modulation of rat aortic smooth muscle cells. Am. J. Physiol., 266, H631-H636.
9. ECKLY, A.E. & LUGNIER, C. (1994). Role of phosphodiesterases III and IV in the modulation of vascular cyclic AMP content by the NO cyclic GMP pathway. Br. J. Pharmacol., 113, 445-450.
10. ECKLY, A.E., STOCLET, J.-C. & LUGNIER, C. (1994). Isoprenaline induces endothelium-independent relaxation and accumulation of cyclic nucleotides in the rat aorta. Eur. J. Pharmacol., 271, 237-240.
11. ECKLY, A.E., STOCLET, J.-C. & LUGNIER, C. (1995). Involvement of protein kinase G in vascular relaxation induced by the cyclic nucleotide phosphodiesterase IV inhibitor, rolipram. Br. J. Pharmacol., 114, 206P.
12. FOSTER, J.L., GUTTMANN, J. & ROSEN, O.R. (1981). Autophosphorylation of cGMP-dependent protein kinase. J. Biol. Chem., 256, 5029-5036.
13. FRANCIS, S.H., BOBLETT, B.D., TODD, B.W., WELLS, J.N. & CORBIN, J.D. (1988). Relaxation of vascular and tracheal smooth muscle by cyclic nucleotide analogs that preferentially activate purified cGMP-dependent protein kinase. Mol. Pharmacol., 34, 506-517.
14. GIEMBYCZ, M.A. & DIAMOND, J. (1990). Evaluation of Kemptide, a synthetic serine-containing heptapeptide, as a phosphate acceptor for the estimation of cyclic AMP-dependent protein kinase activity in respiratory tissues. Biochem. Pharmacol., 39, 271-283.
15. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
16. HAYNES, J., ROBINSON, J., SAUNDERS, L., TAYLOR, A.E. & SIRADA, S.J. (1992). Role of cAMP-dependent protein kinase in cAMP-mediated vasodilation. Am. J. Physiol., 262, H511-H516.
17. 2+ signalling and contraction, of airway smooth muscle by cyclic AMP-dependent mechanisms. Br. J. Pharmacol., 117, 419-426.
18. 2+ channels by cAMP and cGMP in vascular smooth muscle cells. Circ. Res., 73, 1128-1137.
19. 2+ channels by β-adrenergic agonists. Proc. Natl. Acad. Sci. USA, 93, 295-299.
20. KOMALAVILAS, P. & LINCOLN, T.M. (1996) Phosphorylation of the inositol. 1,4,5-trisphosphate by receptor-cyclic GMP-dependent protein kinase mediates cAMP and cGMP dependent phosphorylation in the intact rat aorta. J. Biol. Chem., 271, 21933-21938.
21. KOMAS, N., LUGNIER, C. & STOCLET, J.-C. (1991). Endothelium-dependent and -independent relaxation of the rat aorta by cyclic nucleotide phosphodiesterase inhibitors. Br. J. Pharmacol., 104, 495-503.
22. Ca channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J. Clin. Invest., 93, 371-379.
23. LANDGRAF, W., HULLIN, R., GOBEL, C. & HOFMANN, F. (1986). Phosphorylation of cGMP-dependent protein kinase increase the affinity for cAMP. Eur. J. Biochem., 154, 113-117.
24. 2+ by cAMP in vascular smooth muscle cells. Am. J. Physiol., 258, C399-C407.
25. LINCOLN, T.M. & CORNWELL, T.L. (1993). Intracellular cyclic GMP receptor protein. FASEB J., 7, 328-338.
26. LUGNIER, C., BRUCH, M., STOCLET, J.-C., STRUB, M.P., MARIVET, M. & WERMUTH, C.G. (1985). Substituted carbostyrils as inhibitors of cyclic AMP phosphodiesterase. Eur. J. Med. Chem., 20, 121-125.
27. MURRAY, K.J. (1990). Cyclic AMP and mechanism of vasodilatation. Pharmacol. Ther., 47, 329-354.
28. MURPHY, K.S. & MAKHLOUF, G.M. (1995). Interaction of cA-kinase and cG-kinase in mediating relaxation of dispersed smooth muscle cells. Am. J. Physiol., 268, C171-C180.
29. OUEDRAOGO, S., TSCHOPL, M., STOCLET, J.-C. & BUCHER, B. (1994). Effects of cyclic GMP analogs on neurogenic transmission in the rat tail artery. Br. J. Pharmacol., 112, 867-872.
30. RUBANYI, G. & VANHOUTTE, P.M. (1985). Endothelium-removal decreases relaxations of canine coronary arteries caused by β-adrenergic agonists and adenosine. J. Cardiovasc. Pharmacol., 7, 139-144.
31. SCHOEFFTER, P., LUGNIER, C., DEMESY-WAEDELE, F. & STOCLET, J.-C. (1987). Role of cyclic AMP- and cyclic GMP phosphodiesterases in the control of cyclic nucleotide levels and smooth muscle tone in rat isolated aorta. Biochem. Pharmacol., 36, 3965-3972.
32. SILVER, P.J., SCHMIDT-SILVER, C. & DISALVO, J. (1983). β-Adrenergic relaxation and cAMP kinase in coronary arterial smooth muscle. Am. J. Physiol., 242, H177-H184.
33. TRAVO, P., BARRET, G. & BURNSTOCK, G. (1980). Differences in profilerationof primary cultures of vascular smooth muscle cells taken from male and female rats. Blood Vessels, 17, 110-116.
34. USHIO-FUKAI, M., ABE, S., KOBAYASHI, S., NISHIMURA, J. & KANAIDE, H. (1983). Effects of isoprenaline on cytosolic calcium concentrations and on tension in the porcine coronary artery. J. Physiol., 462, 679-696.
35. 1 and forskolin is accompanied by contraction and relaxation respectively. Proc. West. Pharmacol. Soc., 29, 303-311.