Localization of adenylyl cyclase isoforms and G protein-coupled receptors in vascular smooth muscle cells: Expression in caveolin-rich and noncaveolin domains

Molecular Pharmacology

Volumn 62, Issue 5, 2002, Pages 983-992

  Ostrom, Rennolds S ^a   Liu, Xiaoqiu ^a   Head, Brian P ^a   Gregorian, Caroline ^a   Seasholtz, Tammy M ^a   Insel, Paul A ^a  

^a San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE RECEPTOR; ADENYLATE CYCLASE; BETA 1 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR; CALCIUM ION; CAVEOLIN; CYCLIC AMP; FORSKOLIN; G PROTEIN COUPLED RECEPTOR; ISOPRENALINE; MESSENGER RNA; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E2;

ANIMAL CELL; ARTICLE; CELL COMPARTMENTALIZATION; CELL MEMBRANE; CELL SPECIFICITY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LOCALIZATION; ENZYME POLYMORPHISM; ENZYME REGULATION; GENE OVEREXPRESSION; HEART MUSCLE CELL; IMMUNOBLOTTING; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE;

ADENYLATE CYCLASE; ANIMALS; CALCIUM; CAVEOLIN 1; CAVEOLINS; CELLS, CULTURED; CYCLIC AMP; GENE EXPRESSION; GTP-BINDING PROTEINS; ISOENZYMES; MALE; MUSCLE, SMOOTH, VASCULAR; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE;

EID: 0036839744     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.62.5.983     Document Type: Article

References (47)

1. Anand-Srivastava MB (1992) Enhanced expression of inhibitory guanine nucleotide regulatory protein in spontaneously hypertensive rats. Relationship to adenylate cyclase inhibition. Biochem J 288:79-85.
2. Anderson R (1998) The eaveolae membrane system. Annu Rev Biochem 67:199-225.
3. Bakalyar HA and Reed RR (1990) Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science (Wash DC) 250, 1403-1406.
4. Breyer RM, Bagdassarian CK, Myers SA, and Breyer MD (2001) Prostanoid receptors: Subtypes and signaling. Annu Rev Pharmacol Toxicol 41:661-690.
5. Brodde OE and Michel MC (1992) Adrenergic receptors and their signal transduction mechanisms in hypertension. J Hypertens Suppl 10:S133-S145.
6. 2+ entry pathway. FASEB J 15:1727-1738.
7. Chamley-Campbell J, Campbell GR, and Ross R (1979) The smooth muscle cell in culture. Physiol Rev 59:1-61.
8. Dubey RK, Gillespie DG, Shue H, and Jackson EK (2000) A(2B) receptors mediate antimitogenesis in vascular smooth muscle cells. Hypertension 35:267-272.
9. 2+ entry requires localization in cholesterol-rich domains. J Biol Chem 275:26530-26537.
10. Feldman AM (2002) Adenylyl cyclase: A new target for heart failure therapeutics. Circulation 105:1876-1878.
11. Feldman RD (1987) Beta-adrenergic receptor alterations in hypertension-physiological and molecular correlates. Can J Physiol Pharmacol 65:1666-1672.
12. Feldman RD and Gros R (1998) Impaired vasodilator function in hypertension: The role of alterations in receptor-G protein coupling. Trends Cardiovasc Med 8:297-305.
13. Galbiati F, Razani B, and Lisanti MP (2001) Emerging themes in lipid rafts and caveolae. Cell 106:403-411.
14. Gao M, Ping P, Post S, Insel PA, Tang R, and Hammond HK (1998) Increased expression of adenylyl cyclase type VI proportionately increases beta-adrenergic receptor-stimulated production of cAMP in neonatal rat cardiac myocytes. Proc Natl Acad Sci USA 95:1038-1043.
15. Gros R, Chorazyezewski J, Meek MD, Benovic JL, Ferguson SS, and Feldman RD (2000) G-protein-coupled receptor kinase activity in hypertension: Increased vascular and lymphocyte G-protein receptor kinase-2 protein expression. Hypertension 35:38-42.
16. Hanoune J and Defer N (2001) Regulation and role of adenylyl cyclase isoforms. Annu Rev Pharmacol Toxicol 41:145-174.
17. Ishizaka N, Griendling KK, Lassegue B, and Alexander RW (1998) Angiotensin II type 1 receptor: Relationship with caveolae and caveolin after initial agonist stimulation. Hypertension 32:459-466.
18. Kume H, Hall IP, Washabau PJ, Takagi K, and Kotlikoff MI (1994) Beta-adrenergic agonists regulate KCa channels in airway smooth muscle by cAMP-dependent and -independent mechanisms. J Clin Invest 93:371-379.
19. Lincoln TM and Cornwell TL (1991) Towards an understanding of the mechanism of action of cyclic AMP and cyclic GMP in smooth muscle relaxation. Blood Vessels 28:129-137.
20. Nishikawa M, de Lanerolle P, Lincoln TM, and Adelstein RS (1984) Phosphorylation of mammalian myosin light chain kinases by the catalytic subunit of cyclic AMP-dependent protein kinase and by cyclic GMP-dependent protein kinase. J Biol Chem 259:8429-8436.
21. s target lipid rafts by default. Mol Biol Cell 12:685-698.
22. Okamoto T, Schlegel A, Scherer PE, and Lisanti MP (1998) Caveolins, a family of scaffolding proteins for organizing "preassembled signaling complexes" at the plasma membrane. J Biol Chem 273:5419-5422.
23. Ostrom RS and Ehlert FJ (1998) M2 muscarinic receptors inhibit forskolin- but not isoproterenol-mediated relaxation in bovine tracheal smooth muscle. J Pharmacol Exp Ther 286:234-242.
24. Ostrom RS, Gregorian C, Drenan RM, Xiang Y, Regan JW, and Insel PA (2001) Receptor number and caveolar co-localization determine receptor coupling efficiency to adenylyl cyclase. J Biol Chem 276:42063-42069.
25. Ostrom RS, Post SR, and Insel PA (2000a) Stoichiometry and compartmentation in G protein-coupled receptor signaling: Implications for therapeutic interventions involving Gs. J Pharmacol Exp Ther 294:407-412.
26. Ostrom RS, Violin JD, Coleman S, and Insel PA (2000b) Selective enhancement of β-adrenergic receptor signaling by overexpression of adenylyl cyclase type 6: Colocalization of receptor and adenylyl cyclase in caveolae of cardiac myocytes. Mol Pharmacol 57:1075-1079.
27. 2b-Purinoceptor. Circ Res 86:76-85.
28. Roth DM, Gao MH, Lai NC, Drumm J, Dalton N, Zhou JY, Zhu J, Entrikin D, and Hammond HK (1999) Cardiac-directed adenylyl cyclase expression improves heart function in murine cardiomyopathy. Circulation 99:3099-3102.
29. Rybin VO, Xu X, Lisanti MP, and Steinberg SF (2000) Differential targeting of β-adrenergic receptor subtypes and adenylyl cyclase to cardiomyocyte caveolae. A mechanism to functionally regulate the cAMP signaling pathway. J Biol Chem 275:41447-41457.
30. Schwencke C, Okumura S, Yamamoto M, Geng YJ, and Ishikawa Y (1999a) Colocalization of beta-adrenergic receptors and caveolin within the plasma membrane. J Cell Biochem 75:64-72.
31. Schwencke C, Yamamoto M, Okumura S, Toya Y, Kim SJ, and Ishikawa Y (1999b) Compartmentation of cyclic adenosine 3′,5′-monophosphate signaling in caveolae. Mol Endocrinol 13:1061-1070.
32. Seasholtz TM, Majumdar M, Kaplan DD, and Brown JH (1999) Rho and Rho kinase mediate thrombin-stimulated vascular smooth muscle cell DNA synthesis and migration. Circ Res 84:1186-1193.
33. Shaul PW, Smart EJ, Robinson LJ, German Z, Yuhanna IS, Ying Y, Anderson RG, and Michel T (1996) Acylation targets endothelial nitric-oxide synthase to plasmalemmal caveolae. J Biol Chem 271:6518-6522.
34. Simons K and Toomre D (2000) Lipid rafts and signal transduction. Nat Rev Mol Cell Biol 1:31-39.
35. 2+ entry. J Biol Chem 277:6025-6031.
36. Somlyo AP and Somlyo AV (1994) Signal transduction and regulation in smooth muscle. Nature (Lond) 372:231-236.
37. Song SK, Li S, Okamoto T, Quilliam LA, Sargiacomo M, and Lisanti MP (1996) Co-purification and direct interaction of Ras with caveolin, an integral membrane protein of caveolae microdomains. Detergent-free purification of caveolae microdomains. J Biol Chem 271:9690-9697.
38. Spicuzza L, Belvisi MG, Birrell MA, Barnes PJ, Hele DJ, and Giembycz MA (2001) Evidence that the anti-spasmogenic effect of the beta-adrenoceptor agonist, isoprenaline, on guinea-pig trachealis is not mediated by cyclic AMP-dependent protein kinase. Br J Pharmacol 133:1201-1212.
39. Steinberg SF and Brunton LL (2001) Compartmentation of G protein-coupled signaling pathways in cardiac myocytes. Annu Rev Pharmacol Toxicol 41:751-773.
40. Taggart MJ (2001) Smooth muscle excitation-contraction coupling: A role for caveolae and caveolins? News Physiol Sci 16:61-65.
41. Tang WJ and Gilman AG (1992) Adenylyl cyclases. Cell 70:869-872.
42. Thyberg J (2000) Differences in caveolae dynamics in vascular smooth muscle cells of different phenotypes. Lab Invest 80:915-929.
43. Ushio-Fukai M, Hilenski L, Santanam N, Becker PL, Ma Y, Griendling KK, and Alexander RW (2001) Cholesterol depletion inhibits epidermal growth factor receptor transactivation by angiotensin II in vascular smooth muscle cells: Role of cholesterol-rich microdomains and focal adhesions in angiotensin II signaling. J Biol Chem 276:48269-75.
44. Wei J, Wayman G, and Storm DR (1996) Phosphorylation and inhibition of type III adenylyl cyclase by calmodulin-dependent protein kinase II in vivo. J Biol Chem 271:24231-5.
45. Werstiuk ES and Lee RM (2000) Vascular beta-adrenoceptor function in hypertension and in ageing. Can J Physiol Pharmacol 78:433-452.
46. 2-induced growth inhibition in arterial smooth muscle cells. J Biol Chem 29:34206-34212.
47. Zhang J, Sato M, Duzic E, Kubalak SW, Lanier SM, and Webb JG (1997) Adenylyl cyclase isoforms and vasopressin enhancement of agonist-stimulated cAMP in vascular smooth muscle cells. Am J Physiol 273:H971-H980.