Ca 2+/calcineurin regulation of cloned vascular K ATP channels: Crosstalk with the protein kinase a pathway

British Journal of Pharmacology

Volumn 157, Issue 4, 2009, Pages 554-564

  Orie, N N ^b   Thomas, A M ^b   Perrino, B A ^a   Tinker, A ^b   Clapp, L H ^b  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

Author keywords

Atp sensitive potassium channels; Calcineurin; K ir6.1 SUR2B; Protein kinase A; Vascular; Whole cell patch clamp

Indexed keywords

12 (2 CYANOETHYL) 6,7,12,13 TETRAHYDRO 13 METHYL 5 OXOINDOLO[2,3 A]PYRROLO[3,4 C]CARBAZOLE; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; CALCINEURIN; CALCINEURIN A ALPHA; CALCINEURIN A BETA; CALCINEURIN INHIBITOR; CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; CYCLOSPORIN A; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; OKADAIC ACID; PEPTIDE; UNCLASSIFIED DRUG; VASODILATOR AGENT; CALCIUM; INWARDLY RECTIFYING POTASSIUM CHANNEL; ISOENZYME; POTASSIUM CHANNEL BLOCKING AGENT;

ARTICLE; CALCIUM CELL LEVEL; CELL STRAIN HEK293; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME SUBUNIT; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE CHANNEL; MOLECULAR CLONING; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; WHOLE CELL; BIOLOGICAL MODEL; CELL LINE; CELL MEMBRANE POTENTIAL; DRUG ANTAGONISM; DRUG EFFECT; DRUG POTENTIATION; PATCH CLAMP; PHOSPHORYLATION; PHYSIOLOGY; SYNTHESIS; VASCULAR SMOOTH MUSCLE;

CALCINEURIN; CALCIUM; CELL LINE; CLONING, MOLECULAR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; HUMANS; ISOENZYMES; MEMBRANE POTENTIALS; MODELS, BIOLOGICAL; MUSCLE, SMOOTH, VASCULAR; PATCH-CLAMP TECHNIQUES; PHOSPHORYLATION; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 70349934615     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2009.00221.x     Document Type: Article

References (46)

1. Alexander SP, Mathie A, Peters JA (2008). Guide to Receptors and Channels (GRAC), 3rd edn. Br J Pharmacol 153 (Suppl. 2): S1-209.
2. ATP channel: separate roles of Kir6.2 and SUR subunit phosphorylation. EMBO J 18: 4722-4732.
3. ATP channels in sepsis. Cardiovasc Res 72: 220-230.
4. ATP channels. J Clin Invest 110: 203-208.
5. Crabtree GR (2001). Calcium, calcineurin, and the control of transcription. J Biol Chem 276: 2313-2316.
6. Cui Y, Giblin JP, Clapp LH, Tinker A (2001). A mechanism for ATPsensitive potassium channel diversity: functional coassembly of two pore forming subunits. Proc Natl Acad Sci USA 98: 729-734. (Pubitemid 32105111)
7. ATP channels in human pulmonary artery smooth muscle cells and their modulation by growth. Am J Respir Cell Mol Biol 26: 135-143.
8. + channel, TRESK. J Biol Chem 281: 14677-14682.
9. Eastwood SL, Burnet PW, Harrison PJ (2005). Decreased hippocampal expression of the susceptibility gene PPP3CC and other calcineurin subunits in schizophrenia. Biol Psychiatry 57: 702-710.
10. ATP channels by protein kinase C and phosphatases in gallbladder smooth muscle. Am J Physiol 278: C1031-C1037.
11. Cl(Ca) in rabbit pulmonary artery smooth muscle cells. J Biol Chem 279: 38830-38837.
12. Halpain S, Girault JA, Greengard P (1990). Activation of NMDA receptors induces dephosphorylation of DARPP-32 in rat striatal slices. Nature 343: 369-372. (Pubitemid 20032854)
13. ATP channels by inhibiting steady-state protein kinase A activity and activating protein kinase Ce. J Physiol 530: 193-205.
14. Herzig S, Neumann J (2000). Effects of serine/threonine protein phosphatases on ion channels in excitable membranes. Physiol Rev 80: 173-210. (Pubitemid 30060564)
15. Huang HS, Pozarowski P, Gao Y, Darzynkiewicz Z, Lee EY (2005). Protein phosphatase-1 inhibitor-3 is co-localized to the nucleoli and centrosomes with PP1gamma1 and PP1alpha, respectively. Arch Biochem Biophys 443: 33-44. (Pubitemid 41562323)
16. Hubbard MJ, Cohen P (1989). Regulation of protein phosphatase-1G from rabbit skeletal muscle. 1. Phosphorylation by cAMPdependent protein kinase at site 2 releases catalytic subunit from the glycogen-bound holoenzyme. Eur J Biochem 186: 701-709. (Pubitemid 20030125)
17. Jabr RI, Wilson AJ, Riddervold MH, Jenkins AH, Perrino BA, Clapp LH (2007). Nuclear translocation of calcineurin Aβ but not calcineurin Aα by platelet-derived growth factor in rat aortic smooth muscle. Am J Physiol 292: C2213-C2225.
18. ATP channel imparts fatal susceptibility to endotoxemia. FASEB J 20: 2271-2280.
19. + channel by membranebound protein phosphatases in rat principal tubule cell. Am J Physiol 269: F355-F362.
20. + channel activity in rat ventricular myocytes by phosphorylation of tyrosine and serine threonine residues. Life Sci 58: 897-904.
21. Li L, Wu J, Jiang C (2003). Differential expression of Kir6.1 and SUR2B mRNAs in the vasculature of various tissues in rats. J Membr Biol 196: 61-69. (Pubitemid 37500815)
22. - channels. A possible mechanistic link to ischemic preconditioning. Circ Res 79: 399-406.
23. Loane DJ, Hicks GA, Perrino BA, Marrion NV (2006). Inhibition of BK channel activity by association with calcineurin in rat brain. Eur J Neurosa 24: 433-441. (Pubitemid 44100335)
24. Miki T, Suzuki M, Shibasaki T, Uemura H, Sato T, Yamaguchi K et al. (2002). Mouse model of Prinzmetal angina by disruption of the inward rectifier Kir6.1. Nat Med 8: 466-472. (Pubitemid 34546748)
25. Morimoto H, Okamura H, Yoshida K, Kitamura S, Haneji T (2004). Double-stranded RNA mediates selective gene silencing of protein phosphatase type 1 delta isoform in HEK-293 cells. J Enzyme Inhib Med Chem 19:327-331. (Pubitemid 39172895)
26. Mulkey RM, Endo S, Shenolikar S, Malenka RC (1994). Involvement of a calcineurin/inhibitor-1 phosphatase cascade in hippocampal long-term depression. Nature 369: 486-488. (Pubitemid 2088233)
27. Park KS, Mohapatra DP, Misonou H, Trimmer JS (2006). Graded regulation of the Kv2.1 potassium channel by variable phosphorylation. Science 313: 976-979. (Pubitemid 44267390)
28. Perrino BA, Soderling TR (1998). Biochemistry and pharmacology of calmodulin-regulated phosphatase calcinuerin. In: van Eldik L, Watterson DM (ed.). Calmodulin and Signal Transduction. Academic Press, New York, pp. 169-236.
29. Perrino BA, Wilson AJ, Ellison P, Clapp LH (2002). Substrate selectivity and sensitivity to inhibition by FK506 and cyclosporin A of calcineurin heterodimers composed of the alpha or beta catalytic subunit. Eur f Biochem 269: 3540-3548. (Pubitemid 34988998)
30. Quayle JM, Nelson MT, Standen NB (1997). ATP-sensitive and inwardly rectifying potassium channels in smooth muscle. Physiol Rev 77: 1166-1232.
31. Quinn K, Cui Y, Giblin JP, Clapp LH, Tinker A (2003). Do anionic phospholipids serve as cofactors or second messengers for the regulation of activity of cloned ATP-sensitive K+ channels? Circ Res 93: 646-655. (Pubitemid 37222161)
32. Quinn KV, Giblin JP, Tinker A (2004). Multisite phosphorylation mechanism for protein kinase A activation of the smooth muscle ATP-sensitive K+ channel. Circ Res 94: 1359-1366. (Pubitemid 38724482)
33. Rusnak F, Mertz P (2000). Calcineurin: form and function. Physiol Rev 80: 1483-1521.
34. Sampson LJ, Davies LM, Barrett-Jolley R, Standen NB, Dart C (2007). Angiotensin II-activated protein kinase C targets caveolae to inhibit aortic ATP-sensitive potassium channels. Cardiovasc Res 76: 61-70. (Pubitemid 47371116)
35. Santana LF, Chase EG, Votaw VS, Nelson MT, Greven R (2002). Functional coupling of calcineurin and protein kinase A in mouse ventricular myocytes. J Physiol 544: 57-69.
36. 2+ channels by activation of protein phosphatase type 2B and by direct interaction with the channel. J Gen Physiol 110: 503-513.
37. + channels. Prog Biophys Mol Biol 81: 133-176.
38. ATP channel activation by beta-adrenergic receptors. Am J Physiol Regul Integr Comp Physiol 293: R1205-R1214.
39. ATP channel. J Biol Chem 283: 7523-7530.
40. ATP channel inhibition by protein kinase C. J Biol Chem 283: 2488-2494.
41. Singer M, Coluzzi F, O'Brien AJ, Clapp LH (2005). Reversal of life-threatening, drug-related potassium-channel syndrome by glibenclamide. Lancet 365: 1873-1875. (Pubitemid 40744965)
42. Sommer D, Coleman S, Swanson SA, Stemmer PM (2002). Differential susceptibilities of serine/threonine phosphatases to oxidative and nitrosative stress. Arch Biochem Biophys 404: 271-278. (Pubitemid 34913558)
43. + channels composed of Kir6.1 and/or Kir6.2 expressed with SUR2B. J Physiol 541: 65-80.
44. ATP channel inhibitors to reverse NOS-mediated vasorelaxation. Cardiovasc Res 56: 154-163.
45. + channels: role of protein phosphatases. Circ Res 87: 1019-1025.
46. ATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery. Biochlm Biophys Acta 1778: 88-96.