Upregulation of phosphodiesterase 1A1 expression is associated with the development of nitrate tolerance

Circulation

Volumn 104, Issue 19, 2001, Pages 2338-2343

  Kim, Dongsoo ^a   Rybalkin, Sergei D ^b   Pi, Xinchun ^a   Wang, Yining ^a   Zhang, Changxi ^a   Munzel, Thomas ^c   Beavo, Joseph A ^b   Berk, Bradford C ^a   Yan, Chen ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Univ Eppendorf   (Germany)

Author keywords

Nitrates; Phosphodiesterase; Vasculature

Indexed keywords

ANGIOTENSIN; CALCIUM ION; CALMODULIN; CYCLIC GMP; GLYCERYL TRINITRATE; GUANYLATE CYCLASE; NITRATE; NITRIC OXIDE; PHOSPHODIESTERASE 1A1; PHOSPHODIESTERASE I; UNCLASSIFIED DRUG; VINPOCETINE;

ANIMAL EXPERIMENT; ARTICLE; CALCIUM CELL LEVEL; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVITY; HYDROLYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR UPREGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE FIBER; VASCULAR SMOOTH MUSCLE; VASODILATATION; WESTERN BLOTTING;

EID: 0035818615     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/hc4401.098432     Document Type: Article

References (25)

1. A reappraisal of nitrate therapy
2. New insights into mechanisms underlying nitrate tolerance
3. Dissociation of coronary vascular tolerance and neurohormonal adjustments during long-term nitroglycerin therapy in patients with stable coronary artery disease
4. Prevention and reversal of nitrate tolerance in patients with congestive heart failure
5. Evidence for a role of endothelin 1 and protein kinase C in nitroglycerin tolerance
6. Effects of a nitrate-free interval on tolerance, vasoconstrictor sensitivity and vascular superoxide production
7. Effects of selective inhibitors on cyclic nucleotide phosphodiesterases of rabbit aorta
8. Effects of long-term nitroglycerin treatment on endothelial nitric oxide synthase (NOS III) gene expression, NOS III-mediated superoxide production, and vascular NO bioavailability
9. Calmodulin-stimulated cyclic nucleotide phosphodiesterase (PDE1C) is induced in human arterial smooth muscle cells of the synthetic, proliferative phenotype
10. Identification, quantitation, and cellular localization of PDE1 calmodulin-stimulated cyclic nucleotide phosphodiesterases
11. Zaprinast, but not dipyridamole, reverses hemodynamic tolerance to nitroglycerin in vivo
12. Agonist-stimulated cytoskeletal reorganization and signal transduction at focal adhesions in vascular smooth muscle cells require c-Src
13. 2+ X calmodulin-sensitive phosphodiesterase activity in porcine coronary artery
14. Molecular cloning of a cDNA encoding the "61-kDa" calmodulin-stimulated cyclic nucleotide phosphodiesterase: Tissue-specific expression of structurally related isoforms
15. 2+-sensitivity of the contractile apparatus during angiotensin II-induced desensitization in the rabbit femoral artery
16. Role of selective cyclic GMP phosphodiesterase inhibition in the myorelaxant actions of M&B 22,948, MY-5445, vinpocetine and 1-methyl-3-isobutyl-8-(methylamino)xanthine
17. Evidence for enhanced vascular superoxide anion production in nitrate tolerance: A novel mechanism underlying tolerance and cross-tolerance
18. Effect of in vivo nitroglycerin therapy on endothelium-dependent and independent vascular relaxation and cyclic GMP accumulation in rat aorta
19. Tolerance towards nitroglycerin, induced in vivo, is correlated to a reduced cGMP response and an alteration in cGMP turnover
20. Endothelin inhibits the atrial natriuretic factor stimulated cGMP production by activating the protein kinase C in rat aortic smooth muscle cells
21. Nonatheromatous ischemic heart disease following withdrawal from chronic industrial nitroglycerin exposure
22. Biotransformation of glyceryl trinitrate occurs concurrently with relaxation of rabbit aorta
23. Nitrate tolerance from a biochemical point of view
24. Effects of in vivo nitroglycerin treatment on activity and expression of the guanylyl cyclase and cGMP-dependent protein kinase and their downstream target vasodilator-stimulated phosphoprotein in aorta
25. Reversal of nitroglycerin tolerance in vitro by the cGMP-phosphodiesterase inhibitor zaprinast