The vasorelaxant effect of H2S as a novel endogenous gaseous KATP channel opener

EMBO Journal

Volumn 20, Issue 21, 2001, Pages 6008-6016

  Zhao, W ^a   Zhang, J ^a   Lu, Y ^a   Wang, R ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

Blood pressure; Hydrogen sulfide; Nitric oxide; Smooth muscle cells; Vasorelaxation

Indexed keywords

CYSTEINE; GLIBENCLAMIDE; HYDROGEN SULFIDE; NITRIC OXIDE; PINACIDIL; POTASSIUM CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL TONE; CONTROLLED STUDY; DRUG POTENTIATION; HEART RATE; HYPERPOLARIZATION; HYPOTENSION; IN SITU HYBRIDIZATION; MALE; MEMBRANE POTENTIAL; NONHUMAN; PATCH CLAMP; POTASSIUM CURRENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SMOOTH MUSCLE RELAXATION; VASCULAR SMOOTH MUSCLE; VASCULAR TISSUE; VASOCONSTRICTION; VASODILATATION;

ANIMALS; ARTERIES; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CELL SEPARATION; CELLS, CULTURED; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; ENDOTHELIUM, VASCULAR; HYDROGEN SULFIDE; IN SITU HYBRIDIZATION; INJECTIONS, INTRAVENOUS; MALE; MEMBRANE POTENTIALS; MUSCLE, SMOOTH, VASCULAR; NITRIC OXIDE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; VASODILATION; VASODILATOR AGENTS; VASOMOTOR SYSTEM;

ANIMALIA;

EID: 0035503695     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/20.21.6008     Document Type: Article

References (37)

1. The possible role of hydrogen sulfide as an endogenous neuromodulator
2. K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells
3. S-nitrosylation of proteins
4. Charybdotoxin and apamin block EDHF in rat mesenteric artery if selectively applied to the endothelium
5. 2+-dependent delayed contractions in diabetic rat aorta
6. The possible role of hydrogen sulfide as an endogenous smooth muscle relaxant in synergy with nitric oxide
7. Inhibitory effect of noradrenaline uptake inhibitors on contractions of rat aortic smooth muscle
8. Rapid estimation of sulfide in rumen and blood with a sulfide-specific ion electrode
9. Nitric oxide-generating compounds inhibit total protein and collagen synthesis in cultured vascular smooth muscle cells
10. Nitric oxide regulates the expression of vasoconstrictors and growth factors by vascular endothelium under both normoxia and hypoxia
11. The role of sulphide and sulphide oxidation in the copper molybdenum antagonism in rats and guinea pigs
12. Physiological roles and properties of potassium channels in arterial smooth muscle
13. The formation and properties of sulphmyoglobin and sulphcatalase
14. Identification of probasin-related antigen as cystathionine γ-lyase by molecular cloning
15. Calcitonin gene-related peptide activated ATP-sensitive K+ currents in rabbit arterial smooth muscle via protein kinase A
16. Pharmacology of ATP-sensitive K+ currents in smooth muscle cells from rabbit mesenteric artery
17. Mechanism of inhibition of delayed rectifier K+ current by 4-aminopyridine in rabbit coronary myocytes
18. Renal microvascular actions of calcitonin gene-related peptide
19. Contractile responses elicited by hydrogen peroxide in aorta from normotensive and hypertensive rats. Endothelial modulation and mechanism involved
20. The single-channel dose-response relation is consistently steep for rod cyclic nucleotide-gated channels: Implications for the interpretation of macroscopic dose-response relations
21. A direct microdetermination for sulfide
22. Hydrogen sulfide poisoning
23. NO Signals: Translocation, regulation and a consensus motif
24. Characterization of the enzymic capacity for cysteine desulphhydration in liver and kidney of the rat
25. Rat cystathionine β-synthase: Gene organization and alternative splicing
26. Mechanisms of vasodilation by cochlear nerve stimulation. Role of calcitonin generelated peptide
27. Characterization of the PGE receptor subtype mediating inhibition of superoxide production in human neutrophils
28. Effects of nicotine on K+ channel currents in vascular smooth muscle cells from rat tail arteries
29. Resurgence of carbon monoxide: An endogenous gaseous vasorelaxing factor
30. Two types of calcium channels in isolated smooth muscle cells from rat tail artery
31. Carbon monoxide-induced vasorelaxation and the underlying mechanisms
32. ca channels in vascular smooth muscle cells
33. Hydrogen sulfide in combination with taurine or cysteic acid reversibly abolishes sodium currents in neuroblastoma cells
34. The Hill equation revisited: Uses and misuses
35. The seat of action of sulfide on pulmonary ventilation
36. Inhibition by cyclic AMP of basal and induced inositol phosphate production in cultured aortic smooth muscle cells from Wistar-Kyoto and spontaneously hypertensive rats
37. Nitric oxide modulates the expression of monocyte chemoattractant protein-1 in cultured human endothelial cells