Hydrogen sulfide is an endogenous inhibitor of phosphodiesterase activity

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 30, Issue 10, 2010, Pages 1998-2004

  Bucci, Mariarosaria ^a   Papapetropoulos, Andreas ^b   Vellecco, Valentina ^a   Zhou, Zongmin ^c   Pyriochou, Anastasia ^b   Roussos, Charis ^c   Roviezzo, Fiorentina ^a   Brancaleone, Vincenzo ^a   Cirino, Giuseppe ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY OF PATRAS   (Greece)

^c UNIVERSITY OF ATHENS   (Greece)

Author keywords

cAMP; cGMP; cystathione lyase; endothelium; hydrogen sulfide; hypertension; phosphodiesterase; signal transduction; vascular muscle; vasodilation

Indexed keywords

ALANINE DERIVATIVE; CYANOALANINE; CYCLIC AMP; CYCLIC GMP; CYSTEINE; HYDROGEN SULFIDE; ISOBUTYLMETHYLXANTHINE; ISOPRENALINE; NITROPRUSSIDE SODIUM; PHOSPHODIESTERASE; PROPARGYLGLYCINE; UNCLASSIFIED DRUG; 3-CYANOALANINE; ALANINE; ALKYNE; CYSTATHIONINE GAMMA LYASE; GLYCINE; PHOSPHODIESTERASE INHIBITOR; SMALL INTERFERING RNA;

ANIMAL TISSUE; AORTA; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; GENE SILENCING; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; VASODILATATION; ANALOGS AND DERIVATIVES; ANIMAL; ANTAGONISTS AND INHIBITORS; CELL CLONE; DRUG EFFECTS; ENDOTHELIUM CELL; GENETICS; HUMAN; IN VITRO STUDY; METABOLISM; PHYSIOLOGY; THORACIC AORTA; WISTAR RAT;

1-METHYL-3-ISOBUTYLXANTHINE; ALANINE; ALKYNES; ANIMALS; AORTA, THORACIC; CLONE CELLS; CYCLIC AMP; CYCLIC GMP; CYSTATHIONINE GAMMA-LYASE; CYSTEINE; ENDOTHELIAL CELLS; GLYCINE; HUMANS; HYDROGEN SULFIDE; MALE; PHOSPHODIESTERASE INHIBITORS; RATS; RATS, WISTAR; RNA, SMALL INTERFERING; VASODILATION; IN VITRO TECHNIQUES;

EID: 77957718685     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/ATVBAHA.110.209783     Document Type: Article

References (29)

1. Moncada S, Palmer RM, Higgs EA. Nitric oxide: physiology, pathophys-iology, and pharmacology. Pharmacol Rev. 1991;43:109-142.
2. Ignarro L, Cirino G, Casini A, Napoli C. Nitric oxide as a signaling molecule in the vascular system: an overview. J Cardiovasc Pharmacol. 1999;34:879-886.
3. Hofmann F. The biology of cyclic GMP-dependent protein kinases. J Biol Chem. 2004;280:1-4.
4. Elsey D, Fowkes R, Baxter G. Regulation of cardiovascular cell function by hydrogen sulfide (H(2)S). Cell Biochem Funct. 2010;28:95-106.
5. Szabó C. Hydrogen sulphide and its therapeutic potential. Nat Rev Drug Discov. 2007;6:917-935.
6. 2S as a physiologic vasorelaxant: hypertension in mice with deletion of cystathionine gamma-lyase. Science. 2008;322:587-590.
7. Wang R. Hydrogen sulfide: a new EDRF. Kidney Int. 2009;76:700-704.
8. 2S is impaired in non-obese diabetic (NOD) mice. Br J Pharmacol. 2008;155:673-680.
9. Li L, Hsu A, Moore P. Actions and interactions of nitric oxide, carbon monoxide and hydrogen sulphide in the cardiovascular system and in inflammation: a tale of three gases! Pharmacol Ther. 2009;123:386-400.
10. Sanderson K. Hydrogen sulphide biology: emissions control. Nature. 2009;459:500-502.
11. Cheng Y, Ndisang J, Tang G, Cao K, Wang R. Hydrogen sulfide-induced relaxation of resistance mesenteric artery beds of rats. Am J Physiol Heart Circ Physiol. 2004;287:H2316-H2323.
12. Stipanuk M, Beck P. Characterization of the enzymatic capacity for cysteine desulphydration in liver and kidney of the rat. Biochem J. 1982;206:267-277.
13. Shibuya N, Mikami Y, Kimura Y, Nagahara N, Kimura H. Vascular endothelium expresses 3-mercaptopyruvate sulfurtransferase and produces hydrogen sulfide. J Biochem. 2009;146:623-626.
14. Johnston M, Jankowski D, Marcotte P, Tanaka H, Esaki N, Soda K, Walsh C. Suicide inactivation of bacterial cystathionine gamma-synthase and methionine gamma-lyase during processing of L-propargylglycine. Biochemistry. 1979;18:4690-4701.
15. Pfeffer M, Ressler C. Beta-cyanoalanine, an inhibitor of rat liver cysta-thionase. Biochem Pharmacol. 1967;16:2299-2308.
16. Papapetropoulos A, Pyriochou A, Altaany Z, Yang G, Marazioti A, Zhou Z, Jeschke M, Branski L, Herndon D, Wang R, Szabó C. Hydrogen sulfide is an endogenous stimulator of angiogenesis. Proc Natl Acad Sci\USA. 2009;106:21972-21977.
17. Whiteman M, Li L, Kostetski I, Chu S, Siau J, Bhatia M, Moore P. Evidence for the formation of a novel nitrosothiol from the gaseous mediators nitric oxide and hydrogen sulfide. Biochem Biophys Res Commun. 2006;343:303-310.
18. Whiteman M, Moore P. Hydrogen sulfide and the vasculature: a novel vasculoprotective entity and regulator of nitric oxide bioavailability? J Cell Mol Med. 2008;13:488-507.
19. Essayan DM. Cyclic nucleotide phosphodiesterases. J Allergy Clin Immunol. 2001;108:671-680.
20. Lucas KA, Pitari GM, Kazerounian S, Ruiz-Stewart I, Park J, Schulz S, Chepenik KP, Waldman SA. Guanylyl cyclases and signaling by cyclic GMP. Pharmacol Rev. 2000;52:375-414.
21. Pavlik J, Noll B, Oliver A, Schulz C, Scheidt W. Hydrosulfide (HS-) coordination in iron porphyrinates. Inorg Chem. 2010;49:1017-1026.
22. Cai W, Wang M, Moore P, Jin H, Yao T, Zhu Y. The novel proangiogenic effect of hydrogen sulfide is dependent on Akt phosphorylation. Cardiovasc Res. 2007;76:29-40.
23. 2S as a novel endogenous gaseous KATP channel opener. EMBO J. 2001;20: 6008-6016.
24. Bender A, Beavo J. Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use. Pharmacol Rev. 2006;58:433-520.
25. 2S signals through protein S-sulfhydration. Sci Signal. 2009;2:ra72.
26. Jiang B, Tang G, Cao K, Wu L, Wang R. Molecular mechanism for H(2)S-induced activation of K(ATP) channels. Antioxid Redox Signal. 2010;12:1167-1178.
27. 2S-donating sildenafil (ACS6) inhibits superoxide formation and gp91phox expression in arterial endothelial cells: role of protein kinases A and G. Br J Pharmacol. 2008;155:984-994.
28. Alioua A, Tanaka Y, Wallner M, Hofmann F, Ruth P, Meera P, Toro L. The large conductance, voltage-dependent, and calcium-sensitive K + channel, Hslo, is a target of cGMP-dependent protein kinase phosphorylation in vivo. J Biol Chem. 1998;273:32950-32956.
29. Han J, Kim N, Joo H, Kim E, Earm Y. ATP-sensitive K(+) channel activation by nitric oxide and protein kinase G in rabbit ventricular myocytes. Am J Physiol Heart Circ Physiol. 2002;283:H1545-H1554