메뉴 건너뛰기




Volumn 4, Issue SPEC. ISSUE 2, 2010, Pages 240-256

Glycoxidative stress and cardiovascular complications in experimentally- induced diabetes: Effects of antioxidant treatment

Author keywords

Antioxidant; Cardiovascular; Diabetes mellitus; Glycation; Glycoxidative stress

Indexed keywords

1 METHYLNICOTINAMIDE; ADVANCED GLYCATION END PRODUCT; ALPHA TOCOPHEROL; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; ANTIOXIDANT; ASCORBIC ACID; CALCIUM CHANNEL BLOCKING AGENT; CHROMIUM PICOLINATE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ENDOTHELIAL NITRIC OXIDE SYNTHASE; FOLIC ACID; FREE RADICAL; ICOSANOID; PHOSPHODIESTERASE V INHIBITOR; PLACEBO; PROTEIN KINASE C; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; RETINOL; RETINOL ACETATE; STOBADINE; SUPEROXIDE; THIOCTIC ACID;

EID: 84855509329     PISSN: None     EISSN: 18741924     Source Type: Journal    
DOI: 10.2174/1874192401004010240     Document Type: Review
Times cited : (78)

References (224)
  • 1
    • 0031445908 scopus 로고    scopus 로고
    • The rising global burden ofdiabetes and its complications: Estimates and projections to the year2010
    • Amos A, McCarthy D, Zimmet P. The rising global burden ofdiabetes and its complications: estimates and projections to the year2010. Diabet Med 1997; 14: S1-S85.
    • (1997) Diabet Med , vol.14
    • Amos, A.1    McCarthy, D.2    Zimmet, P.3
  • 2
    • 0034327520 scopus 로고    scopus 로고
    • Diabetes and cardiovascular disease
    • Howard BV, Magee MF. Diabetes and cardiovascular disease. CurrAtheroscler Rep 2000; 2: 476-81.
    • (2000) CurrAtheroscler Rep , vol.2 , pp. 476-481
    • Howard, B.V.1    Magee, M.F.2
  • 3
    • 0035856980 scopus 로고    scopus 로고
    • Biochemistry and molecular biology of diabetic complications
    • Brownlee M. Biochemistry and molecular biology of diabetic complications. Nature 2001; 414: 813-20.
    • (2001) Nature , vol.414 , pp. 813-820
    • Brownlee, M.1
  • 4
    • 0028897751 scopus 로고
    • Diabetes mellitus, hypertension, and cardiovascular disease: Which role for oxidative stress?
    • Giugliano D, Ceriello A, Paolisso G. Diabetes mellitus, hypertension, and cardiovascular disease: which role for oxidative stress?Metabolism 1995; 44: 363-8.
    • (1995) Metabolism , vol.44 , pp. 363-368
    • Giugliano, D.1    Ceriello, A.2    Paolisso, G.3
  • 5
    • 0036796875 scopus 로고    scopus 로고
    • Oxidativestress and stress-activated signalling pathways: A unifying hypothesisof type 2 diabetes
    • Evans JL, Goldfine ID, Maddux BA, Grodsky GM. Oxidativestress and stress-activated signalling pathways: a unifying hypothesisof type 2 diabetes. Endocr Rev 2002; 23: 599-622.
    • (2002) Endocr Rev , vol.23 , pp. 599-622
    • Evans, J.L.1    Goldfine, I.D.2    Maddux, B.A.3    Grodsky, G.M.4
  • 6
    • 42049118293 scopus 로고    scopus 로고
    • Clinical review: The role of advanced glycationend products in progression and complications of diabetes
    • Goh SY, Cooper ME. Clinical review: The role of advanced glycationend products in progression and complications of diabetes. JClin Endocrinol Metab 2008; 93: 1143-52.
    • (2008) JClin Endocrinol Metab , vol.93 , pp. 1143-1152
    • Goh, S.Y.1    Cooper, M.E.2
  • 8
    • 34249948613 scopus 로고    scopus 로고
    • Endothelial dysfunction and vascular pathology
    • Vanhoutte PM. Endothelial dysfunction and vascular pathology. Bull Mem Acad R Med Belg 2006; 161: 529-36.
    • (2006) Bull Mem Acad R Med Belg , vol.161 , pp. 529-536
    • Vanhoutte, P.M.1
  • 10
    • 43749084209 scopus 로고    scopus 로고
    • Hyperglycemia and the pathobiology of diabetic complications
    • Aronson D. Hyperglycemia and the pathobiology of diabetic complications. Adv Cardiol 2008; 45: 1-16.
    • (2008) Adv Cardiol , vol.45 , pp. 1-16
    • Aronson, D.1
  • 11
    • 0034568891 scopus 로고    scopus 로고
    • The role of free radicals, oxidative stress and antioxidantsystems in diabetic vascular disease
    • Jakus V. The role of free radicals, oxidative stress and antioxidantsystems in diabetic vascular disease. Bratisl Lek Listy 2000; 101:541-51.
    • (2000) Bratisl Lek Listy , vol.101 , pp. 541-551
    • Jakus, V.1
  • 12
    • 65349167787 scopus 로고    scopus 로고
    • The receptor for advancedglycation endproducts (RAGE) and cardiovascular disease
    • Yan SF, Ramasamy R, Schmidt AM. The receptor for advancedglycation endproducts (RAGE) and cardiovascular disease. ExpertRev Mol Med 2009; 11: e9.
    • (2009) ExpertRev Mol Med , vol.11
    • Yan, S.F.1    Ramasamy, R.2    Schmidt, A.M.3
  • 13
    • 71949107479 scopus 로고    scopus 로고
    • Advanced glycation end products and receptoroxidativestress system in diabetic vascular complications
    • Yamagishi S. Advanced glycation end products and receptoroxidativestress system in diabetic vascular complications. TherApher Dial 2009; 13: 534-9.
    • (2009) TherApher Dial , vol.13 , pp. 534-539
    • Yamagishi, S.1
  • 14
    • 0043025552 scopus 로고    scopus 로고
    • Heart failure: The frequent, forgotten, and often fatal complicationof diabetes
    • Bell DS. Heart failure: the frequent, forgotten, and often fatal complicationof diabetes. Diabetes Care 2003; 26: 2433-41.
    • (2003) Diabetes Care , vol.26 , pp. 2433-2441
    • Bell, D.S.1
  • 15
    • 0016424590 scopus 로고
    • Preclinical abnormalityof left ventricular function in diabetes mellitus
    • Ahmed SS, Jakeri GA, Narang RM, Regan TJ. Preclinical abnormalityof left ventricular function in diabetes mellitus. Am Heart J1975; 89: 153-58.
    • (1975) Am Heart J , vol.89 , pp. 153-158
    • Ahmed, S.S.1    Jakeri, G.A.2    Narang, R.M.3    Regan, T.J.4
  • 20
    • 0027478738 scopus 로고
    • Effect ofinsulin on the decreased b-adrenergic responses of duodenum andatrium isolated from streptozotocin diabetic rats
    • Öztürk Y, Yildizoglu-Ari N, Altan VM, Özçelikay AT. Effect ofinsulin on the decreased b-adrenergic responses of duodenum andatrium isolated from streptozotocin diabetic rats. Gen Pharmacol1993; 24: 217-23.
    • (1993) Gen Pharmacol , vol.24 , pp. 217-223
    • Öztürk, Y.1    Yildizoglu-Ari, N.2    Altan, V.M.3    Özçelikay, A.T.4
  • 21
    • 0027478735 scopus 로고
    • The effects of glyburide and insulin on the cardiac performance inrats with non-insulin dependent diabetes mellitus
    • Özüari A, Öztürk Y, Yldizoglu-Ari N, Özçelikay AT, Altan VM. The effects of glyburide and insulin on the cardiac performance inrats with non-insulin dependent diabetes mellitus. Gen Pharmacol1993; 24: 165-9
    • (1993) Gen Pharmacol , vol.24 , pp. 165-169
    • Özüari, A.1    Öztürk, Y.2    Yldizoglu-Ari, N.3    Özçelikay, A.T.4    Altan, V.M.5
  • 22
    • 36849027587 scopus 로고    scopus 로고
    • The ADIC Study Group. Cod liver oilsupplementation improves cardiovascular and metabolic abnormalitiesin streptozotocin diabetic rats
    • (Antioxidants in Diabetes-Induced Complications)
    • Ceylan-Isik A, Hünkar T, Asan E, et al. (Antioxidants in Diabetes-Induced Complications) The ADIC Study Group. Cod liver oilsupplementation improves cardiovascular and metabolic abnormalitiesin streptozotocin diabetic rats. J Pharm Pharmacol 2007;59: 1629-41.
    • (2007) J Pharm Pharmacol , vol.59 , pp. 1629-1641
    • Ceylan-Isik, A.1    Hünkar, T.2    Asan, E.3
  • 23
    • 33644604271 scopus 로고    scopus 로고
    • Left ventricular dysfunction and remodeling in streptozotocin-induced diabetic rats
    • Nemoto O, Kawaguchi M, Yaoita H, Miyake K, Maehara K, MaruyamaY. Left ventricular dysfunction and remodeling in streptozotocin-induced diabetic rats. Circ J 2006; 70: 327-34.
    • (2006) Circ J , vol.70 , pp. 327-334
    • Nemoto, O.1    Kawaguchi, M.2    Yaoita, H.3    Miyake, K.4    Maehara, K.5    Maruyama, Y.6
  • 25
    • 34948812476 scopus 로고    scopus 로고
    • The role ofgender differences in beta-adrenergic receptor responsiveness ofdiabetic rat heart
    • Bilginoglu A, Cicek FA, Ugur M, Gurdal H, Turan B. The role ofgender differences in beta-adrenergic receptor responsiveness ofdiabetic rat heart. Mol Cell Biochem 2007; 305: 63-9.
    • (2007) Mol Cell Biochem , vol.305 , pp. 63-69
    • Bilginoglu, A.1    Cicek, F.A.2    Ugur, M.3    Gurdal, H.4    Turan, B.5
  • 26
    • 0035051427 scopus 로고    scopus 로고
    • Serial changes in themyocardial beta-adrenergic signalling system in two models ofnon-insulin dependent diabetes mellitus
    • Huisamen B, Marais E, Genade S, Lochner A. Serial changes in themyocardial beta-adrenergic signalling system in two models ofnon-insulin dependent diabetes mellitus. Mol Cell Biochem 2001;219: 73-82.
    • (2001) Mol Cell Biochem , vol.219 , pp. 73-82
    • Huisamen, B.1    Marais, E.2    Genade, S.3    Lochner, A.4
  • 27
    • 0346146975 scopus 로고    scopus 로고
    • Left-ventricular diastolic dysfunctionmay be prevented by chronic treatment with PPAR-alpha or-gamma agonists in a type 2 diabetic animal model
    • Kim SK, Zhao ZS, Lee YJ, et al. Left-ventricular diastolic dysfunctionmay be prevented by chronic treatment with PPAR-alpha or-gamma agonists in a type 2 diabetic animal model. Diabetes MetabRes Rev 2003; 19: 487-93.
    • (2003) Diabetes MetabRes Rev , vol.19 , pp. 487-493
    • Kim, S.K.1    Zhao, Z.S.2    Lee, Y.J.3
  • 28
    • 0028510483 scopus 로고
    • Pharmacological studies on alterations in myocardialbeta-adrenoceptors and their intracellular signal transduction in experimentaldiabetic rats
    • Gando S. Pharmacological studies on alterations in myocardialbeta-adrenoceptors and their intracellular signal transduction in experimentaldiabetic rats. Hokkaido Igaku Zasshi 1994; 69: 1140-53.
    • (1994) Hokkaido Igaku Zasshi , vol.69 , pp. 1140-1153
    • Gando, S.1
  • 29
    • 0035140242 scopus 로고    scopus 로고
    • The effect of diabetes on expression of beta1-, beta2-, and beta3-adrenoreceptors in rat hearts. 1
    • Dinçer UD, Bidasee KR, Güner S, Tay A, Ozçelikay AT, AltanVM. The effect of diabetes on expression of beta1-, beta2-, andbeta3-adrenoreceptors in rat hearts. 1: Diabetes 2001; 50: 455-61.
    • (2001) Diabetes , vol.50 , pp. 455-461
    • Dinçer, U.D.1    Bidasee, K.R.2    Güner, S.3    Tay, A.4    Ozçelikay, A.T.5    Altan, V.M.6
  • 30
    • 0028003464 scopus 로고
    • G protein expressionand adenylate cyclase regulation in ventricular cardiomyocytesfrom STZ-diabetic rats
    • Wichelhaus A, Russ M, Petersen S, Eckel J. G protein expressionand adenylate cyclase regulation in ventricular cardiomyocytesfrom STZ-diabetic rats. Am J Physiol 1994; 267: H548-55.
    • (1994) Am J Physiol , vol.267
    • Wichelhaus, A.1    Russ, M.2    Petersen, S.3    Eckel, J.4
  • 31
    • 0027279933 scopus 로고
    • Altered cardiac adrenergic neurotransmissionin streptozotocin-induced diabetic rats
    • Gando S, Hattori Y, Kanno M. Altered cardiac adrenergic neurotransmissionin streptozotocin-induced diabetic rats. Br J Pharmacol1993; 109: 1276-81.
    • (1993) Br J Pharmacol , vol.109 , pp. 1276-1281
    • Gando, S.1    Hattori, Y.2    Kanno, M.3
  • 32
    • 0030853622 scopus 로고    scopus 로고
    • Changes in electrophysiologicaland mechanical responses of the rat papillary muscleto alpha-and beta-agonist in streptozotocin-induced diabetes
    • Kamata K, Satoh T, Tanaka H, Shigenobu K. Changes in electrophysiologicaland mechanical responses of the rat papillary muscleto alpha-and beta-agonist in streptozotocin-induced diabetes. Can JPhysiol Pharmacol 1997; 75: 781-8.
    • (1997) Can JPhysiol Pharmacol , vol.75 , pp. 781-788
    • Kamata, K.1    Satoh, T.2    Tanaka, H.3    Shigenobu, K.4
  • 33
    • 0028233674 scopus 로고
    • Increased alpha 1-adrenergicresponsiveness of alloxan diabetic rat atria: Effects of insulin therapyand thyroidectomy
    • Lafçi-Erol D, Altan VM, Oztürk Y. Increased alpha 1-adrenergicresponsiveness of alloxan diabetic rat atria: effects of insulin therapyand thyroidectomy. Gen Pharmacol 1994; 25: 559-64.
    • (1994) Gen Pharmacol , vol.25 , pp. 559-564
    • Lafçi-Erol, D.1    Altan, V.M.2    Oztürk, Y.3
  • 34
    • 0026648972 scopus 로고
    • Abnormalities incardiac alpha 1-adrenoceptor and its signal transduction in streptozocin-induced diabetic rats
    • Tanaka Y, Kashiwagi A, Saeki Y, Shigeta Y. Abnormalities incardiac alpha 1-adrenoceptor and its signal transduction in streptozocin-induced diabetic rats. Am J Physiol 1992; 263: E425-9.
    • (1992) Am J Physiol , vol.263
    • Tanaka, Y.1    Kashiwagi, A.2    Saeki, Y.3    Shigeta, Y.4
  • 35
    • 0023281038 scopus 로고
    • Altered muscarinic receptor propertiesand function in the heart in diabetes
    • Carrier GO, Aronstam RS. Altered muscarinic receptor propertiesand function in the heart in diabetes. J Pharmacol Exp Ther 1987;242: 531-5.
    • (1987) J Pharmacol Exp Ther , vol.242 , pp. 531-535
    • Carrier, G.O.1    Aronstam, R.S.2
  • 36
    • 20344400109 scopus 로고    scopus 로고
    • The role of sorbitol pathwayand treatment effect of aldose reductase inhibitor ONO2235 inthe up-regulation of cardiac M2-muscarinic receptors in streptozotocin-induced diabetic rats
    • Liu TP, Juang SW, Cheng JT, Tong YC. The role of sorbitol pathwayand treatment effect of aldose reductase inhibitor ONO2235 inthe up-regulation of cardiac M2-muscarinic receptors in streptozotocin-induced diabetic rats. Neurosci Lett 2005; 383: 131-5.
    • (2005) Neurosci Lett , vol.383 , pp. 131-135
    • Liu, T.P.1    Juang, S.W.2    Cheng, J.T.3    Tong, Y.C.4
  • 38
    • 0024331878 scopus 로고
    • Insulin prevention of altered muscarinicreceptor-G protein coupling in diabetic rat atria
    • Aronstam RS, Carrier GO. Insulin prevention of altered muscarinicreceptor-G protein coupling in diabetic rat atria. Diabetes 1989; 38:1611-6.
    • (1989) Diabetes , vol.38 , pp. 1611-1616
    • Aronstam, R.S.1    Carrier, G.O.2
  • 39
    • 0031002118 scopus 로고    scopus 로고
    • Cardiovascular and metaboliceffects of adenosine A1-receptor agonists in streptozotocintreatedrats
    • Cox BF, Clark KL, Perrone MH, et al. Cardiovascular and metaboliceffects of adenosine A1-receptor agonists in streptozotocintreatedrats. J Cardiovasc Pharmacol 1997; 29: 417-26.
    • (1997) J Cardiovasc Pharmacol , vol.29 , pp. 417-426
    • Cox, B.F.1    Clark, K.L.2    Perrone, M.H.3
  • 41
    • 0033799919 scopus 로고    scopus 로고
    • Diabetes-induced myocardial structural changes: Role of endothelin-1and its receptors
    • Chen S, Evans T, Mukherjee K, Karmazyn M, Chakrabarti S. Diabetes-induced myocardial structural changes: role of endothelin-1and its receptors. J Mol Cell Cardiol 2000; 32: 1621-9.
    • (2000) J Mol Cell Cardiol , vol.32 , pp. 1621-1629
    • Chen, S.1    Evans, T.2    Mukherjee, K.3    Karmazyn, M.4    Chakrabarti, S.5
  • 42
    • 53449085723 scopus 로고    scopus 로고
    • Endothelin-1 actions on vascularsmooth muscle cell functions as a target for the prevention of atherosclerosis
    • Little PJ, Ivey ME, Osman N. Endothelin-1 actions on vascularsmooth muscle cell functions as a target for the prevention of atherosclerosis. Curr Vasc Pharmacol 2008; 6: 195-203.
    • (2008) Curr Vasc Pharmacol , vol.6 , pp. 195-203
    • Little, P.J.1    Ivey, M.E.2    Osman, N.3
  • 43
    • 41149118362 scopus 로고    scopus 로고
    • Diabetic cardiomyopathy--atype of coronary artery disease?
    • (Berl)
    • Stratmann B, Stork I, Tschoepe D. Diabetic cardiomyopathy--atype of coronary artery disease? Internist (Berl). 2008; 49: 436-40.
    • (2008) Internist , vol.49 , pp. 436-440
    • Stratmann, B.1    Stork, I.2    Tschoepe, D.3
  • 44
    • 33746308986 scopus 로고    scopus 로고
    • 2+-ATPase activity contributes to cardiacdysfunction in streptozotocin-induced diabetic rats
    • 2+-ATPase activity contributes to cardiacdysfunction in streptozotocin-induced diabetic rats. PhysiolBiochem 2006; 62: 1-8.
    • (2006) PhysiolBiochem , vol.62 , pp. 1-8
    • Zhao, X.Y.1    Hu, S.J.2    Li, J.3    Mou, Y.4    Chen, B.P.5    Xia, Q.6
  • 46
    • 0037048615 scopus 로고    scopus 로고
    • 2+-ATPase activity inheart and liver of streptozotocin-diabetic rats: Comparison with vitaminE
    • 2+-ATPase activity inheart and liver of streptozotocin-diabetic rats: comparison with vitaminE. Biochim Biophys Acta 2002; 1588: 71-8.
    • (2002) Biochim Biophys Acta , vol.1588 , pp. 71-78
    • Pekiner, B.1    Ulusu, N.N.2    Das-Evcimen, N.3
  • 48
    • 33745685229 scopus 로고    scopus 로고
    • Altered calcium handling isan early sign of streptozotocin-induced diabetic cardiomyopathy
    • Ligeti L, Szenczi O, Prestia CM, et al. Altered calcium handling isan early sign of streptozotocin-induced diabetic cardiomyopathy. IntJ Mol Med 2006; 17: 1035-43.
    • (2006) IntJ Mol Med , vol.17 , pp. 1035-1043
    • Ligeti, L.1    Szenczi, O.2    Prestia, C.M.3
  • 49
    • 34249989152 scopus 로고    scopus 로고
    • Inhibition of nitric oxidesynthase enhances contractile response of ventricular myocytesfrom streptozotocin-diabetic rats
    • Smith JM, Sondgeroth KB, Wahler GM. Inhibition of nitric oxidesynthase enhances contractile response of ventricular myocytesfrom streptozotocin-diabetic rats. Mol Cell Biochem 2007; 300:129-37.
    • (2007) Mol Cell Biochem , vol.300 , pp. 129-137
    • Smith, J.M.1    Sondgeroth, K.B.2    Wahler, G.M.3
  • 50
    • 0026443095 scopus 로고
    • Correlation of contractile dysfunctionand abnormal tissue energy metabolism during hypoperfusionwith norepinephrine in isolated rat hearts: Differences betweennormal and diabetic hearts
    • Higuchi M, Ikema S, Sakanashi M. Correlation of contractile dysfunctionand abnormal tissue energy metabolism during hypoperfusionwith norepinephrine in isolated rat hearts: differences betweennormal and diabetic hearts. J Mol Cell Cardiol 1992; 24: 1125-41.
    • (1992) J Mol Cell Cardiol , vol.24 , pp. 1125-1141
    • Higuchi, M.1    Ikema, S.2    Sakanashi, M.3
  • 51
    • 40749126070 scopus 로고    scopus 로고
    • Diabetes-related metabolic perturbationsin cardiac myocyte
    • Feuvray D, Darmellah A. Diabetes-related metabolic perturbationsin cardiac myocyte. Diabetes Metab 2008; 34 Suppl 1: S3-9.
    • (2008) Diabetes Metab , vol.34 , Issue.SUPPL. 1
    • Feuvray, D.1    Darmellah, A.2
  • 52
    • 0031764798 scopus 로고    scopus 로고
    • Diabetes mellitus and coronary heart disease
    • Wilson PW. Diabetes mellitus and coronary heart disease. Am JKidney Dis 1998; 32: S89-100.
    • (1998) Am JKidney Dis , vol.32
    • Wilson, P.W.1
  • 53
    • 21644435395 scopus 로고    scopus 로고
    • Endothelial cell dysfunction and the vascularcomplications associated with type 2 diabetes: Assessing the healthof the endothelium
    • Ding H, Triggle CR. Endothelial cell dysfunction and the vascularcomplications associated with type 2 diabetes: assessing the healthof the endothelium. Vasc Health Risk Manage 2005; 1: 55-71.
    • (2005) Vasc Health Risk Manage , vol.1 , pp. 55-71
    • Ding, H.1    Triggle, C.R.2
  • 55
    • 0020123798 scopus 로고
    • Incsulin reversal ofdiabetes-induced inhibition of vascular contractility in the rat
    • Pfaffman MA, Ball CR, Darby A, Hilman R. Incsulin reversal ofdiabetes-induced inhibition of vascular contractility in the rat. Am JPhysiol 1982; 242: H490-95.
    • (1982) Am JPhysiol , vol.242
    • Pfaffman, M.A.1    Ball, C.R.2    Darby, A.3    Hilman, R.4
  • 56
    • 0023217593 scopus 로고
    • A contrasting effectof the diabetic state upon the contractile responses of aortic preparationsfrom therat and rabbit
    • Head PJ, Longhurst PA, Panek RL, Stitzel RE. A contrasting effectof the diabetic state upon the contractile responses of aortic preparationsfrom therat and rabbit. Br J Pharmacol 1987; 91: 275-86.
    • (1987) Br J Pharmacol , vol.91 , pp. 275-286
    • Head, P.J.1    Longhurst, P.A.2    Panek, R.L.3    Stitzel, R.E.4
  • 58
    • 0018652513 scopus 로고
    • Alteration in vascular smooth muscle sensitivityto vasoconstrictor agents by streptozotocin induced diabetes
    • Owen MP, Carrier GO. Alteration in vascular smooth muscle sensitivityto vasoconstrictor agents by streptozotocin induced diabetes. Proc West Pharmacol Soc 1979; 22: 363-66.
    • (1979) Proc West Pharmacol Soc , vol.22 , pp. 363-366
    • Owen, M.P.1    Carrier, G.O.2
  • 59
    • 0023759554 scopus 로고
    • Infuence of the endothelium on contractileresponses of arteries from diabetic rats
    • Harris KH, MacLeod KM. Infuence of the endothelium on contractileresponses of arteries from diabetic rats. Eur J Pharmacol 1988;153: 55-64.
    • (1988) Eur J Pharmacol , vol.153 , pp. 55-64
    • Harris, K.H.1    McLeod, K.M.2
  • 60
    • 0024419087 scopus 로고
    • The effects of type-1 and type-2diabetes on endothelium-dependent relaxation in rat aorta
    • Altan VM, Karasu C, Ozüari A. The effects of type-1 and type-2diabetes on endothelium-dependent relaxation in rat aorta. PharmacolBiochem Behav 1989; 33: 519-22.
    • (1989) PharmacolBiochem Behav , vol.33 , pp. 519-522
    • Altan, V.M.1    Karasu, C.2    Ozüari, A.3
  • 61
    • 0027212817 scopus 로고
    • The role of endothelial cells on the alterationsin vascular reactivity induced by insulin-dependent diabetesmellitus: Effects of insulin treatment
    • Karasu Ç, Altan VM. The role of endothelial cells on the alterationsin vascular reactivity induced by insulin-dependent diabetesmellitus: Effects of insulin treatment. Gen Pharmacol 1993; 24:743-57.
    • (1993) Gen Pharmacol , vol.24 , pp. 743-757
    • Karasu, C.1    Altan, V.M.2
  • 62
    • 0028357859 scopus 로고
    • The role of the endothelium on enhancedcontractile response of non-insulin-dependent diabetic rat aortae: Ffects of insulin treatment
    • Karasu C, Altan VM. The role of the endothelium on enhancedcontractile response of non-insulin-dependent diabetic rat aortae:effects of insulin treatment. Gen Pharmacol 1994; 25: 795-802.
    • (1994) Gen Pharmacol , vol.25 , pp. 795-802
    • Karasu, C.1    Altan, V.M.2
  • 63
    • 0030762477 scopus 로고    scopus 로고
    • Antioxidantand triglyceride-lowering effects of vitamin E associatedwith the prevention of abnormalities in the reactivity and morphologyof aorta from streptozotocin-diabetic rats. Antioxidants in Diabetes-Induced Complications (ADIC) Study Group
    • Karasu C, Ozansoy G, Bozkurt O, Erdogan D, Omeroglu S. Antioxidantand triglyceride-lowering effects of vitamin E associatedwith the prevention of abnormalities in the reactivity and morphologyof aorta from streptozotocin-diabetic rats. Antioxidants in Diabetes-Induced Complications (ADIC) Study Group. Metabolism1997; 46: 872-9.
    • (1997) Metabolism , vol.46 , pp. 872-879
    • Karasu, C.1    Ozansoy, G.2    Bozkurt, O.3    Erdogan, D.4    Omeroglu, S.5
  • 64
    • 0034536369 scopus 로고    scopus 로고
    • ADIC Study Group--Antioxidants in Diabetes-Induced Complications. Alpha-lipoic acidtreatment ameliorates metabolic parameters, blood pressure, vascularreactivity and morphology of vessels already damaged by streptozotocin-diabetes
    • Koçak G, Aktan F, Canbolat O, et al. ADIC Study Group--Antioxidants in Diabetes-Induced Complications. Alpha-lipoic acidtreatment ameliorates metabolic parameters, blood pressure, vascularreactivity and morphology of vessels already damaged by streptozotocin-diabetes. Diabetes Nutr Metab 2000; 13: 308-18.
    • (2000) Diabetes Nutr Metab , vol.13 , pp. 308-318
    • Koçak, G.1    Aktan, F.2    Canbolat, O.3
  • 65
    • 69449096561 scopus 로고    scopus 로고
    • Temporalchanges in vascular reactivity in early diabetes mellitus in rats: Roleof changes in endothelial factors and in phosphodiesterase acitvity
    • Abboud K, Bassila JC, Ghali-El-Ghoul R, Sabra R. Temporalchanges in vascular reactivity in early diabetes mellitus in rats: roleof changes in endothelial factors and in phosphodiesterase acitvity. Am J Physiol Heart Circ Physiol 2009; 297: H836-45.
    • (2009) Am J Physiol Heart Circ Physiol , vol.297
    • Abboud, K.1    Bassila, J.C.2    Ghali-El-Ghoul, R.3    Sabra, R.4
  • 66
    • 0035031176 scopus 로고    scopus 로고
    • Contractile responses of diabeticrat aorta to phenylephrine at different stages of diabetic duration
    • Zhu BH, Guan YY, Min J, He H. Contractile responses of diabeticrat aorta to phenylephrine at different stages of diabetic duration. Acta Pharmacol Sin 2001; 22: 445-9.
    • (2001) Acta Pharmacol Sin , vol.22 , pp. 445-449
    • Zhu, B.H.1    Guan, Y.Y.2    Min, J.3    He, H.4
  • 67
    • 0029055530 scopus 로고
    • Effects of non-insulin dependentdiabetes mellitus on the reactivity of human internal mammary arteryand human saphenous vein
    • Karasu C, Soncul H, Altan VM. Effects of non-insulin dependentdiabetes mellitus on the reactivity of human internal mammary arteryand human saphenous vein. Life Sci 1995; 57: 103-12.
    • (1995) Life Sci , vol.57 , pp. 103-112
    • Karasu, C.1    Soncul, H.2    Altan, V.M.3
  • 68
    • 0031822944 scopus 로고    scopus 로고
    • Acute probucol treatment partially restores vasomotoractivity and abnormal lipid metabolism whereas morphologicalchanges are not affected in aorta from long-term STZ-diabetic rats
    • Karasu C. Acute probucol treatment partially restores vasomotoractivity and abnormal lipid metabolism whereas morphologicalchanges are not affected in aorta from long-term STZ-diabetic rats. Exp Clin Endocrinol Diabetes 1998; 106: 189-96.
    • (1998) Exp Clin Endocrinol Diabetes , vol.106 , pp. 189-196
    • Karasu, C.1
  • 69
    • 73349130405 scopus 로고    scopus 로고
    • Stobadine regulates vascularreactivity and blood pressure via the effects on calcium channelsin chronically diabetic rat aorta
    • Vascular Biology Section, May7-10
    • Ceylan A, Karasu C, Ari N, Stefek M. Stobadine regulates vascularreactivity and blood pressure via the effects on calcium channelsin chronically diabetic rat aorta. 12th International Congress onCardiovascular Pharmacotherapy; Vascular Biology Section, May7-10, 2003; P15
    • (2003) 12th International Congress onCardiovascular Pharmacotherapy , pp. 15
    • Ceylan, A.1    Karasu, C.2    Ari, N.3    Stefek, M.4
  • 71
    • 0024391773 scopus 로고
    • Functional changes in potassiumchannels in aortas from rats with streptozotocin-induced diabetes
    • Kamata K, Miyata N, Kasuya Y. Functional changes in potassiumchannels in aortas from rats with streptozotocin-induced diabetes. Eur J Pharmacol 1989; 166: 319-23.
    • (1989) Eur J Pharmacol , vol.166 , pp. 319-323
    • Kamata, K.1    Miyata, N.2    Kasuya, Y.3
  • 72
    • 33845972651 scopus 로고    scopus 로고
    • Alteration of vascular reactivityin diabetic human mammary artery and the effects of thiazolidinediones
    • Irat AM, Aslamaci S, Karasu C, Ari N. Alteration of vascular reactivityin diabetic human mammary artery and the effects of thiazolidinediones. J Pharm Pharmacol 2006; 58: 1647-53.
    • (2006) J Pharm Pharmacol , vol.58 , pp. 1647-1653
    • Irat, A.M.1    Aslamaci, S.2    Karasu, C.3    Ari, N.4
  • 73
    • 0034704288 scopus 로고    scopus 로고
    • Troglitazone has no effect on K(ATP) channel opener inducedrelaxationsin rat aorta and in human saphenous veins from patientswith type 2 diabetes
    • Yöntem O, Sahilli M, Karasu C, Ozçelikay AT, Altan VM, Ari N. Troglitazone has no effect on K(ATP) channel opener inducedrelaxationsin rat aorta and in human saphenous veins from patientswith type 2 diabetes. Life Sci 2000; 68: 557-68.
    • (2000) Life Sci , vol.68 , pp. 557-568
    • Yöntem, O.1    Sahilli, M.2    Karasu, C.3    Ozçelikay, A.T.4    Altan, V.M.5    Ari, N.6
  • 74
    • 0019195506 scopus 로고
    • The obligatory role of endothelialcells in the relaxation of arterial smooth muscle by acetylcholine
    • Furchgott RF, Zawadzki JV. The obligatory role of endothelialcells in the relaxation of arterial smooth muscle by acetylcholine. Nature 1980; 288: 373-6.
    • (1980) Nature , vol.288 , pp. 373-376
    • Furchgott, R.F.1    Zawadzki, J.V.2
  • 75
    • 0023518452 scopus 로고
    • Endothelium-derivedrelaxing factor from pulmonary artery and vein possesses pharmacologicand chemical properties identical to those of nitric oxideradical
    • Ignarro LJ, Byrns RE, Buga GM, Wood KS. Endothelium-derivedrelaxing factor from pulmonary artery and vein possesses pharmacologicand chemical properties identical to those of nitric oxideradical. Circ Res 1987; 61: 866-79.
    • (1987) Circ Res , vol.61 , pp. 866-879
    • Ignarro, L.J.1    Byrns, R.E.2    Buga, G.M.3    Wood, K.S.4
  • 76
    • 0023198721 scopus 로고
    • Nitric oxide release accountsfor the biological activity of endothelium-derived relaxing factor
    • Palmer RM, Ferrige AG, Moncada S. Nitric oxide release accountsfor the biological activity of endothelium-derived relaxing factor. Nature 1987; 327: 524-6.
    • (1987) Nature , vol.327 , pp. 524-526
    • Palmer, R.M.1    Ferrige, A.G.2    Moncada, S.3
  • 77
    • 0023912670 scopus 로고
    • Vascular endothelialcells synthesize nitric oxide from L-arginine
    • Palmer RM, Ashton DS, Moncada S. Vascular endothelialcells synthesize nitric oxide from L-arginine. Nature 1988; 333:664-6.
    • (1988) Nature , vol.333 , pp. 664-666
    • Palmer, R.M.1    Ashton, D.S.2    Moncada, S.3
  • 78
    • 0017365359 scopus 로고
    • Stimulation of guanylatecyclase by sodium nitroprusside, nitroglycerin and nitric oxide invarious tissue preparations and comparison to the effects of sodiumazide and hydroxylamine
    • Katsuki S, Arnold W, Mittal C, Murad F. Stimulation of guanylatecyclase by sodium nitroprusside, nitroglycerin and nitric oxide invarious tissue preparations and comparison to the effects of sodiumazide and hydroxylamine. J Cyclic Nucleotide Res 1977; 3: 23-35.
    • (1977) J Cyclic Nucleotide Res , vol.3 , pp. 23-35
    • Katsuki, S.1    Arnold, W.2    Mittal, C.3    Murad, F.4
  • 79
    • 0027062910 scopus 로고
    • The molecule of the year
    • Koshland DE Jr. The molecule of the year. Science 1992; 258:1861.
    • (1992) Science , vol.258 , pp. 1861
    • Koshland Jr., D.E.1
  • 81
    • 0022828334 scopus 로고
    • Attenuation of endothelium-dependent relaxation in aorta from diabetic rats
    • Oyama Y, Kawasaki H, Hattori Y, Kanno M. Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur JPharmacol 1986; 132: 75-8.
    • (1986) Eur JPharmacol , vol.132 , pp. 75-78
    • Oyama, Y.1    Kawasaki, H.2    Hattori, Y.3    Kanno, M.4
  • 82
    • 0023724763 scopus 로고
    • Impairment of endotheliumdependentrelaxation in aortae from spontaneously diabetic rats
    • Durante W, Sen AK, Sunahara FA. Impairment of endotheliumdependentrelaxation in aortae from spontaneously diabetic rats. BrJ Pharmacol 1988; 94: 463-8.
    • (1988) BrJ Pharmacol , vol.94 , pp. 463-468
    • Durante, W.1    Sen, A.K.2    Sunahara, F.A.3
  • 83
    • 0026760160 scopus 로고
    • Endotheliumdependentrelaxation and noradrenaline sensitivity in mesentericresistance arteries of streptozotocin-induced diabetic rats
    • Taylor PD, McCarthy AL, Thomas CR, Poston L. Endotheliumdependentrelaxation and noradrenaline sensitivity in mesentericresistance arteries of streptozotocin-induced diabetic rats. Br JPharmacol 1992; 107: 393-9.
    • (1992) Br JPharmacol , vol.107 , pp. 393-399
    • Taylor, P.D.1    McCarthy, A.L.2    Thomas, C.R.3    Poston, L.4
  • 84
  • 85
    • 0031940054 scopus 로고    scopus 로고
    • Review of alterations in endothelial nitric oxide productionin diabetes: Protective role of arginine on endothelial dysfunction
    • Pieper GM. Review of alterations in endothelial nitric oxide productionin diabetes: protective role of arginine on endothelial dysfunction. Hypertension 1998; 31: 1047-60.
    • (1998) Hypertension , vol.31 , pp. 1047-1060
    • Pieper, G.M.1
  • 86
    • 0025249357 scopus 로고
    • Decreasein endothelium-dependent relaxation and levels of cyclic nucleotidesin aorta from rabbits with alloxan-induced diabetes
    • Abiru T, Watanabe Y, Kamata K, Miyata N, Kasuya Y. Decreasein endothelium-dependent relaxation and levels of cyclic nucleotidesin aorta from rabbits with alloxan-induced diabetes. ResCommun Chem Pathol Pharmacol 1990; 68: 13-25
    • (1990) ResCommun Chem Pathol Pharmacol , vol.68 , pp. 13-25
    • Abiru, T.1    Watanabe, Y.2    Kamata, K.3    Miyata, N.4    Kasuya, Y.5
  • 87
    • 0024843529 scopus 로고
    • Effects of experimental diabetes on theresponsiveness of rat aorta
    • Mulhern M, Docherty JR. Effects of experimental diabetes on theresponsiveness of rat aorta. Br J Pharmacol 1989; 97: 1007-12
    • (1989) Br J Pharmacol , vol.97 , pp. 1007-1012
    • Mulhern, M.1    Docherty, J.R.2
  • 88
    • 0032950298 scopus 로고    scopus 로고
    • Enhanced, unaltered and impaired nitric oxidemediatedendothelium-dependent relaxation in experimental diabetesmellitus: Importance of disease duration
    • Pieper, G.M. Enhanced, unaltered and impaired nitric oxidemediatedendothelium-dependent relaxation in experimental diabetesmellitus: importance of disease duration. Diabetologia 1999; 42:204-13.
    • (1999) Diabetologia , vol.42 , pp. 204-213
    • Pieper, G.M.1
  • 91
    • 33751104760 scopus 로고    scopus 로고
    • Nitric oxide and the endothelium:History and impact on cardiovascular disease
    • Yetik-Anacak G, Catravas JD. Nitric oxide and the endothelium:History and impact on cardiovascular disease. Vasc Pharmacol2006; 45: 268-76.
    • (2006) Vasc Pharmacol , vol.45 , pp. 268-276
    • Yetik-Anacak, G.1    Catravas, J.D.2
  • 93
  • 94
    • 0029763252 scopus 로고    scopus 로고
    • Monocyteinduceddownregulation of nitric oxide synthase in cultured aorticendothelial cells
    • Marczin N, Antonov A, Papapetropoulos A, et al. Monocyteinduceddownregulation of nitric oxide synthase in cultured aorticendothelial cells. Arterioscler Thromb Vasc Biol 1996; 16: 1095-103.
    • (1996) Arterioscler Thromb Vasc Biol , vol.16 , pp. 1095-1103
    • Marczin, N.1    Antonov, A.2    Papapetropoulos, A.3
  • 95
    • 0030762906 scopus 로고    scopus 로고
    • Changes in isoprenaline-induced endothelium-dependent and-independent relaxations of aorta in long-term STZ-diabetic rats: Reversaleffect of dietary vitamin E
    • Karasu C, Ozansoy G, Bozkurt O, Erdogan D, Omeroglu S. Changes in isoprenaline-induced endothelium-dependent and-independent relaxations of aorta in long-term STZ-diabetic rats: reversaleffect of dietary vitamin E. Gen Pharmacol 1997; 29: 561-7.
    • (1997) Gen Pharmacol , vol.29 , pp. 561-567
    • Karasu, C.1    Ozansoy, G.2    Bozkurt, O.3    Erdogan, D.4    Omeroglu, S.5
  • 96
    • 2442421194 scopus 로고    scopus 로고
    • Is oxidative stress the pathogenic mechanismunderlying insulin resistance, diabetes, and cardiovascular disease?The common soil hypothesis revisited
    • Ceriello A, Motz E. Is oxidative stress the pathogenic mechanismunderlying insulin resistance, diabetes, and cardiovascular disease?The common soil hypothesis revisited. Arterioscler Thromb VascBiol 2004; 24: 816-23.
    • (2004) Arterioscler Thromb VascBiol , vol.24 , pp. 816-823
    • Ceriello, A.1    Motz, E.2
  • 97
    • 55049085236 scopus 로고    scopus 로고
    • Endothelial nitric oxide (NO) and itspathophysiologic regulation
    • Chatterjee A, Catravas JD. Endothelial nitric oxide (NO) and itspathophysiologic regulation. Vasc Pharmacol 2008; 49: 134-40.
    • (2008) Vasc Pharmacol , vol.49 , pp. 134-140
    • Chatterjee, A.1    Catravas, J.D.2
  • 98
    • 0027374618 scopus 로고
    • Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats
    • Chang KC, Chung SY, Chong WS, et al. Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther 1993; 266: 992-1000.
    • (1993) J Pharmacol Exp Ther , vol.266 , pp. 992-1000
    • Chang, K.C.1    Chung, S.Y.2    Chong, W.S.3
  • 99
    • 0026584089 scopus 로고
    • Ca2+/calmodulindependentformation of hydrogen peroxide by brain nitric oxidesynthase
    • Heinzel B, John M, Klatt P, Böhme E, Mayer B. Ca2+/calmodulindependentformation of hydrogen peroxide by brain nitric oxidesynthase. Biochem J 1992; 281: 627-30.
    • (1992) Biochem J , vol.281 , pp. 627-630
    • Heinzel, B.1    John, M.2    Klatt, P.3    Böhme, E.4    Mayer, B.5
  • 100
    • 0030048496 scopus 로고    scopus 로고
    • Oxidative stress and diabeticvascular complications
    • Giugliano D, Ceriello A, Paolisso G. Oxidative stress and diabeticvascular complications. Diabetes Care1996; 19: 257-67.
    • (1996) Diabetes Care , vol.19 , pp. 257-267
    • Giugliano, D.1    Ceriello, A.2    Paolisso, G.3
  • 102
    • 0035668056 scopus 로고    scopus 로고
    • Diabetes-associated nitration oftyrosine and inactivation of succinyl-CoA: 3-oxoacid CoA transferase
    • Turko IV, Marcondes S, Murad F: Diabetes-associated nitration oftyrosine and inactivation of succinyl-CoA: 3-oxoacid CoA transferase. Am J Physiol Heart Circ Physiol 2001; 281: H2289-94
    • (2001) Am J Physiol Heart Circ Physiol , vol.281
    • Turko, I.V.1    Marcondes, S.2    Murad, F.3
  • 104
    • 1942438654 scopus 로고    scopus 로고
    • Advanced glycation end-products and theprogress of diabetic vascular complications
    • Jakus V, Rietbrock N. Advanced glycation end-products and theprogress of diabetic vascular complications. Physiol Res 2004; 53:131-42.
    • (2004) Physiol Res , vol.53 , pp. 131-142
    • Jakus, V.1    Rietbrock, N.2
  • 105
    • 0032835194 scopus 로고    scopus 로고
    • Hyperglycaemia: The bridge between non-enzymaticglycation and oxidative stress in the pathogenesis of diabetic complications
    • Ceriello A. Hyperglycaemia: the bridge between non-enzymaticglycation and oxidative stress in the pathogenesis of diabetic complications. Diabetes Nutr Metab 1999; 12: 42-6.
    • (1999) Diabetes Nutr Metab , vol.12 , pp. 42-46
    • Ceriello, A.1
  • 107
    • 33748802532 scopus 로고    scopus 로고
    • Advanced glycation endproduct (AGE) receptor 1 suppresses cell oxidant stress and activationsignaling via EGF receptor
    • Cai W, He JC, Zhu L, Lu C, Vlassara H. Advanced glycation endproduct (AGE) receptor 1 suppresses cell oxidant stress and activationsignaling via EGF receptor. Proc Natl Acad Sci USA 2006;103: 13801-6.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 13801-13806
    • Cai, W.1    He, J.C.2    Zhu, L.3    Lu, C.4    Vlassara, H.5
  • 108
    • 33747828219 scopus 로고    scopus 로고
    • Roleof oxidative stress in development of cardiovascular complicationsin diabetes mellitus
    • Haidara MA, Yassin HZ, Rateb M, Ammar H, Zorkani MA. Roleof oxidative stress in development of cardiovascular complicationsin diabetes mellitus. Curr Vasc Pharmacol 2006; 4: 215-27
    • (2006) Curr Vasc Pharmacol , vol.4 , pp. 215-227
    • Haidara, M.A.1    Yassin, H.Z.2    Rateb, M.3    Ammar, H.4    Zorkani, M.A.5
  • 109
    • 0037046214 scopus 로고    scopus 로고
    • Mechanisms of increasedvascular superoxide production in human diabetes mellitus: Role ofNAD(P)H oxidase and endothelial nitric oxide synthase
    • Guzik TJ, Mussa S, Gastaldi D, et al. Mechanisms of increasedvascular superoxide production in human diabetes mellitus: role ofNAD(P)H oxidase and endothelial nitric oxide synthase. Circulation2002; 105: 1656-62
    • (2002) Circulation , vol.105 , pp. 1656-1662
    • Guzik, T.J.1    Mussa, S.2    Gastaldi, D.3
  • 111
    • 26844564082 scopus 로고    scopus 로고
    • Oxidative stress andthe use of antioxidants in diabetes: Linking basic science to clinicalpractice
    • Johansen JS, Harris AK, Rychly DJ, Ergul A. Oxidative stress andthe use of antioxidants in diabetes: linking basic science to clinicalpractice. Cardiovasc Diabetol 2005; 4: 5.
    • (2005) Cardiovasc Diabetol , vol.4 , pp. 5
    • Johansen, J.S.1    Harris, A.K.2    Rychly, D.J.3    Ergul, A.4
  • 112
    • 62349116866 scopus 로고    scopus 로고
    • Vascular NAD(P)H oxidase activation in diabetes: Double-edged sword in redox signalling
    • Gao L, Mann GE. Vascular NAD(P)H oxidase activation in diabetes:a double-edged sword in redox signalling. Cardiovasc Res2009; 82: 9-20
    • (2009) Cardiovasc Res , vol.82 , pp. 9-20
    • Gao, L.1    Mann, G.E.2
  • 113
    • 33947258419 scopus 로고    scopus 로고
    • Increased oxidative stress in thestreptozotocin-induced diabetic apoE-deficient mouse: Changes inexpression of NADPH oxidase subunits and eNOS
    • Ding H, Hashem M, Triggle C. Increased oxidative stress in thestreptozotocin-induced diabetic apoE-deficient mouse: changes inexpression of NADPH oxidase subunits and eNOS. Eur J Pharmacol2007; 561: 121-8.
    • (2007) Eur J Pharmacol , vol.561 , pp. 121-128
    • Ding, H.1    Hashem, M.2    Triggle, C.3
  • 114
    • 0034737625 scopus 로고    scopus 로고
    • Time course of changes in endothelium-dependent and-independent relaxation of chronically diabetic aorta: Role of reactiveoxygen species
    • Karasu C. Time course of changes in endothelium-dependent and-independent relaxation of chronically diabetic aorta: role of reactiveoxygen species. Eur J Pharmacol 2000; 392: 163-73.
    • (2000) Eur J Pharmacol , vol.392 , pp. 163-173
    • Karasu, C.1
  • 115
    • 0026008802 scopus 로고
    • Superoxide dismutaserecovers altered endothelium-dependent relaxation in diabetic rataorta
    • Hattori Y, Kawasaki H, Abe K, Kanno M. Superoxide dismutaserecovers altered endothelium-dependent relaxation in diabetic rataorta. Am J Physiol 1991; 261: H1086-94.
    • (1991) Am J Physiol , vol.261
    • Hattori, Y.1    Kawasaki, H.2    Abe, K.3    Kanno, M.4
  • 116
    • 0029128672 scopus 로고
    • The role of nitric oxide and other endothelium-derivedvasoactive substances in vascular disease
    • Cohen RA. The role of nitric oxide and other endothelium-derivedvasoactive substances in vascular disease. Prog Cardiovasc Dis1995; 38: 105-28.
    • (1995) Prog Cardiovasc Dis , vol.38 , pp. 105-128
    • Cohen, R.A.1
  • 117
    • 0029835248 scopus 로고    scopus 로고
    • Changes in superoxide dismutase mRNAexpression by streptozotocin-induced diabetes
    • Kamata K, Kobayashi T. Changes in superoxide dismutase mRNAexpression by streptozotocin-induced diabetes. Br J Pharmacol1996; 119: 583-9.
    • (1996) Br J Pharmacol , vol.119 , pp. 583-589
    • Kamata, K.1    Kobayashi, T.2
  • 118
    • 0032587936 scopus 로고    scopus 로고
    • 2in aorta isolated from chronicallystreptozotocin-diabetic rats: Effects of antioxidant enzymesand enzymes inhibitors
    • 2in aorta isolated from chronicallystreptozotocin-diabetic rats: effects of antioxidant enzymesand enzymes inhibitors. Free Radic Biol Med 1999; 27: 16-27.
    • (1999) Free Radic Biol Med , vol.27 , pp. 16-27
    • Karasu, C.1
  • 119
    • 0036211948 scopus 로고    scopus 로고
    • 2by alpha-lipoic acidmediates the recovery of basal EDRF/NO availability and thereversal of superoxide dismutase-induced relaxation in diabetic rataorta
    • 2by alpha-lipoic acidmediates the recovery of basal EDRF/NO availability and thereversal of superoxide dismutase-induced relaxation in diabetic rataorta. Diabetes Obes Metab 2002; 4: 69-74.
    • (2002) Diabetes Obes Metab , vol.4 , pp. 69-74
    • Koçak, G.1    Karasu, C.2
  • 120
    • 0034521371 scopus 로고    scopus 로고
    • Hydrogen peroxideis an endothelium-derived hyperpolarizing factor in mice
    • Matoba, T, Shimokawa H, Nakashima M, et al. Hydrogen peroxideis an endothelium-derived hyperpolarizing factor in mice. J ClinInvest 2000; 106: 1521-30.
    • (2000) J ClinInvest , vol.106 , pp. 1521-1530
    • Matoba, T.1    Shimokawa, H.2    Nakashima, M.3
  • 121
    • 0023713429 scopus 로고
    • Oxygen free radicals abolish endotheliumdependentrelaxation in diabetic rat aorta
    • Pieper GM, Gross GJ. Oxygen free radicals abolish endotheliumdependentrelaxation in diabetic rat aorta. Am J Physiol 1988; 255:H825-33.
    • (1988) Am J Physiol , vol.255
    • Pieper, G.M.1    Gross, G.J.2
  • 122
    • 0026759488 scopus 로고
    • Free radicals mediate endothelial celldysfunction caused by elevated glucose
    • Tesfamariam B, Cohen RA. Free radicals mediate endothelial celldysfunction caused by elevated glucose. Am J Physiol 1992; 263:H321-6.
    • (1992) Am J Physiol , vol.263
    • Tesfamariam, B.1    Cohen, R.A.2
  • 123
    • 0029798152 scopus 로고    scopus 로고
    • Chronic treatment in vivo with dimethylthiourea, a hydroxyl radicalscavenger, prevents diabetes-induced endothelial dysfunction
    • Pieper GM, Siebeneich W, Roza AM, Jordan M, Adams MB. Chronic treatment in vivo with dimethylthiourea, a hydroxyl radicalscavenger, prevents diabetes-induced endothelial dysfunction. JCardiovasc Pharmacol 1996; 28: 741-5
    • (1996) JCardiovasc Pharmacol , vol.28 , pp. 741-745
    • Pieper, G.M.1    Siebeneich, W.2    Roza, A.M.3    Jordan, M.4    Adams, M.B.5
  • 124
    • 0035169008 scopus 로고    scopus 로고
    • Endothelium-derived free radicals: For worse andfor beter
    • Vanhoutte PM. Endothelium-derived free radicals: for worse andfor beter. J Clin Invest 2001; 107: 23-25.
    • (2001) J Clin Invest , vol.107 , pp. 23-25
    • Vanhoutte, P.M.1
  • 126
    • 0034033539 scopus 로고    scopus 로고
    • Oxidative stress augments secretionof endothelium-derived relaxing peptides, C-type natriureticpeptide and adrenomedulin
    • Chun TH, Itoh H, Saito T, et al. Oxidative stress augments secretionof endothelium-derived relaxing peptides, C-type natriureticpeptide and adrenomedulin. J Hyperten 2000; 18: 575-80.
    • (2000) J Hyperten , vol.18 , pp. 575-580
    • Chun, T.H.1    Itoh, H.2    Saito, T.3
  • 127
    • 0035098023 scopus 로고    scopus 로고
    • Effect of chronic insulin treatment on NOproduction and endothelium-dependent relaxation in aortae fromestablished STZ-induced diabetic rats
    • Kobayashi T, Kamata K. Effect of chronic insulin treatment on NOproduction and endothelium-dependent relaxation in aortae fromestablished STZ-induced diabetic rats. Atherosclerosis 2001; 155:313-20.
    • (2001) Atherosclerosis , vol.155 , pp. 313-320
    • Kobayashi, T.1    Kamata, K.2
  • 128
    • 0036021738 scopus 로고    scopus 로고
    • Nitrotyrosine: New findings as a marker of postprandialoxidative stress
    • Ceriello A. Nitrotyrosine: new findings as a marker of postprandialoxidative stress. Int J Clin Pract Suppl 2002; 129: 51-8.
    • (2002) Int J Clin Pract Suppl , vol.129 , pp. 51-58
    • Ceriello, A.1
  • 129
    • 64149103180 scopus 로고    scopus 로고
    • Role of nitrosative stress in the pathogenesis of diabeticvascular dysfunction
    • Szabo C. Role of nitrosative stress in the pathogenesis of diabeticvascular dysfunction. Br J Pharmacol 2009; 156: 713-27
    • (2009) Br J Pharmacol , vol.156 , pp. 713-727
    • Szabo, C.1
  • 130
    • 4444236143 scopus 로고    scopus 로고
    • Peroxynitrite and vascular endothelialdysfunction in diabetes mellitus
    • Zou MH, Cohen R, Ullrich V. Peroxynitrite and vascular endothelialdysfunction in diabetes mellitus. Endothelium 2004; 11: 89-97.
    • (2004) Endothelium , vol.11 , pp. 89-97
    • Zou, M.H.1    Cohen, R.2    Ullrich, V.3
  • 131
    • 0034938434 scopus 로고    scopus 로고
    • Effects of peroxynitrite on thereactivity of diabetic rat aorta
    • Zobali F, Cakici I, Karasu C. Effects of peroxynitrite on thereactivity of diabetic rat aorta. Pharmacology 2001; 63: 58-64.
    • (2001) Pharmacology , vol.63 , pp. 58-64
    • Zobali, F.1    Cakici, I.2    Karasu, C.3
  • 132
    • 0037142095 scopus 로고    scopus 로고
    • Hypertension, angiotensin II, and oxidative stress
    • Sowers JR. Hypertension, angiotensin II, and oxidative stress. NEngl J Med 2002; 346: 1999-2001.
    • (2002) NEngl J Med , vol.346 , pp. 1999-2001
    • Sowers, J.R.1
  • 133
    • 0037230550 scopus 로고    scopus 로고
    • Cardiovascular deterioration inSTZ-diabetic rats: Possible role of vascular RAS
    • Crespo MJ, Moreta S, González J. Cardiovascular deterioration inSTZ-diabetic rats: possible role of vascular RAS. Pharmacology2003; 68: 1-8.
    • (2003) Pharmacology , vol.68 , pp. 1-8
    • Crespo, M.J.1    Moreta, S.2    González, J.3
  • 134
    • 33846039817 scopus 로고    scopus 로고
    • Enalapril improves impairment of SERCA-derived relaxationand enhancement of tyrosine nitration in diabetic rat aorta
    • Taguchi K, Kobayashi T, Hayashi Y, Matsumoto T, Kamata K. Enalapril improves impairment of SERCA-derived relaxationand enhancement of tyrosine nitration in diabetic rat aorta. Eur JPharmacol 2007; 556: 121-8.
    • (2007) Eur JPharmacol , vol.556 , pp. 121-128
    • Taguchi, K.1    Kobayashi, T.2    Hayashi, Y.3    Matsumoto, T.4    Kamata, K.5
  • 135
    • 38149142583 scopus 로고    scopus 로고
    • Endothelial dysfunction in diabetes mellitus
    • Hadi HA, Suwaidi JA. Endothelial dysfunction in diabetes mellitus. Vasc Health Risk Manag 2007; 3: 853-76.
    • (2007) Vasc Health Risk Manag , vol.3 , pp. 853-876
    • Hadi, H.A.1    Suwaidi, J.A.2
  • 136
    • 34547485312 scopus 로고    scopus 로고
    • The endothelium and vascularinflammation in diabetes
    • Hartge MM, Unger T, Kintscher U. The endothelium and vascularinflammation in diabetes. Diab Vasc Dis Res 2007; 4: 84-8.
    • (2007) Diab Vasc Dis Res , vol.4 , pp. 84-88
    • Hartge, M.M.1    Unger, T.2    Kintscher, U.3
  • 137
    • 0026583353 scopus 로고
    • Functional changes invascular smooth muscle and endothelium of arteries during diabetesmellitus
    • Kamata K, Miyata N, Abiru T, Kasuya Y. Functional changes invascular smooth muscle and endothelium of arteries during diabetesmellitus. Life Sci 1992; 50: 1379-87.
    • (1992) Life Sci , vol.50 , pp. 1379-1387
    • Kamata, K.1    Miyata, N.2    Abiru, T.3    Kasuya, Y.4
  • 138
    • 0036065962 scopus 로고    scopus 로고
    • Vasoprotection by nitric oxide: Echanisms and therapeutic potential
    • Gewaltig MT, Kojda G. Vasoprotection by nitric oxide:mechanisms and therapeutic potential. Cardiovasc Res 2002; 55:250-60.
    • (2002) Cardiovasc Res , vol.55 , pp. 250-260
    • Gewaltig, M.T.1    Kojda, G.2
  • 139
    • 0028962722 scopus 로고
    • Amelioration by L-arginine of a dysfunctionalarginine/nitric oxide pathway in diabetic endothelium
    • Pieper GM, Peltier BA. Amelioration by L-arginine of a dysfunctionalarginine/nitric oxide pathway in diabetic endothelium. J Cardiovasc Pharmacol 1995; 25: 397-403
    • (1995) J Cardiovasc Pharmacol , vol.25 , pp. 397-403
    • Pieper, G.M.1    Peltier, B.A.2
  • 142
    • 1542286128 scopus 로고    scopus 로고
    • Effectsof simvastatin treatment on oxidant/antioxidant state and ultrastructureof diabetic rat myocardium
    • Ceylan A, Karasu C, Aktan F, Güven C, Can B, Ozansoy G. Effectsof simvastatin treatment on oxidant/antioxidant state and ultrastructureof diabetic rat myocardium. Gen Physiol Biophys2003; 22: 535-47.
    • (2003) Gen Physiol Biophys , vol.22 , pp. 535-547
    • Ceylan, A.1    Karasu, C.2    Aktan, F.3    Güven, C.4    Can, B.5    Ozansoy, G.6
  • 143
    • 8644232765 scopus 로고    scopus 로고
    • Simvastatin treatmentrestores vasoconstriction and the inhibitory effect of LPC on endothelialrelaxation via affecting oxidizing metabolism in diabeticrats
    • Ceylan A, Karasu C, Aktan F, Ozansoy G. Simvastatin treatmentrestores vasoconstriction and the inhibitory effect of LPC on endothelialrelaxation via affecting oxidizing metabolism in diabeticrats. Diabetes Nutr Metab 2004; 17: 203-10.
    • (2004) Diabetes Nutr Metab , vol.17 , pp. 203-210
    • Ceylan, A.1    Karasu, C.2    Aktan, F.3    Ozansoy, G.4
  • 144
    • 33745591964 scopus 로고    scopus 로고
    • Cardioprotective effects of atrasentan, an endothelin-A receptorantagonist, but not of nitric oxide in diabetic mice with myocytespecificoverexpression of endothelial nitric oxide synthase
    • Wölkart G, Stessel H, Saad Z, Kirchengast M, BrunnerF. Cardioprotective effects of atrasentan, an endothelin-A receptorantagonist, but not of nitric oxide in diabetic mice with myocytespecificoverexpression of endothelial nitric oxide synthase. Br JPharmacol 2006; 148: 671-81.
    • (2006) Br JPharmacol , vol.148 , pp. 671-681
    • Wölkart, G.1    Stessel, H.2    Saad, Z.3    Kirchengast, M.4    Brunner, F.5
  • 145
    • 42549117206 scopus 로고    scopus 로고
    • 1-Methylnicotinamide(MNA) prevents endothelial dysfunction in hypertriglyceridemicand diabetic rats
    • Bartuoe M, Lomnicka M, Kostogrys RB, et al. 1-Methylnicotinamide(MNA) prevents endothelial dysfunction in hypertriglyceridemicand diabetic rats. Pharmacol Rep 2008; 60: 127-38.
    • (2008) Pharmacol Rep , vol.60 , pp. 127-138
    • Bartuoe, M.1    Lomnicka, M.2    Kostogrys, R.B.3
  • 146
    • 0142055950 scopus 로고    scopus 로고
    • Oxidative stress and cardiovascularinjury: Part I: Basic mechanisms and in vivo monitoring of ROS
    • Griendling KK, FitzGerald GA. Oxidative stress and cardiovascularinjury: Part I: basic mechanisms and in vivo monitoring of ROS. Circulation 2003; 108: 1912-16.
    • (2003) Circulation , vol.108 , pp. 1912-1916
    • Griendling, K.K.1    FitzGerald, G.A.2
  • 147
    • 0036093766 scopus 로고    scopus 로고
    • Effects of vitamin A andinsulin on the antioxidative state of diabetic rat heart: A comparisonstudy with combination treatment
    • Zobali F, Avci A, Canbolat O, Karasu C. Effects of vitamin A andinsulin on the antioxidative state of diabetic rat heart: a comparisonstudy with combination treatment. Cell Biochem Funct 2002; 20:75-80.
    • (2002) Cell Biochem Funct , vol.20 , pp. 75-80
    • Zobali, F.1    Avci, A.2    Canbolat, O.3    Karasu, C.4
  • 148
    • 0037409980 scopus 로고    scopus 로고
    • Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense duringoxidative stress in diabetic rodent brain and peripheral organs: Effectsof stobadine and vitamin E
    • Ulusu NN, Sahilli M, Avci A, et al. Pentose phosphate pathway, glutathione-dependent enzymes and antioxidant defense duringoxidative stress in diabetic rodent brain and peripheral organs: effectsof stobadine and vitamin E. Neurochem Res 2003; 28: 815-23.
    • (2003) Neurochem Res , vol.28 , pp. 815-823
    • Ulusu, N.N.1    Sahilli, M.2    Avci, A.3
  • 149
    • 33646525680 scopus 로고    scopus 로고
    • Vascular NADPH oxidases as drug targetsfor novel antioxidant strategies
    • Guzik TJ, Harrison DG. Vascular NADPH oxidases as drug targetsfor novel antioxidant strategies. Drug Discov Today 2006; 11: 524-33.
    • (2006) Drug Discov Today , vol.11 , pp. 524-533
    • Guzik, T.J.1    Harrison, D.G.2
  • 151
    • 46649117646 scopus 로고    scopus 로고
    • Chronic administration ofgenistein improves aortic reactivity of streptozotocin-diabetic rats: Ode of action
    • Baluchnejadmojarad T, Roghani M. Chronic administration ofgenistein improves aortic reactivity of streptozotocin-diabetic rats:mode of action. Vascul Pharmacol 2008; 49: 1-5.
    • (2008) Vascul Pharmacol , vol.49 , pp. 1-5
    • Baluchnejadmojarad, T.1    Roghani, M.2
  • 152
    • 59449098842 scopus 로고    scopus 로고
    • Endothelial function in the time of the giants
    • Heistad DD. Endothelial function in the time of the giants. J CardiovascPharmacol 2008; 52: 385-92.
    • (2008) J CardiovascPharmacol , vol.52 , pp. 385-392
    • Heistad, D.D.1
  • 153
    • 0347753692 scopus 로고    scopus 로고
    • Oxidative stress as a therapeutic target in diabetes: Evisiting the controversy
    • Wiernsperger NF. Oxidative stress as a therapeutic target in diabetes:revisiting the controversy. Diabetes Metab 2003; 29: 579-85.
    • (2003) Diabetes Metab , vol.29 , pp. 579-585
    • Wiernsperger, N.F.1
  • 154
    • 0036249133 scopus 로고    scopus 로고
    • (Antioxidants in Diabetes-Induced Complications) The ADIC Study Group. Hydrogen peroxide-induced inhibition of vasomotor activity: Evaluation of singleand combined treatments with vitamin A and insulin in streptozotocin-diabetic rats
    • Zobali F, Besler T, Ari N, Karasu C. (Antioxidants in Diabetes-Induced Complications) The ADIC Study Group. Hydrogen peroxide-induced inhibition of vasomotor activity: evaluation of singleand combined treatments with vitamin A and insulin in streptozotocin-diabetic rats. Int J Exp Diabetes Res 2002; 3: 119-30.
    • (2002) Int J Exp Diabetes Res , vol.3 , pp. 119-130
    • Zobali, F.1    Besler, T.2    Ari, N.3    Karasu, C.4
  • 155
    • 33846849277 scopus 로고    scopus 로고
    • Advanced glycationendproduct crosslink breaker (alagebrium) improves endothelialfunction in patients with isolated systolic hypertension
    • Zieman SJ, Melenovsky V, Clattenburg L, et al. Advanced glycationendproduct crosslink breaker (alagebrium) improves endothelialfunction in patients with isolated systolic hypertension. J Hypertens2007; 25: 577-83.
    • (2007) J Hypertens , vol.25 , pp. 577-583
    • Zieman, S.J.1    Melenovsky, V.2    Clattenburg, L.3
  • 156
    • 33845295849 scopus 로고    scopus 로고
    • Benfotiamine preventsmacro-and microvascular endothelial dysfunction and oxidativestress following a meal rich in advanced glycation end products inindividuals with type 2 diabetes
    • Stirban A, Negrean M, Stratmann B, et al. Benfotiamine preventsmacro-and microvascular endothelial dysfunction and oxidativestress following a meal rich in advanced glycation end products inindividuals with type 2 diabetes. Diabetes Care 2006; 29: 2064-71.
    • (2006) Diabetes Care , vol.29 , pp. 2064-2071
    • Stirban, A.1    Negrean, M.2    Stratmann, B.3
  • 157
    • 9944255758 scopus 로고    scopus 로고
    • Reversal byaminoguanidine of the age-related increase in glycoxidation andlipoxidation in the cardiovascular system of Fischer 344 rats
    • Moreau R, Nguyen BT, Doneanu CE, Hagen TM. Reversal byaminoguanidine of the age-related increase in glycoxidation andlipoxidation in the cardiovascular system of Fischer 344 rats. BiochemPharmacol 2005; 69: 29-40.
    • (2005) BiochemPharmacol , vol.69 , pp. 29-40
    • Moreau, R.1    Nguyen, B.T.2    Doneanu, C.E.3    Hagen, T.M.4
  • 158
    • 70349236876 scopus 로고    scopus 로고
    • Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associatedvascular and neurodegenerative disorders
    • Mattson MP. Roles of the lipid peroxidation product 4-hydroxynonenal in obesity, the metabolic syndrome, and associatedvascular and neurodegenerative disorders. Exp Gerontol 2009; 44:625-34.
    • (2009) Exp Gerontol , vol.44 , pp. 625-634
    • Mattson, M.P.1
  • 159
    • 0036889174 scopus 로고    scopus 로고
    • Antioxidants in Diabetes-Induced Complications (ADIC) Study Group. Effects of cod liveroil on tissue antioxidant pathways in normal and streptozotocindiabeticrats
    • Hünkar T, Aktan F, Ceylan A, Karasu C. Antioxidants in Diabetes-Induced Complications (ADIC) Study Group. Effects of cod liveroil on tissue antioxidant pathways in normal and streptozotocindiabeticrats. Cell Biochem Funct 2002; 20: 297-302.
    • (2002) Cell Biochem Funct , vol.20 , pp. 297-302
    • Hünkar, T.1    Aktan, F.2    Ceylan, A.3    Karasu, C.4
  • 160
    • 13444270631 scopus 로고    scopus 로고
    • Reactive oxygen species mediate abnormal contractileresponse to sympathetic nerve stimulation and noradrenaline in thevas deferens of chronically diabetic rats: Effects of in vivo treatmentwith antioxidants
    • Antioxidants in Diabetes-induced Complications (ADIC) StudyGroup
    • Günes A, Ceylan A, Sarioglu Y, Stefek M, Bauer V, Karasu C. Antioxidants in Diabetes-induced Complications (ADIC) StudyGroup. Reactive oxygen species mediate abnormal contractileresponse to sympathetic nerve stimulation and noradrenaline in thevas deferens of chronically diabetic rats: effects of in vivo treatmentwith antioxidants. Fundam Clin Pharmacol 2005; 19: 73-9
    • (2005) Fundam Clin Pharmacol , vol.19 , pp. 73-79
    • Günes, A.1    Ceylan, A.2    Sarioglu, Y.3    Stefek, M.4    Bauer, V.5    Karasu, C.6
  • 161
    • 34249990014 scopus 로고    scopus 로고
    • Effects of stobadine and vitamin Ein diabetes-induced retinal abnormalities: Involvement of oxidativestress
    • Yülek F, Or M, Ozoǧul C, et al. Effects of stobadine and vitamin Ein diabetes-induced retinal abnormalities: involvement of oxidativestress. Arch Med Res 2007; 38: 503-11.
    • (2007) Arch Med Res , vol.38 , pp. 503-511
    • Yülek, F.1    Or, M.2    Ozoǧul, C.3
  • 162
    • 8444242514 scopus 로고    scopus 로고
    • Adenosinetriphosphatase activity of streptozotocin-induced diabetic rat brainmicrosomes: Effect of vitamin E
    • Das Evcimen N, Ulusu NN, Karasu C, Doǧru B. Adenosinetriphosphatase activity of streptozotocin-induced diabetic rat brainmicrosomes: Effect of vitamin E. Gen Physiol Biophys 2004; 23:347-55.
    • (2004) Gen Physiol Biophys , vol.23 , pp. 347-355
    • Das Evcimen, N.1    Ulusu, N.N.2    Karasu, C.3    Doǧru, B.4
  • 164
    • 0028982688 scopus 로고
    • Effects of antioxidanttreatment on sciatic nerve dysfunction in streptozotocindiabeticrats; comparison with essential fatty acids
    • Karasu C, Dewhurst M, Stevens EJ, Tomlinson DR. Effects of antioxidanttreatment on sciatic nerve dysfunction in streptozotocindiabeticrats; comparison with essential fatty acids. Diabetologia1995; 38: 129-34.
    • (1995) Diabetologia , vol.38 , pp. 129-134
    • Karasu, C.1    Dewhurst, M.2    Stevens, E.J.3    Tomlinson, D.R.4
  • 165
  • 166
    • 0028790808 scopus 로고
    • Chronic vitaminE treatment prevents defective endothelium-dependent relaxation indiabetic rat aorta
    • Keegan A, Walbank H, Cotter MA, Cameron NE. Chronic vitaminE treatment prevents defective endothelium-dependent relaxation indiabetic rat aorta. Diabetologia 1995; 38: 1475-8.
    • (1995) Diabetologia , vol.38 , pp. 1475-1478
    • Keegan, A.1    Walbank, H.2    Cotter, M.A.3    Cameron, N.E.4
  • 167
    • 36649026948 scopus 로고    scopus 로고
    • Dietary supplementation withvitamin E ameliorates cardiac failure in type I diabetic cardiomyopathyby suppressing myocardial generation of 8-isoprostaglandinF2alpha and oxidized glutathione
    • Hamblin M, Smith HM, Hill MF. Dietary supplementation withvitamin E ameliorates cardiac failure in type I diabetic cardiomyopathyby suppressing myocardial generation of 8-isoprostaglandinF2alpha and oxidized glutathione. J Card Fail 2007;13: 884-92.
    • (2007) J Card Fail , vol.13 , pp. 884-892
    • Hamblin, M.1    Smith, H.M.2    Hill, M.F.3
  • 169
    • 0033910718 scopus 로고    scopus 로고
    • Vitamin Esupplementation improves endothelial function in type I diabetesmellitus: A randomized, placebo-controlled study
    • Skyrme-Jones RA, O'Brien RC, Berry KL, Meredith IT. Vitamin Esupplementation improves endothelial function in type I diabetesmellitus: a randomized, placebo-controlled study. J Am Coll Cardiol2000; 36: 94-102.
    • (2000) J Am Coll Cardiol , vol.36 , pp. 94-102
    • Skyrme-Jones, R.A.1    O'Brien, R.C.2    Berry, K.L.3    Meredith, I.T.4
  • 171
    • 0034688195 scopus 로고    scopus 로고
    • Vitamin E supplementationand cardiovascular events in high-risk patients. TheHeart Outcomes Prevention Evaluation Study Investigators
    • Yusuf S, Dagenais G, Pogue J, Bosch J, Sleight P. Vitamin E supplementationand cardiovascular events in high-risk patients. TheHeart Outcomes Prevention Evaluation Study Investigators. N EnglJ Med 2000; 342: 154-60.
    • (2000) N EnglJ Med , vol.342 , pp. 154-160
    • Yusuf, S.1    Dagenais, G.2    Pogue, J.3    Bosch, J.4    Sleight, P.5
  • 172
    • 20044383911 scopus 로고    scopus 로고
    • HOPE and HOPE-TOO TrialInvestigators. Effects of long-term vitamin E supplementation oncardiovascular events and cancer: A randomized controlled trial
    • Lonn E, Bosch J, Yusuf S, et al. HOPE and HOPE-TOO TrialInvestigators. Effects of long-term vitamin E supplementation oncardiovascular events and cancer: a randomized controlled trial. JAMA 2005; 293: 1338-47.
    • (2005) JAMA , vol.293 , pp. 1338-1347
    • Lonn, E.1    Bosch, J.2    Yusuf, S.3
  • 173
    • 67949092845 scopus 로고    scopus 로고
    • Effects of vitamins C and E and beta-carotene on the risk of type 2diabetes in women at high risk of cardiovascular disease: A randomizedcontrolled trial
    • Song Y, Cook NR, Albert CM, Van Denburgh M, Manson JE. Effects of vitamins C and E and beta-carotene on the risk of type 2diabetes in women at high risk of cardiovascular disease: a randomizedcontrolled trial. Am J Clin Nutr 2009; 90: 429-37.
    • (2009) Am J Clin Nutr , vol.90 , pp. 429-437
    • Song, Y.1    Cook, N.R.2    Albert, C.M.3    Van Denburgh, M.4    Manson, J.E.5
  • 174
    • 67649827502 scopus 로고    scopus 로고
    • Antioxidants and lipid peroxidationstatus in diabetic patients with and without complications
    • Srivatsan R, Das S, Gadde R, et al. Antioxidants and lipid peroxidationstatus in diabetic patients with and without complications. Arch Iran Med 2009; 12: 121-7
    • (2009) Arch Iran Med , vol.12 , pp. 121-127
    • Srivatsan, R.1    Das, S.2    Gadde, R.3
  • 175
    • 62349096829 scopus 로고    scopus 로고
    • The responseof gamma vitamin E to varying dosages of alpha vitamin E plus vitaminC
    • Gutierrez AD, de Serna DG, Robinson I, Schade DS. The responseof gamma vitamin E to varying dosages of alpha vitamin E plus vitaminC. Metabolism 2009; 58: 469-78.
    • (2009) Metabolism , vol.58 , pp. 469-478
    • Gutierrez, A.D.1    de Serna, D.G.2    Robinson, I.3    Schade, D.S.4
  • 177
    • 0032031104 scopus 로고    scopus 로고
    • Evaluation of the antioxidant capacity of ubiquinoland dihydrolipoic acid
    • Nohl H, Gille L. Evaluation of the antioxidant capacity of ubiquinoland dihydrolipoic acid. Z Naturforsch C 1998; 53: 250-3.
    • (1998) Z Naturforsch C , vol.53 , pp. 250-253
    • Nohl, H.1    Gille, L.2
  • 178
    • 70249110417 scopus 로고    scopus 로고
    • Effect of alpha lipoicacid on oxidative stress and vascular wall of diabetic rats
    • Balkis Budin S, Othman F, Louis SR, et al. Effect of alpha lipoicacid on oxidative stress and vascular wall of diabetic rats. Rom JMorphol Embryol 2009; 50: 23-30.
    • (2009) Rom JMorphol Embryol , vol.50 , pp. 23-30
    • Balkis Budin, S.1    Othman, F.2    Louis, S.R.3
  • 180
    • 0037707713 scopus 로고    scopus 로고
    • Effects of alpha-lipoicacid on biomarkers of oxidative stress in streptozotocin-induceddiabetic rats
    • Maritim AC, Sanders RA, Watkins JB 3rd. Effects of alpha-lipoicacid on biomarkers of oxidative stress in streptozotocin-induceddiabetic rats. J Nutr Biochem 2003; 14: 288-94
    • (2003) J Nutr Biochem , vol.14 , pp. 288-294
    • Maritim, A.C.1    Sanders, R.A.2    Watkins III, J.B.3
  • 181
    • 12944307850 scopus 로고    scopus 로고
    • Antioxidative treatment prevents activation of death-receptor-andmitochondrion-dependent apoptosis in the hearts of diabetic rats
    • Bojunga J, Nowak D, Mitrou PS, Hoelzer D, Zeuzem S, Chow KU. Antioxidative treatment prevents activation of death-receptor-andmitochondrion-dependent apoptosis in the hearts of diabetic rats. Diabetologia 2004; 47: 2072-80.
    • (2004) Diabetologia , vol.47 , pp. 2072-2080
    • Bojunga, J.1    Nowak, D.2    Mitrou, P.S.3    Hoelzer, D.4    Zeuzem, S.5    Chow, K.U.6
  • 182
    • 33745216214 scopus 로고    scopus 로고
    • Heat shock protein60 response to exercise in diabetes: Effects of alpha-lipoic acidsupplementation
    • Oksala NK, Laaksonen DE, Lappalainen J, et al. Heat shock protein60 response to exercise in diabetes: effects of alpha-lipoic acidsupplementation. J Diabetes Complicat 2006; 20: 257-61.
    • (2006) J Diabetes Complicat , vol.20 , pp. 257-261
    • Oksala, N.K.1    Laaksonen, D.E.2    Lappalainen, J.3
  • 183
    • 2642548826 scopus 로고    scopus 로고
    • Thioctic acid for patients with symptomatic diabeticpolyneuropathy: A critical review
    • Ziegler D. Thioctic acid for patients with symptomatic diabeticpolyneuropathy: a critical review. Treat Endocrinol 2004; 3: 173-89.
    • (2004) Treat Endocrinol , vol.3 , pp. 173-189
    • Ziegler, D.1
  • 184
    • 0028845524 scopus 로고
    • Treatment of symptomaticdiabetic peripheral neuropathy with the anti-oxidant alphalipoicacid. A 3-week multicentre randomized controlled trial(ALADIN Study)
    • Ziegler D, Hanefeld M, Ruhnau KJ, et al. Treatment of symptomaticdiabetic peripheral neuropathy with the anti-oxidant alphalipoicacid. A 3-week multicentre randomized controlled trial(ALADIN Study). Diabetologia 1995; 38: 1425-33.
    • (1995) Diabetologia , vol.38 , pp. 1425-1433
    • Ziegler, D.1    Hanefeld, M.2    Ruhnau, K.J.3
  • 185
    • 0032881613 scopus 로고    scopus 로고
    • Treatment of diabetic polyneuropathywith the antioxidant thioctic acid (alpha-lipoic acid): Atwo year multicenter randomized double-blind placebo-controlledtrial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy
    • Reljanovic M, Reichel G, Rett K, et al. Treatment of diabetic polyneuropathywith the antioxidant thioctic acid (alpha-lipoic acid): atwo year multicenter randomized double-blind placebo-controlledtrial (ALADIN II). Alpha Lipoic Acid in Diabetic Neuropathy. Free Radic Res 1999; 31: 171-9.
    • (1999) Free Radic Res , vol.31 , pp. 171-179
    • Reljanovic, M.1    Reichel, G.2    Rett, K.3
  • 186
    • 0032788081 scopus 로고    scopus 로고
    • Treatment of symptomaticdiabetic polyneuropathy with the antioxidant alpha-lipoic acid: A 7-month multicenter randomized controlled trial (ALADIN IIIStudy). ALADIN III Study Group. Alpha-Lipoic Acid in DiabeticNeuropathy
    • Ziegler D, Hanefeld M, Ruhnau K, et al. Treatment of symptomaticdiabetic polyneuropathy with the antioxidant alpha-lipoic acid: a 7-month multicenter randomized controlled trial (ALADIN IIIStudy). ALADIN III Study Group. Alpha-Lipoic Acid in DiabeticNeuropathy. Diabetes Care 1999; 22: 1296-301
    • (1999) Diabetes Care , vol.22 , pp. 1296-1301
    • Ziegler, D.1    Hanefeld, M.2    Ruhnau, K.3
  • 187
    • 0031028636 scopus 로고    scopus 로고
    • Effectsof treatment with the antioxidant alpha-lipoic acid on cardiacautonomic neuropathy in NIDDM patients. A 4-month randomizedcontrolled multicenter trial (DEKAN Study). DeutscheKardiale Autonome Neuropathie
    • Ziegler D, Schatz H, Conrad F, Gries FA, Ulrich H, Reichel G. Effectsof treatment with the antioxidant alpha-lipoic acid on cardiacautonomic neuropathy in NIDDM patients. A 4-month randomizedcontrolled multicenter trial (DEKAN Study). DeutscheKardiale Autonome Neuropathie. Diabetes Care 1997; 20: 369-73.
    • (1997) Diabetes Care , vol.20 , pp. 369-373
    • Ziegler, D.1    Schatz, H.2    Conrad, F.3    Gries, F.A.4    Ulrich, H.5    Reichel, G.6
  • 188
    • 75549084221 scopus 로고    scopus 로고
    • Painful diabetic neuropathy: Advantage of novel drugsover old drugs?
    • Ziegler D. Painful diabetic neuropathy: advantage of novel drugsover old drugs? Diabetes Care 2009; 32 (Suppl 2): S414-9.
    • (2009) Diabetes Care , vol.32 , Issue.SUPPL. 2
    • Ziegler, D.1
  • 189
    • 0042668303 scopus 로고    scopus 로고
    • The sensorysymptoms of diabetic polyneuropathy are improved with {alpha}-Lipoic Acid: The SYDNEY Trial
    • Low PA, Nehrdich D, Novosadova M, O'Brien PC, et al. The sensorysymptoms of diabetic polyneuropathy are improved with {alpha}-Lipoic Acid: The SYDNEY Trial. Diabetes Care 2003; 26:770-6.
    • (2003) Diabetes Care , vol.26 , pp. 770-776
    • Low, P.A.1    Nehrdich, D.2    Novosadova, M.3    O'Brien, P.C.4
  • 190
    • 1242337352 scopus 로고    scopus 로고
    • Treatment ofsymptomatic diabetic polyneuropathy with the antioxidant alphalipoicacid: A meta-analysis
    • Ziegler D, Nowak H, Kempler P, Vargha P, Low PA. Treatment ofsymptomatic diabetic polyneuropathy with the antioxidant alphalipoicacid: a meta-analysis. Diabet Med 2004; 21: 114-21.
    • (2004) Diabet Med , vol.21 , pp. 114-121
    • Ziegler, D.1    Nowak, H.2    Kempler, P.3    Vargha, P.4    Low, P.A.5
  • 191
    • 0034099364 scopus 로고    scopus 로고
    • The effect of vitamin E, probucol, and lovastatin on oxidative status and aortic fatty lesionsin hyperlipidemic-diabetic hamsters
    • El-Swefy S, Schaefer EJ, Seman LJ, et al. The effect of vitamin E, probucol, and lovastatin on oxidative status and aortic fatty lesionsin hyperlipidemic-diabetic hamsters. Atherosclerosis 2000; 149:277-86.
    • (2000) Atherosclerosis , vol.149 , pp. 277-286
    • El-Swefy, S.1    Schaefer, E.J.2    Seman, L.J.3
  • 192
  • 193
    • 84855502300 scopus 로고    scopus 로고
    • The prevention ofprogression of arterial disease and diabetes (POPADAD) trial: Factorialrandomised placebo controlled trial of aspirin and antioxidantsin patients with diabetes and asymptomatic peripheral arterialdisease
    • Prevention of Progressionof Arterial Disease and Diabetes Study Group; Diabetes RegistryGroup; Royal College of Physicians Edinburgh
    • Belch J, MacCuish A, Campbell I, et al. Prevention of Progressionof Arterial Disease and Diabetes Study Group; Diabetes RegistryGroup; Royal College of Physicians Edinburgh. The prevention ofprogression of arterial disease and diabetes (POPADAD) trial: factorialrandomised placebo controlled trial of aspirin and antioxidantsin patients with diabetes and asymptomatic peripheral arterialdisease. Ann Intern Med 2009; 150: JC1-8.
    • (2009) Ann Intern Med , vol.150
    • Belch, J.1    McCuish, A.2    Campbell, I.3
  • 194
    • 58949086229 scopus 로고    scopus 로고
    • Drugs for the treatment of diabetes complications. Zycose: New player in the field?
    • (Barc)
    • Stirban A. Drugs for the treatment of diabetes complications. Zycose:a new player in the field? Drugs Today (Barc) 2008; 44: 783-96.
    • (2008) Drugs Today , vol.44 , pp. 783-796
    • Stirban, A.1
  • 195
    • 41949098732 scopus 로고    scopus 로고
    • Anti-atherosclerotic and antidiabeticproperties of probucol and related compounds
    • Tanous D, Hime N, Stocker R. Anti-atherosclerotic and antidiabeticproperties of probucol and related compounds. Redox Rep2008; 13: 48-59.
    • (2008) Redox Rep , vol.13 , pp. 48-59
    • Tanous, D.1    Hime, N.2    Stocker, R.3
  • 196
    • 0036235710 scopus 로고    scopus 로고
    • Probucol preservespancreatic beta-cell function through reduction of oxidative stressin type 2 diabetes
    • Gorogawa S, Kajimoto Y, Umayahara Y, et al. Probucol preservespancreatic beta-cell function through reduction of oxidative stressin type 2 diabetes. Diabetes Res Clin Pract 2002; 57: 1-10.
    • (2002) Diabetes Res Clin Pract , vol.57 , pp. 1-10
    • Gorogawa, S.1    Kajimoto, Y.2    Umayahara, Y.3
  • 197
    • 0032103277 scopus 로고    scopus 로고
    • Atorvastatinand gemfibrozil metabolites, but not the parent drugs, are potentantioxidants against lipoprotein oxidation
    • Aviram M, Rosenblat M, Bisgaier CL, Newton RS. Atorvastatinand gemfibrozil metabolites, but not the parent drugs, are potentantioxidants against lipoprotein oxidation. Atherosclerosis 1998;138: 271-80.
    • (1998) Atherosclerosis , vol.138 , pp. 271-280
    • Aviram, M.1    Rosenblat, M.2    Bisgaier, C.L.3    Newton, R.S.4
  • 198
    • 0035124867 scopus 로고    scopus 로고
    • Short-term gemfibroziltreatment reverses lipid profile and peroxidation but does not alterblood glucose and tissue antioxidant enzymes in chronically diabeticrats
    • Ozansoy G, Akin B, Aktan F, Karasu C. Short-term gemfibroziltreatment reverses lipid profile and peroxidation but does not alterblood glucose and tissue antioxidant enzymes in chronically diabeticrats. Mol Cell Biochem 2001; 216: 59-63.
    • (2001) Mol Cell Biochem , vol.216 , pp. 59-63
    • Ozansoy, G.1    Akin, B.2    Aktan, F.3    Karasu, C.4
  • 199
    • 1242286545 scopus 로고    scopus 로고
    • Effects of gemfibrozil treatment on vascularreactivity of streptozotocin-diabetic rat aorta
    • Ozansoy G, Akin FB. Effects of gemfibrozil treatment on vascularreactivity of streptozotocin-diabetic rat aorta. J Pharm Pharmacol2004; 56: 241-6.
    • (2004) J Pharm Pharmacol , vol.56 , pp. 241-246
    • Ozansoy, G.1    Akin, F.B.2
  • 200
    • 34250807673 scopus 로고    scopus 로고
    • A lackof synergistic interaction between insulin and pioglitazone onreactivity of rat aorta from chronically high dose insulin-treateddiabetic rats
    • Sahilli M, Irat AM, Isik AC, Karasu C, Ozansoy G, Ari N. A lackof synergistic interaction between insulin and pioglitazone onreactivity of rat aorta from chronically high dose insulin-treateddiabetic rats. Gen Physiol Biophys 2007; 26: 48-55.
    • (2007) Gen Physiol Biophys , vol.26 , pp. 48-55
    • Sahilli, M.1    Irat, A.M.2    Isik, A.C.3    Karasu, C.4    Ozansoy, G.5    Ari, N.6
  • 201
    • 0034646746 scopus 로고    scopus 로고
    • Dietarytroglitazone decreases oxidative stress in early stage type II diabeticrats
    • Fukui T, Noma T, Mizushige K, Aki Y, Kimura S, Abe Y. Dietarytroglitazone decreases oxidative stress in early stage type II diabeticrats. Life Sci 2000; 66: 2043-9.
    • (2000) Life Sci , vol.66 , pp. 2043-2049
    • Fukui, T.1    Noma, T.2    Mizushige, K.3    Aki, Y.4    Kimura, S.5    Abe, Y.6
  • 202
    • 0038177982 scopus 로고    scopus 로고
    • Effect of thiazolidinedionesand metformin on LDL oxidation and aortic endothelium relaxationin diabetic GK rats
    • Lida KT, Kawakami Y, Suzuki M, et al. Effect of thiazolidinedionesand metformin on LDL oxidation and aortic endothelium relaxationin diabetic GK rats. Am J Physiol 2003; 284: E1125-30.
    • (2003) Am J Physiol , vol.284
    • Lida, K.T.1    Kawakami, Y.2    Suzuki, M.3
  • 203
    • 0345676510 scopus 로고    scopus 로고
    • Antioxidant and pharmacodynamic effects ofpyridoindole stobadine
    • Horakova L, Stolc S. Antioxidant and pharmacodynamic effects ofpyridoindole stobadine. Gen Pharmacol 1998; 30: 627-38.
    • (1998) Gen Pharmacol , vol.30 , pp. 627-638
    • Horakova, L.1    Stolc, S.2
  • 204
    • 0033213529 scopus 로고    scopus 로고
    • Oxidative modification ofserum albumin in an experimental glycation model of diabetes mellitusin vitro: Effect of the pyridoindole antioxidant stobadine
    • Stefek M, Krizanova L, Trnkova Z. Oxidative modification ofserum albumin in an experimental glycation model of diabetes mellitusin vitro: effect of the pyridoindole antioxidant stobadine. LifeSci 1999; 65: 1995-7.
    • (1999) LifeSci , vol.65 , pp. 1995-1997
    • Stefek, M.1    Krizanova, L.2    Trnkova, Z.3
  • 205
    • 0036873473 scopus 로고    scopus 로고
    • The pyridoindole antioxidantstobadine attenuates albuminuria, enzymuria, kidney lipidperoxidation and matrix collagen cross-linking in streptozotocininduceddiabetic rats
    • Stefek M, Gajdosik A, Tribulova N, et al. The pyridoindole antioxidantstobadine attenuates albuminuria, enzymuria, kidney lipidperoxidation and matrix collagen cross-linking in streptozotocininduceddiabetic rats. Methods Find Exp Clin Pharmacol 2002; 24:565-71.
    • (2002) Methods Find Exp Clin Pharmacol , vol.24 , pp. 565-571
    • Stefek, M.1    Gajdosik, A.2    Tribulova, N.3
  • 206
    • 0034489540 scopus 로고    scopus 로고
    • Effect of dietarysupplementation with the pyridoindole antioxidant stobadine on antioxidantstate and ultrastructure of diabetic rat myocardium
    • Stefek M, Sotnikova R, Okruhlicova L, et al. Effect of dietarysupplementation with the pyridoindole antioxidant stobadine on antioxidantstate and ultrastructure of diabetic rat myocardium. ActaDiabetol 2000; 37: 111-7.
    • (2000) ActaDiabetol , vol.37 , pp. 111-117
    • Stefek, M.1    Sotnikova, R.2    Okruhlicova, L.3
  • 207
    • 47849124034 scopus 로고    scopus 로고
    • Effects ofantioxidant stobadine on protein carbonylation, advanced oxidationprotein products and reductive capacity of liver in streptozotocindiabeticrats: Role of oxidative/nitrosative stress
    • Cumaoglu A, Cevik C, Rackova L, Ari N, Karasu C. Effects ofantioxidant stobadine on protein carbonylation, advanced oxidationprotein products and reductive capacity of liver in streptozotocindiabeticrats: role of oxidative/nitrosative stress. Biofactors 2007;30: 171-8.
    • (2007) Biofactors , vol.30 , pp. 171-178
    • Cumaoglu, A.1    Cevik, C.2    Rackova, L.3    Ari, N.4    Karasu, C.5
  • 209
    • 0033213545 scopus 로고    scopus 로고
    • Stobadine and heart mitochondria
    • Guzy J, Barnová E, Benes L. Stobadine and heart mitochondria. Life Sci 1999; 65: 1935-7.
    • (1999) Life Sci , vol.65 , pp. 1935-1937
    • Guzy, J.1    Barnová, E.2    Benes, L.3
  • 210
    • 0344197640 scopus 로고    scopus 로고
    • Effect of stobadineon leukocyte free radical generation in streptozotocin-diabetic rats: Omparison with vitamin E
    • Demiryürek AT, Karasu C, Stefek M, Stolc S. Effect of stobadineon leukocyte free radical generation in streptozotocin-diabetic rats:comparison with vitamin E. Pharmacology 2004; 70: 1-4.
    • (2004) Pharmacology , vol.70 , pp. 1-4
    • Demiryürek, A.T.1    Karasu, C.2    Stefek, M.3    Stolc, S.4
  • 211
    • 20444442574 scopus 로고    scopus 로고
    • Effect of the pyridoindoleantioxidant stobadine on development of experimentaldiabetic cataract and on lens protein oxidation in rats: Comparisonwith vitamin E and BHT
    • Kyselova Z, Gajdosik A, Gajdosikova A, et al. Effect of the pyridoindoleantioxidant stobadine on development of experimentaldiabetic cataract and on lens protein oxidation in rats: comparisonwith vitamin E and BHT. Mol Vis 2005; 11: 56-65.
    • (2005) Mol Vis , vol.11 , pp. 56-65
    • Kyselova, Z.1    Gajdosik, A.2    Gajdosikova, A.3
  • 212
    • 0026784064 scopus 로고
    • Antioxidant activity of the pyridoindole stobadine. Pulse radiolyticcharacterization of one-electron-oxidized stobadine and quenchingof singlet molecular oxygen
    • Steenken S, Sundquist AR, Jovanovic SV, Crockett R, Sies H. Antioxidant activity of the pyridoindole stobadine. Pulse radiolyticcharacterization of one-electron-oxidized stobadine and quenchingof singlet molecular oxygen. Chem Res Toxicol 1992; 5: 355-60.
    • (1992) Chem Res Toxicol , vol.5 , pp. 355-360
    • Steenken, S.1    Sundquist, A.R.2    Jovanovic, S.V.3    Crockett, R.4    Sies, H.5
  • 213
    • 0027398196 scopus 로고
    • Interactionof the pyridoindole stobadine with peroxyl, superoxide and chromanoxylradicals
    • Kagan VE, Tsuchiya M, Serbinova E, Packer L, Sies H. Interactionof the pyridoindole stobadine with peroxyl, superoxide and chromanoxylradicals. Biochem Pharmacol 1993; 45: 393-400.
    • (1993) Biochem Pharmacol , vol.45 , pp. 393-400
    • Kagan, V.E.1    Tsuchiya, M.2    Serbinova, E.3    Packer, L.4    Sies, H.5
  • 215
    • 0034894589 scopus 로고    scopus 로고
    • Dietary supplementationof the pyridoindole antioxidant stobadine reduces vascular impairmentin streptozotocin-diabetic rats
    • Sotnikova R, Stefek M, Okruhlicova L, et al. Dietary supplementationof the pyridoindole antioxidant stobadine reduces vascular impairmentin streptozotocin-diabetic rats. Methods Find Exp ClinPharmacol 2001; 23: 121-9.
    • (2001) Methods Find Exp ClinPharmacol , vol.23 , pp. 121-129
    • Sotnikova, R.1    Stefek, M.2    Okruhlicova, L.3
  • 216
    • 0027546764 scopus 로고
    • Antioxidative properties of cardioactiveagents
    • Misík V, Ondrias K, Gergel D. Antioxidative properties of cardioactiveagents. Bratisl Lek Listy 1993; 94: 66-70.
    • (1993) Bratisl Lek Listy , vol.94 , pp. 66-70
    • Misík, V.1    Ondrias, K.2    Gergel, D.3
  • 217
    • 0028152740 scopus 로고
    • Pyridoindole stobadine is a nonselective inhibitor of voltage-operated ion channels in rat sensory neurons
    • Stolc S. Pyridoindole stobadine is a nonselective inhibitor of voltage-operated ion channels in rat sensory neurons. Gen Physiol Biophys1994; 13: 259-66.
    • (1994) Gen Physiol Biophys , vol.13 , pp. 259-266
    • Stolc, S.1
  • 218
    • 2542480928 scopus 로고    scopus 로고
    • Endothelial protectiveeffect of stobadine on ischaemia/reperfusion-induced injury
    • Sotníková R, Okruhlicová L, Noskovic P. Endothelial protectiveeffect of stobadine on ischaemia/reperfusion-induced injury. GenPhysiol Biophys 1998; 17: 253-64.
    • (1998) GenPhysiol Biophys , vol.17 , pp. 253-264
    • Sotníková, R.1    Okruhlicová, L.2    Noskovic, P.3
  • 220
    • 33846428762 scopus 로고    scopus 로고
    • Stobadine protects ratkidney against ischaemia/reperfusion injury
    • Guz G, Demirogullari B, Ulusu NN, et al. Stobadine protects ratkidney against ischaemia/reperfusion injury. Clin Exp PharmacolPhysiol. 2007; 34: 210-6.
    • (2007) Clin Exp Pharmacol Physiol. , vol.34 , pp. 210-216
    • Guz, G.1    Demirogullari, B.2    Ulusu, N.N.3
  • 221
    • 43049159358 scopus 로고    scopus 로고
    • Carboxymethylatedpyridoindole antioxidants as aldose reductase inhibitors: Synthesis, activity, partitioning, and molecular modeling
    • Stefek M, Snirc V, Djoubissie PO, et al. Carboxymethylatedpyridoindole antioxidants as aldose reductase inhibitors: synthesis, activity, partitioning, and molecular modeling. Bioorg Med Chem2008; 16: 4908-20.
    • (2008) Bioorg Med Chem , vol.16 , pp. 4908-4920
    • Stefek, M.1    Snirc, V.2    Djoubissie, P.O.3
  • 222
    • 34249331320 scopus 로고    scopus 로고
    • Stobadine inhibits doxorubicin-induced apoptosis through acaspase-9 dependent pathway in P815 mastocytoma cells
    • Umit Baǧriaçik E, Uslu K, Yurtçu E, Stefek M, Karasu C. Stobadine inhibits doxorubicin-induced apoptosis through acaspase-9 dependent pathway in P815 mastocytoma cells. Cell BiolInt 2007; 31: 979-84.
    • (2007) Cell BiolInt , vol.31 , pp. 979-984
    • Umit Baǧriaçik, E.1    Uslu, K.2    Yurtçu, E.3    Stefek, M.4    Karasu, C.5
  • 224
    • 70349333841 scopus 로고    scopus 로고
    • Metabolism-induced oxidative stress is a mediator of glucose toxicityin HT22 neuronal cells
    • Rackova L, Snirc V, Jung T, Stefek M, Karasu C, Grune T. Metabolism-induced oxidative stress is a mediator of glucose toxicityin HT22 neuronal cells. Free Radic Res 2009; 43: 876-86.
    • (2009) Free Radic Res , vol.43 , pp. 876-886
    • Rackova, L.1    Snirc, V.2    Jung, T.3    Stefek, M.4    Karasu, C.5    Grune, T.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.