Endothelial Protective Effect of Stobadine on Ischaemia/Reperfusion-Induced Injury

General Physiology and Biophysics

Volumn 17, Issue 3, 1998, Pages 253-264

  Sotnikova R ^a   Okruhlicova L' ^b   Noskovic P ^c  

^a INSTITUTE OF EXPERIMENTAL PHARMACOLOGY AND TOXICOLOGY   (Slovakia)

^b INSTITUTE OF CHEMISTRY   (Slovakia)

^c Drug Research Institute   (Slovakia)

Author keywords

Ischaemia reperfusion; Rat abdominal aorta; Stobadine

Indexed keywords

ACETYLCHOLINE; NITROPRUSSIDE SODIUM; NORADRENALIN; STOBADINE; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ABDOMINAL AORTA; ANIMAL MODEL; ANTIOXIDANT ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; INTRAVENOUS DRUG ADMINISTRATION; ISCHEMIA; LIPID PEROXIDATION; MALE; MITOCHONDRION; NONHUMAN; RAT; REPERFUSION INJURY; TRANSMISSION ELECTRON MICROSCOPY; VASCULAR ENDOTHELIUM; VASCULAR RING;

ACETYLCHOLINE; ANIMALS; ANTI-ARRHYTHMIA AGENTS; AORTA, ABDOMINAL; CARBOLINES; ENDOTHELIUM, VASCULAR; ISCHEMIA; LIPID PEROXIDATION; MALE; MITOCHONDRIA; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; NITROPRUSSIDE; NOREPINEPHRINE; RATS; RATS, WISTAR; REPERFUSION INJURY; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VASOCONSTRICTION; VASODILATION;

EID: 2542480928     PISSN: 02315882     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Gibala P., Sotníková R., Dřímal J. (1985): Antiarrhythmic activity of the substnace DH 1011. Bratisl. Lek. Listy 84, 137-144 (in Slovak)
2. Horáková L'., Uraz V., Ondrejičková O., Lukovič L'., Juránek I. (1991): Effect of stobadine on brain lipid peroxidation induced by incomplete ischemia and subsequent reperfusion. Biomed, Biochim. Acta 50, 1019-1025
3. Korthuis R. J., Granger D. N., Townsley M, I., Taylor A. E. (1985): The role of oxygen-derived free radicals in ischemia-induced increases in canine skeletal muscle vascular permeability. Circ. Res. 57, 599-609
4. Lowry O. H., Rosebrough N. J., Farr A. L., Randall R. J. (1951): Protein measurement with the Folin phenol reagent. J. Biol. Chem. 193, 265-275
5. Lukáčová N., Chavko M., Halát G. (1993): Effect of stobadine on lipid peroxidation and phospholipids in rabbit spinal cord after ischaemia. Neuropharmacology 32, 235-241
6. Lukovič L., Machová J. (1988): Antihistaminic activity of stobadine in the peripheral and central nervous system. Agent. Action. 23, 257-259
7. Mišík V., Gergel' D., Ondriaš K. (1991): Comparison of the effect of stobadine on lipid peroxidation of liver, heart, kidney and brain homogenates. Pharmazie 46, 468-469
8. Ondriaš K., Mišík V., Gergel' D., Staško A. (1989): Lipid peroxidation of phosphatidylcholine liposomes depressed by the calcium channel blockers nifedipine and verapamil and by the antiarrhythmic-antihypoxic drug stobadine. Biochim. Biophys. Acta 1003, 238-245
9. Palmer R. M. J., Ferrige A. G., Moncada S. (1987): Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor. Nature 327, 524-526
10. Quillen J. E., Selke F. W., Brooks L. A., Harrison D. G. (1990): Ischemia-reperfusion impairs endothelium-dependent relaxation of coronary microvessels but does not affect large arteries. Circulation 82, 586-594
11. Sotníková R., Gibala P., Dřímal J. (1985): Alpha-adrenolytic activity of the substance DH 1011. Bratisl. Lek. Listy 84, 536-541 (in Slovak)
12. Staško A., Ondriaš K., Mišík V. (1990): Stobadine - a novel scavenger of free radicals. Chem. Papers 44, 493-500
13. Steenken S., Sundquist A. R., Jovanovic S. V. (1992): Antioxidant activity of the pyridoindole stobadine. Pulse radiolytic characterization of one - electron - oxidized stobadine and quenching of singlet molecular oxygen. Chem. Res. Toxicol. 5, 355-360
14. Štolc S., Horáková L'. (1988): Effect of stobadine on postischemic lipid peroxidation in the brain. In: New Trends in Clinical Neuropharmacology. (Eds. D. Bartko, P. Turčáni, G. Stern, J. Libbey) pp. 59-63, John Libbey & Company Ltd, London
15. Štolc S., Bauer V., Beneš L., Tichý M. (1988): Medicine with antiarrhythmic and antihypoxic activity and its method of preparation. BRD Patent P - 3231088
16. Štolc S., Vlkolinský R., Pavlásek J. (1997): Neuroprotection by pyridoindole stobadine: A minireview. Brain Res. Bull. 42, 335-340
17. Styk J., Gabauer I., Okoličány J., Holec J., Bauer V., Beneš L. (1986): Protective effect of stobadine (DH 1011) on rat ischaemic heart. Bratisl. Lek. Listy 85, 274-281 (in Slovak)
18. Summers S. T., Zinner M. J., Freischlag J. A. (1993): Production of endothelium-derived relaxing factor (EDRF) is compromised after ischemia and reperfusion. Amer. J. Surg. 166, 16-220
19. Tao P. S., Aoki N., Lefer D. J., Johnson G., Lefer A. M. (1990): Time course of endothelial dysfunction and myocardial injury during myocardial ischemia and reperfusion in the cat. Circulation 82, 1402-1412
20. Wei E. P., Kontos H. A., Dietrich W. D., Povlishock J. T., Ellis E. F. (1981): Inhibition by free radical scavengers and cyclooxygenase inhibitors of pial arteriolar abnormalities from concussive brain injury in cats. Circ. Res. 48, 95-103