Review of alterations in endothelial nitric oxide production in diabetes: Protective role of arginine on endothelial dysfunction

Hypertension

Volumn 31, Issue 5, 1998, Pages 1047-1060

  Pieper, Galen M ^a  

^a FROEDTERT MEMORIAL LUTHERAN HOSPITAL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CYCLIC GMP; ENDOTHELIUM DERIVED RELAXING FACTOR; GLUCOSE; GLYCOSYLATED PROTEIN; GUANYLATE CYCLASE INHIBITOR; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; NITRITE; PROSTANOID; SUPEROXIDE DISMUTASE;

DIABETES MELLITUS; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; REVIEW; VASCULAR ENDOTHELIUM; VASODILATATION;

EID: 0031940054     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.31.5.1047     Document Type: Review

References (221)

1. Moncada S, Palmer RMJ, Higgs EA. Nitric oxide: physiology, pathophysiology and pharmacology. Pharmacol Rev. 1991;43:109-142.
2. Kubes P, Suzuki M, Granger DN. Nitric oxide: an endogenous modulator of leukocyte adhesion. Proc Natl Acad Sci USA. 1991;88: 4651-4655.
3. Garg UC, Hassid S. Nitric oxide-generating nitrovasodilators and 8-bromo-cyclic guanosine monophosphate inhibit mitogenesis and proliferation of cultured rat vascular smooth muscle cells. J Clin Invest. 1989;83:1774-1777.
4. Palmer RMJ, Ashton DS, Moncada S. Vascular endothelial cells synthesize nitric oxide from L-arginine. Nature. 1988;333:694-666.
5. Pieper GM, Gross GJ. Endothelial dysfunction in diabetes. In: Rubanyi GM, ed. Cardiovascular Significance of Endothelium-Derived Vasoactive Factors. Mount Kisco, NY: Futura Publishing; 1991:223-249.
6. Kamata N, Miyata N, Abiru T, Kasuya Y. Functional changes in vascular smooth muscle and endothelium of arteries during diabetes mellitus. Life Sci. 1992;50:1379-1387.
7. Cohen RA. Dysfunction of vascular endothelium in diabetes mellitus. Circulation. 1993;87(suppl V):V-67-V-76.
8. Poston L, Taylor PD. Endothelium-mediated vascular function in insulin-dependent diabetes mellitus. Clin Sci. 1995;88:245-255.
9. Oyama Y, Kawasaki H, Hattori Y, Kanno M. Attenuation of endothelium-dependent relaxation in aorta from diabetic rats. Eur J Pharmacol. 1986;131:75-78.
10. Pieper GM, Gross GJ. Oxygen free radicals abolish endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol. 1988;255: H825-H833.
11. Gebremedhin D, Koltai MZ. Pogátsa G, Magyar K, Hadházy P. Influence of experimental diabetes on the mechanical responses of canine coronary arteries: role of endothelium. Cardiovasc Res. 1988;22: 537-544.
12. Kamata K, Miyata N, Kasuya Y. Impairment of endothelium-dependent relaxation and changes in levels of cyclic GMP in aorta from streptozotocin-induced diabetic rats. Br J Pharmacol. 1989;97: 614-618.
13. 2. Am J Physiol. 1989;257:H1327-H1333.
14. Hattori Y, Kawasaki H, Abe K, Kanno M. Superoxide dismutase recovers altered endothelium-dependent relaxation in diabetic rat aorta. Am J Physiol. 1991;261:H1086-H1094.
15. Cameron NE, Cotter MA. Impaired contraction and relaxation in aorta from streptozotocin-diabetic rats: role of polyol pathway. Diabetologia. 1992;35:1011-1019.
16. Chang KSK, Stevens WC. Endothelium-dependent increase in vascular sensitivity to phenylephrine in long-term streptozotocin diabetic rat aorta. Br J Pharmacol. 1992;107:983-990.
17. Otter DJ, Chess-Williams R. The effects of aldose reductase inhibition with ponalrestat on changes in vascular function in streptozotocin diabetic rats. Br J Pharmacol. 1994;113:576-580.
18. Kamata K, Sugiura M, Kojima S, Kasuya Y. Preservation of endothelium-dependent relaxation in cholesterol-fed and streptozotocin-induced diabetic mice by the chronic administration of cholestyramine. Br J Pharmacol. 1996;118:385-391.
19. Abiru T, Watanabe Y, Kamata K, Miyata N, Kasuya Y. Decrease in endothelium-dependent relaxation and levels of cyclic nucleotides in aorta from rabbits with alloxan-induced diabetes. Res Commun Chem Pathol Pharmacol. 1990;68:13-25.
20. Matsunaga T, Okumura K, Ishizaka H, Tsunoda R, Tayama S, Tabuchi T, Yasue H. Impairment of coronary blood flow regulation by endothelium-derived nitric oxide in dogs with alloxan-induced diabetes. J Cardiovasc Pharmacol. 1996;28:60-67.
21. Mayhan WG, Simmons LK, Sharpe GM. Mechanism of impaired responses of cerebral arterioles during diabetes mellitus. Am J Physiol. 1991;260:H319-H326.
22. Takiguchi Y, Satoh N, Hashimoto H, Nakashima M. Changes in vascular reactivity in experimental diabetic rats: comparison with hypothyroid rats. Blood Vessels. 1988;25:250-260.
23. Pelligrino DA, Miletich DJ, Albrecht RF. Diminished muscarinic receptor-mediated cerebral blood flow response in streptozotocin-treated rats. Am J Physiol. 1992;262:E447-E454.
24. Taylor PD, Graves JE, Poston L. Selective impairment of acetylcholine-mediated endothelium-dependent relaxation in isolated resistance arteries of the streptozotocin-induced diabetic rat. Clin Sci. 1995;88: 519-524.
25. Diederich D, Skopec J, Diederich A, Dai FX. Endothelial dysfunction in mesenteric resistance arteries of diabetic rat: role of free radicals. Am J Physiol. 1994;266:H1153-H1161.
26. Rösen P, Ballhausen T, Bloch W, Addicks K. Endothelial relaxation is disturbed by oxidative stress in the diabetic rat: influence of tocopherol as antioxidant. Diabetologia. 1995;38:1157-1168.
27. Ralevic V, Belai A, Burnstock G. Effects of streptozotocin-diabetes on sympathetic nerve, endothelial and smooth muscle function in the rat mesenteric arterial bed. Eur J Pharmacol. 1995;286:193-199.
28. Hill MA, Ege EA. Active and passive mechanical properties of isolated arterioles from STZ-induced diabetic rats: effect of aminoguanidine treatment. Diabetes. 1994;43:1450-1456.
29. Bertuglia S, Malandrino S, Colantuoni A. Effects of the natural flavonoid delphinidin on diabetic microangiopathy. Arzneim Forsch/Drug Res. 1995;45:481-485.
30. Lash JM, Bohlen HG. Structural and functional origins of suppressed acetylcholine vasodilation in diabetic rat intestinal arterioles. Circ Res. 1991;69:1259-1268.
31. Meraji S, Jayakody L, Senaratne MPJ, Thomson ABR, Kappagoda T. Endothelium-dependent relaxation in aorta of BB rat. Diabetes. 1987; 36:978-981.
32. Durante W, Sen AK, Sunahara FA. Impairment of endothelium-dependent relaxation in aortae from spontaneously diabetic rats. Br J Pharmacol 1988;94:463-468.
33. Pieper GM, Moore-Hilton G, Roza AM. Evaluation of the mechanism of endothelial dysfunction in the genetically diabetic BB rat. Life Sci. 1996;58:147-152.
34. Heygate KM, Lawrence IG, Bennett MA, Thurston H. Impaired endothelium-dependent relaxation in isolated resistance arteries of spontaneously diabetic rats. Br J Pharmacol. 1995;116:3251-3259.
35. Lindsay RM, Peet RS, Wilkie GS, Rossiter SP, Smith W, Baird JD, Williams BC. In vivo and in vitro evidence of altered nitric oxide metabolism in the spontaneously diabetic, insulin-dependent BB/Edinburgh rat. Br J Pharmacol 1997;120:1-6.
36. Miyata N, Tsuchida K, Okuyama S, Otomo K, Kamata K, Kasuya Y. Age-related changes in endothelium-dependent relaxation in aorta from genetically diabetic WBN/Kob rats. Am J Physiol. 1992;262: H1104-H1109.
37. Miyata N, Yamaura H, Tsuchida K, Okuyama S, Otomo S, Kamata K, Kasuya Y. Impairment of endothelium-dependent relaxation of superior mesenteric artery in genetically diabetic WBN/Kob rats. Can J Physiol Pharmacol. 1993;71:297-300.
38. Bohen HG, Lash JM. Endothelial-dependent vasodilation is preserved in non-insulin-dependent Zucker fatty diabetic rats. Am J Physiol. 1995; 268:H2366-H2374.
39. Sexl V, Mancusi G, Raberger G, Schütz W. Age-related changes in vascular reactivity in genetically diabetic rats. Pharmacology. 1995;50: 238-246.
40. Turner NC, White P. Effects of streptozotocin-induced diabetes on vascular reactivity in genetically hyperinsulinaemic obese Zucker rats. J Cardiovasc Pharmacol. 1996;27:884-890.
41. McNamee CJ, Kappagoda CT, Kunjara R, Russell JC. Defective endothelium-dependent relaxation in the JCR:LA-corpulent rat. Circ Res. 1994;74:1126-1132.
42. Saenz de Tejada I, Goldstein I, Azadzoi K, Krane RJ, Cohen RA. Impaired neurogenic and endothelium-mediated relaxation of penile smooth muscle from diabetic men with impotence. N Engl J Med. 1989;320:1025-1030.
43. Nitenberg A, Valensi P, Sachs R, Dali M, Aptecar E, Attali J-R. Impairment of coronary vascular reserve and ACh-induced coronary vasodilation in diabetic patients with angiographically normal coronary arteries and normal left ventricular systolic function. Diabetes. 1993;42: 1017-1025.
44. Johnstone MT, Creager SJ, Scales KM, Cusco JA, Lee BK, Creager MA. Impaired endothelium-dependent vasodilation in patients with insulin-dependent diabetes mellitus. Circulation. 1993;88:2510-2516.
45. McNally PG, Watt PAC, Rimmer T, Burden AC, Hearnshaw JR, Thurston H. Impaired contraction and endothelium-dependent relaxation in isolated resistance vessels from patients with insulin dependent diabetes mellitus. Clin Sci. 1994;87:31-36.
46. Mäkimattila S, Virkamäki A, Groop P-H, Cockcroft J, Utriainen T, Fagerudd J, Yki-Järvinen H. Chronic hyperglycemia impairs endothelial function and insulin sensitivity via different mechanisms in insulin-dependent diabetes mellitus. Circulation. 1996;94:1276-1282.
47. O'Driscoll G, Green D, Rankin J, Stanton K, Taylor R. Improvement in endothelial function by angiotensin converting enzyme inhibition in insulin-dependent diabetes mellitus. J Clin Invest. 1997;100:678-684.
48. McVeigh GE, Brennan GM, Johnston GD, McDermott BJ, McGrath LT, Henry WR, Andrews JW, Hayes JR. Impaired endothelium-dependent and independent vasodilation in patients with type 2 (non-insulin-dependent) diabetes mellitus. Diabetologia. 1992;35:771-776.
49. Morris SJ, Shore AC, Tooke JE. Responses of the skin microcirculation to acetylcholine and sodium nitroprusside in patients with NIDDM. Diabetologia. 1995;38:1337-1344.
50. Watts GF, O'Brien SF, Silvester W, Millar JA. Impaired endothelium-dependent and -independent dilatation of forearm resistance arteries in men with diet-treated non-insulin-dependent diabetes: role of dyslipidaemia. Clin Sci. 1996;91:567-573.
51. Karasu C, Soncul H, Altan VM. Effects of non-insulin dependent diabetes mellitus on the reactivity of human internal mammary artery and human saphenous vein. Life Sci. 1995;57:103-112.
52. Ting HH, Timimi FK, Boles KS, Creager SJ, Ganz P, Creager MA. Vitamin C improves endothelium-dependent vasodilation in patients with non-insulin-dependent diabetes mellitus. J Clin Invest. 1996;97: 22-28.
53. Steinberg HO, Chaker H, Learning R, Johnson A, Brechtel G, Baron AD. Obesity/insulin resistance is associated with endothelial dysfunction: implications for the syndrome of insulin resistance. J Clin Invest. 1996;97:2601-2610.
54. Calver A, Collier J, Vallance P. Inhibition and stimulation of nitric oxide synthesis in the human forearm arterial bed of patients with insulin-dependent diabetes. J Clin Invest. 1992;90:2548-2554.
55. Smits P, Kapma J-A, Jacobs M-C, Lutterman J, Thien T. Endothelium-dependent vascular relaxation in patients with type I diabetes. Diabetes. 1993;42:148-153.
56. Elliott TG, Cockcroft JR, Groop P-H, Viberti GC, Ritter JM. Inhibition of nitric oxide synthesis in forearm vasculature of insulin-dependent diabetic patients: blunted vasoconstriction in patients with microalbuminuria. Clin Sci. 1993;85:687-693.
57. Avogara A, Piarulli F, Valerio A, Miola M, Calveri M, Pavan P, Vicini P, Cobelli C, Tiengo A, Calo, Del Prato S. Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients. Diabetes. 1997;46:1040-1046.
58. Cipolla MJ, Harker CT, Porter JM. Endothelial function and adrenergic reactivity in human type-II diabetic resistance arteries. J Vasc Surg. 1996;23:940-949.
59. Schaper NC, Houben AJHM, Schoon Y, Kooman JP, Huvers FC, Niewenhuijzen-Kruseman AC. Venous compliance and the venodilatory effect of nitroglycerin in insulin-dependent diabetic patients with and without (incipient) nephropathy. Eur J Clin Invest. 1994;24:382-387.
60. Goodfellow J, Ramsey MW, Luddington LA, Jones CJH, Coates PA, Dunstan F, Lewis MJ, Owens DR, Henderson AH. Endothelium and inelastic arteries: an early marker of vascular dysfunction in non-insulin dependent diabetes. Br Med J. 1996;312:744-745.
61. Lambert J, Aarsen M, Donker AJM, Stehouwer CDA. Endothelium-dependent and -independent vasodilation of large arteries in normoalbuminuric insulin-dependent diabetes mellitus. Arterioscler Thromb Vasc Biol. 1996;16:705-711.
62. Clarkson P, Celermajer DS, Donald AE, Sampson M, Sorensen KE, Adams M, Yue DK, Betteridge DJ, Deanfield JE. Impaired vascular reactivity in insulin-dependent diabetes mellitus is related to disease duration and low density lipoprotein cholesterol levels. J Am Coll Cardiol. 1996;28:573-579.
63. Zenere BM, Arcaro G, Saggiani F, Rossi L, Muggeo M, Lechi A. Noninvasive detection of functional alterations of the arterial wall in IDDM patients with and without microalbuminuria. Diabetes Care. 1995;18:975-982.
64. Huvers FC, Schaper NC, Houben AJHM, Hofstra L, Kitslaar PJEHM, DeLeeuw PW, Niewenhuijzen Kruseman AC. Impaired arterial but not venous responsiveness to nitroglycerin in non-insulin-dependent diabetes mellitus. Eur J Clin Invest. 1997;27:360-365.
65. McVeigh G, Brennan G, Hager R, Johnston D. Primary nitrate tolerance in diabetes mellitus. Diabetologia. 1994;37:115-117.
66. Lekakis J, Papamichael C, Anastasiou H, Alevizaki M, Desses N, Souvatzoglou A, Stamatelopoulous S, Koutras DA. Endothelial dysfunction of conduit arteries in insulin-dependent diabetes mellitus without microalbuminuria. Cardiovasc Res. 1997;34:164-168.
67. Ewald U, Kobbah M, Tuvemo T. Vascular reactivity and platelet aggregability during the first five years of insulin-dependent diabetes in children. Acta Pædiatr. 1997;suppl 418:15-20.
68. Giugliano D, Marfella R, Verrazzo G, Acampora R, Donzella C, Quatraro A, Coppola L, D'Onofrio F. Abnormal rheologic effect of glyceryl trinitrate in patients with non-insulin-dependent diabetes mellitus and reversal by antioxidants. Ann Intern Med. 1995;123: 338-343.
69. + channel of vascular smooth muscle. FEBS Lett. 1994;345:47-49.
70. Bucala R, Tracey KJ, Cerami A. Advanced glycosylation products quench nitric oxide and mediate defective endothelium-dependent vasodilatation in experimental diabetes. J Clin Invest. 1991;87:432-438.
71. Rodriguez-Manas L, Arribas S, Girón C, Villamor J, Sánchez-Ferrer CF, Marín J. Interference of glycosylated human hemoglobin with endothelium-dependent responses. Circulation. 1993;88:2111-2116.
72. Oltman CL, Gutterman DD, Scott EC, Bocker JM, Dellsperger KC. Effects of glycosylated hemoglobin on vascular responses in vitro. Cardiovasc Res. 1997;34:179-184.
73. Duckrow RB. Decreased cerebral blood flow during acute hyperglycemia. Brain Res. 1995;703:145-150.
74. Cipolla MJ, Porter JM, Osol G. High glucose concentrations dilate cerebral arteries and diminish myogenic tone through an endothelial mechanism. Stroke. 1997;28:405-411.
75. Wascher TC, Bachernegg M, Kickenweiz A, Stark G, Stark U, Toplak H, Graier WF. Involvement of the L-arginine-nitric oxide pathway in hyperglycaemia-induced coronary artery dysfunction of isolated guinea pig hearts. Eur J Clin Invest. 1996;26:707-712.
76. Guigliano D, Marfella R, Coppola L, Verrazzo G, Acampora R, Giunta R, Nappo F, Lucarelli C, D'Onofrio F. Vascular effects of acute hyperglycemia in humans are reversed by L-arginine: evidence for reduced availability of nitric oxide during hyperglycemia. Circulation. 1997;95: 1783-1790.
77. Tesfamariam B, Cohen RA. Free radicals mediate endothelial cell dysfunction caused by elevated glucose. Am J Physiol. 1992;263: H321-H326.
78. Bohlen HG, Lash JM. Topical hyperglycemia rapidly suppresses EDRF-mediated vasodilation of normal rat arterioles. Am J Physiol. 1993;265: H219-H225.
79. Taylor PD, Poston L. The effect of hyperglycaemia on function of rat isolated mesenteric resistance artery. Br J Pharmacol. 1994;113: 801-808.
80. Mayhan WG, Patel KP. Acute effects of glucose on reactivity of cerebral microcirculation: role of protein kinase C. Am J Physiol. 1995;269: H1297-H1302.
81. Dorigo P, Fraccarollo D, Santostasi G, Maragno I. Impairment of endothelium-dependent but not endothelium-independent dilatation in guinea pig aorta rings incubated in the presence of elevated glucose. Br J Pharmacol. 1997;121:972-976.
82. Houben AJHM, Schaper NC, De Haan CHA, Huvers FC, Slaaf DW, DeLeeuw PW, Niewenhuijzen-Kruseman AC. Local 24-hr hyperglycemia does not affect endothelium-dependent or -independent vasoreactivity in humans. Am J Physiol. 1996;270:H2014-H2020.
83. Akbari C, Saouaf R, Barnhill D, Newman P, Logerfo F. Endothelium-dependent vasodilatation is impaired during acute hyperglycemia. Diabetes. 1997;46(suppl 1):114A. Abstract.
84. +) and nitric oxide synthase by elevated glucose and insulin in human endothelial cells. J Physiol. 1996;490: 775-781.
85. Graier WF, Wascher TC, Lackner L, Toplak H, Krejs GJ, Kukovetz WF. Exposure to elevated D-glucose concentration modulates vascular endothelial cell vasodilatatory responses. Diabetes. 1993;42:1497-1505.
86. Pieper GM, Dondlinger L. Glucose elevations alter bradykinin-stimulated intracellular calcium accumulation in cultured endothelial cells. Cardiovasc Res. 1997;34:169-178.
87. Magill SB, Dananberg J. Effects of hyperglycemia on vascular endothelium nitric oxide metabolism. In: Sowers JR, ed. Contemporary Endocrinology: Endocrinology of the Vasculature. Totowa, NJ: Humana Press Inc; 1996:145-156.
88. Salameh A, Dhein S. Influence of chronic high D-glucose exposure and long-term-blocker treatment on intracellular calcium concentrations of porcine aortic endothelial cells. Diabetes. 1998;47:407-413.
89. Kiff RJ, Gardiner SM, Comptom AM, Bennett T. Selective impairment of hindquarter vasodilator responses to bradykinin in conscious Wistar rats with streptozotocin-induced diabetes mellitus. Br J Pharmacol. 1991;103:1357-1362.
90. Alsip NL, Schuscnke DA, Miller FN. Microvascular responses in the skeletal muscle of the diabetic rat. J Lab Clin Med. 1996;128:429-437.
91. Wang SP, West MW, Dresner LS, Fleishhacker JF, Distant DA, Mueller CM, Wait RB. Effects of diabetes and uremia on mesenteric vascular reactivity. Surgery. 1996;120:328-336.
92. Mulhern M, Docherty JR. Effects of experimental diabetes on the responsiveness of rat aorta. Br J Pharmacol. 1989;97:1007-1012.
93. Wakabayashi I, Hatake K, Kimura N, Kakishita E, Nagai K. Modulation of vascular tonus by the endothelium in experimental diabetes. Life Sci. 1987;40:643-648.
94. Murray P, Pitt B, Webb RC. Ramipril prevents hypersensitivity to phenylephrine in aorta from streptozotocin-induced diabetic rats. Diabetologia. 1994;37:664-670.
95. Head RJ, Longhurst PA, Panek RL, Stitzel RE. A contrasting effect of the diabetic state upon the contractile responses of aortic preparations from the rat and rabbit. Br J Pharmacol. 1987;91:275-286.
96. Furman BL, Sneddon P. Endothelium-dependent vasodilator responses of the isolated mesenteric bed are preserved in long-term streptozotocin diabetic rats. Eur J Pharmacol. 1993;232:29-34.
97. Jaap AJ, Tooke JE. Pathophysiology of microvascular disease in non-insulin dependent diabetes. Clin Sci. 1995;89:3-12.
98. Ditzel J. Oxygen transport impairment in diabetes. Diabetes. 1976; 25(suppl 2):832-838.
99. Williamson JR, Chang K, Frangos M, Hasan KS, Ido Y, Kawamura K, Nyengaard JF, Van Den Enden M, Kilo C, Tilton RG. Hyperglycemic pseudohypoxia and diabetic complications. Diabetes. 1993;42:801-813.
100. Allison TB, Bruttig SP, Crass MF III, Eliot RS, Shipp JC. Reduced high-energy phosphate levels in rat hearts, I: effects of alloxan diabetes. Am J Physiol. 1976;230:1744-1750.
101. Santilli SM, Fiegel VD, Knighton DR. Alloxan diabetes alters the rabbit transarterial wall oxygen gradient. J Vasc Surg. 1991;18:227-233.
102. Bhardwaj R, Moore PK. Increased vasodilator response to acetylcholine of renal blood vessels from diabetic rats. J Pharm Pharmacol. 1988;40: 739-742.
103. Dai F-X, Diederich A, Skopec J, Diederich D. Diabetes-induced endothelial dysfunction in streptozotocin-treated rats: role of prostaglandin endoperoxides and free radicals. J Am Soc Nephrol. 1993;4:1327-1336.
104. Heygate KM, Davies J, Holmes M, James RFL, Thurston H. The effect of insulin treatment and of islet transplantation on the resistance artery function in the STZ-induced diabetic rat. Br J Pharmacol. 1996;119: 495-504.
105. Pieper GM. Alterations in reperfusion-stimulated prostacyclin release by the diabetic heart. In: Nagano M, Dhalla NS, eds. The Diabetic Heart. New York, NY: Raven Press Publishers; 1991:465-483.
106. 2 as an endothelium-derived contracting factor in diabetic state. Diabetes. 1993; 42:1246-1252.
107. Koltai MZ, Hadházy P, Pósa I, Kocsis E, Winkler G, Rösen P, Pogátsa G. Characteristics of coronary endothelial dysfunction in experimental diabetes. Cardiovasc Res. 1997;34:157-163.
108. Fujii K, Soma M, Huang YS, Manku MS, Horrobin DF. Increased release of prostaglandins from the mesenteric vascular bed in streptozotocin diabetes. Prog Lipid Res. 1986;25:499-501.
109. White RE, Carrier GO. Supersensitivity and endothelium dependency of histamine-induced relaxation in mesenteric arteries isolated from diabetic rats. Pharmacology. 1986;33:34-38.
110. Mayhan WG. Impairment of endothelium-dependent dilatation of the basilary artery during diabetes mellitus. Brain Res. 1992;580:297-302.
111. Gebremedhin D, Koltai M, Pogátsa G, Magyar K, Hadházy P. Altered responsiveness of diabetic dog renal arteries to acetylcholine and phenylephrine: role of endothelium. Pharmacology. 1989;38:177-184.
112. Kamata K, Kobayashi T. Changes in superoxide dismutase mRNA expression by streptozotocin-induced diabetes. Br J Pharmacol. 1996; 119:583-589.
113. Pieper GM, Langenstroer P, Siebeneich W. Diabetic-induced endothelial dysfunction in rat aorta: role of hydroxyl radicals. Cardiovasc Res. 1997;34:145-156.
114. Pieper GM, Mei DA, Langenstroer P, O'Rourke ST. Bioassay of endothelium-derived relaxing factor in diabetic rat aorta. Am J Physiol. 1992;263:H676-H680.
115. Taylor PD, Oon BB, Thomas CR, Poston L. Prevention by insulin treatment of endothelial dysfunction but enhanced noradrenaline-induced contractility in mesenteric resistance arteries from streptozotocin-induced diabetic rats. Br J Pharmacol. 1994;11:35-41.
116. Olbrich A, Rösen P, Hilgers R-D, Dhein S. Fosinopril improves regulation of vascular tone in mesenteric bed of diabetic rats. J Cardiovasc Pharmacol. 1996;27:187-194.
117. Rösen P, Ballhausen T, Stockklauser K. Impairment of endothelium dependent relaxation in the diabetic rat heart: mechanisms and implications. Diabetes Res Clin Pract. 1996;31(suppl):S143-S155.
118. Knock GA, McCarthy AL, Lowy C, Poston L. Association of gestational diabetes with abnormal maternal vascular endothelial function. Br J Obstet Gynaecol. 1997;104:229-234.
119. Cohen RA, Vanhoutte PM. Endothelium-dependent hyperpolarization: beyond nitric oxide and cyclic GMP. Circulation. 1995;92:3337-3349.
120. Campbell WB, Gebremedhin D, Pratt PF, Harder DR. Identification of epoxyeicosatrienoic acids as endothelium-derived hyperpolarizing factors. Circ Res. 1996;78:415-423.
121. Kamata K, Miyata N, Kasuya Y. Functional changes in potassium channels in aortas from rats with streptozotocin-induced diabetes. Eur J Pharmacol. 1989;166:319-323.
122. + channels, in the aorta from streptozocin-treated diabetic rats. Naunyn Schmiedebergs Arch Pharmacol. 1997;356:210-215.
123. Mayhan WG. Effects of diabetes mellitus on response of the basilar artery to activation of ATP-sensitive potassium channels. Brain Res. 1994;636:35-39.
124. Miyata N, Yamaura H, Tsuchida K, Otomo S, Kamata K, Kasuya Y. Changes in responsiveness of the aorta to vasorelaxant agents in genetically diabetic rats: a study in WBN/KOB rats. Life Sci. 1992;50: 1363-1369.
125. Kersten JR, Brooks LA, Dellsperger KC. Impaired microvascular response to graded coronary occlusion in diabetic and hyperglycemic dogs. Am J Physiol. 1995;268:H1667-H1674.
126. Endo K, Abiru T, Machida H, Kasuya Y, Kamata K. Endothelium-derived hyperpolarizing factor does not contribute to the decrease in endothelium-dependent relaxation in the aorta of streptozotocin-induced diabetic rats. Gen Pharmacol. 1995;26:149-153.
127. Pieper GM, Dondlinger LA. Plasma and vascular tissue arginine are decreased by diabetes: acute arginine supplementation restores endothelium-dependent relaxation by augmenting cGMP production. J Pharmacol Exp Ther. 1997;283:684-691.
128. Kamata K, Hosokawa M. Endothelial dysfunction in the perfused kidney from the streptozotocin-induced diabetic rat. Res Commun Mol Pathol Pharmacol. 1997;96:57-70.
129. Contreras R, Fuentes O, Mann GE, Sobrevia L. Diabetes and insulin-induced stimulation of L-arginine transport and nitric oxide synthesis in rabbit isolated gastric glands. J Physiol (Lond). 1997;498:787-796.
130. + and nitric oxide synthase in human endothelial cells: association with membrane hyperpolarization. J Physiol (Lond). 1995;489:183-192.
131. Fukao M, Hattori Y, Kanno M, Sakuma I, Kitabake A. Alterations in endothelium-dependent hyperpolarization and relaxation in mesenteric arteries from streptozotocin-induced diabetic rats. Br J Pharmacol. 1997;121:1383-1391.
132. Ohishi K, Carmines PK. Superoxide dismutase restores the influence of nitric oxide on renal arterioles in diabetes mellitus. J Am Soc Nephrol. 1995;5:1559-1566.
133. Langenstroer P, Pieper GM. Regulation of spontaneous EDRF release in diabetic rat aorta by oxygen free radicals. Am J Physiol. 1992;263: H257-H265.
134. Sikorski BW, James GM, Glance SD, Hodgson WC, King RG. Effect of endothelium on diabetes-induced changes in constrictor responses mediated by 5-hydroxytryptamine in rat aorta. J Cardiovasc Pharmacol. 1993;22:423-430.
135. Chang KC, Chung SY, Chong WS, Sun JS, Kim SH, Noh HK, Seong BW, Ko HJ, Chun KW. Possible superoxide radical-induced alteration of vascular reactivity in aortas from streptozotocin-treated rats. J Pharmacol Exp Ther. 1993;266:992-1000.
136. Abiru T, Kamata K, Kasuya Y. Attenuation of depressor response induced by platelet activating factor and acetylcholine in streptozotocin-induced diabetic rats. J Pharmacobiol Dyn. 1991;14:293-300.
137. Tada H, Muramatsu I, Nakai T, Kigoshi S, Miyabo S. Effects of chronic diabetes on the responsiveness to endothelin-1 and other agents of rat atria and thoracic aorta. Gen Pharmacol. 1994;25:1221-1228.
138. Pieper GM, Peltier BA. Amelioration by L-arginine of a dysfunctional arginine/nitric oxide pathway in diabetic endothelium. J Cardiovasc Pharmacol. 1995;25:397-403.
139. Pieper GM. Acute amelioration of diabetic endothelial dysfunction with a derivative of the nitric oxide synthase cofactor, tetrahydrobiopterin. J Cardiovasc Pharmacol. 1997;29:8-15.
140. El-Kashef H. Hyperglycemia increased the responsiveness of isolated rabbits pulmonary arterial rings to serotonin. Pharmacology. 1996;53: 151-159.
141. Omawari N, Dewhurst M, Vo P, Mahmood S, Stevens E, Tomlinson DR. Deficient nitric oxide responsible for reduced nerve blood flow in diabetic rats: effects of L-NAME, L-arginine, sodium nitroprusside and evening primrose oil. Br J Pharmacol. 1996;118:186-190.
142. Komers R, Allen TJ, Cooper ME. Role of endothelium-derived nitric oxide in the pathogenesis of the renal hemodynamic changes of experimental diabetes. Diabetes. 1994;43:1190-1197.
143. G-nitro-L-arginine methyl ester in spontaneously diabetic rats. Br J Pharmacol. 1996;118:243-248.
144. Kamata K, Kondoh H. Impairment of endothelium-dependent relaxation of the isolated basilar artery from streptozotocin-induced diabetic rats. Res Commun Mol Pathol Pharmacol. 1996;94:239-249.
145. G-nitro-L-arginine methyl ester in streptozotocin-induced diabetes mellitus. Br J Pharmacol. 1992;106:1035-1040.
146. Mayer B, Brunner F, Schmidt K. Inhibition of nitric oxide synthesis by methylene blue. Biochem Pharmacol. 1993;45:367-374.
147. Wolin MS, Cherry PD, Rodenberg JM, Messina EJ, Kaley G. Methylene blue inhibits vasodilation of skeletal muscle arterioles to acetylcholine and nitric oxide via the extracellular generation of superoxide anion. J Pharmacol Exp Ther. 1990;254:872-876.
148. Pieper GM, Siebeneich W. Use of a nitronyl nitroxide to discriminate the contribution of nitric oxide radical in endothelium-dependent relaxation of control and diabetic blood vessels. J Pharmacol Exp Ther. 1997;283:138-147.
149. 2+ discriminates basal vs agonist-stimulated nitric oxide activity in control vs diabetic rat aorta. Pharmacologist. 1997;39:52. Abstract.
150. Tesfamariam B, Palacino JJ, Weisbrod RM, Cohen RA. Aldose reductase inhibition restores endothelial cell function in diabetic rabbit aorta. J Cardiovasc Pharmacol. 1993;21:205-211.
151. Pieper GM, Siebeneich W, Dondlinger LA. Short-term oral administration of L-arginine reverses defective endothelium-dependent relaxation and cGMP generation in diabetes. Eur J Pharmacol. 1996; 317:317-320.
152. Miller MAW, Morgan RJ, Thompson CS, Mikhailidis DP, Jeremy JY. Adenylate and guanylate cyclase activity in the penis and aorta of the diabetic rat: an in vitro study. Br J Urol. 1994;74:106-111.
153. Wang Y-X, Brooks DP, Edwards RM. Attenuated glomerular cGMP production and renal vasodilation in streptozotocin-induced diabetic rats. Am J Physiol. 1993;264:R952-R956.
154. Craven PA, Studer RK, DeRubertis FR. Impaired nitric oxide-dependent cyclic guanosine monophosphate generation in glomeruli from diabetic rats: evidence for protein kinase C-mediated suppression of the cholinergic response. J Clin Invest. 1994;93:311-320.
155. Mattar AL, Fujihara CK, Ribeiro MO, de Nucci G, Zatz R. Renal effects of acute and chronic nitric oxide inhibition in experimental diabetes. Nephron. 1996;74:136-143.
156. Tolins JP, Shultz PJ, Raij L, Brown DM, Mauer SM. Abnormal renal hemodynamic response to reduced renal perfusion pressure in diabetic rats: role of NO. Am J Physiol. 1993;265:F886-F895.
157. Goor Y, Peer G, Iaina A, Blum M, Wollman Y, Chernihovsky T, Silverberg D, Cabili S. Nitric oxide in ischaemic acute renal failure of streptozotocin diabetic rats. Diabetologia. 1996;39:1036-1040.
158. Bank N, Aynedjian HS. Role of EDRF (nitric oxide) in diabetic renal hyperfiltration. Kidney Int. 1993;43:1306-1312.
159. Reyes AA, Karl IE, Kissane J, Klahr S. L-Arginine administration prevents glomerular hyperfiltration and decreases proteinuria in diabetic rats. J Am Soc Nephrol. 1993;4:1039-1045.
160. Zuccollo A, Navarro M, Prendes GM, Dominguez A, Catanzaro OL. Effects of HOE 140 on some renal functions in type I diabetic mice. Arch Physiol Biochem. 1996;104:252-254.
161. Maree A, Peer G, Iaina A, Blum M, Wollman Y, Csernihovsky T, Silverberg D, Cabili S. Nitric oxide in streptozotocin-induced diabetes mellitus in rats. Clin Sci. 1996;90:379-384.
162. Kwon NS, Lee SH, Choi CS, Kho T, Lee HS. Nitric oxide generation from streptozotocin. FASEB J. 1994;8:529-533.
163. Schmetterer L, Findl O, Fasching P, Ferber W, Strenn K, Breiteneder H, Adam H, Eichler H-G, Wolzt M. Nitric oxide and ocular blood flow in patients with IDDM. Diabetes. 1997;46:653-658.
164. Smits P, Hersbach FMRJ, Jansen TLTA, Thien T, Lutterman JA. Impaired vasodilator response to atrial natriuretic factor in IDDM. Diabetes. 1993;42:1454-1461.
165. Schmidt RE, Dorsey DA, McDaniel ML, Corbett JA. Characterization of NADPH diaphorase activity in rat sympathetic autonomic ganglia: effect of diabetes and aging. Brain Res. 1993;617:343-348.
166. Yagihashi N, Nishida N, Seo HG, Taniguchi N, Yagihashi S. Expression of nitric oxide synthase in macula densa in streptozotocin diabetic rats. Diabetologia. 1996;39:793-799.
167. dp (type II) rats with erectile dysfunction. Endocrinology. 1995;136:5709-5717.
168. Schönfelder G, John M, Hopp H, Fuhr N, Van Der Giet M, Paul M. Expression of inducible nitric oxide synthase in placenta of women with gestational diabetes. FASEB J. 1996;10:777-784.
169. Choi KC, Kim NH, An MR, Kang DG, Kim SW, Lee J-U. Alterations of intrarenal renin-angiotensin and nitric oxide systems in streptozotocin-induced diabetic rats. Kidney Int. 1997;53(suppl 60):S-23-S-27.
170. Cosentino F, Hishikawa K, Katusic ZS, Lüscher TF. High glucose increases nitric oxide synthase expression and superoxide anion generation in human aortic endothelial cells. Circulation. 1997;96:25-28.
171. Mancusi G, Hutter C, Baumgartner-Parzer S, Schmidt K, Schütz W, Sexl V. High-glucose incubation of human umbilical vein endothelial cells does not alter expression and function of G-protein-subunits or of endothelial NO synthase. Biochem J. 1996;315:281-287.
172. Wu G, Meininger CJ. Impaired arginine metabolism and NO synthesis in coronary endothelial cells of the spontaneously diabetic BB rat. Am J Physiol. 1995;269:H1312-H1318.
173. Mans AM, DeJoseph MR, Davis DW, Hawkins RA. Regional amino acid transport into brain during diabetes: effect of plasma amino acids. Am J Physiol. 1987;253:E575-E583.
174. Pieper GM, Jordan M, Adams MB, Roza AM. Syngeneic pancreatic islet transplantation reverses endothelial dysfunction in experimental diabetes. Diabetes. 1995;33:1106-1113.
175. Grill V, Björkman O, Gutniak M, Lindqvist M. Brain uptake and release of amino acids in nondiabetic and insulin-diabetic subjects: important role of glutamine release for nitrogen balance. Metabolism. 1992;41: 28-32.
176. Hagenfeldt L, Dahlquist G, Persson B. Plasma amino acids in relation to metabolic control in insulin-dependent diabetic children. Acta Pædiatr Scand. 1989;794:278-282.
177. Felig P, Marliss E, Ohman JL, Cahill GF Jr. Plasma amino acid levels in diabetic ketoacidosis. Diabetes. 1970;19:727-729.
178. Smulders RA, Stehower CDA, Olthof CG, Van Kamp GJ, Teerlink T, DeVries PMJM, Donker AJM. Plasma endothelin levels and vascular effects of intravenous L-arginine infusion in subjects with uncomplicated insulin-dependent diabetes mellitus. Clin Sci. 1994;87:37-43.
179. Pieper GM, Adams MB, Roza AM. Pancreas transplantation reverses endothelial dysfunction in experimental diabetes mellitus. Surgery. 1998;123:89-95.
180. Pieper GM, Siebeneich W, Moore-Hilton G, Roza AM. Reversal by L-arginine of a dysfunctional arginine/nitric oxide pathway in the endothelium of the genetic diabetic BB rat. Diabetologia. 1997;40: 910-915.
181. Archibald V, Cotter MA, Keegan A, Cameron NE. Contraction and relaxation of aortas from diabetic rats: effects of chronic anti-oxidant and aminoguanidine treatments. Naunyn Schmiedebergs Arch Pharmacol. 1996;353:584-591.
182. Tilton RG, Chang K, Hasan KS, Smith SR, Petrash JM, Misko TP, Moore WM, Currie MG, Corbett JA, McDaniel ML, Williamson JR. Prevention of diabetic vascular dysfunction by guanidines: inhibition of nitric oxide synthase versus advanced glycation end-product formation. Diabetes. 1993;42:221-232.
183. Preik-Steinhoff H, Zink S, Rösen P, Kelm M. Transport of L-arginine in arginine-deprived endothelial cells. Biochem Biophys Res Commun. 1995;213:447-453.
184. Arnal JF, Münzel T, Venema RC, James NL, Bai C, Mitch WE, Harrison DG. Interactions between L-arginine and L-glutamine change endothelial NO production: an effect independent of NO synthase substrate availability. J Clin Invest. 1995;95:2565-2572.
185. Morgan DML, Baydoun AR. Polyamine transport and arginine pool size in vascular endothelial cells. Biochem Soc Trans. 1994;22:387S.
186. Kihara M, Low PA. Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy. Exp Neurol. 1995;132:180-185.
187. Graier WR, Simecek S, Wascher TC, Kukovetz WR, Kostner GM. Bidirectional effects of glycated LDL on endothelial vascular function. Circulation. 1994;90(suppl I):I-29. Abstract.
188. Mayhan WG, Didion SP, Patel KP. L-Arginine does not restore dilatation of the basilar artery during diabetes mellitus. J Cereb Blood Flow Metab. 1996;16:500-506.
189. Mayhan WG, Patel KP, Sharpe GM. Effect of L-arginine on reactivity of hamster cheek pouch arterioles during diabetes mellitus. Int J Microcirc. 1997;17:107-112.
190. Girerd V, Hirsch AT, Cooke JP, Dzau VJ, Creager MA. L-Arginine augments endothelium-dependent vasodilation in cholesterol-fed rabbits. Circ Res. 1990;67:1301-1308.
191. Mügge A, Harrison DG. L-Arginine does not restore endothelial dysfunction in atherosclerotic rabbit aorta in vitro. Blood Vessels. 1991;28: 354-357.
192. Kitazono T, Faraci FM, Heistad DD. L-Arginine restores dilator responses of the basilar artery to acetylcholine during chronic hypertension. Hypertension. 1996;27:893-896.
193. Mayhan WG, Rubinstein I. Acetylcholine induces vasoconstriction in the microcirculation of cardiomyopathic hamsters: reversal by L-arginine. Biochem Biophys Res Commun. 1992;184:1372-1377.
194. Durante W, Liao L, Iftikhar I, O'Brien WE, Schafer AI. Differential regulation of L-arginine transport and nitric oxide production by vascular smooth muscle and endothelium. Circ Res. 1996;78:1075-1082.
195. Inoguchi T, Battan R, Handler E, Sportsman JR, Heath W, King GL. Preferential elevation of protein kinase C isoform beta II and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. Proc Natl Acad Sci USA. 1992;89:11059-11063.
196. Kunisaki M, Bursell S-E, Umeda F, Nawata H, King GL. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels. Diabetes. 1994;43:1372-1377.
197. Pelligrino DA, Koenig HM, Wang Q, Albrecht RF. Protein kinase C suppresses receptor-mediated pial arteriolar relaxation in the diabetic rat. Neuroreport. 1994;5:417-420.
198. Rivera-Correa M, Altieri PI, Escobales N. Parallel regulation of arginine transport and nitric oxide synthesis by angiotensin II in vascular smooth muscle cells: role of protein kinase C. Amino Acids. 1996;11:153-170.
199. Craven PA, Studer RK, DeRubertis FR. Impaired nitric oxide release by glomeruli from diabetic rats. Metabolism. 1995;44:695-698.
200. Das UN, Mohan IK, Kumar KV, Kumar GS, Sekhar CC. Beneficial effect of L-arginine in non-insulin dependent diabetes mellitus: a potential role for nitric oxide. Med Sci Res. 1993;21:669-670.
201. Schmidt HHHW, Warner TD, Ishii K, Sheng H, Murad F. Insulin secretion from pancreatic B cells caused by L-arginine-derived nitrogen oxide. Science. 1992;255:721-723.
202. Giugliano D, Marfella R, Verrazzo G, Acampora R, Nappor F, Ziccardi P, Coppola L, D'Onofrio F. L-Arginine for testing endothelium-dependent vascular functions in health and disease. Am J Physiol. 1997;273(Endocrinol Metab 36):E606-E612.
203. Steinberg HO, Brechtel G, Johnson A, Fineberg N, Baron AD. Insulin-mediated skeletal muscle vasodilation is nitric oxide dependent: a novel action of insulin to increase nitric oxide release. J Clin Invest. 1994;94:1172-1179.
204. Scherrer U, Randin D, Vollenweider P, Vollenweider L, Nicod P. Nitric oxide release accounts for insulin's vascular effects in humans. J Clin Invest. 1994;94:2511-2515.
205. Chen Y-L, Messina EJ. Dilation of isolated skeletal muscle arterioles by insulin is endothelium dependent and nitric oxide mediated. Am J Physiol. 1996;270:H2120-H2124.
206. McKay MK, Hester RL. Role of nitric oxide, adenosine, and ATP-sensitive potassium channels in insulin-induced vasodilation. Hypertension. 1996;28:202-208.
207. Chowienczyk PJ, Barnes DJ, Brett SE, Cockcroft JR, Viberti GC, Ritter JM. Correction of impaired NO-mediated vasodilation by L-arginine in non-insulin dependent diabetics. Endothelium. 1995;3:955. Abstract.
208. MacAllister RJ, Calver AL, Collier J, Edwards CM, Herreros B, Nussey SS, Vallance P. Vascular and hormonal responses to arginine: provision of substrate for nitric oxide or non-specific effect? Clin Sci. 1995;89: 183-190.
209. Wascher TC, Graier WF, Dittrich P, Hussain MA, Bahadori B, Wallner S, Toplak H. Effects of low-dose L-arginine on insulin-mediated vasodilation and insulin sensitivity. Eur J Clin Invest. 1997;27:690-695.
210. Riedel MW, Anneser F, Haberl RL. Different mechanisms of L-arginine-induced dilation of brain arterioles in normotensive and hypertensive rats. Brain Res. 1995;671:21-26.
211. Koller A, Sun D, Messina EJ, Kaley G. L-Arginine analogues blunt prostaglandin-related dilation of arterioles. Am J Physiol. 1993;264: H1194-H1199.
212. + channels. Am J Physiol. 1996;271:H1498-H1506.
213. Wascher TC, Bachernegg M, Kickenweiz E, Stark G, Stark U, Toplak H, Graier WF, Krejs GJ. Elevation of D-glucose impairs coronary artery autoregulation after slight reduction of coronary flow. Eur J Clin Invest. 1995;25:590-594.
214. Gupta S, Sussman I, McArthur CS, Tornheim K, Cohen RA, Ruderman NB. Endothelium-dependent inhibition of NaKATPase activity in rabbit aorta by hyperglycemia: possible role of endothelium-derived nitric oxide. J Clin Invest. 1992;90:727-732.
215. Lubec B, Hayn M, Kitzmüller E, Vierhapper H, Lubec G. L-Arginine reduces lipid peroxidation in patients with diabetes mellitus. Free Radic Biol Med. 1997;22:355-357.
216. Wascher TC, Posch K, Wallner S, Hermetter A, Kostner GM, Graier WF. Vascular effects of L-arginine: anything beyond a substrate for the NO-synthase? Biochem Biophys Res Commun. 1997;234:35-38.
217. Demiryürek AT, Kennedy S, Wainwright CL, Wadsworth RM, Kane KA. Influence of nitric oxide on luminol-enhanced chemiluminescence measured from porcine-stimulated leukocytes. J Cardiovasc Pharmacol. 1997;30:332-337.
218. Radner W, Höger H, Lubec B, Salzer H, Lubec G. L-Arginine reduces kidney collagen accumulation and N-(carboxymethyl)lysine in the aging NMRI-mouse. J Gerontol. 1994;49:M44-M46.
219. Khaidar A, Marx M, Lubec B, Lubec G. L-Arginine reduces heart collagen accumulation in the diabetic db/db mouse. Circulation. 1994; 90:479-483.
220. Weninger M, Zi Z, Lubec B, Szalay S, Höger H, Lubec G. L-Arginine reduces glomerular basement membrane collagen N-carboxymethyllysine in the diabetic db/db mouse. Nephron. 1992;62:80-83.
221. Servetnick DA, Bryant D, Wells-Knecht KJ, Wiesenfeld PL. L-Arginine inhibits in vitro nonenzymatic glycation and advanced glycosylated end product formation of human serum albumin. Amino Acids. 1996;11: 69-81.